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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    Utilization of hydralazine as a reactive matrix for enhanced detection and on-MALDI-target derivatization of saccharides

    Dan OuyangHuan HuangYanting HeJiajing Chen...
    386-391页
    查看更多>>摘要：Saccharides are a sort of ubiquitous and vital molecules within the whole life.However,the application of saccharides analysis with matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)is restricted by their low ionization efficiency and the instability of the sialic acid fraction.Derivatization strategy based on nonreductive amination provides a good solution,however,this is often time consum-ing and may result in sample loss due to removal of excessive derivatization reagents.Herein,hydralazine(HZN)was utilized as a reactive matrix for labeling reducing saccharides directly on MALD1 target which eliminated tedious sample preparation and avoided sample loss.After optimization,effective and repro-ducible on-MALDI-target derivatization of neutral and acidic saccharides was achieved in both positive and negative modes.Compared with 2,5-dihydroxybenzoic acid(DHB)and 9-aminoacridine(9-AA),HZN improved the detection sensitivity of reducing saccharides and provided more abundant fragment ions in MS/MS analysis.Moreover,26 kinds of neutral glycans and 5 kinds of sialic glycans were identified from ovalbumin(OVA)and bovine fetuin,respectively.Combined with the statistical models,this strat-egy could be used to distinguish and predict samples of 6 brands of beer,and discriminate 2 kinds of beer fermentation modes.In addition,HZN was applied for quantitative analysis of glucose in urine samples,and the obtained urine glucose concentrations of diabetic patients were consistent with the clinical test results,showing the potential of qualitative and quantitative analysis of reducing saccharides in complex samples.
      原文链接:
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    Predesigned covalent organic framework with sulfur coordination:Anchoring Au nanoparticles for sensitive colorimetric detection of Hg(Ⅱ)

    Guorong LiYijing WuChao ZhongYixin Yang...
    392-396页
    查看更多>>摘要：Targeted construction of new covalent organic frameworks(COFs)with specific purposes and rationalities to build colorimetric assay platform for environmental pollutant monitoring have attracted increasing in-terest.However,it is still challenging due to lack of available coordination sites inside COFs pores and only a slight bonding ability for anchoring metal.In this work,a two-dimensional(2D)COFs(termed as Tz-COF)with high crystallinity,excellent chemical stability,and abundant sulfur coordination in its skele-tons was synthesized and used for the confined growth of Au NPs.It was found that the Au NPs showed significant dispersibility for the support of Tz-COF.The proposed Tz-COF@Au NPs possessed outstanding Hg2+-activated peroxidase-like activity benefited from physicochemical properties of gold amalgam and synergistic effect between COFs and Au NPs to oxidize chromogenic substrate.Based on highly efficient activity and distinctive color evolution,the strategy for detecting Hg2+was developed and successfully applied to determine the content of Hg2+in real environmental samples.This work manifests that a po-tential strategy to establish a colorimetric assay platform for environmental pollutant monitoring based on the targeted manufacturing of novel COFs with specific functions.
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    Demethylase-assisted site-specific detection of N1-methyladenosine in RNA

    Jun XiongKe-Ke ChenNeng-Bin XieWei Chen...
    397-401页
    查看更多>>摘要：The dynamic RNA modifications have been viewed as new posttranscriptional regulator in modulating gene expression as well as in a broad range of physiological processes.N1-methyladenosine(m1A)is one of the most prevalent modifications existing in multiple types of RNAs.In-depth investigation of the func-tions of m1A requires the site-specific assessment of m1A stoichiometry in RNA.Herein,we established a demethylase-assisted method(DA-m1A)for the site-specific detection and quantification of m1A in RNA.N1-methyl group in m1A could result in the stalling of reverse transcription at m1A site,thus produc-ing the truncated cDNA.E.coli AlkB is a demethylase that can demethylate m1A to produce adenine in RNA,thus generating full-length cDNA from AlkB-treated RNA.Evaluation of the produced amounts of full-length cDNA by quantitative real-time PCR can achieve the site-specific detection and quantification of m1A in RNA.With the DA-m1A method,we examined and successfully confirmed the previously well-characterized m1A sites in various types of RNAs with low false positive rate.In addition,we found that the level of m1A was significantly decreased at the bromodomain containing 2(BRD2)mRNA position 1674 and CST telomere replication complex component 1(CTC1)mRNA position 5643 in human hepa-tocellular carcinoma tissues.The results suggest that these two m1A sites in mRNA may be involved in liver tumorigenesis.Taken together,the DA-m1A method is simple and enables the rapid,cost-effective,and site-specific detection and quantification of m1A in RNA,which provides a valuable tool to decipher the functions of m1A in human diseases.
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    Peptidome data-driven comprehensive individualized monitoring of membranous nephropathy with machine learning

    Zixing XuRuiying ChenChuanming HaoQionghong Xie...
    402-406页
    查看更多>>摘要：As the most common pathological type of nephrotic syndrome,membranous nephropathy(MN)presents diversity in progression trends,facing severe complications.The precise discrimination of MN from healthy people,other types of nephrotic syndrome or those with therapeutic remission has always been huge challenge in clinics,not to mention comprehensive individualized monitoring relied on minimally invasive molecular detection means.Herein,we construct a functionalized pore architecture to couple with machine learning to aid all-round peptidome enrichment and data profiling from hundreds of hu-man serum samples,and finally establish a set of defined peptide panel consisting of 12 specific feature signals.In addition to the realization of above-mentioned precise discrimination with more than 97％of sensitivity,88％of accuracy and f1 score,the simultaneously comprehensive individualized monitoring for MN can also be achieved,including conventionally screening diagnosis,congeneric distinction and prog-nostic evaluation.This work greatly advances the development of peptidome data-driven individualized monitoring means for complex diseases and undoubtedly inspire more devotion into molecular detection field.
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    Theoretical and experimental cocrystal screening of temozolomide with a series of phenolic acids,promising cocrystal coformers

    Hongmei YuBaoxi ZhangMeiju LiuCheng Xing...
    407-417页
    查看更多>>摘要：The virtual cocrystal screening approach based on molecular electrostatic potential surface(MEPS)maps is a fast and feasible computational method to estimate the probability of cocrystal formation by cal-culating the difference in the interaction site pairing energies of monomers and that of their assemblies prior to experimental screening.In this paper,we report 12 cocrystal forms of temozolomide with mono-,di-,and trihydroxy benzoic acids,namely,3-hydroxy-,2,4-dihydroxy-,2,5-dihydroxy-,2,6-dihydroxy-,3,4-dihydroxy-,and 3,4,5-trihydroxy-benzoic acids,as well as benzoic acid,as pharmaceutical coformers for the first time.10 single crystals out of the 12 cocrystal forms were obtained and unequivocally deter-mined by single-crystal X-ray diffraction,which clarified spatial arrangements,molecular conformations,and supramolecular synthons.MEPS further gains some insights into the sites of hydrogen bonding inter-actions for exploring combination patterns in these assemblies.Modulated stability of TMZ was success-fully achieved by cocrystallization with these acids.
      原文链接:
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    Mobile mini-fluorimeter for antibiotic aptasensing based on surface-plasmonic effect of burlike nanogolds enhanced by digitized imaging diagnosis

    Tiantian ManFulin ZhuYaqi HuangYuhao Piao...
    418-422页
    查看更多>>摘要：Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily necessities.The traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of diverse synthetic residuals on site.In an attempt to answer this urgency,here a miniaturized fluorometric aptasensor prototype was contrived that catered to the point-of-care screening norm for two typical additives:chloramphenicol and enrofloxacin.The key target-indicating module worked in vitro based on the competitive binding-induced fluorescence recovery of fluorescein-labeled aptamers,which were photobleached beforehand in the format of double helix on burlike nanogold carriers.The"prickly"geometry of the latter not just enriched the capture probes at preferentially substrate-accessible spires;but also contributed to a tip-enhanced surface plasmon effect,sensitizing the signal-on during the duplex dissociation even at nanomolar threshold of the analytes.On the other hand,to encompass a full portable,a set of optical devices were mounted within a 3D-printed cartridge(adaptor)to converge the light beam and route it towards the detector,for which the smartphone camera came up in handy with a home-developed App for calibrating the emissive bright-ness.Enlightened by the high-dynamic-range compression,an imaging diagnostic algorithm was built in to grid and digitize each slide in the album for augmented detection performance.Thus,a novel bio-to-silico integration was invented that capable of in situ rapid reporting on the antibiotic presence with high sensitivity and selectivity.Further field practices in spiked milk on sales proved the precision and rudi-mentary feasibility of the well-assembled model of appliance,thus holding nice prospects in nonexpert(e.g.,family and local community)utilities for foodborne antibiotic identification.
      原文链接:
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    A distinction of gliomas at cellular and tissue level by surface-enhanced Raman scattering spectroscopy

    Chengde WangLiping HuangShanshan WangLihao Wu...
    423-427页
    查看更多>>摘要：Glioblastoma multiforme(GBM)is the most common malignant primary brain tumor in adults.The pre-cise identification and distinction of GBM heterogeneity from surrounding brain parenchyma at the cel-lular level and even at the tissue level are important for GBM therapy.In this study,GBM cells are distin-guished from normal astrocytes and non-central nervous system(CNS)tumor cells by surface-enhanced Raman scattering(SERS)based on gold nanoshell(SiO2@Au)particles and support vector machine(SVM)algorithm.In addition,the gold nanoisland(AuNI)SERS substrates are further developed and explored for accurate detection of GBM at the tissue level.The distinction between glioma and trauma tissues,identification of different tumor grades,and IDH mutation are realized with the assistance of orthogonal partial least squares discriminant analysis(OPLS-DA)in a rapid,non-invasive,and convenient method.The results show that the developed SERS-based analytical method has the potential for practical appli-cation for the detection of GBM at the single-cell and tissue levels and even for real-time intraoperative diagnosis.
      原文链接:
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    Nitric oxide assists nitrogen reduction reaction on 2D MBene:A theoretical study

    Chaozheng HeJia WangLing FuWei Wei...
    428-433页
    查看更多>>摘要：Electrocatalytic synthesis of ammonia as an environment-friendly and sustainable development method has received widespread attention in recent years.Two-dimensional(2D)materials are a promising cat-alyst for ammonia synthesis due to their large surface area.In this work,we have constructed a series of 2D metal borides(MBenes)with transition metal(TM)defects(TMd-MBenes)and comprehensively calculated the reactivity of electrocatalytic synthesis of ammonia-based on density functional theory.The results have demonstrated that the TMd-MBenes can effectively activate nitrogen oxide(NO)and nitrogen(N2)molecules thermodynamically.Particularly interesting,the co-chemisorption of O atoms,dissociated from NO,can facilitate the spilled of the inert N2 molecules into single N atoms,which can further hy-drogenate into ammonia easily with an ultralow limiting potential of 0.59 V on TMd-MnB.Our research has not only provided clues for catalyst design for experimental study but also paved the way for the industrial application of electrocatalytic ammonia synthesis.
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    Novel 2D bifunctional layered rare-earth hydroxides@GO catalyst as a functional interlayer for improved liquid-solid conversion of polysulfides in lithium-sulfur batteries

    Haodong WangXiaoxu LaiChi ChenPei Shi...
    434-440页
    查看更多>>摘要：The detrimental"shuttle effect"of lithium polysulfides(LiPSs)together with sluggish multi-order reac-tion kinetics are the main drawbacks hindering lithium-sulfur(Li-S)batteries from commercial success.Here,we first propose the implementability of layered rare-earth hydroxides(LREHs)in Li-S batteries to optimize electrochemical performance.In this work,a two-dimensional(2D)rare-earth-based composite constructed by the layered gadolinium hydroxy chloride[Gd2(OH)5(H2O)n]Cl nanoplates(LGdH NPs)and graphene oxide(GO)was designed as a sulfur immobilizer for Li-S batteries.Combining the experimental results and density functional theory(DFT)calculations,it is revealed that the LGdH@GO composite not only provides a strong anchoring of the intermediates during cycling,but also acts as an effective catalyst to accelerate the liquid-solid conversion of polysulfides.The Li-S batteries assembled by LGdH@GO mod-ified separators delivered a superior rate performance with a specific capacity of 605.34 mAh/g at 5 C,as well as excellent cycle stability with a decay rate of 0.087％over 500 cycles at 2 C.This study provided a deep understanding of the mechanism to suppress the"shuttle effect"by the LREHs,and a guide to design effective functional interlayers for high-performance Li-S batteries with excellent electrocatalytic activity.
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    Construction of Cu-Zn Co-doped layered materials for sodium-ion batteries with high cycle stability

    Xiping DongXuan WangZhixiu LuQinhao Shi...
    441-446页
    查看更多>>摘要：Due to its high operational voltage and energy density,P2-type Na0.67Ni0.3Mn0.7O2 has become a leading cathode material for sodium-ion batteries(SIBs),which is an ideal option for large-scale energy storage.However,the practical application of P2-type Na0.67Ni0.3Mn0.7O2 is limited by the capacity constraints and unwanted phase transitions,presenting significant challenges to the widespread application of SIBs.To address these challenges and optimize the electrochemical properties of the P2 phase cathode ma-terial,this study proposes a Cu and Zn co-doped strategy to improve the electrochemical performance.The incorporation of Cu/Zn can stabilize the P2-phase structure against P2-O2 phase transitions,thus en-hancing its electrochemical properties.The as-obtained P2-type Na0.67[Ni0.3Mn0.58Cu0.09Zn0.03]O2 cathode material shows an impressive cycling stability,maintaining 80％capacity retention after 1000 cycles at 2 C.The cyclic voltammetry(CV)tests show that the Cu2+/Cu3+redox reaction is also involved in charge compensation during the charge/discharge process.
      原文链接:
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    • 维普