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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    A DNA micro-complex containing polyaptamer for exosome separation and wound healing

    Jingwen ZhaoJianpu TangZhen CuiLimin Liu...
    257-261页
    查看更多>>摘要：Exosomes(EXOs)have showed great potential in regenerative medicine.The separation of EXOs from complex biological media is essential for the down-stream applications.Herein,we report a deoxyribonu-cleic acid(DNA)-based micro-complex(DMC)containing polyaptamers,which realized the specific sepa-ration of EXOs from cell culture media and the significant promotion of wound healing.The synthesis of DMCs was based on a biomineralization process via rolling circle amplification(RCA)under the catalysis of phi29 DNA polymerase.To endow DMCs with the ability to capture EXOs,the DNA template of RCA was integrated with complementary sequence of aptamer that specifically recognized the CD63 proteins on EXOs.The obtained DMCs contained polyaptamers that can specifically capture the EXOs in cell cul-ture media.The EXOs-capturing DMCs were collected by centrifugation,achieving the separation of EXOs.Mesenchymal stem cell(MSC)-derived EXOs(MSC-EXOs)were separated by this DMC-based strategy,and the separated MSC-EXOs significantly enhanced the migration ability of cells.In particular,the significant therapeutic efficacy of the DMCs with MSC-EXOs was verified in full-thickness wound excision mouse models,in which the wounds completely healed in 10 days.We envision that this DMC-based separation strategy can be a promising route to promote the development of EXOs in biomedicine.
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    Preparation of norovirus GII loop mediated isothermal amplification freeze-drying microsphere reagents and its application in an on-site integrated rapid detection platform

    Yanqi WuYuhong GuanPeilin HuangHui Chen...
    262-265页
    查看更多>>摘要：Norovirus is an infectious disease that can cause non-bacterial gastroenteritis,which has a low infectious dose,rapid onset,and strong transmission ability;therefore,rapid and sensitive detection is essential to reduce the transmission of gastroenteritis.In the study,a norovirus GII loop-mediated isothermal ampli-fication assay was developed and prepared into freeze-drying microspheres,and a closed-cassette-based,integrated,reagent-ambient storage,on-site instant detection platform for norovirus GII was constructed using a commercial,fully automated nucleic acid analyzer with integrated magnetic bearing based nu-clear acid extraction and nucleic acid detection,with a sensitivity of 10 copies/pL,with no cross-reactivity with other 5 viruses.For 28 simulated samples,the integrated assay platform was consistent with the ex-perimental results of reverse transcription-quantitative polymerase chain reaction(RT-qPCR)assays after conventional laboratory nucleic acid extraction.The entire process can be finished in about 1 h,which is ideal for immediate rapid detection.
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    Mapping multiple phases in curcumin binary solid dispersions by fluorescence contrasting

    Ying XuChengying ShenHailong YuanWei Wu...
    266-272页
    查看更多>>摘要：The microphases and miscibility in binary curcumin(Cur)solid dispersions(SDs)with amorphous polyvinylpyrrolidone K30(PVP K30)and semi-crystalline poloxamer(P407)and poly(ethylene glycol)6000(PEG6000)as carriers were investigated by fluorescence contrasting utilizing confocal laser scan-ning microscopy.A super sensitive fluorophore P4 with typical aggregation-caused quenching properties was employed to stain the continuous polymer phases and contrasted with the autofluorescence of the model drug Cur.In addition,differential scanning calorimetry(DSC)and powder X-ray diffraction(PXRD)were utilized to assist in explanation of the fluorescence results.In all three SD systems,there is always a homogenous polymer phase stained by P4 and it is difficult to adulterate Cur crystals by P4.Cur-enriched rather than polymer-enriched domains could be detected.In the Cur-PVP K30 system,Cur exists in an amorphous form at a Cur loading level of 50％and below,while Cur crystallines phase out and continu-ously grow with the increase of Cur loading from 60％to 90％.The phase behaviors in the Cur-P407 and Cur-PEG 6000 systems are similar but with minor differences.In both systems,Cur phases out as clusters of drug-enriched domains at a loading level of 20％and below,which however cannot be correlated with crystallization,as evidenced by both DSC and PXRD.There is a transition from an amorphous to a crys-talline state from 20％to 30％Cur loading,above which Cur crystallines can be detected.It is interesting that a co-mix phase of both Cur-and PEG 6000-enriched domains can be identified at Cur loading levels of 10％and less.Taking together,it is concluded that contrasting Cur autofluorescence with the signals of P4 proves to be a functional strategy to reveal multiple phases in the binary SD systems investigated.
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    Inhaled multilevel size-tunable,charge-reversible and mucus-traversing composite microspheres as trojan horse:Enhancing lung deposition and tumor penetration

    Lishan XiongXinyuan LiXiaojie LuZhendong Zhang...
    273-278页
    查看更多>>摘要：Dry powder inhalation represents a promising approach for the treatment of lung cancer,offering sev-eral advantages such as enhanced targeting,improved bioavailability,and reduced toxicity.However,tra-ditional dry powder formulations suffer from limitations,notably low pulmonary delivery efficiency and inadequate penetration into tumor tissues,thereby limiting their therapeutic efficacy.In response to these challenges,we have developed an innovative trojan horse strategy,harnessing an inhalable nanoparticle-in-microsphere system characterized by tunable size,reversible charge,and mucus-penetrating capa-bilities.The inhalable nanoparticle-in-microsphere system exhibit stable structural properties,excellent environmental responsiveness and high biocompatibility.More importantly,the therapeutic effect of MTX@PAMAM@HA@Gel(MPHG)was demonstrated in vitro and in vivo.This system offers improved pul-monary delivery efficiency,enhanced drug retention within tumor tissues,and effective penetration,thus representing a promising strategy in lung cancer treatment.
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    Galvanostatic method assembled ZIFs nanostructure as novel nanozyme for the glucose oxidation and biosensing

    Erzhuo ChengYunyi LiWei YuanWei Gong...
    279-283页
    查看更多>>摘要：Recently,the composite of soft conductive substrates,such as carbon fiber(CF),with metal-organic frame-works(MOFs)has been employed in a myriad of applications.The composite material has demonstrated exceptional potential in the realm of electrochemical sensing platforms.However,the rapid growth of MOFs on the surface of CF remains a challenge.Herein,we propose a simple galvanostatic method as an effective strategy for rapidly growing zeolitic imidazolate frameworks(ZIFs)on CF,and obtain nano-caltrop-like ZIFs modified CF(NC-ZIFs/CF)glucose(Glu)sensor platform with distinctive morphology.The prepared NC-ZIFs/CF demonstrated significant electrocatalytic activity towards the oxidation of Glu in alkaline media,characterized by a pronounced augmentation in oxidation current density.At an ap-plied potential of 0.4 V,NC-ZIFs/CF exhibited a remarkably broad detection range(3-30,000 μmol/L)and demonstrated outstanding selectivity,repeatability and reproducibility.Additionally,the NC-ZIFs/CF was efficaciously employed for the detection of blood Glu levels in the serum of both normoglycemic and hyperglycemic patients,obtaining highly reliable results.This work demonstrates the feasibility of using galvanostatic method assembly to induce the growth of MOFs on conductive substrates,providing new ideas for electrocatalysis sensors and other electrochemical applications.
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    Tetrahedral framework nucleic acids promote the proliferation and differentiation potential of diabetic bone marrow mesenchymal stem cell

    Yanjing LiJiayin LiYuqi ChangYunfeng Lin...
    284-288页
    查看更多>>摘要：Diabetes mellitus considerably affects bone marrow mesenchymal stem cells(BMSCs),for example,by inhibiting their proliferation and differentiation potential,which enhances the difficulty in endogenous bone regeneration.Hence,effective strategies for enhancing the functions of BMSCs in diabetes have far-reaching consequences for bone healing and regeneration in diabetes patients.Tetrahedral framework nucleic acids(tFNAs)are nucleic acid nanomaterials that can autonomously enter cells and regulate their behaviors.In this study,we evaluated the effects of tFNAs on BMSCs from diabetic rats.We found that tFNAs could promote the proliferation,migration,and osteogenic differentiation of BMSCs from rats with type 2 diabetes mellitus,and inhibited cell senescence and apoptosis.Furthermore,tFNAs effectively scav-enged the accumulated reactive oxygen species and activated the suppressed protein kinase B(Akt)sig-naling pathway.Overall,we show that tFNAs can recover the proliferation and osteogenic potential of diabetic BMSCs by alleviating oxidative stress and activating Akt signaling.The study provides a strategy for endogenous bone regeneration in diabetes and also paves the way for exploiting DNA-based nanoma-terials in regenerative medicine.
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    Poly(ferulic acid)nanocarrier enhances chemotherapy sensitivity of acute myeloid leukemia by selectively targeting inflammatory macrophages

    Weijian ZhangXianyu DengLiying WangJian Wang...
    289-295页
    查看更多>>摘要：Macrophages,as a subset of innate immune cells,play a pivotal role in the initiation,maintenance,and resolution of inflammatory responses during tissue damage repair,defense against infections,and tumor progression.However,the mechanisms by which macrophages regulate inflammation in acute myeloid leukemia(AML)and their involvement in the chemotherapeutic effect remain elusive.In this study,we have identified that AML cells stimulate macrophage expansion by activating the colony-stimulating fac-tor 1 receptor(CSF1R)pathway.The expanded macrophages activate nuclear factor kappa-B(NFκB)to induce the expression of inflammatory factors,thereby maintaining leukemic cell quiescence and pro-moting cell survival following chemotherapy.Furthermore,we have successfully utilized a poly(ferulic acid)nanocarrier to selectively target macrophages for inhibiting the NFκB-mediated inflammation,ulti-mately enhancing chemotherapy efficacy against AML.Taken together,our findings highlight the crucial role of macrophage-induced inflammation in conferring chemoresistance to AML,and demonstrate the potential of a targeted nanocarrier specifically designed for inflammatory macrophages to improve the AML chemotherapeutic outcomes.
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    Utilizing dual-responsive iridium(Ⅲ)complex for hepatocellular carcinoma:Integrating photoacoustic imaging with chemotherapy and photodynamic therapy

    Jinyu GuoYandai LinShaohua HeYueqing Chen...
    296-302页
    查看更多>>摘要：Stimuli-triggered release and alleviating resistance of iridium(Ⅲ)-based drugs at tumor sites re-mains challengeable for clinical hepatoma therapy.Herein,a doxorubicin@iridium-transferrin(DOX@Ir-TF)nanovesicle was synthesized by carboxylated-transferrin(TF)and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium(QA)groups and disulfide bonds.The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species(ROS),while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glu-tathione(GSH);simultaneously,modification of TF improved recognition and endocytosis of the nanovesi-cle for tumor cells.Based on in-vitro results,a controlled-release behavior of DOX upon a dual-responsiveness of GSH and near-infrared ray(NIR)irradiation was presented,along with high-efficiency generation of ROS.After an intravenous injection,the nanovesicle was targeted at tumor sites,realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations.Overall,newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcuta-neous hepatocellular carcinoma therapy due to integrations of targeting delivery,dual-stimuli responsive release,synergistic therapy strategy,and real-time monitoring.
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    Red blood cell membrane-coated FLT3 inhibitor nanoparticles to enhance FLT3-ITD acute myeloid leukemia treatment

    Jisheng LiuJunli ChenXifeng ZhangYin Wu...
    303-308页
    查看更多>>摘要：FMS-like tyrosine kinase 3(FLT3)is a viable and important therapeutic target for acute myeloid leukemia(AML).FLT3 internal tandem duplication(FLT3-ITD)mutations have been identified in approximately 30％of AML patients,and are associated with unfavorable prognosis,higher risk of relapse,drug resistance,and poor clinical outcome.Even FLT3 inhibitors have demonstrated promising efficacy,they cannot cure AML or even significantly extend the lives of patients with FLT3-ITD mutations.This is partly because of poor water solubility,insufficient membrane penetration and short half-life of small molecule inhibitors.Besides,the presence of enzymes like CYP3A4 in bone marrow accelerate the elimination and metabolism of FLT3 inhibitors,resulting in low plasma concentrations and side effects.Here we report the erythro-cyte membrane-camouflaged FLT3 inhibitor nanoparticles to enhance FLT3-ITD AML treatment.Briefly,we physically coextruded red blood cell(RBC)membrane vesicles with nanoparticles derived from FLT3 inhibitor F30 to obtain F30@RBC-M,which exhibited comparable potent FLT3-ITD inhibitory effects com-pared to free F30 in vitro,while displaying a higher potent antitumor efficacy in xenograft models due to the prolonged circulation properties.Furthermore,administration of F30@RBC-M significantly extended the survival of mice in a transplanted mouse model than F30 free drug.These findings suggest that RBC membrane-coated nanoparticles derived from FLT3 inhibitors hold promise as a tool to enhance the ther-apeutic efficacy to treat FLT3-ITD AML.
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    Fe-N-C heterogeneous Fenton-like catalyst for the degradation of tetracycline:Fe-N coordination and mechanism studies

    Weichen ZhuWei ZuoPu WangWei Zhan...
    309-314页
    查看更多>>摘要：Fe-N-C materials have received increasing attention,due to its distinctive catalytic activity.However,the Fe-N coordination number dependence of catalytic ability and mechanism for H2O2 activation remain elusive.Herein,a series of Fe-N-C heterogeneous Fenton-like catalysts with different Fe-N coordination number were prepared for tetracycline degradation.The results demonstrated that samples with Fe-N4 structure exhibited high activity.The excellent performance was mainly ascribed to the high adsorption capacity and the formation of superoxide radicals(·O2-)catalyzed by Fe linked to pyridinic nitrogen.The intermediates and degradation pathways of tetracycline degradation by Fe-N-C/H2O2 system were analyzed by liquid chromatography coupled to tandem mass spectrometry(LC-MS/MS).Furthermore,we applied our Fe-N-C catalysts to treat simulated pharmaceutical wastewater with high tetracycline degra-dation capacity despite high concentrations of organic matter such as oxalic acid and various ionic inter-ferences.Our work reveals the dependence of the activation H2O2 on the Fe-N coordination environment and the degradation mechanism of these catalysts.It provides insights into the prospects for tuning the catalyst in practical applications.
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