查看更多>>摘要：Glutamine,one of the most abundant amino acids in the body,has been shown to exert various beneficial effects in pigs.However,knowledge regarding the role of dietary glutamine in low-protein diet-fed piglets remains scarce.The present study aimed to investigate the effects of different levels of L-gluta-mine on growth performance,serum biochemistry parameters,redox status,amino acids,and fecal microbiota in low-protein diet-fed piglets.A total of 128 healthy crossbred piglets(Landrace x Yorkshire)were randomly allocated into 4 groups of 4 replicate pens,with 8 piglets per pen.Piglets in the 4 groups were fed with corn and soybean meal-based low-protein diets(crude protein level,17％)that contained 0％,1％,2％,and 3％L-glutamine,respectively,for 28 d.Pigs administered 1％L-glutamine had greater body weight on d 28 and average daily gain(ADG,P＜0.01),whereas a lower feed to gain ratio(F:G)from d 1 to 28(P＜0.01),compared to the other three groups.Besides,lower body weight on d 14 and 28,ADG,average daily feed intake,and higher F:G from d 15 to 28 and d 1 to 28 were observed in response to 2％and 3％L-glutamine treatments than 0％and 1％L-glutamine treatments(P＜0.01).Moreover,1％L-glutamine reduced serum glucose,malondialdehyde,hydrogen peroxide concentrations and inhibited aspartate aminotransferase,alanine aminotransferase,myeloperoxidase activities in low-protein diet-fed piglets on d 14,with concomitantly upregulated catalase,total superoxide dismutase activities and glutathione level(P＜0.05).However,dietary 3％L-glutamine enhanced blood urea nitrogen content in pigs on d 14(P＜0.05).Further investigation revealed that 1％L-glutamine upregulated the serum glutamine,lysine,methionine,tyrosine,and reduced plasma valine content(P＜0.05).Additionally,1％L-glutamine upregulated the abundance of p_75_a5,Clostridium,Lactobacillus,Prevotellaceae_Prevotella,and Gemmiger in the stool of piglets on d 14,with the Streptococcus level being concomitantly reduced(P＜0.05).Collectively,dietary 1％L-glutamine enhances the growth performance and improves serum physiochemical parameters and antioxidative capacity in low-protein diet-fed piglets at an early age,which are associated with an increased synthesis of glutathione by modulating amino acid levels,and the optimization of gut microbiota.
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