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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    Flag-hinge-like highly luminescent chiral nanographenes with twist geometry

    Wenying CuiZhetong JinWentao FuChengshuo Shen...
    334-339页
    查看更多>>摘要：Nanographenes(NGs)with twisted backbones are emerging as new candidates for chiroptical materials.In this work,we describe a new strategy for synthesizing a[10]twistacene-embedded NG which exhibits a rare flag-hinge-like geometry.By neatly creating steric crowding on the[6]helicene breaches of the NG skeleton,the synthesis only provided homochiral isomers without generating the"meso-"isomer.The formed NGs showed high luminescence with quantum yield up to 52％,and promising circularly polarized luminescence(CPL)performance with|glum|up to 5.0×10-3.Besides,these NGs also showed outstanding CPL brightness(BCPL)up to 305 L mol-1 cm-1among chiral NGs.
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    Transition metal-free tunable synthesis of 3-(trifluoromethylthio)and 3-trifluoromethylsulfinyl chromones via domino C-H functionalization and chromone annulation of enaminones

    Tao ZhouJing ZhouYunyun LiuJie-Ping Wan...
    340-343页
    查看更多>>摘要：The new reactions between o-hydroxyphenyl enaminones and Langlois reagent(CF3SO2Na)for the tun-able synthesis of 3-(trifluoromethylthio)chromones and 3-trifluoromethylsulfinyl chromones are reported herein.Both type of reactions proceed under transition metal-free conditions.In addition,the conditions for the synthesis of 3-trifluoromethylsulfinyl chromones have also been found to be applicable for the synthesis of 3-alkyl/arylsulfinyl chromones.
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    Copper-catalyzed photoredox 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN:Facile access to α-amido allenyl nitriles

    Liangfeng YangLiang ZengYanping ZhuQiuan Wang...
    344-348页
    查看更多>>摘要：A new 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN using a copper and photoredox synergetic catalysis for producing α-amido allenyl nitriles is developed.Employing N-amidopyridin-1-ium salts as the amidyl radical precursors,the reaction enables the formation of two new bonds,one C(sp3)-N bond and one C(sp2)-C(sp)bond,in a single reaction step.This reaction represents a mild,general route to the construction of the α-amido allenyl nitrile architectures,which characterizes a broad scope,a good functional group compatibility and an excellent selectivity.
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    Ligand-promoted reductive coupling between aryl iodides and cyclic sulfonium salts by nickel catalysis

    Junxin LiChao ChenYuzhen DongJian Lv...
    349-354页
    查看更多>>摘要：Developing applicable methods to forge linkages between sp3 and sp2-hydridized carbons is of great sig-nificance in drug discovery.We show here a new,Ni-catalyzed reductive cross-coupling reaction that forms Csp3-Csp2 bonds from aryl iodides and cyclic sulfonium salts.Notably,Csp3-Csp2 bonds can be forged selectively at the iodine-bearing carbon of bromo(iodo)arenes which is usually recognized as a huge challenge under the catalytic reductive cross-coupling(CRCC)conditions.Experimental and compu-tational mechanistic studies support LNiIAr as an active species,while the untraditional anti-Markovnikov selective alkylation of asymmetric sulfonium salts is determined by the oxidative S-substitution of sul-fonium salts with LNiIAr.This protocol further expands the range of alkyl electrophiles under the CRCC conditions and provides a new strategy for the construction of Csp3-Csp2 bonds.
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    Palladium/Xu-Phos-catalyzed enantioselective arylalkoxylation reaction of γ-hydroxyalkenes at room temperature

    Shuai ZhuMingjie ChenHaichao ShenHanming Ding...
    355-360页
    查看更多>>摘要：Metal-catalyzed alkene arylalkoxylation is a powerful complexity-building strategy for the synthesis of oxygen heterocycles from simple y-unsaturated alcohols,but only a few examples of catalytic enan-tioselective methods exist.Herein,an efficient palladium-catalyzed enantioselective arylalkoxylation ofγ-hydroxyalkenes with aryl halides is reported.The salient features of this transformation include a re-markable broad substrate scope,mild reaction conditions,and good functional group tolerance,delivering a series of chiral tetrahydrofurans containing a tertiary or quaternary stereocenter in good yields with up to 95％ee.The Xu10 ligand with a suitable side-arm was responsible for the high reactivity and good enantioselectivity of this transformation.
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    Photocatalyst/metal-free sequential C-N/C-S bond formation:Synthesis of S-arylisothioureas via photoinduced EDA complex activation

    Guoju GuoXufeng LiJie MaYongjia Shi...
    361-366页
    查看更多>>摘要：A photocatalyst-free visible-light-promoted three-component reaction of thianthrenium salts,isothio-cyanates,and amines is presented,which affords a rapid and efficient approach to S-arylisothioureas under mild conditions.This developed method exhibits the advantages of readily available raw mate-rials,broad substrate scope,good functional tolerance,and operational simplicity.It is worth mentioning that the byproduct thianthrene can be recycled in quantity,ultimately maximizing the atomic economy of the reaction and avoiding chemical waste.Mechanism investigations support the strategy involving a photoinduced EDA complex.
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    Visible-light-induced four-component difunctionalization of alkenes to construct phosphorodithioate-containing quinoxalin-2(1H)-ones

    Xiao-Ming ChenLianhui SongJun PanFei Zeng...
    367-371页
    查看更多>>摘要：A facile visible-light-induced 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene(4CzIPN)catalyzed four-component reaction of alkenes,quinoxalin-2(1H)-ones,P4S10 and alcohols has been developed at room temperature.This tandem reaction provides an efficient strategy for the construction of various phosphorodithioate-containing quinoxalin-2(1H)-ones with moderate to good yields by using air(dioxy-gen)as the green oxidant.Experimental studies revealed a radical process was involved in this photo-chemical reaction.
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    Electrochemical aptasensor based on black phosphorus-porous graphene nanocomposites for high-performance detection of Hg2+

    Jie ZhouChuanxiang ZhangChangchun HuShuo Li...
    372-377页
    查看更多>>摘要：A novel approach was developed to fabricate a label-free electrochemical aptasensor for specific detec-tion of mercury ions(Hg2+).This involved modifying polylysine(PLL)-coated black phosphorus-porous graphene(BP-PG)nanocomposites(PLL/BP-PG)onto the surface of glassy carbon electrodes(GCE),which were further modified with gold nanoparticles(AuNPs)to combine with a thiolated aptamer(Apt)capable of specifically recognizing Hg2+.BP-PG was synthesized using the solvothermal method and covalently bonded to form BP-PG nanosheets,resulting in significant enhanced electrochemical proper-ties of the PLL/BP-PG composite.Furthermore,the PLL/BP-PG composite was improved environmental stability of BP and provided a considerable quantity of-NH2 for bonding to AuNPs firmly by assembling.The physical properties and electrochemical behavior of the substrate materials were investigated using various characterization techniques,and analytical parameters were optimized.It is shown that,the Apt/AuNPs/PLL/BP-PG/GCE had a linear response(R2=0.999)with good selectivity and high sensitivity over the Hg2+range of 1-10,000 nmol/L.The proposed sensor has a detection limit of 0.045 nmol/L and can be employed for detecting of Hg2+.It also obtained satisfying results in river water,soil and vegetable samples.
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    Asymmetric macrocyclization enabled by Rh(Ⅲ)-catalyzed C-H activation:Enantioenriched macrocyclic inhibitor of Zika virus infection

    Chao ChenWenwen YuGuangen HuangXuelian Ren...
    378-383页
    查看更多>>摘要：The development of enantioselective C-H macrocyclizations to efficiently access structurally diversified macrocycles is highly desirable,but remain a big challenge.Herein,we reported the first rhodium(Ⅲ)-catalyzed asymmetric intramolecular C-H macrocyclization,enabling the efficient synthesis of structurally diverse enantioenriched macrocycles.This robust enantioselective C-H macrocyclization has a broad functional group tolerance,excellent enantioselectivities(up to 98.5:1.5 e.r.)and a mild reaction con-dition,releasing CO2 as the single by-product.More significantly,the resulting unique enantioenriched 19-membered macrocycle 2f was found to demonstrate a potent in vitro anti-Zika virus(ZIKV)activity without obvious cytotoxicity.Further investigation revealed that the anti-ZIKV activity is presumably at-tributed to an autophagy inhibition in the early stage of viral infection by down-regulating the expression of autophagy related gene Atg12.
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    Developing selective PI3K degraders to modulate both kinase and non-kinase functions

    Zimo YangYan TongYongbo LiuQianlong Liu...
    384-388页
    查看更多>>摘要：For the first time,proteolysis-targeting chimeras(PROTAC)technology was utilized to achieve the isoform-selective degradation of class I phosphoinositide 3-kinases(PI3Ks)in this study.Through screen-ing and optimization,the PROTAC molecule ZM-PI05 was identified as a selective degrader of p110α in multiple breast cancer cells.More importantly,the degrader can down-regulate p85 regulatory subunit simultaneously,thereby inhibiting the non-enzymatic functions of PI3K that are independent on p110 catalytic subunits.Therefore,compared with PI3K inhibitor copanlisib,ZM-PI05 displayed the stronger anti-proliferative activity on breast cancer cells.In brief,a selective and efficient PROTAC molecule was developed to induce the degradation of p110α and concurrent reduction of p85 proteins,providing a tool compound for the biological study of PI3K-α by blocking its enzymatic and non-enzymatic functions.
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