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国际肝胆胰疾病杂志（英文版）
浙江省医学学术交流管理中心、浙江大学医学院附属第一医院、浙江大学出版社有限责任公司
国际肝胆胰疾病杂志（英文版）

浙江省医学学术交流管理中心、浙江大学医学院附属第一医院、浙江大学出版社有限责任公司

双月

1499-3872

hbpdint@126.com

0571-87236559

310003

杭州市上城区庆春路79号

国际肝胆胰疾病杂志（英文版）/Journal Hepatobiliary & Pancreatic Diseases InternationalCSCD北大核心SCI
查看更多>>《国际肝胆胰疾病杂志（英文版）》（双月刊），创刊于2002年，由浙江省卫生厅主管，浙江大学医学院附属第一医院主办。杂志涵盖主题领域包括医学、外科、放射学、病理学、生化、生理学和组织学等方面的内容。
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    Pre-MASLD:Should it be defined separately?

    Hang-Kai HuangYou-Ming LiCheng-Fu Xu
    1-3页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Recent advances in promising drugs for primary prevention of gastroesophageal variceal bleeding with cirrhotic portal hypertension

    Ji-Yao ShengZi-Fan MengQiao LiYong-Sheng Yang...
    4-13页
    查看更多>>摘要：Background:Gastroesophageal variceal bleeding is one of the most severe complications of patients with cirrhosis.Although primary prevention drugs,including non-selective β-blockers,have effectively reduced the incidence of bleeding,their efficacy is limited due to side effects and related contraindications.With recent advances in precision medicine,precise drug treatment provides better treatment efficacy.Data sources:Literature search was conducted in PubMed,MEDLINE and Web of Science for relevant articles published up to May 2022.Information on clinical trials was obtained from https://clinicaltrials.gov/and http://www.chictr.org.cn/.Results:The in-depth understanding of the pathogenesis and advances of portal hypertension has enabled the discovery of multiple molecular targets for promising drugs.According to the site of action,these drugs could be classified into four classes:intrahepatic,extrahepatic,both intrahepatic and extrahepatic targets and others.All these classes of drugs offer advantages over traditional treatments in prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.Conclusions:This review classified and summarized the promising drugs,which prevent gastroesophageal variceal bleeding by targeting specific markers of pathogenesis of portal hypertension,demonstrating the significance of using the precision medicine strategy to discover and develop promising drugs for the primary prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Stereotactic body radiotherapy in pancreatic adenocarcinoma

    Carolina de la Pinta
    14-19页
    查看更多>>摘要：Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding tissue.This review aimed at the SBRT application in the treatment of pancreatic cancer.Data sources:We retrieved articles published in MEDLINE/PubMed from January 2017 to December 2022.Keywords used in the search included:"pancreatic adenocarcinoma"OR"pancreatic cancer"AND"stereo-tactic ablative radiotherapy(SABR)"OR"stereotactic body radiotherapy(SBRT)"OR"chemoradiotherapy(CRT)".English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were included.All articles were assessed for validity and relevant content.Results:Optimal doses and fractionation have not yet been defined.However,SBRT could be the standard treatment in patients with pancreatic adenocarcinoma in addition to CRT.Furthermore,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic adenocarcinoma.Conclusions:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical prac-tice guidelines as it has demonstrated good tolerance and good disease control.SBRT opens a possibility of improving outcomes for these patients,both in neoadjuvant treatment and with radical intent.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Application of ultrasonography-elastography score to suspect porto-sinusoidal vascular disease in patients with portal vein thrombosis

    Stefania GioiaAdriano De SantisGiulia d'AmatiSilvia Nardelli...
    20-24页
    查看更多>>摘要：Background:Porto-sinusoidal vascular disease(PSVD)and portal vein thrombosis(PVT)are causes of por-tal hypertension characterized respectively by an intrahepatic and a pre-hepatic obstacle to the flow in the portal system.As PVT may be a consequence of PSVD,in PVT patients at presentation,a pre-existing PSVD should be suspected.In these patients the identification of an underlying PSVD would have rele-vant implication regarding follow-up and therapeutic management,but it could be challenging.In this setting ultrasonography may be valuable in differential diagnosis.The aim of the study was to use ul-trasonography to identify parameters to discriminate between PSVD and"pure"PVT and then to suspect PVT secondary to a pre-existing PSVD.Methods:Fifty-three patients with histologically proven PSVD and forty-eight patients affected by chronic PVT were enrolled and submitted to abdominal ultrasonography with elastography by acoustic radiation force impulse(ARFI).Results:ARFI was higher and superior mesenteric vein(SMV)diameter was wider in PSVD patients than in PVT patients.Thus,a prognostic score was obtained as linear combinations of the two parameters with a good discrimination capacity between PSVD and PVT(the area under the curve=0.780;95％confidence interval:0.690-0.869).Conclusions:A score based on ARFI and SMV diameter may be useful to suspect an underlying PSVD in patients with PVT and to identify a subgroup of patients to be submitted to liver biopsy.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization

    Hai-Li BaoChuan-Zhi ChenChang-Zhen RenKe-Yan Sun...
    25-34页
    查看更多>>摘要：Background:Polydatin,a glucoside of resveratrol,has shown protective effects against various diseases.However,little is known about its effect on hepatic ischemia-reperfusion(I/R)injury.This study aimed to elucidate whether polydatin protects liver against I/R-induced injury and to explore the underlying mechanism.Methods:After gavage feeding polydatin once daily for a week,mice underwent a partial hepatic I/R pro-cedure.Serum alanine aminotransferase(ALT)/aspartate aminotransferase(AST),hematoxylin-eosin(H&E)and TdT-mediated dUTP nick-end labeling(TUNEL)staining were used to evaluate liver injury.The sever-ity related to the inflammatory response and reactive oxygen species(ROS)production was also investi-gated.Furthermore,immunofluorescence and Western blotting were used to detect macrophage polariza-tion and the NF-κB signaling pathway in macrophages.Results:Compared with the I/R group,polydatin pretreatment significantly attenuated I/R-induced liver damage and apoptosis.The oxidative stress marker(dihydroethidium fluorescence,malondialdehyde,su-peroxide dismutase and glutathione peroxidase)and I/R related inflammatory cytokines(interleukin-1β,interleukin-10 and tumor necrosis factor-α)were significantly suppressed after polydatin treat-ment.In addition,the result of immunofluorescence indicated that polydatin reduced the polarization of macrophages toward M1 macrophages both in vivo and in vitro.Western blotting showed that polydatin inhibited the pro-inflammatory function of RAW264.7 via down-regulating the NF-κB signaling pathway.Conclusions:Polydatin protects the liver from I/R injury by remodeling macrophage polarization via NF-κB signaling.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma

    Li-Li MiaoJing-Wen WangHui-Hui LiuShuai Gao...
    35-42页
    查看更多>>摘要：Background:Glycine dehydrogenase(GLDC)plays an important role in the initiation and proliferation of several human cancers.In this study,we aimed to detect the methylation status of GLDC promoter and its diagnostic value for hepatitis B virus-associated hepatocellular carcinoma(HBV-HCC).Methods:We enrolled 197 patients,111 with HBV-HCC,51 with chronic hepatitis B(CHB),and 35 healthy controls(HCs).The methylation status of GLDC promoter in peripheral mononuclear cells(PBMCs)was identified by methylation specific polymerase chain reaction(MSP).The mRNA expression was examined using real-time quantitative polymerase chain reaction(qPCR).Results:The methylation frequency of the GLDC promoter was significantly lower in HBV-HCC patients(27.0％)compared to that in CHB patients(68.6％)and HCs(74.3％)(P＜0.001).The methylated group had lower alanine aminotransferase level(P=0.035)and lower rates of tumor node metastasis(TNM)Ⅲ/Ⅳ(P=0.043)and T3/T4(P=0.026).TNM stage was identified to be an independent factor for GLDC pro-moter methylation.GLDC mRNA levels in CHB patients and HCs were significantly lower than those in HBV-HCC patients(P=0.022 and P＜0.001,respectively).GLDC mRNA levels were significantly higher in HBV-HCC patients with unmethylated GLDC promoters than those with methylated GLDC promoters(P=0.003).The diagnostic accuracy of alpha-fetoprotein(AFP)combined with GLDC promoter methy-lation for HBV-HCC was improved compared with that of AFP alone(AUC:0.782 vs.0.630,P＜0.001).In addition,GLDC promoter methylation was an independent predictor for overall survival of HBV-HCC patients(P=0.038).Conclusions:The methylation frequency of GLDC promoter was lower in PBMCs from HBV-HCC patients than that from patients with CHB and HCs.The combination of AFP and GLDC promoter hypomethylation significantly improved the diagnostic accuracy of HBV-HCC.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据
    • 维普

    AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway

    Qing-Qi ZhangQian ChenPan CaoChun-Xia Shi...
    43-51页
    查看更多>>摘要：Background:Acute liver failure(ALF)is an unpredictable and life-threatening critical illness.The patho-logical characteristic of ALF is massive necrosis of hepatocytes and lots of inflammatory cells infiltration which may lead to multiple organ failure.Methods:Animals were divided into 3 groups,normal,thioacetamide(TAA,ALF model)and TAA+AGK2.Cultured L02 cells were divided into 5 groups,normal,TAA,TAA+mitofusin 2(MFN2)-siRNA,TAA+AGK2,and TAA+AGK2+MFN2-siRNA groups.The liver histology was evaluated with hematoxylin and eosin staining,inositol-requiring enzyme 1(IRE1),activating transcription factor 6β(ATF6β),protein kinase R(PKR)-like endoplasmic reticulum kinase(PERK)and phosphorylated-PERK(p-PERK).C/EBP ho-mologous protein(CHOP),reactive oxygen species(ROS),MFN2 and glutathione peroxidase 4(GPX4)were measured with Western blotting,and cell viability and liver chemistry were also measured.Mitochondria-associated endoplasmic reticulum membranes(MAMs)were measured by immunofluorescence.Results:The liver tissue in the ALF group had massive inflammatory cell infiltration and hepatocytes necrosis,which were reduced by AGK2 pre-treatment.In comparison to the normal group,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+in the TAA-induced ALF model group were sig-nificantly increased,which were decreased by AGK2 pre-treatment.The levels of MFN2 and GPX4 were decreased in TAA-induced mice compared with the normal group,which were enhanced by AGK2 pre-treatment.Compared with the TAA-induced L02 cell,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+were further increased and levels of MFN2 and GPX4 were decreased in the MFN2-siRNA group.AGK2 pre-treatment decreased the apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+and enhanced the protein expression of MFN2 and GPX4 in MFN2-siRNA treated L02 cell.Immunofluorescence observation showed that level of MAMs was promoted in the AGK2 pre-treatment group when compared with the TAA-induced group in both mice and L02 cells.Conclusions:The data suggested that AGK2 pre-treatment had hepatoprotective role in TAA-induced ALF via upregulating the expression of MFN2 and then inhibiting PERK and ferroptosis pathway in ALF.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Circulating RNA ZFR promotes hepatocellular carcinoma cell proliferation and epithelial-mesenchymal transition process through miR-624-3p/WEE1 axis

    Li ZhangSai HeHao GuanYao Zhao...
    52-63页
    查看更多>>摘要：Background:Hepatocellular carcinoma(HCC),the most common type of primary liver cancer,is the fourth leading cause of cancer-related deaths worldwide.Previous evidence shows that the expression of circu-lating RNA ZFR(circZFR)is upregulated in HCC tissues.However,the molecular mechanism of circZFR in HCC is unclear.Methods:Quantitative reverse transcriptase polymerase chain reaction(qRT-PCR)was employed to de-tect the expression of circZFR,microRNA-624-3p(miR-624-3p)and WEE1 in HCC tissues and cells.RNase R assay and actinomycin D treatment assay were used to analyze the characteristics of circZFR.For functional analysis,the capacities of colony formation,cell proliferation,cell apoptosis,migration and invasion were assessed by colony formation assay,5-ethynyl-2'-deoxyuridine(EdU)assay,flow cy-tometry assay and transwell assay.Western blot was used to examine the protein levels of WEE1 and epithelial-mesenchymal transition(EMT)-related proteins.The interactions between miR-624-3p and cir-cZFR or WEE1 were validated by dual-luciferase reporter assay and RNA immunoprecipitation(RIP)assay.Xenograft models were established to determine the role of circZFR in vivo.Results:circZFR and WEE1 were upregulated,while miR-624-3p expression was reduced in HCC tissues and cells.circZFR could sponge miR-624-3p,and WEE1 was a downstream gene of miR-624-3p.Knock-down of circZFR significantly reduced the malignant behaviors of HCC and that co-transfection with miR-624-3p inhibitor restored this change.Overexpression of WEE1 abolished the inhibitory effect of miR-624-3p mimic on HCC cells.Mechanistically,circZFR acted as a competitive endogenous RNA(ceRNA)to regulate WEE1 expression by targeting miR-624-3p.Furthermore,in vivo studies have illustrated that circZFR knockdown inhibited tumor growth.Conclusions:circZFR knockdown reduced HCC cell proliferation,migration and invasion and promoted apoptosis by regulating the miR-624-3p/WEE1 axis,suggesting that the circZFR/miR-624-3p/WEE1 axis might be a potential target for HCC treatment.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management:A propensity score-matched cohort study

    Yudai KoyaMichihiko ShibataYuki MarunoYoshitaka Sakamoto...
    64-70页
    查看更多>>摘要：Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute chole-cystitis(AC),and can be more severe in comparison to the first episode of AC.Low skeletal muscle mass or adiposity have various effects in several diseases.We aimed to clarify the relationship between RAC and body parameters.Methods:Patients with AC who were treated at our hospital between January 2011 and March 2022 were enrolled.The psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of AC.The areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI groups.We performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of RAC.Results:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)groups.In the propensity score-matched cohort there were 57 patients in each group.In Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95％confidence interval 1.083-25.450,P=0.039)and 0.158(95％confidence interval:0.026-0.937,P=0.042),respectively.Conclusions:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据
    • 维普

    The outcomes and safety of patients undergoing endoscopic retrograde cholangiopancreatography combining a single-use cholangioscope and a single-use duodenoscope:A multicenter retrospective international study

    Alessandro FugazzaMatteo ColomboMichel KahalehV.Raman Muthusamy...
    71-76页
    查看更多>>摘要：Background:Duodenoscope-related multidrug-resistant organism(MDRO)infections raise concerns.Dis-posable duodenoscopes have been recently introduced in the market and approved by regulatory agencies with the aim to reduce the risk of endoscopic retrograde cholangiopancreatography(ERCP)associated in-fections.The aim of this study was to evaluate the outcome of procedures performed with single-use duodenoscopes in patients with clinical indications to single-operator cholangiopancreatoscopy.Methods:This is a multicenter international,retrospective study combining all patients who underwent complex biliopancreatic interventions using the combination of a single-use duodenoscope and a single-use cholangioscope.The primary outcome was technical success defined as ERCP completion for the in-tended clinical indication.Secondary outcomes were procedural duration,rate of cross-over to reusable duodenoscope,operator-reported satisfaction score(1 to 10)on performance rating of the single-use duo-denoscope,and adverse event(AE)rate.Results:A total of 66 patients(26,39.4％female)were included in the study.ERCP was categorized according to ASGE ERCP grading system as 47(71.2％)grade 3 and 19(28.8％)grade 4.The technical success rate was 98.5％(65/66).Procedural duration was 64(interquartile range 15-189)min,cross-over rate to reusable duodenoscope was 1/66(1.5％).The satisfaction score of the single-use duodenoscope classified by the operators was 8.6±1.3 points.Four patients(6.1％)experienced AEs not directly related to the single-use duodenoscope,namely 2 post-ERCP pancreatitis(PEP),1 cholangitis and 1 bleeding.Conclusions:Single-use duodenoscope is effective,reliable and safe even in technically challenging pro-cedures with a non-inferiority to reusable duodenoscope,making these devices a viable alternative to standard reusable equipment.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据
    • 维普