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结合医学学报（英文版）
结合医学学报（英文版）

赵伟康

月刊

2095-4964

jcim@163.com

021-81873540

200433

上海市杨浦区翔殷路800号第二军医大学中医系2201室

结合医学学报（英文版）/Journal Journal of Chinese Integrative MedicineCSCDCSTPCD北大核心SCI
查看更多>> 《中西医结合学报》于2003年5月创刊，是中国科技论文统计源期刊、中国科技核心期刊、RCCSE中国权威学术期刊、上海市科协系统优秀科技期刊、全国中医药优秀期刊、美国《医学索引》（Index Medicus/MEDLINE/PubMed）收录期刊。 《中西医结合学报》是开放获取期刊，已被列入《开放获取期刊指南》（Directory of Open Access Journals, DOAJ）,所有被录用的稿件均经过同行评议，同时在纸质印刷版和网络电子版发表。 《中西医结合学报》为月刊，设有院士笔谈、专论、述评、学术探讨、系统评价、临床论著、实验论著、经验交流、医案医话、文献研究、文献综述、学术讲座、医学统计学、中医英译、结合医学概览、医学论文写作、国际动态、会议消息、书评、招聘启事、读者来信等栏目。纸质印刷版于每月15日出版，全球发行；网络电子版与纸质印刷版同步出版。网络电子版具有完善的检索和参考文献链接功能。全球用户可在本刊中英文双语网站无任何限制地检索、阅读和下载全部论文。 《中西医结合学报》在国际最权威的医学文献电子数据库PubMed建有免费全文链接。全球用户可在PubMed免费检索任何一篇论文的摘要和题录，并且可以在PubMed即时链接本刊网站，免费阅读所检索的论文全文。 中西医结合学报杂志社（JCIM Press）是出版者国际链接联合会（Publisher International Linking Association, PILA）和CrossRef的机构会员，与CrossRef成员期刊实现了跨平台链接。《中西医结合学报》的每一篇论文都注册了DOI号，并建有参考文献链接和被引链接。 《中西医结合学报》将以最快的速度，最便捷的方式，最大范围地向世界展示您的研究成果。 我们的办刊方针：坚持学术期刊的导向作用，履行学术期刊的社会责任，倡导科学、严谨、务实、创新的学术风尚。我们的办刊理念：只争朝夕，只求卓越；尽我所能，做到更好。 我们的办刊目的：向世界展示中国中西医结合研究的成果，向中国读者介绍世界结合医学的进展，为全球读者提供一个即时和自由交流的学术平台。 我们的办刊方向：编辑出版国际一流医学期刊，打造国际化精品期刊、品牌期刊。
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    Tocotrienol isoforms:The molecular mechanisms underlying their effects in cancer therapy and their implementation in clinical trials

    Maria YounesGhady LoubnaneChristopher SleimanSandra Rizk...
    1-11页
    查看更多>>摘要：Tocotrienols are found in a variety of natural sources,like rice bran,annatto seeds and palm oil,and have been shown to have several health-promoting properties,particularly against chronic diseases such as cancer.The incidence of cancer is rapidly increasing around the world,not only a result of continued aging and population growth,but also due to the adoption of aspects of the Western lifestyle,such as high-fat diets and low-physical activity.The literature provides strong evidence that tocotrienols are able to inhibit the growth of various cancers,including breast,lung,ovarian,prostate,liver,brain,colon,mye-loma and pancreatic cancers.These findings,along with the reported safety profile of tocotrienols in healthy human volunteers,encourage further research into these compounds'potential use in cancer pre-vention and treatment.The current review provided detailed information about the molecular mecha-nisms of action of different tocotrienol isoforms in various cancer models and evaluated the potential therapeutic effects of different vitamin E analogues on important cancer hallmarks,such as cellular pro-liferation,apoptosis,angiogenesis and metastasis.MEDLINE/PubMed and Scopus databases were used to identify recently published articles that investigated the anticancer effects of vitamin E derivatives in var-ious types of cancer in vitro and in vivo along with clinical evidence of adjuvant chemopreventive ben-efits.Following an overview of pre-clinical studies,we describe several completed and ongoing clinical trials that are paving the way for the successful implementation of tocotrienols in cancer chemotherapy.
      原文链接:
    • 万方数据
    • 维普

    Efficacy of scraping therapy on blood pressure and sleep quality in stageⅠ and Ⅱ essential hypertension:A systematic review and meta-analysis

    Zheng-gang ZhuJian-ru WangXiao-yan Pan
    12-21页
    查看更多>>摘要：Background:Scraping therapy is widely used in treating stage Ⅰ and Ⅱ essential hypertension in China.However,there has been no systematic evaluation of the efficacy of scraping therapy on blood pressure and sleep quality in stage Ⅰ and Ⅱ essential hypertension.Search strategy:Seven electronic databases(PubMed,Scopus,Cochrane Library,Web of Science,EBSCO,China National Knowledge Infrastructure and Wanfang Data electronic databases)were searched from inception to December 2022.Based on the principle of combining subject words with text words,the search strategy was constructed around search terms for"scraping therapy,""scraping,""Guasha,""Gua sha,""hypertension,"and"high blood pressure"during the database searches.Inclusion criteria:Randomized controlled trials(RCTs)were included if they recruited patients with stageⅠ and Ⅱ essential hypertension and included a scraping therapy intervention.The intervention group received antihypertensive drugs and scraping therapy,while the control group only took antihyperten-sive drugs.Data extraction and analysis:Review Manager 5.4.0 and STATA 15.1 were used to enter all the relevant outcome variables to conduct the meta-analysis.The quality of the selected RCTs was assessed using the PEDro scale.The sensitivity analysis was carried out by iteratively excluding individual studies and repeating the analysis to determine the stability of the findings and identify any studies with greater influence on the outcome.Subgroup analysis was performed to find the source of heterogeneity.Funnel plots were used to evaluate the publication bias of included studies.Results:Nine RCTs including 765 participants were selected.Meta-analysis showed that scraping therapy combined with medication had an advantage over the use of medication alone in lowering systolic blood pressure(mean difference[MD]=-5.09,95％confidence interval[CI]=-6.50 to-3.67,P＜0.001)and diastolic blood pressure(MD=-2.66,95％CI=-3.17 to-2.14,P＜0.001).Subgroup analysis showed that scraping therapy improved sleep quality in middle-aged patients with hypertension,but the efficacy was better in elderly patients(MD=-7.91,95％CI=-8.65 to-7.16,P＜0.001)than in middle-aged patients(MD=-2.67,95％CI=-4.12 to-1.21,P=0.0003).Conclusion:The available evidence indicates that scraping therapy has significant effects on patients with stage Ⅰ and Ⅱ hypertension,and it improves sleep quality for elderly patients with hypertension better than for middle-aged ones.Scraping therapy can be an adjunctive treatment for stage Ⅰ and Ⅱ essential hypertension.However,further high-quality studies are needed to verify its effectiveness and the best therapeutic strategies.
      原文链接:
    • 万方数据

    Acupuncture and moxibustion for irritable bowel syndrome:An umbrella systematic review

    Yue-ying MaZhou HaoZi-yi ChenYan-xi Shen...
    22-31页
    查看更多>>摘要：Background:Irritable bowel syndrome(IBS)is a functional bowel disease characterized by abdominal pain or discomfort associated with altered bowel habits.Several clinical studies have demonstrated the effectiveness of acupuncture and moxibustion for IBS.Many systematic reviews of acupuncture and moxibustion for IBS have been published in recent years,but their results are not entirely consistent.Objective:To evaluate the methodological,reporting,and evidence quality of systematic reviews of acupuncture and moxibustion for IBS.Search strategy:Systematic reviews of acupuncture and moxibustion for IBS published before February 20,2023 were searched in eight databases:PubMed,Embase,Cochrane Library,Web of Science,China National Knowledge Infrastructure,Wanfang Data,VIP Database for Chinese Technical Periodicals,and China Biology Medicine.The keywords used for literature search were acupuncture,moxibustion,sys-tematic review,meta-analysis,and irritable bowel syndrome.Inclusion criteria:Systematic reviews and meta-analyses of randomized controlled trials of acupuncture and moxibustion for IBS were included.Data extraction and analysis:Relevant information was independently extracted by two investigators.The A MeaSurement Tool to Assess systematic Reviews 2(AMSTAR 2),Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA 2020),and Grading of Recommendations Assessment,Development and Evaluation(GRADE)were used to evaluate the methodological quality,reporting qual-ity and evidence quality,respectively.Results:A total of 342 studies were retrieved and 15 systematic reviews were included.The results of AMSTAR 2 showed low methodological quality in 2 studies and very low methodological quality in the remaining 13 studies,with main issues being failure to register a protocol,incomplete search strategy,not providing a list of excluded studies,incomplete consideration of the risk of bias in the included studies,and a failure to assess the publication bias.The results of PRISMA 2020 showed seriously deficient report-ing quality of 2 studies,somewhat deficient reporting quality of 12 studies,and relatively complete report-ing quality of 1 study,with the main problems being lack of a complete search strategy,non-availability of a list of excluded studies with justification for their exclusion,not conducting heterogeneity and sensitiv-ity analyses,not evaluating the credibility of the evidence,and not registering the protocol.The results of GRADE showed that the quality of the evidence is low or very low.Conclusion:Most included systematic reviews interpreted findings to suggest that acupuncture and mox-ibustion have benefits for IBS.However,there is a need to improve the methodological,reporting and evi-dence quality of the systematic reviews.Larger,multicenter,rigorously designed randomized controlled trials and high-quality systematic reviews are required to obtain more robust evidence.
      原文链接:
    • 万方数据
    • 维普

    Transcutaneous electrical acupoint stimulation benefits postoperative pain relief of oocyte retrieval:A randomized controlled trial

    Li-ying LiuYang SuaRong-rong WangYuan-yuan Lai...
    32-38页
    查看更多>>摘要：Background:Transvaginal oocyte retrieval is frequently followed by adverse events related to anesthesia and the procedure.Some research showed that transcutaneous electrical acupoint stimulation(TEAS)can relieve intraoperative pain and postoperative nausea.Objective:This study examined whether TEAS can alleviate pain and relieve adverse symptoms after oocyte retrieval.Design,setting,participants and interventions:Altogether 128 patients were randomly divided into the TEAS group and the mock TEAS group.The two groups received a 30-minute-long TEAS or mock TEAS treatment that began 30 min after oocyte retrieval.Main outcome measures:The primary outcome was the visual analog scale(VAS)pain score.Secondary outcomes were pressure pain threshold,McGill score,pain rating index(PRI),present pain intensity(PPI),VAS stress score,VAS anxiety score,and postoperative adverse symptoms.Results:The baseline characteristics of the two groups were comparable(P＞0.05).The VAS pain scores of the TEAS group were lower than those of the mock TEAS group at 60 and 90 min after oocyte retrieval(P＜0.05).The McGill score,PRI and PPI in the TEAS group were significantly lower than those in the con-trol group at 60 min after oocyte retrieval(P＜0.05).However,the two groups had equivalent beneficial effects regarding the negative emotions,such as nervousness and anxiety(P＞0.05).The TEAS group was superior to the mock TEAS group for relieving postoperative adverse symptoms(P＜0.05).Conclusion:TEAS treatment can relieve postoperative pain and postoperative adverse symptoms for patients undergoing oocyte retrieval.
      原文链接:
    • 万方数据
    • 维普

    Short-term effects of cupping and scraping therapy for chronic nonspecific low-back pain:A prospective,multicenter randomized trial

    Jun-yan HeXiao-yu TuZi-fei YinHui Mu...
    39-45页
    查看更多>>摘要：Background:As one of the most common musculoskeletal ailments,chronic nonspecific low-back pain(CNLBP)causes persistent disability and substantial medical expenses.Epidemiological evidence shows that the incidence rate of CNLBP in young and middle-aged people who are demanded rapidly recovery and social contribution is rising.Recent guidelines indicate a reduced role for medicines in the manage-ment of CNLBP.Objective:The present study investigates the short-term effects of cupping and scraping therapy using a medicated balm,compared to nonsteroidal anti-inflammatory drug(NSAID)with a capsaicin plaster,in the treatment of CNLBP.Design,setting,participants and interventions:We designed a prospective multicenter randomized clinical trial enrolling patients from January 1,2022 to December 31,2022.A total of 156 patients with CNLBP were randomized into two parallel groups.Diclofenac sodium-sustained release tablets were adminis-tered orally to participants in the control group for one week while a capsaicin plaster was applied exter-nally.Patients in the test group were treated with cupping and scraping using a medical device and medicated balm.Main outcome measures:Primary outcome was pain recorded using the visual analogue scale(VAS).Two secondary outcomes were recorded using the Japanese Orthopedic Association low-back pain scale(JOA)and the traditional Chinese medicine(TCM)syndrome integral scale(TCMS)as assessment tools.Results:Between baseline and postintervention,all changes in outcome metric scales were statistically significant(P＜0.001).Compared to the control group,patients in the test group had a significantly greater treatment effect in all outcome variables,as indicated by lower VAS and TCMS scores and higher JOA scores,after the one-week intervention period(P＜0.001).Further,according to the findings of mul-tivariate linear regression analysis,the participants'pain(VAS score)was related to their marital status,age,smoking habits and body mass index.No adverse reactions were reported for any participants in this trial.Conclusion:The effectiveness of TCM combined with the new physiotherapy tool is superior to that of NSAID combined with topical plasters,regarding to pain intensity,TCM symptoms and quality of life.The TCM plus physiotherapy also showed more stable and long-lasting therapeutic effects.Trial registration:This study was registered at Chinese Clinical Trial Registry(ChiCTR2200055655).
      原文链接:
    • 万方数据
    • 维普

    Predictors of the placebo response in a nutraceutical randomized controlled trial for depression

    Rosemary ArnoldJenifer Murphy-SmithChee H.NgDavid Mischoulon...
    46-53页
    查看更多>>摘要：Objective:The placebo response in depression studies is the change in symptoms amongst those who receive an inactive treatment.Many well-designed randomized controlled trials(RCTs)of depression have a high proportion of placebo responders,with little understanding as to why.The present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large propor-tion of placebo responders.Methods:This is a secondary analysis of a nutraceutical depression RCT which identified no overall treat-ment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their association with the placebo response.Monoaminergic genetic polymorphisms were also assessed.Placebo response was measured based on change in Montgomery-Asberg Depression Rating Scale score.The association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects models.Results:Greater levels of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were associated with greater placebo response.An increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant therapy.Single nucleotide polymorphisms from the tryptophan hydroxylase 1(TPH1)gene(A779C and A218C)were weakly associated with greater placebo response,although the evidence was attenuated after accounting for multiple comparisons.Conclusion:This is,to our knowledge,the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo response.Several variables appeared to predict the placebo response.Such findings may encourage future trial designs which could dampen placebo response,improve assay sensitivity,and allow for treatment effects to be potentially more detectable.
      原文链接:
    • 万方数据
    • 维普

    Identifying behavioral determinants and stage of readiness for performing knee massage among individuals with knee osteoarthritis:An observational study

    Donya NematiNiki MunkNavin Kaushal
    54-63页
    查看更多>>摘要：Objective:Patients who experience knee osteoarthritis or chronic knee pain can alleviate their symptoms by performing self-knee massage.Understanding the readiness and types of determinants needed to facilitate self-knee massage is needed to design effective,theory-informed interventions.The primary objective of this study was to apply the transtheoretical model of behavior change to identify how factors,which include the type of knee condition and pain level,predict an individual's readiness to adopt self-knee massage.The secondary objective employed the capability,opportunity and motivation-behavior(COM-B)model to identify relevant determinants that are predictive of an individual's readiness to undertake self-knee massage.Methods:An observational study design was used to recruit individuals with knee osteoarthritis(n=270)and chronic knee pain(n=130).Participants completed an online survey that assessed the transtheoret-ical model of behavior change stages,COM-B determinants(capability,opportunity and motivation),along with self-administered massage behavior.Multivariate analysis of covariance and structural equa-tion modeling were used to test the primary and secondary objective,respectively.Results:Participants who had knee osteoarthritis scored higher on the action stage compared to those with chronic pain(P=0.003),and those who experienced greater level of pain scored higher in the con-templation(P＜0.001)and action phases(P＜0.001)of performing knee massage compared to those with milder pain.The COM-B structural equation model revealed self-administered knee massage to be predicted by capability(β=0.31,P=0.004)and motivation(β=0.29,P＜0.001),but not opportunity(β=-0.10,P=0.39).Pain level predicted motivation(β=0.27,P＜0.001),but not capability(β=0.09,P=0.07)or opportunity(β=0.01,P=0.83).Tests for mediating effects found that determinants of COM-B(motivation and capability)mediate between pain level and self-administered massage behavior(β=0.10,P=0.002).Conclusion:Clinicians and researchers can expect that patients diagnosed with knee osteoarthritis or who have chronic knee pain are ready(action stage)or are considering the behavior(contemplation stage)of self-knee massage.Individuals who report having knee osteoarthritis or chronic knee pain should be coached to develop the skills to perform self-knee massage and helped to develop the motiva-tion to carry out the therapy.
      原文链接:
    • 万方数据
    • 维普

    Mapping the clinical practice of traditional,complementary and integrative medicine in oncology in Western countries:A multinational cross-sectional survey

    Matthias HuemerSandro GracaSarah BitscheGuenter Hofmann...
    64-71页
    查看更多>>摘要：Background:Many cancer patients seek adjunctive therapies to biomedical cancer treatments at some point of their disease trajectory.While acupuncture is increasingly recommended by leading oncological associations,limited evidence exists concerning the evidence-informed practice and adherence to current guidelines of traditional complementary and integrative medicine(TCIM)practitioners treating cancer patients.Methods:An international online-survey assessed the demographical data,clinical practice,and sources of information used by TCIM practitioners in Austria,Germany,United States of America,Australia,and New Zealand.Results:In total,404 respondents completed the survey,of which 254(62.9％)treated cancer patients.Most practitioners were acupuncturists and herbalists(57.1％),had(16.8±9.9)years of clinical experi-ence and see a median of 2(1,4)cancer patients per week.Breast cancer(61.8％)is the most common cancer type seen in TCIM clinics.Adjunctive TCIM treatments are frequently concurrent with the patient's cancer specific treatment(39.9％),which is also reflected by the main goal of a TCIM treatment to alleviate side effects(52.4％).However,only 28.0％of the respondents are in contact with the treating oncologist.According to the respondents,pain is most effectively treated using acupuncture,while herbal medicine is best for cancer-related fatigue.TCIM practitioners mostly use certified courses(33.1％)or online data-bases(28.3％)but often believe that experts are more reliable to inform their practice(37.0％)than research publications(32.7％).Conclusion:Acupuncturists and herbalists commonly treat cancer patients.Most practitioners use TCIM as an adjunct to biomedicine as supportive care and use it largely in accordance with current oncological guidelines.
      原文链接:
    • 万方数据
    • 维普

    Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency

    Jing-shun MengYun HeHeng-bin YangLi-ping Zhou...
    72-82页
    查看更多>>摘要：Objective:Melittin and its derivative have been developed to support effective gene delivery systems.Their ability to facilitate endosomal release enhances the delivery of nanoparticle-based gene therapy.Nevertheless,its potential application in the context of viral vectors has not received much attention.Therefore,we would like to optimize the rAAV vector by Melittin analog to improve the transduction effi-ciency of rAAV in liver cancer cells and explore the mechanism of Melittin analog on rAAV.Methods:Various melittin-derived peptides were inserted into loop Ⅷ of the capsid protein in recom-binant adeno-associated virus vectors.These vectors carrying either gfp or fluc genes were subjected to quantitative polymerase chain reaction assays and transduction assays in human embryonic kidney 293(HEK293T)cells to investigate the efficiency of vector production and gene delivery.In addition,the ability of a specific p5RHH-rAAV vector to deliver genes was examined through in vitro transduction of different cultured cells and in vivo tail vein administration to C57BL/6 mice.Finally,the intricate details of the vector-mediated transduction mechanisms were explored by using pharmacological inhi-bitors of every stage of the rAAV2 intracellular life cycle.Results:A total of 76 melittin-related peptides were identified from existing literature.Among them,CMA-3,p5RHH and aAR3 were found to significantly inhibit transduction of rAAV2 vector crude lysate.The p5RHH-rAAV2 vectors efficiently transduced not only rAAV-potent cell lines but also cell lines pre-viously considered resistant to rAAV.Mechanistically,bafilomycin A1,a vacuolar endosome acidification inhibitor,completely inhibited the transgene expression mediated by the p5RHH-rAAV2 vectors.Most importantly,p5RHH-rAAV8 vectors also increased hepatic transduction in vivo in C57BL/6 mice.Conclusion:The incorporation of melittin analogs into the rAAV capsids results in a significant improve-ment in rAAV-mediated transgene expression.While further modifications remain an area of interest,our studies have substantially broadened the pharmacological prospects of melittin in the context of viral vector-mediated gene delivery.
      原文链接:
    • 万方数据
    • 维普

    Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling

    Lu-lu HanXin ZhangHui ZhangTing Li...
    83-92页
    查看更多>>摘要：Objective:Obesity is a global health concern with management strategies encompassing bariatric surgery and anti-obesity drugs;however,concerns regarding complexities and side effects persist,driving research for more effective,low-risk strategies.The promotion of white adipose tissue(WAT)browning has emerged as a promising approach.Moreover,alisol B 23-acetate(AB23A)has demonstrated efficacy in addressing metabolic disorders,suggesting its potential as a therapeutic agent in obesity management.Therefore,in this study,we aimed to investigate the therapeutic potential of AB23A for mitigating obesity by regulating metabolic phenotypes and lipid distribution in mice fed a high-fat diet(HFD).Methods:An obesity mouse model was established by administration of an HFD.Glucose and insulin metabolism were assessed via glucose and insulin tolerance tests.Adipocyte size was determined using hematoxylin and eosin staining.The expression of browning markers in WAT was evaluated using Western blotting and quantitative real-time polymerase chain reaction.Metabolic cage monitoring involved the assessment of various parameters,including food and water intake,energy metabolism,res-piratory exchange rates,and physical activity.Moreover,oil red O staining was used to evaluate intracel-lular lipid accumulation.A bioinformatic analysis tool for identifying the molecular mechanisms of traditional Chinese medicine was used to examine AB23A targets and associated signaling pathways.Results:AB23A administration significantly reduced the weight of obese mice,decreased the mass of inguinal WAT,epididymal WAT,and perirenal adipose tissue,improved glucose and insulin metabolism,and reduced adipocyte size.Moreover,treatment with AB23A promoted the expression of browning markers in WAT,enhanced overall energy metabolism in mice,and had no discernible effect on food intake,water consumption,or physical activity.In 3T3-L1 cells,AB23A inhibited lipid accumulation,and both AB23A and rapamycin inhibited the mammalian target of rapamycin-sterol regulatory element-binding protein-1(mTOR-SREBP1)signaling pathway.Furthermore,3-isobutyl-1-methylxanthine,dexamethasone and insulin,at concentrations of 0.25 mmol/L,0.25 μmol/L and 1 μg/mL,respectively,induced activation of the mTOR-SREBP1 signaling pathway,which was further strength-ened by an mTOR activator MHY1485.Notably,MHY1485 reversed the beneficial effects of AB23A in 3T3-L1 cells.Conclusion:AB23A promoted WAT browning by inhibiting the mTOR-SREBP1 signaling pathway,offering a potential strategy to prevent obesity.
      原文链接:
    • 万方数据
    • 维普