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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    Sensitive measurement of silver ions in environmental water samples integrating magnetic ion-imprinted solid phase extraction and carbon dot fluorescent sensor

    Shuangying LiQingxiang ZhouZhi LiMenghua Liu...
    272-276页
    查看更多>>摘要：Increasing use of silver in various fields has caused Ag+pollution in water environment,taking great threats to people's health.As a consequence,establishing rapid and reliable methods for sensitive de-termination of Ag+is of great significance.Fluorescent(FL)sensors based on carbon dots(CDs),an ex-cellent carbonaceous nanomaterial with strong and stable fluorescence,have absorbed extensive atten-tions in analysis of pollutants due to its advantages of carbon sources being readily available,low cost,easy operation and fast response.Moreover,ion-imprinting is a better way to increase the selectivity of the proposed method.Present work described an effective method for the sensitive measurement of sil-ver ion in water samples in combination with magnetic ion-imprinted solid phase extraction and CDs based fluorescent sensor,which took full advantages of easy separation and high enrichment of magnetic solid phase extraction,high selectivity of ion-imprinting technology,and sensitivity and rapid response of fluorescent sensor from CDs.Sulfur-doped CDs derived from dithizone and magnetic ion-imprinted nanomaterial were prepared,and characterized with Fourier transform infrared spectroscopy and trans-mission electron microscope,etc.Magnetic Ag+imprinted nanomaterial based solid phase extraction was employed for separating and enriching Ag+from water samples.The significant parameters were opti-mized in detail.Under the optimal conditions,the proposed method provided good linearity in the range of 0.01-0.4 μmol/L and low detection limit of 3nmol/L.The reliability of the proposed method was val-idated with real water samples,and the results demonstrated that the proposed method was simple,robust,selective and sensitive detection tool for Ag+in real water samples.
      原文链接:
    • 万方数据
    • 维普

    Facile synthesis of high-brightness green-emitting carbon dots with narrow bandwidth towards backlight display

    Rui ChengTingting ZhangXin HuangJian Yu...
    277-282页
    查看更多>>摘要：High-performance carbon dots(CDs)allowing the application in high-end display devices are highly de-sirable and usually limited by the absence of simple and easy synthesis methods.In this work,we ex-ploited an easy-to-implement strategy for the one-step synthesis of green-emitting CDs(G-CDs)with superb optical properties.The G-CDs were synthesized using m-phenylenediamine(m-PD)as a single pre-cursor,and the reaction reacted at 180 ℃ for 12 h The resultant G-CDs exhibit high-purity and excitation-independent green fluorescence with the photoluminescence(PL)peak located at 516 nm,full width at half maximum(FWHM)of 46 nm,and PL quantum yield(QY)of～80％under the 470 nm excitation light.The G-CDs and corresponding composite film prepared with polyvinyl butyral(G-CDs@PVB)exhibit good PL stability after undergoing long-time storage for one year and 360 h exposure under 460 nm blue light.The G-CDs@PVB film was used as color-conversion materials in green-emitting light-emitting diode(LED)application,exhibiting a Commission internationale de l'Eclairage(CIE)chromaticity coordinate of(0.21,0.44).The film was also used in CD-based liquid crystal display(CD-LCD)application,achieving a color gamut value of 85％.This work will offer a working basis for the synthesis of high-performance CDs as well as their application in displays.
      原文链接:
    • 万方数据
    • 维普

    An AIPE-active fluorinated cationic Pt(Ⅱ)complex for efficient detection of picric acid in aqueous media

    Yingying YanWanhe JiaRui CaiChun Liu...
    283-286页
    查看更多>>摘要：A novel cationic Pt(Ⅱ)complex 2 with 2-(2,4-difluorophenyl)pyridine as the cyclometalating ligand and 1,10-phenanthroline as the auxiliary ligand has been synthesized and fully characterized.This com-plex exhibits much higher aggregation-induced phosphorescent emission activity than that of a non-fluorinated complex 1 in CH3CN/H2O.The complex 2 demonstrates efficient detection on picric acid(PA)in CH3CN/H2O,providing a high quenching constant(Ksv=2.3 × 104 L/mol)and a low limit of detection(LOD=0.26 μmol/L).In addition,complex 2 shows high selectivity for detection of PA in real water sam-ples.Density functional theory calculations and proton nuclear magnetic resonance spectra suggest that the detection mechanism is attributed to the photo-induced electron transfer.
      原文链接:
    • 万方数据
    • 维普

    Design,synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells

    Wenyi MeiLijuan XieXiaodong ZhangCunjian Shi...
    287-289页
    查看更多>>摘要：Ursolic acid(UA)is a naturally occurring ursane triterpenoid,which exhibits a wide range of unique biological activities.To clarify its mechanism of action(MOA),a series of fluorescent derivatives of UA(5a-c)were designed and synthesized by conjugation with 7-nitrobenzo-2-oxa-1,3-diazole(NBD)fluo-rophore.Among them,5c exhibited similar anti-proliferative activity with UA against HCT116 cells(half maximal inhibitory concentration(IC50)=9.21±0.50 μmol/L).Cell imaging experiment indicated that 5c was rapidly taken up in HCT116 cells in a dose and time-dependent manner.Then,5c was found to lo-calize in endoplasmic reticulum(ER),lysosomes,and mitochondria,but not in nucleus of HCT116 cells by confocal microscopy studies.Preliminary MOA proved that UA induced autophagy with a unique in-tracellular distribution mechanism involving ER and lysosome.In all,our work provides new clues for revealing the molecular mechanism of UA as an antitumor agent.
      原文链接:
    • 万方数据
    • 维普

    Rational design of hydroxytricyanopyrrole-based probes with high affinity and rapid visualization for amyloid-β aggregates in vitro and in vivo

    Jiajia LvJie GaoHongyu LiZeli Yuan...
    290-295页
    查看更多>>摘要：As key biomarkers,amyloid-β(Aβ)plaques are frequently used to diagnose Alzheimer's disease(AD).Although fluorescence imaging has proven to be effective in detecting these plaques,the gold standard probe thioflavin T(ThT),used for Aβ aggregates,cannot be applied in vivo owing to its invasive na-ture.Therefore,the development of novel fluorescent probes capable of identifying Aβ plaques in situ is necessary.Based on the ThT structure,two π-conjugated heterocyclic D-π-A probes were designed bearing the hydroxytricyanopyrrole acceptor and N,N-dimethylaminophenyl donor.These probes exhib-ited red to near-infrared fluorescence emission(λmax=732 nm),large Stokes shifts(＞100nm),excep-tional signal-to-noise ratio,rapid response(＜30s),and high binding affinity(NT-HTCP=33.32 nmol/L;NF-HTCP=53.35 nmol/L)for Aβ aggregates.As the best candidate,NT-HTCP was used for in situ imag-ing of Aβ plaques in AD mouse models.Furthermore,in vivo research demonstrated that NT-HTCP could cross the blood-brain barrier and continue imaging the Aβ plaques with a good signal-to-noise ratio.Additionally,the outcomes of the docking computations helped guide the development of the Aβ probes.This study expands the family of N,N-dimethylaminophenyl-based Aβ-sensitive fluorophores,with NT-HTCP emerging as a highly promising imaging agent.
      原文链接:
    • 万方数据
    • 维普

    A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H2S and its applications in living system

    Yudi ChengXiao WangJiao ChenZihan Zhang...
    296-301页
    查看更多>>摘要：Sulfydryl-contained(-SH)substances including hydrogen sulfide(H2S),cysteine(Cys),homocysteine(Hcy)and glutathione(GSH)play crucial roles in living systems,and their variations are closely associated with various diseases.Herein,we developed a near-infrared intramolecular charge transfer(ICT)based fluores-cent probe Y-NBD,achieving detection of Cys/Hcy and H2S with different fluorescent signals(green-red for Cys/Hcy,red for H2S),large Stokes shifts(～100/105nm or 191 nm)and high signal-background-ratio,but not responding to GSH.Y-NBD was successfully applied to image exogenous/endogenous Cys/Hcy and H2S in various living cancer cells(HeLa,A549,and HepG2)and in zebrafish.It not only visualized the transformation pathway of several thiols in HepG2 cells but also verified that the intestine is the main site for the activation and metabolism of Y-NBD in zebrafish,as well as realized to evaluate the degree of drug-induced liver injury.This work provides a promising tool for imaging Cys/Hcy and H2S in living systems and shows great potency in evaluating drug-induced liver injury and its treatment.
      原文链接:
    • 万方数据
    • 维普

    Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor

    Yihao ZhangYang JiaoXianchao JiaQiaojia Guo...
    302-306页
    查看更多>>摘要：Porphyrins and their derivatives are excellent photosensitizers in photodynamic therapy(PDT).The mod-ification of porphyrin molecules into metal-organic cages(MOCs)is a viable strategy to improve their bioavailability.In this work,MOC C66 based on porphyrin was synthesised by a one-pot self-assembly method.The three-dimensional structure of the metal-organic cage ameliorated the aggregation and self-quenching of porphyrins and increased the molar absorption coefficient in the visible light region,which enhanced the reactive oxygen species(ROS)yield of porphyrins and effectively improved the efficiency of photodynamic therapy.ROS generation ability tests in solution confirmed the improved reactive oxygen capacity of the cage,which showed greater phototoxicity to HeLa and MCF-7 cells in vitro,suggesting a new strategy for future modifications of the simple synthesis of porphyrins as photosensitizers.
      原文链接:
    • 万方数据
    • 维普

    Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid

    Fengyun LiZerong PeiShuting ChenGen li...
    307-313页
    查看更多>>摘要：Multifunctional drug delivery systems(DDSs)have shown great prospects in overcoming the heteroge-neous barrier of delivery drugs to the complex tumor microenvironment(TME).In this study,multifunc-tional AS/Ge-pNAB microgels with dual-active targeting,triple environment responsiveness,and fluores-cence imaging capability were prepared through a straightforward procedure.This was aimed to improve the antitumor therapeutic application of gambogic acid(GA)based on the biological characteristics of TME.The microgels have a uniform double-layer structure with aptamer in the outer layer which helps in recognizing receptors on the tumor cells.The GA loaded nano-herb exhibited environment-responsive drug release profiles under acidic pH,reductant and high temperature.The nano-herb significantly im-proved the accumulation of GA in tumor sites through the synergistic combination of the enhanced per-meability and retention effect and dual-ligand mediated internalization.Then,it accelerated intracellular drug release and killed tumor cells.Therefore,the nano-herb had specific therapeutic effects on the tu-mor in vitro and in vivo as they remarkably inhibited tumor growth while depicting optimal biosafety and lower levels of off-target toxicity.Overall,these findings demonstrate the great potential of the mul-tifunctional AS/Ge-pNAB microgels for precisely targeted GA delivery and open a new avenue for the facile preparation of multifunctional DDSs.
      原文链接:
    • 万方数据
    • 维普

    PEG400-mediated nanocarriers improve the delivery and therapeutic efficiency of mRNA tumor vaccines

    Wen XiaoFazhan WangYangzhuo GuXi He...
    314-319页
    查看更多>>摘要：Dendritic cell(DC)-targeted delivery of mRNA is a prominent method to boost the efficacy of mRNA tu-mor vaccines.The targeting ligands are often modified on nanocarriers by polyethylene glycol(PEG)linker in mRNA delivery systems.Whether the PEG linker length influences the targeting delivery efficiency of mRNA nanocarrier in vivo remains unclear.Here,we designed and constructed DC-targeted mRNA deliv-ery systems modified by mannose via different PEG linker lengths(100/400/1000/2000)(MPn-LPX).The top candidate MP400-LPX(the linker was PEG400)showed the optimal mRNA expression and antigen presentation owing to the highly efficient uptake by DCs.Furthermore,MP400-LPX could better inhib-ited tumor growth and extended survival in the E.G7-OVA lymphoma and TC-1 cervical tumor mouse model.Collectively,these results demonstrated that PEG400 was the optimal linker for the PEGylated DC-targeted mRNA vaccines.Our findings provided a new platform for the rational design of targeted mRNA nanovaccines with shorter-length PEG.
      原文链接:
    • 万方数据
    • 维普

    Ba2+/Ca2+co-crosslinked alginate hydrogel filtration membrane with high strength,high flux and stability for dye/salt separation

    Ningning GaoYue ZhangZhenhao YangLijing Xu...
    320-324页
    查看更多>>摘要：Alginate is a natural polysaccharide polymer.Hydrogel filtration membranes prepared from alginate show excellent fouling resistance and controllable separation performance,but poor mechanical properties limit the use of algae hydrogels.In this study,Ba2+/Ca2+co-crosslinked alginate(Ba/CaAlg)hydrogel mem-brane was prepared by cross-linking sodium alginate with a blend aqueous solution of barium ions and calcium ions,and the membrane was applied to the separation of dyes/salts from dyeing wastewater.Compared with the CaAlg membrane,the Ba/CaAlg hydrogel membrane exhibited more stable structure,and the mechanical properties and salt tolerance of the membrane were significantly improved.The flux of Ba/CaAlg membrane for methyl blue/sodium chloride mixed solution reached 43.5 L m-2 h-1,which was significantly higher than that of CaAlg membrane.Besides,the Ba/CaAlg membrane showed higher dye rejection(＞99.6％)and lower salt rejection(＜8.2％).The structure of Ba/CaAlg membrane was pre-liminarily simulated by molecular dynamics,and the pore size and distribution of the membrane were calculated.The Ba/CaAlg membrane has a broad application prospect in dyes/salts separation.
      原文链接:
    • 万方数据