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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    Functionalization of cellulose carbon dots with different elements(N,B and S)for mercury ion detection and anti-counterfeit applications

    Xiaoning LiQuanyu ShiMeng LiNingxin Song...
    355-359页
    查看更多>>摘要：Mercury ion(Hg2+),as one of the most toxic heavy metal ions,accumulates easily in the environment,which can generate potential hazards to the ecosystem and human health.To effectively detect and re-move Hg2+,we fabricated four types of carbon dots(CDs)using carboxymethyl nanocellulose as a carbon source doped with different elements using a hydrothermal method.All the CDs exhibited a strong fluo-rescence emission,excitation-dependent emission and possessed good water dispersibility.Moreover,the four fluorescent CDs were used for Hg2+recognition in aqueous solution,where the CDs-N exhibited better sensitivity and selectivity for Hg2+detection,with a low limit of detection of 8.29×10-6 mol/L.It was determined that the fluorescence quenching could be ascribed to a photoinduced charge-transfer processes between Hg2+and the CDs.In addition,the CDs-N were used as a smart invisible ink for anti-counterfeiting,information encryption and decryption.Furthermore,the CDs-N were immersed into a cellulose(CMC)-based hydrogel network to prepare fluorescent hydrogels capable of simultaneously de-tecting and adsorbing Hg2+.We anticipate that this research will open possibilities for a green method to synthesize fluorescent CDs for metal ion detection and fluorescent ink production.
      原文链接:
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    Microenvironment responsive pod-structured astaxanthin nanocarrier for ameliorating inflammatory bowel disease

    Jingting WangYuanyuan ChenLinlin HanShasha Xia...
    360-366页
    查看更多>>摘要：Anti-inflammatory drugs targeting inflammatory bowel disease(IBD)have attracted considerable atten-tion but still face low therapeutic outcomes and frequent side effects.Astaxanthin(ATX),a natural ketone,possesses potent antioxidant and anti-inflammatory properties.However,it faces problems such as poor water solubility,photothermal instability,and low bioavailability.Here,we employed a supramolecular encapsulation strategy to create a nanoscale oral delivery system for ATX(referred to as FC-ATX NPs)by coupling fucoidan(FUC)with chitosan oligosaccharides(COS).The obtained FC-ATX NPs exhibited a particular"bean pod"structure with uniform size,good encapsulation efficiency,excellent physical and chemical stability,pH-triggered intestinal targeted slow-release properties,and potent antioxidant capac-ity.In vitro cell culture experiments showed that FC-ATX NPs promoted cellular uptake and scavenged excessive intracellular reactive oxygen species(ROS).In mouse models of colitis,FC-ATX NPs enhanced the drug absorption of intestinal epithelial cells and effectively accumulated at the site of inflammation.This work provides an efficient approach to enhance the bioavailability of ATX and has excellent applica-tion potential as an oral targeted delivery system for colitis therapy.
      原文链接:
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    Ionic liquid-based in situ dynamically self-assembled cationic lipid nanocomplexes(CLNs)for enhanced intranasal siRNA delivery

    Luyu ZhangZirong DongShuai YuGuangyue Li...
    367-371页
    查看更多>>摘要：This research aims to develop a non-invasive strategy for small interfering RNA(siRNA)nasal deliv-ery based on ionic liquids(ILs)and cationic lipid(2,3-dioleoyloxy-propyl)-trimethylammonium-chloride(DOTAP).Other than the classical role of penetration enhancer,ILs also acted as superior solvents to si-multaneously load siRNA and DOTAP,forming siRNA-DOTAP-ILs(siRNA-DILs)formulations.During nasal mucosa penetration,DOTAP and ILs components self-assembled into cationic lipid nanocomplexes to load siRNA for enhanced in situ transfection.The siRNA-DILs demonstrated resistance against RNase,significant mucosa penetration,prolonged nasal retention,and satisfying gene-silencing efficacy at lower dosage.Meanwhile,DILs were also able to deliver KCa3.1-targeted siRNA effectively for the treatment of allergic rhinitis in rat model by nasal route.Thus,DILs have great potentials to deliver biological macromolecules across nasal mucosa by in situ dynamic self-assembly.
      原文链接:
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    • 维普

    Regulable toehold lock for the effective control of strand displacement reaction sequence and circuit leakage

    Kuangdi LuoYang QinXuehao ZhangHanxu Ji...
    372-376页
    查看更多>>摘要：Strand displacement reaction enables the construction of enzyme-free DNA reaction networks,thus has been widely applied to DNA circuit and nanotechnology.It has the characteristics of high efficiency,uni-versality and regulatability.However,the existing regulation tools cannot enable effective control of the reaction sequence,which undoubtedly limits the construction of complex nucleic acid circuits.Herein,we developed a regulation tool,toehold lock,and achieved strict control of reaction sequence without loss of the main reaction signal output.Furthermore,we applied the tool to scenarios such as seesaw circuits,AND/OR logic gates,and entropy-driven circuits,and respectively demonstrated its significant superiority compared to the original method.We believe that the proposed toehold lock has greatly optimized the efficiency of DNA strand displacement-based networks,and we anticipate that the tool will be widely used in multiple fields.
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    Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy

    Mengjuan SunMuye ZhouYifang XiaoHailei Tang...
    377-382页
    查看更多>>摘要：Size is one of the most important characteristics of nanoparticles to influence their biodistribution and antitumoral efficacy.Particles with large sizes have difficulty in deep tumor penetration,while small par-ticles are easily removed from tumor tissues due to the high tumor interstitial fluid pressure.To ad-dress these issues,an intelligent core-crosslinked polyion complex micelle(cPCM)with a reversibly size-switchable feature was engineered in this study.The micelles are consisting of methoxy poly(ethylene glycol)-poly(d,l-lactide)copolymer(mPEG-PLA),mPEG-PLA-(HE)6CC,and mPEG-PLA-(RG)6CC at an opti-mal mass ratio of 6:1:1 with an antiangiogenic compound,dabigatran etexilate(DE),encapsulated.The net charge inside the micelles is switchable when exposed to different pH conditions,thereby leading to revisable size-change of micelles.DE-loaded micelles(DE@cPCM)can swell and release drugs at the tumor sites with a mildly acidic pH,while they shrink and protect the cargo from leaking into the blood circulation with a neutral pH.Results indicated that DE@cPCM can inhibit tumor angiogenesis in vitro and in vivo,thereby efficiently restraining tumor growth in a 4T1-bearing mouse model.Collectively,the size-switchable cPCM is a promising nanoplatform for targeting delivery of anticarcinogens into the matrix of tumor tissues.
      原文链接:
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    Luminescence-activated Pt(Ⅳ)prodrug for in situ triggerable cancer therapy

    Huijie AnChen YangZhihui JiangJunjie Yuan...
    383-387页
    查看更多>>摘要：Anticancer platinum prodrugs that can be controllably activated are highly desired for personalized precision medicine and patient compliance in cancer therapy.However,the clinical application of plat-inum(Ⅳ)prodrugs(Pt(Ⅳ))is restricted by tissue penetration of external irradiation.Here,we report a novel Pt(Ⅳ)activation strategy based on endogenous luminescence of tumor microenvironment respon-siveness,which completely circumvents the limitation of external irradiation.The designed Pt(Ⅳ)-Lu,a mixture of trans,trans,trans-[Pt(N3)2(OH)2(py)2]and luminol(Lu),has controllable activation property:it remains inert in reductant environment and normal tissues,but under tumor microenvironment,Lu will be oxidized to produce blue luminescence,which rapidly reduce Pt(Ⅳ)to Pt(Ⅱ)without the need of any external activator.Pt(Ⅳ)-Lu shows excellent responsive antitumor ability both in vitro and in vivo.Compared to cisplatin,the median lethal dose in BALB/c mice increased by an order of magnitude.Our results suggest that Pt(Ⅳ)-Lu exhibits highly controllable activation property,superior antitumor activity,and good biosafety,which may provide a novel strategy for the design of platinum prodrugs.
      原文链接:
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    Legumain-triggered aggregable gold nanoparticles for enhanced intratumoral retention

    Zhi LiWenpei LiShaoping JiangChuan Hu...
    388-393页
    查看更多>>摘要：Insufficient intratumoral retention of nanomedicines remains the major challenge for broad implemen-tation in clinical sets.Herein,we proposed a legumain-triggered aggregable gold nanoparticle(GNP)delivery platform(GNPs-A&C).GNPs-A&C could form intratumoral or intracellular aggregates in response to the overexpressed legumain.The aggregates with size increase not only could reduce back-flow from interstitial space to peripheral bloodstream but also could restrict the cellular exocytosis,leading to enhanced intratumoral retention.In vitro studies demonstrated that GNPs-A&C possessed an excellent legumain responsiveness and the increased size was closely relevant with legumain expression.In vivo studies demonstrated GNPs-A&C possessed slower clearance rate and much higher intratumoral retention within legumain-overexpressed tumor compared to non-aggregable NPs,regardless of intravenous or intratumoral injection.More importantly,this delivery platform significantly improved the chemother-apeutic effect of doxorubicin(DOX)towards subcutaneous xenograft C6 tumor.The effectiveness of this stimulus-responsive aggregable delivery system provides a thinking for designing more intelligent size-tunable nanomedicine that can substantially improve intratumoral retention.
      原文链接:
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    O2-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma

    Yu QinMingyang HuangChenlu HuangHannah L.Perry...
    394-399页
    查看更多>>摘要：Photothermal therapy(PTT)and photodynamic therapy(PDT)have received tremendous attention ow-ing to their great potential for tumor treatment.However,two main issues hamper the antitumor per-formance of PDT:overexpression of glutathione(GSH)in tumors,which consumes PDT-induced reac-tive oxygen species(ROS),and hypoxia within the tumor microenvironment.The drawbacks of PTT in-clude uneven temperature distribution and the upregulation of the heat-shock proteins in tumors,both of which result in ineffective treatment.To address these issues,a MnO2 doped nano-delivery system(HTIM-PMs)was synthesized by one-step self-assembly of disulfide bond bridged copolymers for indo-cyanine green(ICG)and MnO2 loading.The surface of polymeric micelles was layered with hyaluronan(HA)and transactivator(TAT)peptides to improve active targeting and increase cell penetration.After internalization,HTIM-PMs showed responsiveness to the tumor microenvironment(acid pH,high glu-tathione,high H2O2).Breaking the disulfide bond reduced the intratumoral GSH level and simultaneously released the MnO2 and ICG.The released MnO2 further reduced the GSH level and promoted O2 gener-ation,thus enhancing the PDT effect.The PTT-mediated hyperthermia accelerated blood flow,which is beneficial for O2 distribution,and promotes ROS diffusion.These PTT-mediated adjuvant effects further overcame the limitations of PDT and the robust PDT effect in turn compensated for the deficiency of PTT.This promising platform exhibited a significant improvement in the PTT-PDT cancer treatment strategy compared to previously reported nanostructures.
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    Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy

    Zhaomin TangQian HeJianren ZhouShuang Yan...
    400-406页
    查看更多>>摘要：Fe-based Fenton agents can generate highly reactive and toxic hydroxyl radicals(·OH)in the tumor mi-croenvironment(TME)for chemodynamic therapy(CDT)with high specificity.However,the low pH en-vironment and insufficient endogenous hydrogen peroxide(H2O2)of the highly efficient Fenton reaction limits its practical application in clinic.Here,a Cu(Ⅱ)-doped mesoporous silica nanoagent(Cu-MSN)with excellent dispersity was successfully developed.After loaded with doxorubicin(DOX)and ascorbate(AA),Cu-MSN@DA was coated with active targeting ligand folic acid(FA),dimethyl maleic an-hydride(DMMA)and carboxymethyl chitosan(CMC)to obtain an active transporting nanoagent(FCDC@Cu-MSN@DA)with tunable charge-reversal property,which is more adaptable to the pH value of TME than Fe-based Fenton agents,and can self-supply exogenous H2O2 by ascorbate to produce more toxic·OH to trigger the apop-tosis of cancer cells.Meanwhile,the high level of glutathione(GSH)in TME can reduce Cu(Ⅱ)to Cu(Ⅰ)by Fenton-like reaction,increasing the generation rate of·OH and relieving tumor antioxidant ability.The supply of exogenous H2O2 significantly enhanced the synergistic effect of CDT by oxidative damage.To-gether with DOX-induced cell apoptosis,this novel nanoagent FCDC@Cu-MSN@DA can achieve maximum therapeutic efficacy,creating a new model of safe and effective tumor treatment with high specificity.
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    Double stimulus-responsive palladium catalysts for ethylene polymerization and copolymerization

    Hailong HeWenbing WangWenmin PangChen Zou...
    407-411页
    查看更多>>摘要：The external stimulus response strategy has been evolved rapidly in the field of olefin polymerization.In this work,we modularly synthesized three types of double stimulus responsive α-diimine palladium catalysts,combining redox regulation and other regulation together,such as light,Lewis acid and alkali cations.The catalytic activities and the molecular weight of polyethylene products can be regulated for 4 times in ethylene polymerization.These palladium complexes were also used for the copolymerization reaction of ethylene and polar monomers,such as methyl 10-undecylenate and methyl acrylate,effec-tively regulating the catalytic activities,the molecular weight and polar monomer incorporation of the prepared copolymers.The research on these dual-regulated palladium complexes makes full use of pre-pared catalysts and provides new inspirations for regulating olefin polymerization.
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