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中华医学杂志（英文版）
中华医学会
中华医学杂志（英文版）

中华医学会

照日格图

半月刊

0366-6999

renlihua@cma.org.cn

010-85158321

100710

北京市东城区东四西大街42号

中华医学杂志（英文版）/Journal Chinese Medical JournalCSCDCSTPCD北大核心SCI
查看更多>>1887年创刊，中华医学会主办。中华医学杂志英文版(Chinese Medical Journal)是中华医学会会刊，是中国惟一被SCI核心版收录、具有百年以上历史的医学期刊。重点报道我国医学各学科最新进展和高水平科研成果，目前已被《科学引文索引（SCI）》、《医学索引（IM）》、Medline等国际著名检索系统收录。2009年SCI影响因子0.952，SCI被引频次3407。2010年被国际医学期刊编辑委员会（ICMJE）吸收为新成员。多次获得国家期刊奖、科协专项基金、自然基金等奖项和资助。实行全文上网 （），网上投稿审稿()。
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    Split liver transplantation in China:Past,present,and future

    Xiao FengShuhong YiYang Yang
    2773-2775页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Are we prepared for the next pandemic:Monitor on increasing human and animal H5N1 avian influenza infection

    Qing WangYanxia SunZhongjie LiWeizhong Yang...
    2776-2781页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Effect of endothelial responses on sepsis-associated organ dysfunction

    Miao WuYan YanXinyu XieJiawei Bai...
    2782-2792页
    查看更多>>摘要：Sepsis-related organ dysfunction is associated with increased morbidity and mortality.Previous studies have found that the endothelium plays crucial roles in maintaining the vascular permeability during sepsis,as well as in regulating inflammation and thrombosis.During sepsis,endothelial cells may release cytokines,chemokines,and pro-coagulant factors,as well as express adhesion molecules.In general,endothelial responses during sepsis typically inhibit bacterial transmission and coordinate leu-kocyte recruitment to promote bacterial clearance.However,excessive or prolonged endothelial activation can lead to impaired microcirculation,tissue hypoperfusion,and organ dysfunction.Given the structural and functional heterogeneity of endothelial cells in different organs,there are potential differences in endothelial responses by organ type,and the risk of organ damage may vary accordingly.This article reviews the endothelial response observed in sepsis and its effects on organ function,summarizes current progress in the development of therapeutic interventions targeting the endothelial response,and discusses future research directions to serve as a reference for researchers in the field.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Vascular cognitive impairment:Advances in clinical research and management

    Tongyao YouYingzhe WangShufen ChenQiang Dong...
    2793-2807页
    查看更多>>摘要：Vascular cognitive impairment(VCI)encompasses a wide spectrum of cognitive disorders,ranging from mild cognitive impair-ment to vascular dementia.Its diagnosis relies on thorough clinical evaluations and neuroimaging.VCI predominately arises from vascular risk factors(VRFs)and cerebrovascular disease,either independently or in conjunction with neurodegeneration.Growing evidence underscores the prevalence of VRFs,highlighting their potential for early prediction of cognitive impairment and dementia in later life.The precise mechanisms linking vascular pathologies to cognitive deficits remain elusive.Chronic cerebrovascular pathology is the most common neuropathological feature of VCI,often interacting synergistically with neu-rodegenerative processes.Current research efforts are focused on developing and validating reliable biomarkers to unravel the etiology of vascular brain changes in VCI.The collaborative integration of these biomarkers into clinical practice,alongside routine incorporation into neuropathological assessments,presents a promising strategy for predicting and stratifying VCI.The cornerstone of VCI prevention remains the control of VRFs,which includes multi-domain lifestyle modifications.Identifying appropriate pharmacological approaches is also of paramount importance.In this review,we synthesize recent advancements in the field of VCI,including its definition,determinants of vascular risk,pathophysiology,neuroimaging and fluid-correlated biomarkers,predictive methodologies,and current intervention strategies.Increasingly evident is the notion that more rigorous research for VCI,which arises from a complex interplay of physiological events,is still needed to pave the way for better clinical outcomes and enhanced quality of life for affected individuals.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Cell therapy for end-stage liver disease:Current state and clinical challenge

    Lin ZhangYuntian DengXue BaiXiao Wei...
    2808-2820页
    查看更多>>摘要：Liver disease involves a complex interplay of pathological processes,including inflammation,hepatocyte necrosis,and fibrosis.End-stage liver disease(ESLD),such as liver failure and decompensated cirrhosis,has a high mortality rate,and liver transplanta-tion is the only effective treatment.However,to overcome problems such as the shortage of donor livers and complications related to immunosuppression,there is an urgent need for new treatment strategies that need to be developed for patients with ESLD.For instance,hepatocytes derived from donor livers or stem cells can be engrafted and multiplied in the liver,substituting the host hepatocytes and rebuilding the liver parenchyma.Stem cell therapy,especially mesenchymal stem cell therapy,has been widely proved to restore liver function and alleviate liver injury in patients with severe liver disease,which has contributed to the clinical application of cell therapy.In this review,we discussed the types of cells used to treat ESLD and their therapeutic mechanisms.We also summarized the progress of clinical trials around the world and provided a perspective on cell therapy.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Current trends and advances in antiviral therapy for chronic hepatitis B

    Juan LiSiyi LiuQijuan ZangRuijie Yang...
    2821-2832页
    查看更多>>摘要：Chronic hepatitis B virus(HBV)infection is a global public health concern.Existing antiviral drugs,including nucleos(t)ide analogs and interferon-α,can suppress HBV replication and improve the prognosis.However,the persistence of covalently closed circular DNA(cccDNA),the integration of HBV-DNA into the host genome,and compromised immune responses impede the successful treatment of hepatitis B.While achieving a functional cure of HBV remains elusive with the current treatment methods,this is the goal of new therapeutic approaches.Therefore,developing novel antiviral drugs is necessary for achieving a functional or complete cure for chronic hepatitis B.In recent years,substantial progress has been made in drug discovery and development for HBV infection.Direct-acting antiviral agents such as entry inhibitors,capsid assembly modulators,subviral particle release inhibitors,cccDNA silencers,and RNA interference molecules have entered clinical trials.In addition,several immunomodulatory agents,including toll-like receptor agonists,therapeutic vaccines,checkpoint inhibitors,and monoclonal antibodies,are also making their way toward clinical use.In this review,we summarize the recent progress and limitations of chronic hepatitis B treatment and discuss perspectives on approaches to achieving functional cure.Although it will take some time for these new antiviral drugs to be widely used in clinical practice,combination therapy may become a preferable treatment option in the future.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Impacts of Helicobacter pylori infection and eradication on gastrointestinal microbiota:An up-to-date critical review and future perspectives

    Yu LiCong HeNonghua Lu
    2833-2842页
    查看更多>>摘要：Helicobacter pylori(H.pylori)infects approximately half of the population worldwide and causes chronic gastritis,peptic ulcers,and gastric cancer.Test-and-treat strategies have been recommended for the prevention of H.pylori-associated diseases.Advancements in high-throughput sequencing technologies have broadened our understanding of the complex gastrointestinal(GI)microbiota and its role in maintaining host homeostasis.Recently,an increasing number of studies have indicated that the colonization of H.pylori induces dramatic alterations in the gastric microbiota,with a predominance of H.pylori and a reduction in microbial diversity.Dysbiosis of the gut microbiome has also been observed after H.pylori infection,which may play a role in the development of colorectal cancer.However,there is concern regarding the impact of antibiotics on the gut microbiota during H.pylori eradication.In this review,we summarize the current literature concerning how H.pylori infection reshapes the GI microbiota and the underlying mechanisms,including changes in the gastric environment,immune responses,and persistent inflammation.Additionally,the impacts of H.pylori eradication on GI microbial homeostasis and the use of probiotics as adjuvant therapy are also discussed.The shifts in the GI microbiota and their crosstalk with H.pylori may provide potential targets for H.pylori-related gastric diseases and extragastric manifestations.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Efferocytosis:A new therapeutic target for stroke

    Li GaoAnatol ManaenkoFeng ZengJingchen Li...
    2843-2850页
    查看更多>>摘要：Efferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells,which is essential for maintaining tissue homeostasis both in physiological and pathological conditions.Numerous studies have demonstrated that efferocytosis can prevent secondary necrosis and proinflammatory factor release,leading to the resolution of inflammation and tissue immunologi-cal tolerance in numerous diseases such as stroke.Stroke is a leading cause of death and morbidity for adults worldwide.Persistent inflammation triggered by the dead cells or cell debris is a major contributor to post-stroke brain damage.Effective efferocytosis might be an efficient strategy to minimize inflammation and restore brain homeostasis for neuronal regeneration and function recovery.In this review,we will discuss the phagocytes in the brain,the molecular mechanisms underlying efferocytosis,the role of efferocytosis in inflammation resolution,and the potential therapeutic applications targeting efferocytosis in stroke.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Growing burden of inflammatory bowel disease in China:Findings from the Global Burden of Disease Study 2021 and predictions to 2035

    Ziqing YuGechong RuanXiaoyin BaiYinghao Sun...
    2851-2859页
    查看更多>>摘要：Background:Inflammatory bowel disease(IBD)imposes a significant economic and social burden in China.We aim to assess the epidemiological trends of IBD in China,and to predict the burden in the near future.Methods:The incidence,mortality,prevalence,and disability-adjusted life year(DALYs)of IBD from 1990 to 2021 were obtained from Global Burden of Disease Study 2021.Estimated annual percentage change(EAPC),average annual percent change,total percent change,and age-period-cohort model were used to access trends.Bayesian age-period-cohort model was utilized to predict the risk of incidence and mortality.Results:In 2021,IBD affected 168,077 people in China,with 24,941 new cases and 5640 deaths.The age-standardized rate(ASR)of incidence and death was 1.4 and 0.3,respectively.The incidence and prevalence in China were lower than the global and high socio-demographic index(SDI)regions,but the ASR of incidence and prevalence(EAPC:2.93 and 2.54,respectively)had rapidly increased from 1990 to 2021.The ASR of death and DALYs had significantly decreased(EAPC:-3.05 and-2.93,respectively).Middle-aged and elderly populations faced a severe burden of incidence and prevalence,while the elderly population faced a severe mortality burden.It is projected that by 2035,the ASR of incidence will continue to rise,whereas the death rate will continue to decline.Conclusions:The burden of IBD in China is serious and increasingly severe.Establishing a comprehensive disease management system in China will help better control the medical burden of IBD.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Trends in mortality due to tracheal,bronchial,and lung cancer across the BRICS:An age-period-cohort analysis based on the Global Burden of Disease Study 1990-2019

    Ruhai BaiWanyue DongMeng ChuBian Liu...
    2860-2867页
    查看更多>>摘要：Background:Tracheal,bronchus,and lung cancer(TBL)is a major cause of mortality and top contributor to productivity loss in large emerging economies such as the BRICS(Brazil,Russia,India,China,and South Africa).We examined the time trends of TBL mortality across the BRICS to better understand the disease burden in these countries and inform public health and healthcare resource allocation.Methods:TBL mortality-related data between 1990 and 2019 were obtained from the Global Burden of Disease Study 2019 and analyzed using age-period-cohort models.Net drift(local drift)was used to describe the expected age-adjusted TBL mortality rate over time overall(each age group);the longitudinal age curve was used to reflect the age effect;the period rate ratios(RRs)were used to reflect the period effect;and the cohort RR was used to reflect the cohort effect.Results:In 2019,there were 958.3 thousand TBL deaths across the BRICS,representing 46.9％of the global TBL deaths.From 1990 to 2019,the age-standardized mortality rate(ASMR)of TBL decreased in Russia,Brazil,and South Africa while increased in China and India,with the largest reduction reported in Russia(-29.6％)and the largest increase in China(+22.4％).India showed an overall increase(+15.7％)in TBL mortality but the mortality risk decreased among individuals born after 1990(men)and 1995(women).Although South Africa and Brazil experienced an overall decline in TBL mortality,their recent birth cohorts,such as Brazilian individuals born after 1985(men)and 1980(women),and South African men born after 1995,had an increasing TBL mortality risk.China has experienced an overall increase in TBL mortality,with the mortality risk rising among individuals born after 1995 for both men and women.Russia,which had the highest TBL mortality among the BRICS countries in 1990,has demonstrated significant improvement over the past three decades.Conclusions:Over the past 30 years,the BRICS accounted for an increasing proportion of global TBL mortality.TBL mortality increased in older women in all the BRICS countries except Russia.Among the recent birth cohort,the risk of TBL mortality increased in Brazil,China,and South Africa.More effective efforts are needed in the BRICS to reduce the burden of TBL and help achieve the United Nation's Sustainable Development Goals.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据