查看更多>>摘要：Although single-atom Cu sites exhibit high efficiency in CO2 hydrogenation to methanol,they are prone to forming Cu nanoparticles due to reduction and aggregation under reaction conditions,especially at high temperatures.Herein,single-atom Cu sites stabilized by adjacent Na+ions have been successfully constructed within a metal-organic framework(MOF)-based catalyst,namely MOF-808-NaCu.It is found that the electrostatic interaction between the Na+and Hδ-species plays a pivotal role in upholding the atomic dispersion of Cu in MOF-808-NaCu during CO2 hydrogenation,even at temperatures of up to 275℃.This exceptional stabilization effect endows the catalyst with excellent activity(306 g.kgcat-1-h-1),high selectivity to methanol(93％)and long-term stability at elevated reaction temperatures,far surpassing the counterpart in the absence of Na+(denoted as MOF-808-Cu).This work develops an effective strategy for the fabrication of stable single-atom sites for advanced catalysis by creating an alkali-decorated microenvironment in close proximity.
查看更多>>摘要：Noise-induced hearing loss(NIHL)is a highly prevalent form of sensorineural hearing damage that has significant negative effects on individuals of all ages and there are no effective drugs approved by the US Food and Drug Administration.In this study,we unveil the potential of superparamagnetic iron oxide nanoparticle assembly(SPIOCA)to reshape the dysbiosis of gut microbiota for treating NIHL.This modulation inhibits intestinal inflammation and oxidative stress responses,protecting the integrity of the intestinal barrier.Consequently,it reduces the transportation of pathogens and inflammatory factors from the bloodstream to the cochlea.Additionally,gut microbiota-modulated SPIOCA-induced metabolic reprogramming in the gut-inner ear axis mainly depends on the regulation of the sphingolipid metabolic pathway,which further contributes to the restoration of hearing function.Our study confirms the role of the microbiota-gut-inner ear axis in NIHL and provides a novel alternative for the treatment of NIHL and other microbiota dysbiosis-related diseases.
查看更多>>摘要：Lipid nanoparticles(LNPs)have gained clinical approval as carriers for both siRNA and mRNA.Among the crucial components of LNPs,ionizable lipids play a pivotal role in determining the efficiency of RNA delivery.In this study,we synthesized a series of ionizable lipids,denoted as HTO,with a higher count of hydroxyl groups compared to SM-102.Remarkably,LNPs based on HTO 12 lipid demonstrated comparable mRNA delivery efficiency and biosafety to those based on SM-102.However,the former reduced the ratio of ionizable lipid/total lipids to mRNA in LNPs by 2.5 times compared to SM-102.The HTO 12 LNP efficiently encapsulated adenine base editor mRNA and sgRNA targeting Pcsk9,leading to substantial gene editing within the liver of mice and effective reduction of the target protein.Our study underscores that ionizable lipids with multiple hydroxyl groups may facilitate an improved lipid-to-mRNA ratio to minimize the dosage of ionizable lipids for in vivo delivery.
查看更多>>摘要：Dural defects and subsequent complications,including cerebrospinal fluid(CSF)leakage,are common in both spine surgery and neurosurgery,and existing clinical treatments are still unsatisfactory.In this study,a tissue-adhesive and low-swelling hydrogel sealant comprising gelatin and o-phthalaldehyde(OPA)-terminated 4-armed poly(ethylene glycol)(4aPEG-OPA)is developed via the OPA/amine condensation reaction.The hydrogel shows an adhesive strength of 79.9±12.0 kPa on porcine casing and a burst pressure of208.0±38.0 cmH2O.The hydrogel exhibits a low swelling ratio at physiological conditions,avoiding nerve compression in the limited spinal and intracranial spaces.In rat and rabbit models of lumbar and cerebral dural defects,the 4aPEG-OPA/gelatin hydrogel achieves excellent performance in dural defect sealing and preventing CSF leakage.Moreover,local inflammation,epidural fibrosis and postoperative adhesion in the defect areas are markedly reduced.Thus,these findings establish the strong potential of the hydrogel sealant for the effective watertight closure of dural defects.
查看更多>>摘要：Direct synthesis of organophosphorus compounds from white phosphorus represents a significant but challenging subject,especially in the context of ongoing efforts to comprehensively improve the phosphorus-derived chemical industry driven by sustainability and safety concerns.China is the world's largest producer of white phosphorus,creating a significant demand for the green transformation of this crucial feedstock.This review provides an overview of advancements in white phosphorus activation by Chinese research teams,focusing on the direct construction of P-C/N/O/S/M bonds from white phosphorus.Additionally,we offer some insights into prospective directions for the activation and transformation of white phosphorus in the future.This review paper aims to attract more researchers to engage in this area,stimulating follow-up exploration and fostering enduring advances.
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