查看更多>>摘要：赖氨酸特异性去甲基化酶1（LSD1）是首个被发现的组蛋白去甲基化酶。近年来在恶性肿瘤的发生及发展研究中成为热点话题，其表达与恶性肿瘤的不良预后密切相关。目前已有研究指出，LSD1与三阴性乳腺癌（TNBC）的增殖、侵袭和转移有较强相关性，然而，关于其中的具体机制尚未完全清楚。文章总结了LSD1与TNBC发生、发展可能存在的机制，并综述LSD1在TNBC临床研究应用上的最新进展，为TNBC患者的药物联合治疗提供参考。 Lysine-specific demethylase 1 (LSD1) is the firstly discovered histone demethylase. In recent years, LSD1 has become a hot topic in the study of the development and progression of malignancies, and its expression is closely related to the poor prognosis of malignancies. At present, some studies have showed that LSD1 is strongly related to the proliferation, invasion and metastasis of triple-negative breast cancer (TNBC). However, the specific mechanism is not fully understood. This article summarizes the possible mechanism of the development and progression in LSD1 and TNBC, and reviews the latest progress of LSD1 in the clinical research application of TNBC, so as to provide a reference for drug combination therapy in TNBC patients.
查看更多>>摘要：套细胞淋巴瘤（MCL）是一种罕见的B细胞淋巴瘤，其发病率在逐年升高。MCL兼具惰性淋巴瘤和侵袭性淋巴瘤的共同特点，病情进展迅速且预后不佳。最新研究认为，MCL的发病机制是一个连续统一体，细胞周期失调、SOX11过表达、表观遗传畸变等多种因素在疾病的不同阶段发挥作用。文章主要从分子遗传学角度讨论MCL的发病机制和不同亚型的新发现，进一步分析MCL的临床多样性。同时，通过对MCL发病机制的认识，旨在为MCL未来的治疗提供潜在的治疗靶点。 Mantle cell lymphoma (MCL) is a rare B cell lymphoma, and its incidence rate is increasing year by year. MCL has the common characteristics of both inert lymphoma and aggressive lymphoma: rapid progress and poor prognosis. The latest research believes that the pathogenesis of MCL is a continuum, and many factors such as cell cycle disorder, SOX11 overexpression, epigenetic aberration play a role in different stages of the disease. This paper mainly reviews the pathogenesis of MCL and new findings of different subtypes from the perspective of molecular genetics,and further analyzes the clinical diversity of MCL. At the same time, the understanding of the pathogenesis of MCL aims to provide potential targets for future treatment of MCL.
查看更多>>摘要：肺微乳头型腺癌发病率低，术后易复发和转移，患者预后差。文章总结了肺微乳头型腺癌的影像学与组织病理学特征，并讨论了外科术式、化疗及靶向药物治疗方案对患者预后的影响，旨在加深对肺微乳头型腺癌的认识。 The incidence of lung micropapillary adenocarcinoma is low, and it is easy to relapse and metastasize after operation, which leads to poor prognosis. This article mainly summarizes the imaging and histopathological features of lung micropapillary adenocarcinoma and discusses the effects of surgical procedures, chemotherapy and targeted drug therapy on the prognosis of patients, in order to deepen the understanding of lung micropapillary adenocarcinoma.
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