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结合医学学报（英文版）
结合医学学报（英文版）

赵伟康

月刊

2095-4964

jcim@163.com

021-81873540

200433

上海市杨浦区翔殷路800号第二军医大学中医系2201室

结合医学学报（英文版）/Journal Journal of Chinese Integrative MedicineCSCDCSTPCD北大核心SCI
查看更多>> 《中西医结合学报》于2003年5月创刊，是中国科技论文统计源期刊、中国科技核心期刊、RCCSE中国权威学术期刊、上海市科协系统优秀科技期刊、全国中医药优秀期刊、美国《医学索引》（Index Medicus/MEDLINE/PubMed）收录期刊。 《中西医结合学报》是开放获取期刊，已被列入《开放获取期刊指南》（Directory of Open Access Journals, DOAJ）,所有被录用的稿件均经过同行评议，同时在纸质印刷版和网络电子版发表。 《中西医结合学报》为月刊，设有院士笔谈、专论、述评、学术探讨、系统评价、临床论著、实验论著、经验交流、医案医话、文献研究、文献综述、学术讲座、医学统计学、中医英译、结合医学概览、医学论文写作、国际动态、会议消息、书评、招聘启事、读者来信等栏目。纸质印刷版于每月15日出版，全球发行；网络电子版与纸质印刷版同步出版。网络电子版具有完善的检索和参考文献链接功能。全球用户可在本刊中英文双语网站无任何限制地检索、阅读和下载全部论文。 《中西医结合学报》在国际最权威的医学文献电子数据库PubMed建有免费全文链接。全球用户可在PubMed免费检索任何一篇论文的摘要和题录，并且可以在PubMed即时链接本刊网站，免费阅读所检索的论文全文。 中西医结合学报杂志社（JCIM Press）是出版者国际链接联合会（Publisher International Linking Association, PILA）和CrossRef的机构会员，与CrossRef成员期刊实现了跨平台链接。《中西医结合学报》的每一篇论文都注册了DOI号，并建有参考文献链接和被引链接。 《中西医结合学报》将以最快的速度，最便捷的方式，最大范围地向世界展示您的研究成果。 我们的办刊方针：坚持学术期刊的导向作用，履行学术期刊的社会责任，倡导科学、严谨、务实、创新的学术风尚。我们的办刊理念：只争朝夕，只求卓越；尽我所能，做到更好。 我们的办刊目的：向世界展示中国中西医结合研究的成果，向中国读者介绍世界结合医学的进展，为全球读者提供一个即时和自由交流的学术平台。 我们的办刊方向：编辑出版国际一流医学期刊，打造国际化精品期刊、品牌期刊。
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    Acupuncture for obesity and related diseases:Insight for regulating neural circuit

    Lin-yan JiangJun TianYa-nan YangShao-hui Jia...
    93-101页
    查看更多>>摘要：Obesity is defined as abnormal or excessive fat accumulation that may impair health.Obesity is associ-ated with numerous pathological changes including insulin resistance,fatty liver,hyperlipidemias,and other obesity-related diseases.These comorbidities comprise a significant public health threat.Existing anti-obesity drugs have been limited by side effects that include depression,suicidal thoughts,cardiovas-cular complications and stroke.Acupuncture treatment has been shown to be effective for treating obe-sity and obesity-related conditions,while avoiding side effects.However,the mechanisms of acupuncture in treating obesity-related diseases,especially its effect on neural circuits,are not well understood.A growing body of research has studied acupuncture's effects on the endocrine system and other mecha-nisms related to the regulation of neural circuits.In this article,recent research that was relevant to the use of acupuncture to treat obesity and obesity-related diseases through the neuroendocrine system,as well as some neural circuits involved,was summarized.Based on this,acupuncture's potential ability to regulate neural circuits and its mechanisms of action in the endocrine system were reviewed,leading to a deeper mechanistic understanding of acupuncture's effects and providing insight and direction for future research about obesity.
      原文链接:
    • 万方数据
    • 维普

    Cordyceps as potential therapeutic agents for atherosclerosis

    Yi ZhangSi-jing Liu
    102-114页
    查看更多>>摘要：Atherosclerosis is a leading cause of mortality and morbidity worldwide.Despite the challenges in managing atherosclerosis,researchers continue to investigate new treatments and complementary ther-apies.Cordyceps is a traditional Chinese medicine that has recently gained attention as a potential ther-apeutic agent for atherosclerosis.Numerous studies have demonstrated the effectiveness of cordyceps in treating atherosclerosis through various pharmacological actions,including anti-inflammatory and antioxidant activities,lowering cholesterol,inhibiting platelet aggregation,and modulating apoptosis or autophagy in vascular endothelial cells.Notably,the current misuse of the terms cordyceps and Ophiocordyceps sinensis has caused confusion among researchers,and complicated the current academic research on cordyceps.This review focuses on the chemical composition,pharmacological actions,and underlying mechanisms contributing to the anti-atherosclerotic effects of cordyceps and the mycelium of Ophiocordyceps spp.This review provides a resource for the research on the development of new drugs for atherosclerosis from cordyceps.
      原文链接:
    • 万方数据
    • 维普

    Chrononutrition in traditional European medicine-Ideal meal timing for cardiometabolic health promotion

    Nora Selena EberliLudivine ColasAnne Gimalac
    115-125页
    查看更多>>摘要：Meal timing plays a crucial role for cardiometabolic health,given the circadian regulation of car-diometabolic function.However,to the best of our knowledge,no concept of meal timing exists in tradi-tional European medicine(TEM).Therefore,in this narrative review,we aim to define the optimal time slot for energy intake and optimal energy distribution throughout the day in a context of TEM and explore further implications.By reviewing literature published between 2002 and 2022,we found that optimal timing for energy intake may be between 06:00 and 09:00,12:00 and 14:00,and between 15:00 and 18:00,with high energy breakfast,medium energy lunch and low energy dinner and possibly further adjustments according to one's chronotype and genetics.Also,timing and distribution of energy intake may serve as a novel therapeutic strategy to optimize coction,a concept describing digestion and meta-bolism in TEM.
      原文链接:
    • 万方数据
    • 维普

    Associations between the use of red yeast rice preparations and adverse health outcomes:An umbrella review of meta-analyses of randomized controlled trials

    Zhen-yu MaShu-ping YangYing LiTian-tian Xu...
    126-136页
    查看更多>>摘要：Background:Red yeast rice(RYR),a natural lipid-lowering agent,is widely used in clinical practice.However,the existing meta-analyses concerning the safety of RYR preparations have yielded inconsistent results,and the credibility of the evidence has not been quantified.Objective:This study was designed to evaluate the existing evidence and offer a comprehensive under-standing of the associations between the use of RYR preparations and various adverse health outcomes.Search strategy:Seven literature databases were searched from inception to May 5,2023,using medical subject headings and free-text terms(e.g.,"red yeast rice,""Xuezhikang,"and"Zhibitai").Inclusion criteria:Meta-analyses that investigated and quantitatively estimated associations between the use of RYR preparations and adverse health outcomes were included in this study.Data extraction and analysis:Two researchers independently extracted data using a standardized data col-lection table;any disagreements were resolved by consulting a third researcher.Based on the participant,intervention,comparator and outcome(PICO)framework in each eligible meta-analysis,a series of unique associations between the use of RYR preparations and adverse health outcomes were determined.The associations'effect estimates were re-evaluated using random-effect models.Results:Fifteen meta-analyses,comprising 186(164 unique)randomized controlled trials,were identi-fied.Based on A MeaSurement Tool to Assess Systematic Reviews version 2,3(20％)and 12(80％)of these meta-analyses had low and critically low confidence,respectively.A total of 61 unique associations between the use of RYR preparations and adverse health outcomes were extracted from eligible meta-analyses.Based on the random-effect models,10(16.4％)associations indicated a significant protective effect of RYR preparations against adverse health outcomes,while 5(8.2％)indicated an increased risk of adverse health outcomes related to uric acid,alanine transaminase and aspartate transaminase levels.The other 46(75.4％)associations showed no significant difference between the use of RYR preparations and control treatments.Regarding the credibility of the evidence,21(34.4％),34(55.7％)and 6(9.8％)associations showed moderate,low and very low credibility,respectively.Conclusion:The evidence examined in this study suggests that RYR preparations are safe;however,the credibility of the evidence was not high.Further high-quality evidence is required.
      原文链接:
    • 万方数据
    • 维普

    Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer:A systematic review

    Bizhar Ahmed TayebIkhwan Yuda KusumaAlaa A.M.OsmanRenáta Minorics...
    137-162页
    查看更多>>摘要：Background:The field of personalized medicine has gained increasing attention in cancer care,with the aim of tailoring treatment strategies to individual patients for improved outcomes.Herbal medicine,with its long-standing historical use and extensive bioactive compounds,offers a rich source of potential treat-ments for various diseases,including cancer.Objective:To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer diseases.Additionally,to explore the general characteristics of the studies included in the analysis,focusing on their key features and trends.Search strategy:A comprehensive literature search was conducted from multiple online databases,including PubMed,Scopus,Web of Science,and CINAHL-EBSCO.The search strategy was designed to identify studies related to personalized cancer medicine and herbal interventions.Inclusion criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clin-ical studies,employing natural products were included in this review.Data extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessments of methodological quality.The quality assessment and biases of the studies were evaluated based on modified Jadad scales.A detailed quantitative summary of the included studies is presented,providing a comprehensive description of their key features and findings.Results:A total of 121 studies were included in this review for analysis.Some of them were considered as comprehensive experimental investigations both in vitro and in vivo.The majority(n=85)of the studies included in this review were conducted in vitro,with 44 of them specifically investigating the effects of herbal medicine on animal models.Additionally,7 articles with a combined sample size of 31,271 patients,examined the impact of herbal medicine in clinical settings.Conclusion:Personalized medication can optimize the use of herbal medicine in cancer treatment by con-sidering individual patient factors such as genetics,medical history,and other treatments.Additionally,active phytochemicals found in herbs have shown potential for inhibiting cancer cell growth and induc-ing apoptosis,making them a promising area of research in preclinical and clinical investigations.
      原文链接:
    • 万方数据
    • 维普

    Chinese herbal medicine Ginkgo biloba L.preparations for ischemic stroke:An overview of systematic reviews and meta-analyses

    Tian-tian MengYa-ping YouMin LiJian-bo Guo...
    163-179页
    查看更多>>摘要：Background:Ginkgo biloba L preparations(GBLPs)are a class of Chinese herbal medicine used in the adju-vant treatment of ischemic stroke(IS).Recently,several systematic reviews(SRs)and meta-analyses(MAs)of GBLPs for IS have been published.Objective:This overview aims to assess the quality of related SRs and MAs.Search strategy:PubMed,Embase,Cochrane Library,Web of Science,Chinese Biological Medicine,China National Knowledge Infrastructure,Wanfang,and Chinese Science and Technology Journals databases were searched from their inception to December 31,2022.Inclusion criteria:SRs and MAs of randomized controlled trials(RCTs)that explored the efficacy of GBLPs for patients with IS were included.Data extraction and analysis:Two independent reviewers extracted data and assessed the methodological quality,risk of bias(ROB),reporting quality,and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),respectively.Additionally,descriptive analysis and data synthesis were conducted.Results:Twenty-nine SRs/MAs involving 119 outcomes were included in this review.The overall method-ological quality of all SRs/MAs was critically low based on AMSTAR 2,and 28 had a high ROB based on the ROBIS.According to the PRISMA statement,the reporting items of the included SRs/MAs are relatively complete.The results based on GRADE showed that of the 119 outcomes,8 were rated as moderate qual-ity,24 as low quality,and 87 as very low quality.Based on the data synthesis,GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function scores.Conclusion:GBLPs can be considered a beneficial supplemental therapy for IS.However,because of the low quality of the existing evidence,high-quality RCTs and SRs/MAs are warranted to further evaluate the benefits of GBLPs for treating IS.
      原文链接:
    • 万方数据
    • 维普

    The acceptance of traditional Chinese medicine among patients with Parkinson's disease:A hospital survey

    Peng WangJing HongZhu-qian TangBi-zhen Gong...
    180-187页
    查看更多>>摘要：Objective:The efficacy of medications for Parkinson's disease(PD)tend to decline over time,which has a serious impact on patients'health and quality of life.To some extent,traditional Chinese medicine(TCM)can resolve the distressing problem of ineffective dopaminergic medication in PD patients.The purpose of this study was to investigate the attitude,acceptance,and independent predictors of TCM in PD patients admitted to the outpatient department of a tertiary hospital.Methods:A cross-sectional study of PD patients was conducted in the outpatient department of a large tertiary hospital in Beijing from March 2022 to June 2023.A self-report questionnaire was developed to investigate PD patients'attitudes and acceptance of TCM based on the questionnaire.Multivariate logistic regression analyses were also performed to further clarify the independent predictors influencing patients'adoption of TCM therapy.Results:A total of 397 patients completed the questionnaire,of which 78.09％were willing to be treated with TCM and 21.91％indicated that they were not willing to use TCM.Multifactorial logistic regression analysis showed that several parameters were correlated with a patient's willingness to include TCM in their therapeutic regime.These included education level of a bachelor's degree(odds ratio[OR)=8.554;95％confidence interval[CI]:4.112-17.794;P＜0.001,vs junior high school education),living in an urban setting(OR=8.022;95％CI:4.577-14.060;P＜0.001,vs rural),having other underlying diseases(OR=5.126;95％CI:3.078-8.537;P＜0.001,vs none),having previously used TCM(OR=3.083;95％CI:1.852-5.134;P＜0.001,vs not used),believing that TCM therapy is safe(OR=3.530;95％CI:1.446-8.616;P=0.006,vs not thought),believing that TCM therapy is effective(OR=3.859;95％CI:1.482-10.047;P=0.006,vs not understood),and being willing to discuss ongoing TCM therapy with an attending physician(OR=62.468;95％CI:30.350-128.574;P＜0.001,vs not informed).Conclusion:This study initially investigated the acceptance,attitude,and independent predictors of TCM use among PD patients.To expand the prevalence of TCM use among patients with PD,we recommend to broadening the public outreach for TCM via contemporary means of Internet and broadcast communica-tion,enhancing access to TCM services in rural communities,and strengthening the communication between doctors and patients.
      原文链接:
    • 万方数据

    Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation

    Meng LiYang ZhouHui ZhuLie-ming Xu...
    188-198页
    查看更多>>摘要：Objective:This study explores the mechanism of action of Danhongqing formula(DHQ),a compound-based Chinese medicine formula,in the treatment of cholestatic liver fibrosis.Methods:In vivo experiments were conducted using 8-week-old multidrug resistance protein 2 knockout(Mdr2-/-)mice as an animal model of cholestatic liver fibrosis.DHQ was administered orally for 8 weeks,and its impact on cholestatic liver fibrosis was evaluated by assessing liver function,liver histopathology,and the expression of liver fibrosis-related proteins.Real-time polymerase chain reaction,Western blot,immunohistochemistry and other methods were used to observe the effects of DHQ on long non-coding RNA H19(H19)and signal transducer and activator of transcription 3(STAT3)phosphorylation in the liver tissue of Mdr2-/-mice.In addition,cholangiocytes and hepatic stellate cells(HSCs)were cultured in vitro to measure the effects of bile acids on cholangiocyte injury and H19 expression.Cholangiocytes overex-pressing H19 were constructed,and a conditioned medium containing H19 was collected to measure its effects on STAT3 protein expression and cell activation.The intervention effect of DHQ on these processes was also investigated.HSCs overexpressing H19 were constructed to measure the impact of H19 on cell activation and assess the intervention effect of DHQ.Results:DHQ alleviated liver injury,ductular reaction,and fibrosis in Mdr2-/-mice,and inhibited H19 expression,STAT3 expression and STAT3 phosphorylation.This formula also reduced hydrophobic bile acid-induced cholangiocyte injury and the upregulation of H19,inhibited the activation of HSCs induced by cholangiocyte-derived conditioned medium,and decreased the expression of activation markers in HSCs.The overexpression of H19 in a human HSC line confirmed that H19 promoted STAT3 phosphory-lation and HSC activation,and DHQ was able to successfully inhibit these effects.Conclusion:DHQ effectively alleviated spontaneous cholestatic liver fibrosis in Mdr2-/-mice by inhibiting H19 upregulation in cholangiocytes and preventing the inhibition of STAT3 phosphorylation in HSC,thereby suppressing cell activation.
      原文链接:
    • 万方数据
    • 维普