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药物分析学报（英文）
西安交通大学
药物分析学报（英文）

西安交通大学

双月刊

2095-1779

jpa2011@126.com

029-82655433

710061

西安市雁塔西路76号

药物分析学报（英文）/Journal Journal of Pharmaceutical AnalysisCSCD北大核心SCI
查看更多>>《药物分析学报（英文）》（Journal of Pharmaceutical Analysis，简称JPA），2011年创刊，双月刊，为大16开本，系教育部主管、西安交通大学主办的药物分析专业英文期刊。JPA以搭建高水平的国际学术交流平台、创办具有国际影响力的高水平的专业学术期刊为办刊宗旨。主要报道药物分析新方法、新技术，药品质量控制和用药安全等最新研究成果。创刊之初与Elsevier国际出版集团合作，已组建国际化编委会，采用EVISE投稿审稿系统，开放获取，通过ScienceDirect平台在线向全球读者开放阅读，实现稿源国际化、同行评议国际化、出版国际化和读者国际化。
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    AI comes to the Nobel Prize and drug discovery

    Ying ZhouYintao ZhangZhichao ZhangZhimeng Zhou...
    1539-1541页
      原文链接:
    • 万方数据
    • 维普

    Green analytical chemistry metrics for evaluating the greenness of analytical procedures

    Lei YinLuyao YuYingxia GuoChuya Wang...
    1542-1555页
    查看更多>>摘要：Green analytical chemistry(GAC)focuses on mitigating the adverse effects of analytical activities on human safety,human health,and environment.In addition to the 12 principles of GAC,proper GAC tools should be developed and employed to assess the greenness of different analytical assays.The 15 widely used GAC metrics,i.e.,national environmental methods index(NEMI),advanced NEMI,assessment of green profile(AGP),chloroform-oriented toxicity estimation scale(ChlorTox Scale),Analytical Eco-Scale,Green Certificate Modified Eco-Scale,analytical method greenness score(AMGS),green analytical pro-cedure index(GAPI),ComplexGAPI,red-green-blue(RGB)additive color model,RGB 12 algorithm,analytical greenness calculator(AGREE),AGREE preparation(AGREEprep),HEXAGON,and blue appli-cability grade index(BAGI),are selected as the typical tools.This article comprehensively presents and elucidates the principles,characteristics,merits,and demerits of 15 widely used GAC tools.This review is helpful for researchers to use the current GAC metrics to assess the environmental sustainability of analytical assays.
      原文链接:
    • 万方数据
    • 维普

    A holistic visualization for quality of Chinese materia medica:Structural and metabolic visualization by magnetic resonance imaging

    Jing WuKai ZhongHongyi YangPeiliang Zhang...
    1556-1566页
    查看更多>>摘要：The quality of Chinese materia medica(CMM)is a challenging and focused topic in the modernization of traditional Chinese medicine(TCM).A profound comprehension of the morphology,structure,active constituents,and dynamic changes during the whole process of CMM growth is essential,which needs highly precise contemporary techniques for in-depth elucidation.Magnetic resonance imaging(MRI)is a cutting-edge tool integrating the benefits of both nuclear magnetic resonance(NMR)spectroscopy and imaging technology.With real-time,non-destructive,and in situ detection capabilities,MRI has been previously used for monitoring internal and external structures of plants alongside compounds during physiological processes in vivo.Here,factors involved in the holistic quality evaluation of CMMs were investigated.Given the applications of MRI in various plants,several representative CMMs were used as examples to demonstrate a methodology of quality visualization by MRI,embodying holistically monitoring the real-time macroscopic morphology,mesoscopic structure,and microscopic metabolites non-destructively in situ.Taken together,the review not only presents a pioneering application mode for uti-lizing MRI for CMM quality visualization but also holds promise for advancing the quality control and evaluation of CMMs.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury

    Kai YangPing ZhangJixin LiGenming Zhang...
    1567-1587页
    查看更多>>摘要：Myocardial injury(MI)is a common occurrence in clinical practice caused by various factors such as ischemia,hypoxia,infection,metabolic abnormalities,and inflammation.Such damages are character-ized by a reduction in myocardial function and cardiomyocyte death that can result in dangerous out-comes such as cardiac failure and arrhythmias.An endoplasmic reticulum stress(ERS)-induced unfolded protein response(UPR)is triggered by several stressors,and its intricate signaling networks are instrumental in both cell survival and death.Cardiac damage frequently triggers ERS in response to different types of injuries and stress.High levels of ERS can exacerbate myocardial damage by inducing necrosis and apoptosis.To target ERS in MI prevention and treatment,current medical research is focused on identifying effective therapy approaches.Traditional Chinese medicine(TCM)is frequently used because of its vast range of applications and low risk of adverse effects.Various studies have demonstrated that active components of Chinese medicines,including polyphenols,saponins,and al-kaloids,can reduce myocardial cell death,inflammation,and modify the ERS pathway,thus preventing and mitigating cardiac injury.Thus,this paper aims to provide a new direction and scientific basis for targeting ERS in MI prevention and treatment.We specifically summarize recent research progress on the regulation mechanism of ERS in MI by active ingredients of TCM.
      原文链接:
    • 万方数据
    • 维普

    SnoRNAs:The promising targets for anti-tumor therapy

    Xiaoyun HuWanlin CuiMin LiuFangxiao Zhang...
    1588-1602页
    查看更多>>摘要：Recently,small nucleolar RNAs(snoRNAs)have transcended the genomic"noise"to emerge as pivotal molecular markers due to their essential roles in tumor progression.Substantial evidence indicates a strong association between snoRNAs and critical clinical features such as tumor pathology and drug resistance.Historically,snoRNA research has concentrated on two classical mechanisms:2'-O-ribose methylation and pseudouridylation.This review specifically summarizes the novel regulatory mecha-nisms and functional patterns of snoRNAs in tumors,encompassing transcriptional,post-transcriptional,and post-translational regulation.We further discuss the synergistic effect between snoRNA host genes(SNHGs)and snoRNAs in tumor progression.More importantly,snoRNAs extensively contribute to the development of tumor cell resistance as oncogenes or tumor suppressor genes.Accordingly,we provide a comprehensive review of the clinical diagnosis and treatment associated with snoRNAs and explore their significant potential as novel drug targets.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Recent trends and impact of localized surface plasmon resonance(LSPR)and surface-enhanced Raman spectroscopy(SERS)in modern analysis

    Bibhu Prasad NandaPriyanka RaniPriyanka PaulAman...
    1603-1624页
    查看更多>>摘要：An optical biosensor is a specialized analytical device that utilizes the principles of optics and light in bimolecular processes.Localized surface plasmon resonance(LSPR)is a phenomenon in the realm of nanophotonics that occurs when metallic nanoparticles(NPs)or nanostructures interact with incident light.Conversely,surface-enhanced Raman spectroscopy(SERS)is an influential analytical technique based on Raman scattering,wherein it amplifies the Raman signals of molecules when they are situated near specific and specially designed nanostructures.A detailed exploration of the recent ground-breaking developments in optical biosensors employing LSPR and SERS technologies has been thoroughly discussed along with their underlying principles and the working mechanisms.A biosensor chip has been created,featuring a high-density deposition of gold nanoparticles(AuNPs)under varying ligand concentration and reaction duration on the substrate.An ordinary description,along with a visual illustration,has been thoroughly provided for concepts such as a sensogram,refractive index shift,surface plasmon resonance(SPR),and the evanescent field,Rayleigh scattering,Raman scattering,as well as the electromagnetic enhancement and chemical enhancement.LSPR and SERS both have advantages and disadvantages,but widely used SERS has some advantages over LSPR,like chemical specificity,high sensitivity,multiplexing,and versatility in different fields.This review confirms and elucidates the significance of different disease biomarker identification.LSPR and SERS both play a vital role in the detection of various types of cancer,such as cervical cancer,ovarian cancer,endometrial cancer,prostate cancer,colorectal cancer,and brain tumors.This proposed optical biosensor offers potential applications for early diagnosis and monitoring of viral disease,bacterial infectious diseases,fungal diseases,diabetes,and cardiac disease biosensing.LSPR and SERS provide a new direction for environmental monitoring,food safety,refining impurities from water samples,and lead detection.The understanding of these biosensors is still limited and challenging.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats

    Junping ZhuYe LinGejing LiYini He...
    1625-1644页
    查看更多>>摘要：Rheumatoid arthritis(RA)is a prevalent autoimmune disease characterized by chronic inflammation and excessive proliferation of the synovium.Currently,treatment options focus on either reducing inflam-mation or inhibiting synovial hyperplasia.However,these modalities are unsatisfactory in achieving the desired therapeutic outcomes.Halofuginone hydrobromide(HF),an herbal active ingredient,has demonstrated pharmacological effects of both anti-inflammation and inhibition of synovial hyperplasia proliferation.However,HF's medical efficacy is limited due to its poor water solubility,short half-life(ti/2),and non-target toxicity.In the current study,by using the advantages of nanotechnology,we presented a novel dual-targeted nanocomplex,termed HA-M@P@HF NPs,which consisted of a hyaluronic acid(HA)-modified hybrid membrane(M)-camouflaged poly lactic-co-glycolic acid(PLGA)nanosystem for HF delivery.These nanocomplexes not only overcame the limitations of HF but also achieved simultaneous targeting of inflammatory macrophages and human fibroblast-like synoviocytes-RA(HFLS-RA).In vivo experiments demonstrated that these nanocomplexes effectively suppressed immune-mediated inflam-mation and synovial hyperplasia,safeguarding against bone destruction in rats with adjuvant-induced arthritis(AIA).Remarkable anti-arthritic effects of these nanocomplexes were accomplished through promoting repolarization of M1-to-M2 macrophages and apoptosis of HFLS-RA,thereby offering a promising therapeutic strategy for RA.
      原文链接:
    • 万方数据
    • 维普

    Machine learning-driven optimization of mRNA-lipid nanoparticle vaccine quality with XGBoost/Bayesian method and ensemble model approaches

    Ravi MaharjanKi Hyun KimKyeong LeeHyo-Kyung Han...
    1645-1660页
    查看更多>>摘要：To enhance the efficiency of vaccine manufacturing,this study focuses on optimizing the microfluidic conditions and lipid mix ratios of messenger RNA-lipid nanoparticles(mRNA-LNP).Different mRNA-LNP formulations(n=24)were developed using an I-optimal design,where machine learning tools(XGBoost/Bayesian optimization and self-validated ensemble(SVEM))were used to optimize the process and predict lipid mix ratio.The investigation included material attributes,their respective ratios,and process attributes.The critical responses like particle size(PS),polydispersity index(PDI),Zeta potential,pKa,heat trend cycle,encapsulation efficiency(EE),recovery ratio,and encapsulated mRNA were eval-uated.Overall prediction of SVEM(＞97％)was comparably better than that of XGBoost/Bayesian opti-mization(＞94％).Moreover,in actual experimental outcomes,SVEM prediction is close to the actual data as confirmed by the experimental PS(94-96 nm)is close to the predicted one(95-97 nm).The other parameters including PDI and EE were also close to the actual experimental data.
      原文链接:
    • 万方数据
    • 维普

    Depression of Cav1.2 activation and expression in mast cells ameliorates allergic inflammation diseases

    Yongjing ZhangYingnan ZengHaoyun BaiWen Zhang...
    1661-1674页
    查看更多>>摘要：Allergic inflammation is closely related to the activation of mast cells(MCs),which is regulated by its intracellular Ca2+level,but the intake and effects of the intracellular Ca2+remain unclear.The Ca2+influx is controlled by members of Ca2+channels,among which calcium voltage-gated channel subunit alpha1 C(Cav1.2)is the most robust.This study aimed to reveal the role and underlying mechanism of MC Cav1.2 in allergic inflammation.We found that Cav1.2 participated in MC activation and allergic inflammation.Nimodipine(Nim),as a strong Cav1.2-specific antagonist,ameliorated allergic inflammation in mice.Further,Cav1.2 activation in MC was triggered by phosphatizing at its Ser1928 through protein kinase C(PKC),which calcium/calmodulin-dependent protein kinase Ⅱ(CaMKⅡ)catalyzed.Overexpression or knockdown of MC Cav1.2 influenced MC activation.Importantly,Cav1.2 expression in MC had detrimental effects,while its deficiency ameliorated allergic pulmonary inflammation.Results provide novel insights into Cav1.2 function and a potential drug target for controlling allergic inflammation.
      原文链接:
    • 万方数据
    • 维普

    Comparative study of trastuzumab modification analysis using mono/multi-epitope affinity technology with LC-QTOF-MS

    Chengyi ZuoJingwei ZhouSumin BianQing Zhang...
    1675-1685页
    查看更多>>摘要：Dynamic tracking analysis of monoclonal antibodies(mAbs)biotransformation in vivo is crucial,as certain modifications could inactivate the protein and reduce drug efficacy.However,a particular chal-lenge(i.e.immune recognition deficiencies)in biotransformation studies may arise when modifications occur at the paratope recognized by the antigen.To address this limitation,a multi-epitope affinity technology utilizing the metal organic framework(MOF)@Au@peptide@aptamer composite material was proposed and developed by simultaneously immobilizing complementarity determining region(CDR)mimotope peptide(HH24)and non-CDR mimotope aptamer(CH1S-6T)onto the surface of MOF@Au nanocomposite.Comparative studies demonstrated that MOF@Au@peptide@aptamer exhibited signifi-cantly enhanced enrichment capabilities for trastuzumab variants in comparison to mono-epitope af-finity technology.Moreover,the higher deamidation ratio for LC-Asn-30 and isomerization ratio for HC-Asn-55 can only be monitored by the novel bioanalytical platform based on MOF@Au@peptide@aptamer and liquid chromatography-quadrupole time of flight-mass spectrometry(LC-QTOF-MS).Therefore,multi-epitope affinity technology could effectively overcome the biases of traditional affinity materials for key sites modification analysis of mAb.Particularly,the novel bioanalytical platform can be suc-cessfully used for the tracking analysis of trastuzumab modifications in different biological fluids.Compared to the spiked phosphate buffer(PB)model,faster modification trends were monitored in the spiked serum and patients'sera due to the catalytic effect of plasma proteins and relevant proteases.Differences in peptide modification levels of trastuzumab in patients'sera were also monitored.In summary,the novel bioanalytical platform based on the multi-epitope affinity technology holds great potentials for in vivo biotransformation analysis of mAb,contributing to improved understanding and paving the way for future research and clinical applications.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据