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中华整形外科杂志
中华整形外科杂志

曹谊林

双月刊

1009-4598

cjpls@cma.org.cn

010-88960006

100144

北京市石景山区八大处路33号

中华整形外科杂志/Journal Chinese Journal of Plastic SurgeryCSCD北大核心CSTPCD
查看更多>>1985年创刊,中华医学会主办。本刊是中国协和医科大学整形外科研究所出版的整形外科专业学术期刊。以整形外科、烧伤外科、显微外科、骨科、口腔科、耳鼻喉科、眼科、泌尿外科、皮肤科等学科临床医师及科研工作者为读者对象,刊登对整形外科发展具有导向性、指导性的评论和文件,报道整形外科领域先进的科研成果和诊疗经验,以及对整形外科临床有指导作用、与整形外科临床密切结合的基础理论研究。主要栏目有:论著、工作研究、经验交流、病例报告、技术改进、综述、讲座、警钟等。本刊被多家国内外生物医学期刊数据库和医学文摘所收录。
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    枣核形组织切除法在鼻翼缩窄术中的应用效果

    吴乐昊徐奕昊王欢郑若冰...
    88-93页
    查看更多>>摘要:目的 探讨枣核形组织切除法在内切型鼻翼缩窄整形术中的临床应用效果。 方法 回顾性分析2019年2月至2022年6月中国医学科学院整形外科医院收治的行鼻翼缩窄术患者的临床资料。于鼻翼小叶基底部外缘设计梭形切口线,宽度为4~5 mm,长度为8~12 mm。切口线距离鼻翼面颊沟1~2 mm,设计线内侧延长至鼻前庭内部;沿切口设计线切开表面皮肤后,先用尖头弯剪扩大剥离切口下鼻翼软组织,再切除相应的鼻翼内组织,扩大切除的组织形态类似于枣核;充分减张后,切口两端的皮肤行垂直褥式外翻缝合。术后对手术效果和并发症进行随访,并由1位第三方整形外科主治医师采用观察者总体美容改善评分法(GAIS)和温哥华瘢痕量表评分法(VSS),通过对比患者术前和术后末次随访时的照片对手术效果和术后鼻部瘢痕情况进行评价。其中GAIS包括1、2、3、4、5分,评分越低改善效果越好,改善的标准为评分≤3分;VSS包括颜色(0~3分)、厚度(0~4分)、血管分布(0~3分)、柔软度(0~5分)4个指标,评分越高瘢痕越严重。 结果 共纳入20例患者,其中男6例,女14例,年龄20~33岁,平均24.9岁;患者均有不同程度的鼻翼外扩、鼻翼肥厚的表现。术后13例患者术区出现轻度肿胀、皮下淤斑和黄染,3 d后逐渐消退;术后无感染、切口裂开、延迟不愈等近期并发症发生。术后随访3~16个月,有2例患者因联合了肋软骨植入隆鼻术,术后6~9个月逐渐出现软骨变形而影响鼻孔外观,再次通过手术调整后获得满意效果,鼻孔对称度显著提高;其余患者鼻翼形态均一次性得到较大改善,患者对术后效果表示满意;术后远期无鼻孔变形、鼻小柱偏斜、通气障碍等表现,鼻翼切口瘢痕不明显,位置隐蔽。术后第三方医师对20例患者的GAIS评分为(1.20±0.41)分,其中16例评为1分,4例评为2分,均达到改善标准;VSS总评分为(1.45±0.60)分,其中颜色平均分为0.60分、厚度为0.05分、血管分布为0.55分、柔软度为0.30分。 结论 将枣核形组织切除法应用于内切型鼻翼缩窄术中,可以在切口宽度相同的情况下增加组织去除量,不仅能够充分缩窄鼻翼,而且对鼻翼组织肥厚也有一定的矫正效果。 Objective To investigate the clinical effect of jujube core-shaped tissue resection technique in the treatment of alar reduction. Methods A retrospective analysis was performed for the clinical data of patients who underwent alar reduction from February 2019 to June 2022. A spindle-shaped incision line was designed along the outer edge of the base of the nasal lobule, with a width of 4-5 mm and a length of 8-12 mm. The incision line was 1-2 mm away from the alar groove, and the inner side of the design line was extended to the inside of the nasal vestibule. After the incision was made, the subcutaneous tissue was undermining dissected with curved sharp scissors, and the shape of the extended excision tissue was similar to that of jujube core. After reduction, the incision was closed with vertical mattress suture. The surgical effect and complications were followed up after surgery, and an independent attending plastic surgeon evaluated the outcome and scarring based on photos before and at the last postoperative follow-up using the global aesthetic improvement scale (GAIS) and the Vancouver scar scale (VSS). GAIS is graded as 1, 2, 3, 4, and 5 points, and the lower the score, the better the improvement(≤3 points as effective improvement). VSS includes four parameters: color (0-3 points), thickness (0-4 points), vascular distribution (0-3 points), and softness (0-5 points). The higher the score, the more significant the scar is. Results A total of 20 patients were enrolled, including 6 males and 14 females, aged 20 to 33 years, with an average age of 24.9 years. Before the operation, there were different degrees of alar flare and alar hypertrophy. After surgery, 13 patients had mild swelling, ecchymosis, which resolved after 3 days. There were no major complications as infection, incision dehiscence, and delayed healing. After 3 to 16 months of postoperative follow-up, 2 patients gradually developed cartilage deformation and affected the appearance of the nostrils 6 to 9 months after surgery due to the combination of rib-based rhinoplasty, and the satisfactory results were obtained after revision surgery. The symmetry of the nostrils was significantly improved. The GAIS score of 20 patients was (1.20±0.41) points, of which, 16 patients were rated as 1 point and 4 patients were rated as 2 points, all of which met the improvement criteria, and the VSS score was (1.45±0.60) points, in which the average score for color, thickness, vasculature and compliance are 0.60, 0.05, 0.55 and 0.30 points respectively. Conclusion The application of jujube core-shaped tissue resection technique for alar reduction can increase the amount of tissue removal with the same incision width, which can not only fully narrow the alar effectively but also correct the hypertrophy of the alar tissue.

    鼻成形术鼻翼肥大鼻翼缩窄枣核形组织切除法

    PIK3CA相关过度生长综合征1例

    熊菲王诗琪袁斯明丁国兰...
    94-98页
    查看更多>>摘要:2022年8月,解放军东部战区总医院烧伤整形科收治1例PIK3CA相关过度生长综合征(PROS)患者。患者男,15岁,自出生时即发现左下肢肥大,半年前进行性加重,同时左侧腰部出现红斑及扩张静脉(42 cm×24 cm)。MRI检查显示左、右大腿软组织不对称,左侧大腿软组织较肥厚,左腰部血管畸形,左肾囊肿。对左腰部血管畸形注射3%聚多卡醇注射液进行硬化治疗,注射量为7.1 ml。病灶组织免疫组织化学染色显示,脉管内皮细胞、表皮基底层细胞中PIK3CA、AKT、mTOR呈阳性;基因检测结果为PIK3CA基因发生c.3190_3191insA(p.H1065fs)突变。治疗后1年随访,患者腰部红斑面积减小,左下肢肥大无明显进展。该例患者通过临床表现、病理学检查及基因检测得到确诊,扩充了PROS疾病临床表型及PIK3CA基因突变谱,为研究此类疾病提供了相关临床资料。 In August 2022, a patient diagnosed with PIK3CA-related overgrowth syndrome (PROS) was admitted to the Department of Burn and Plastic Surgery of the General Hospital of Eastern Theater Command. A 15-year-old male patient presented with overgrowth of the left lower limb since birth, which had progressive aggravation six months ago, accompanied by erythema and dilated veins (42 cm ×24 cm) on the left waist. MRI showed that the soft tissue of the left and right thighs was asymmetrical. There was soft tissue hypertrophy of the left thigh, vascular malformation on the left waist and a left renal cyst. The vascular malformations on the left waist were treated by sclerotherapy with 3% polydocaol injection, for which the injection volume of was 7.1 ml. Immunohistochemistry of the pathological tissue showed that PIK3CA, AKT and mTOR were positive in vascular endothelial cells and epidermal basal cells. The genetic testing suggested that there was a mutation at c. 3190_3191insA (p.H1065fs) in PIK3CA gene. On the first year after the interventional sclerotherapy, the area of erythema decreased and the overgrowth of the left lower limb did not progress significantly. This case was diagnosed by clinical manifestations, pathological examination and genetic testing, which expanded the clinical phenotype of PROS and PIK3CA mutation spectrum, providing relevant clinical data for the study of this diseases.

    血管畸形PIK3CA相关过度生长综合征硬化疗法移码突变

    三维打印在软骨组织工程中的应用

    于淑颖李昱程新好张怡君...
    99-106页
    查看更多>>摘要:在过去的几十年中,软骨的再生已经取得了巨大的进展。传统构建组织工程软骨支架的技术主要包括孔剂法(或模板法)、相分离法、气体发泡法、冷冻干燥法、静电纺丝法等。软骨是异质性的,传统支架很难模拟软骨的高度各向异性结构。因此,软骨的功能再生具有挑战性。随着三维打印技术的进步,通过生物材料、细胞和活性生物分子的共沉积,使制备精细结构、梯度变化的功能性仿生支架成为可能,从而实现功能性软骨再生。该文详细阐述了三维打印技术及其在不同解剖位置(关节、耳廓、鼻)软骨再生中的应用。此外,还讨论了制备具有区域结构梯度和区域成分梯度的仿生构建体的重要性。三维生物打印、四维打印技术及智能材料为仿生组织和器官的构建带来了希望。 In the past decades, significant progress has been achived in cartilage regeneration. The traditional techniques for constructing tissue engineering cartilage scaffold mainly include pore agent method (or template method), phase separation method, gas foaming method, freeze-drying method, electrospinning method, etc. Cartilage is heterogeneous, and it is difficult for traditional scaffolds to simulate the high anisotropy of cartilage. Therefore, functional regeneration of cartilage is challenging. With the progress of three-dimensional(3D) printing technology, it is possible to prepare functional bionic scaffolds with fine structure and gradient changes through co-deposition of biomaterials, cells and active biomolecules, so as to achieve functional cartilage regeneration. This article reviewed 3D printing technology of cartilage tissue engineering, and the application of 3D printing technology in cartilage regeneration at different anatomical positions (articular cartilage, auricle cartilage, nasal cartilage). In addition, the importance of preparing bionic constructs with regional structure gradient and regional composition gradient was discussed. 3D bioprinting technology, 4D printing techniques, smart biomaterials brought hope for the construction of bionic tissues and organs.

    组织工程学软骨三维打印三维生物打印关节软骨耳软骨鼻软骨

    机器人手术系统在整形外科领域的应用

    文俊贤王晓军程铭吴镝...
    107-111页
    查看更多>>摘要:机器人手术系统近年来得到了迅速发展,在整形外科领域的应用也日益广泛,但相对于其他专科依然处于初级阶段。该文着重介绍了机器人手术系统在整形外科领域的发展现状,并对该技术的未来发展做出展望,为促进机器人手术系统在整形手术中的应用提供参考。 The robot surgery system has developed rapidly in recent years. The application of robot surgery systems in plastic and reconstructive surgery is also increasingly wide, but it is still in the initial stage compared to other specialties. This article focuses on the development status of the robot surgery system in the field of plastic and reconstructive surgery, and makes an outlook on the future development of the technology, to promote the application of the robot surgery system in the plastic and reconstructive surgery.

    机器人学手术系统整形外科重建美容

    间充质干细胞来源外泌体在毛发再生中的研究进展

    张琬君张培华丁国兰李竹君...
    112-117页
    查看更多>>摘要:间充质干细胞(MSCs)是一类来源于中胚层的成体干细胞,具有自我更新和多向分化的能力。间充质干细胞来源外泌体(MSCs-Exo)是各类MSCs分泌至体液且具有生物活性的细胞外囊泡,具有抗炎、修复、促进细胞增殖和分化、调节毛发生长周期等优势。毛发再生涉及多种细胞及细胞因子的共同作用,其中毛乳头细胞(DPCs)被认为是一种独特的MSCs,具有自体干细胞的功能特性;且作为毛囊的信号中心,在调节毛发生长中发挥重要作用。MSCs-Exo可通过调节毛发生长周期促进DPCs增殖和分化。近年来,MSCs-Exo的研究为毛发再生提供了新策略,该文对相关研究进行了综述,以期对脱发的治疗提供新思路。 Mesenchymal stem cells (MSCs) are a type of adult stem cells derived from the mesoderm, with the ability for self-renewal and multidirectional differentiation. Mesenchymal stem cell-derived exosomes (MSCs-Exo) are bioactive extracellular vesicles secreted by various MSCs into body fluids. They offer advantages such as anti-inflammatory properties, tissue repair, promotion of cell proliferation and differentiation, and regulation of the hair growth cycle. Hair regeneration involves the interaction of various cells and cytokines. Dermal papilla cells (DPCs) are considered as a unique MSCs with the functional properties of autologous stem cells. As the signaling center of the hair follicle, it plays an important role in regulating hair growth. MSCs-Exo can promote the proliferation and differentiation of DPCs by regulating the hair growth cycle. In recent years, research on MSCs-Exo has provided a new strategy for hair regeneration. This article reviewed the research on the use of MSCs-Exo for hair regeneration, aiming to offer new insights for the treatment of alopecia.

    间质干细胞外泌体毛乳头细胞毛囊

    脂肪来源干细胞在皮片和皮瓣移植中的应用

    高宏胡哲源结祥朱晓海...
    118-123页
    查看更多>>摘要:皮片移植和皮瓣移植是整形外科应用最广泛的修复重建方式,如何避免移植后皮片和皮瓣的坏死,提高皮片和皮瓣的存活质量一直是整形外科基础与临床研究中的基本问题之一,脂肪来源干细胞(ADSCs)的出现为解决这一问题带来了新的思路。该文从ADSCs的分离、鉴定和生物学特性,ADSCs在皮片移植和皮瓣移植中的应用研究等方面进行综述;同时提出了ADSCs应用中存在的问题,并对其未来进行了展望。 Skin graft and skin flap transplantation are the most widely used reparative and reconstructive method in plastic surgery. How to avoid the necrosis of skin graft and skin flap together with the improvement of survival quality of skin graft and skin flap have always been one of the basic problem in plastic surgery basic and clinical research. The emergence of adipose-derived stem cells has brought a new idea to solve this problem. In this paper, the isolation, identification and biological characteristics of adipose-derived stem cells, application of adipose-derived stem cells in skin graft and skin flap transplantation were reviewed. At the same time, the problems of adipose-derived stem cells and their future prospects were discussed.

    干细胞移植细胞培养技术皮肤移植组织移植同种异体移植物

    正颌外科虚拟手术规划研究现状

    李磊乔嘉牛峰丁国兰...
    124-128页
    查看更多>>摘要:正颌手术是治疗牙颌面畸形的经典手术。由于牙颌面解剖结构的复杂性,术前通常需要进行详细而准确的手术规划。随着近年来医学成像技术和手术规划软件的快速发展,虚拟手术规划(VSP)越来越多地被用于正颌外科,以提供准确、高效、可预测的规划和模拟。正颌外科VSP的设计和发展涉及图像采集和复合头部模型构建、三维参考框架定义、虚拟咬合设置、虚拟截骨和手术模拟、软组织预测、转移工具等几个方面,该文对相关步骤的研究进行了总结,以为临床提供参考。 Orthognathic surgery is a classic procedure to correct dentomaxillofacial deformities. Due to the complexity of the dentomaxillofacial anatomy, detailed and accurate surgical planning is usually required before the operation. With the rapid development of medical imaging technologies and surgical planning softwares in recent years, virtual surgical planning(VSP) has been increasingly applied in orthognathic surgery to provide more accurate, efficient and predictable planning and simulation. The design and development of VSP in orthognathic surgery involves image acquisition and composite head model construction, three-dimensional reference frame definition, virtual occlusion setup, virtual osteotomy and surgical simulation, soft tissue prediction and transfer tools. This paper summarizes the research of related steps for clinical reference.

    外科手术,计算机辅助虚拟手术规划正颌外科手术

    经双骨隧道"8"字捆绑骨块治疗陈旧性骨性锤状指

    江起庭李智程健邱福平...
    319-325页
    查看更多>>摘要:目的 探讨经双骨隧道"8"字捆绑骨块治疗陈旧性骨性锤状指的临床效果。 方法 回顾性分析2021年5月至2023年2月南京江北医院手足显微外科收治的陈旧性骨性锤状指患者临床资料。术中采用0. 8 mm克氏针于末节指骨基底部缺损远端及近端各制作1条横向骨隧道,先采用肌腱缝线沿远、近端骨隧道"8"字捆绑骨块于末节指骨基底部缺损处,再用克氏针弹性加压固定。术后3周拔除克氏针后逐步加强患指伸屈运动。末次随访时测量患指与对应健指各关节的主动屈伸活动范围,记录手指(患指与健指)远指间关节(DIPJ)活动度及总主动活动度(TAM);参照美国手外科协会TAM系统评定手指功能,分为优、良、可、差4个等级。采用SPSS 13. 0软件对数据进行统计分析,符合正态分布的计量资料以±s表示,术后6个月患指DIPJ活动度、TAM与对侧健指比较采用配对样本t检验,P<0. 05表示差异有统计学意义。 结果 共纳入30例患者(30指),男19例,女11例;年龄18~ 62岁,平均31岁;受伤至手术时间24~ 65 d,平均35 d。根据Wehbe和Schneider分型:Ⅰa型8例,Ⅰb型6例,Ⅱa型7例,Ⅱb型5例,Ⅲa型2例,Ⅲb型2例。术后切口出血极少,无感染,均一期愈合。30例患指术后均获随访,随访时间为6~ 7个月,骨折处均对位可、愈合佳,锤状指畸形均完全矫正,无针道感染及断针现象。术后末次随访时测量显示,患指DIPJ活动度与对侧健指比较,差异无统计学意义[(30. 2±3. 5)°vs.(30. 4±3. 3)°,t=2. 57,P=0. 463];患指TAM与对侧健指比较,差异亦无统计学意义[(235. 3±3. 6)°vs.(237. 7±4. 2)°,t=1. 78,P=0. 247]。患指功能评价:优27例,良3例,优良率为100%。 结论 经双骨隧道"8"字捆绑骨块,可多维度立体独立地固定骨块,稳定牢固,治疗陈旧性骨性锤状指效果好,且利于早期功能锻炼。 Objective To discuss the clinical curative effect of the treatment of bundling bone fragment with figure-of-eight suture through double bone tunnels in the chronic bong mallet finger. Methods A retrospective analysis was performed on patients with chronic bong mallet fingers who underwent surgery in the Department of Hand and Foot Microsurgery of Nanjing Jiangbei Hospital from May 2021 to February 2023. During the procedure, made into transverse double bone tunnels on the base of the distal phalanx with 0. 8 mm Kirschner wire, bundling bone fragment with figure-of-eight suture through double bone tunnels, then fixed with Kirschner wire elastic compression. Removal of the Kirschner wire 3 weeks after the procedure, the active flexion and extension range of the joints of the affected finger and the corresponding finger were measured at the last follow-up, then the range of motion (ROM) of the distal interphalangeal joint (DIPJ) and total action movement (TAM) of the fingers (affected and healthy finger) were recorded. The curative effects were evaluated according to the TAM system of the American Association of Hand Surgeons, including 4 grades: excellent, good, fair, and poor. SPSS 13. 0 software was used for statistical analysis of the data, and the measurement data conforming to normal distribution were expressed as Mean ± SD. The ROM of DIPJ and TAM of the affected finger were compared with the corresponding healthy finger 6 months after surgery by a paired sample t test. P<0. 05 indicates that the difference is statistically significant. Results A total of 30 patients (30 digits) were enrolled, including 19 males and 11 females, and the age ranged from 18 to 62 years old, with an average age of 31 years old. The time from injury to operation was 24 to 65 days (mean of 35 days) . According to Wehbe and Schneider classification, there were 8 cases of type Ⅰa, 6 cases of type Ⅰb, 7 cases of type Ⅱa, 5 cases of type Ⅱb, 2 cases of type Ⅲa and 2 cases of type Ⅲb. All incisions healed well, the intraoperative blood loss was minimal, with no infection. All 30 cases were followed up for 6 to 7 months. All fractures were well aligned and healed, malformed fingers were completely corrected, and no needle tunnel infection or needle breakage were observed. At the last follow-up, the differences of the ROM of the DIPJ [ (30. 2±3. 5) °vs. (30. 4±3. 3) °, t=2. 57, P=0. 463] and the TAM [ (235. 3± 3. 6) ° vs. (237. 7± 4. 2) °, t=1. 78, P= 0. 247 ] between the affected and healthy fingers were not statistically significant. Finger function assessment: 27 cases were excellent, and 3 cases were good, and the excellent and good rate was 100%. Conclusion Satisfactory therapeutic outcome for the treatment of chronic bong mallet finger deformity can be achieved by bundling bone fragment with figure-of-eight suture through double bone tunnels. It is an effective and practical method.

    指损伤骨隧道"8"字捆绑锤状指骨折固定术,内

    透明质酸注射美容治疗疼痛的横断面研究

    史礼帅齐莉莉张军王涛...
    326-333页
    查看更多>>摘要:目的 了解医生在进行透明质酸注射时解决注射疼痛的观念和常用方法,为注射疼痛管理的进一步规范化提供可供参考的数据。 方法 本研究为横断面研究,采用方便抽样方法向美容注射医生及有透明质酸注射经验的患者发放问卷以收集其对透明质酸注射相关疼痛观点的数据。医生部分于2022年6月15日至7月20日线下收集,共17个问题,题目类型包含单选题、多选题及问答题;患者部分于2022年11月14日至12月6日通过问卷星平台收集,共6个问题,题目类型包含单选题和多选题。相关数据使用SPSS 22.0软件进行描述性统计分析,数据呈现形式为人数及百分比(%)。 结果 收集医生问卷62份,患者问卷123份。42名(67.74%)医生从日常工作中观察到超过50%的患者非常在意注射时疼痛;101名(82.11%)患者在注射透明质酸前,对即将到来的疼痛在意程度≥5分(满分10分)。治疗时,48名(77.42%)医生建议患者选择含利多卡因的透明质酸填充剂,原因包括注射疼痛可显著减轻(53名,85.48%)及患者治疗体验舒适(59名,95.16%)。60例(48.78%)患者注射时愿意选择含麻透明质酸,但含麻透明质酸的价格会影响患者的选择(55名,44.72%)。 结论 透明质酸注射美容治疗的疼痛是医生与患者都重视的问题。含利多卡因透明质酸以其镇痛效果明显、安全性高的特点受到医生与患者的认可。注射美容治疗的疼痛目前还没有完善的解决方案,可能需要多学科协作解决。 Objective To learn about physicians’ concepts and commonly employed method in hyaluronic acid injection and provide reference data for the standardization of pain management. Methods This study was a cross-sectional study. Convenient sampling method was used to distribute questionnaires to cosmetic injectors and patients experienced with hyaluronic acid injections to collect data on their views of pain associated with hyaluronic acid injections. The physician portion was collected offline from June 15 to July 20, 2022, and the patient portion was collected from November 14, 2022, to December 6, 2022, via the Questionnaire Star platform. The physician questionnaire consisted of 17 questions, question types included single choice, multiple choice and essay questions. The patient questionnaire consisted of 6 questions, question types included single choice and multiple choice. Relevant data were analyzed using SPSS 22.0 software for descriptive statistics, and data were presented in the form of cases and percentages (%). Results Sixty-two physician questionnaires and 123 patient questionnaires were collected. 42 (67.74%) physicians observed from their daily practice that more than 50% of their patients were very concerned about pain during injection 101 (82.11%) patients scored ≥5 out of 10 for concern about impending pain prior to hyaluronic acid filler injection. At the time of treatment, 48 (77.42%) physicians advised patients to choose a lidocaine-containing hyaluronic acid filler for reasons including a significant reduction in injection pain (53 cases, 85.48%) and patient comfort with the treatment experience (59 cases, 95.16%). 60 (48.78%) patients were willing to choose an anesthesia-containing product at the time of injection, but the price of the anesthesia-containing product influenced the patient’ s choice (55 cases 44.72%) . Conclusions Pain from cosmetic injectable treatments is an important issue to both physicians and patients. Lidocaine-containing hyaluronic acid is recognized by physicians and patients for its analgesic effect and high safety profile. There is no perfect solution for pain in cosmetic injection treatment, and multidisciplinary collaboration may be needed to solve the problem.

    透明质酸注射疼痛美容治疗利多卡因