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科学通报（英文版）
科学通报（英文版）

周光召

旬刊

1001-6538

csb@scichina.com

010-64036120

100717

北京东黄城根北街16号

科学通报（英文版）/Journal Chinese Science BulletinEISCI
查看更多>>《科学通报》创刊于1950年，是中国科学院主办、中国科学杂志社承办的自然科学综合性学术刊物，报道自然科学各学科基础理论和应用研究方面具有创新性和和高水平的、具有重要意义的最新研究成果，要求文章的可读性强，能在一个比较宽范的学术领域产生深刻的影响。我们的目标是：成为国内外读者了解中国乃至世界范围的自然科学各研究领域最新成果的主要窗口之一。《科学通报》进入了国际上主要检索系统，如CA，EI，日本《科技速报》和美国科学信息研究所（ISI）的以下系统：Science Citation Index(SCI-CDE)，SCISearch，Current Contents(PC&E)和Research Alert。
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    Targeting modulation of intestinal flora through oral route by an antimicrobial nucleic acid-loaded exosome-like nanovesicles to improve Parkinson's disease

    Weitong CuiZhiyong GuoXingyu ChenRan Yan...
    3925-3935页
    查看更多>>摘要：Parkinson's disease(PD)is one of the most prevalent neurodegenerative diseases.It is usually accompa-nied by motor and non-motor symptoms that seriously threaten the health and the quality of life.Novel medications are urgently needed because current pharmaceuticals can relieve symptoms but cannot stop disease progression.The microbiota-gut-brain axis(MGBA)is closely associated with the occurrence and development of PD and is an effective therapeutic target.Tetrahedral framework nucleic acids(tFNAs)can modulate the microbiome and immune regulation.However,such nucleic acid nanostructures are very sensitive to acids which hinder this promising approach.Therefore,we prepared exosome-like nanovesicles(Exo@tac)from ginger that are acid resistant and equipped with tFNAs modified by antimi-crobial peptides(AMP).We verified that Exo@tac regulates intestinal bacteria associated with the microbial-gut-brain axis in vitro and significantly improves PD symptoms in vivo when administered orally.Microbiota profiling confirmed that Exo@tac normalizes the intestinal flora composition of mouse models of PD.Our findings present a novel strategy for the development of PD drugs and the innovative delivery of nucleic acid nanomedicines.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate

    Taoxing PengXinyue ShaoWenqin SongWeihua Xu...
    3936-3948页
    查看更多>>摘要：Glycolysis-related lactic acid overproduction creates an"ion-trapping"barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy.Therefore,normalization of tumor microenvironment via lactic acid neutralization can be a promising avenue for overcoming this therapeutic hurdle.In this study,the flexible liposomes loaded with sodium bicarbonate(NaHCO3@Flip)were used as a nano-adjuvant to boost chemoimmunotherapy.Their effects on assisting DOXIL and anti-programmed cell death protein 1(PD-1)therapy were investigated.NaHCO3@Flip achieved deep tumor penetration,with the ability to neutralize lactic acid and normalize the acidic tumor microenvironment.NaHCO3@Flip is biosafe and can enhance cellular uptake efficiency of doxorubicin(DOX)by overcoming the ion-trapping barrier and amplify immunogenic cell death induced by DOX.The combination therapy of liposomal DOX and NaHCO3@Flip demonstrated enhanced inhibition of tumor growth.NaHCO3@Flip can also synergize with PD-1 antibody therapy.NaHCO3@Flip has the potential to serve as a therapeutic adjuvant for boosting chemoimmunotherapy by overcoming the ion-trapping effect and normalizing the tumor microenvironment.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Lacustrine carbon sink:A hidden driver of the Late Cretaceous Cooling Event

    Shuichang ZhangHuajian WangYuke LiuXiaomei Wang...
    3949-3958页
    查看更多>>摘要：Lacustrine systems since the Mesozoic have sequestered large quantities of organic carbon,which may have important value for global climate cooling,but there is still a lack of geological evidence of this sequestration.Taking the Songliao Basin in China as a case study,we elucidate the important function of lacustrine basins as sinks of a large amount of organic carbon,particularly when the contemporaneous marine sediments were poor sinks of organic carbon.Volcanic activities and orbital forcing were likely key factors influencing the water transportation between the land and oceans,as well as the alternating burial of organic carbon in the oceans and land.Microorganisms related to methane metabolism may have been highly involved in the mineralization and sequestration of lacustrine organic carbon.This study provides new insights into the coupled carbon-water cycle between the land and oceans and the influence of this process on global climate evolution.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    The evolution of cropping structure in prehistoric Xizang

    Yanren WangQi YangJishuai YangShalini Sharma...
    3959-3967页
    查看更多>>摘要：The origin and spread of agriculture facilitated a decline in human mobility and eventually led to a pre-dominantly sedentary lifestyle globally,including on the Tibetan Plateau.Previous studies have proposed an evolution of prehistoric agriculture,from millet-based to barley-based farming.However,details regarding the process are vague.Here,we present diachronic changes in cropping structure from Xizang on the basis of a quantitative analysis of archaeobotanical remains from 12 sites located in south-eastern Xizang.The advent of agriculture in Xizang began in the southeastern region around 4800 cal a BP and resulted in a quick spread of millet agriculture from the Hengduan Mountains to the Yarlung Zangbo River region.Subsequently,the introduction of barley and wheat to Xizang led to the transformation of millet-based farming into mixed farming after 3600 cal a BP.Eventually,around 3000 cal a BP,barley and wheat dominated across the entire Xizang with declining occurrences of millet.It took more than 600 years for barley and wheat to dominate in the Tibetan cropping system,which may reflect the time required for these exotic species to adapt physiologically to their new niche.In addition to the diachronic changes in crop farming,the ratio of barley to wheat and foxtail millet to broomcorn millet also varied at different elevations possibly due to local environmental variations and the crops'physiological requirements.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Shifting agricultural land use and its unintended water consumption in the North China Plain

    Liang DongDi LongCaijin ZhangYingjie Cui...
    3968-3977页
    查看更多>>摘要：Agricultural land use(ALU)critically influences food production and water resource allocation.This study examines the dynamics of ALU in the North China Plain(NCP),a region characterized by intensive agri-culture and severe groundwater over-exploitation,focusing on the multidimensional drivers and their implications for water resource management.By employing an elaborate classification scheme based on satellite imagery and extensive first-hand field data,we identified significant shifts in crop patterns.From 2013 to 2017,there was a notable transition from double crops(primarily wheat-maize)to single crops(primarily maize),covering 4600 km2 and accounting for 42％of single crops in 2013.From 2017 to 2022,there was a shift from single crops to economic forests,encompassing 3600 km2 and 22％of eco-nomic forests in 2017,including orchards,timber trees,and shelter forest belts.These shifts resulted in an 11％decrease in grain acreage(6800 km2)but an 11％increase in crop water consumption(6.3 km3)during 2013-2022.Notably,water consumption by economic forests increased by 126％(9.4 km3)during this period.This study highlights the critical need to balance competing demands for food and water security,providing valuable insights applicable to other agriculturally intensive regions worldwide.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Bone aging and extracellular vesicles

    Jian WangYuanwei ZhangSicheng WangXinglong Wang...
    3978-3999页
    查看更多>>摘要：Bone aging,a major global health concern,is the natural decline in bone mass and strength.Concurrently,extracellular vesicles(EVs),tiny membrane-bound particles produced by cells,have gained recognition for their roles in various physiological processes and age-related diseases.The interaction between EVs and bone aging is of growing interest,particularly their effects on bone metabolism,which become increasingly critical with advancing age.In this review,we explored the biology,types,and functions of EVs and emphasized their regulatory roles in bone aging.We examined the effects of EVs on bone metabolism and highlighted their potential as biomarkers for monitoring bone aging progression.Furthermore,we discussed the therapeutic applications of EVs,including targeted drug delivery and bone regeneration,and addressed the challenges associated with EV-based therapies,including the technical complexities and regulatory issues.We summarized the current research and clinical trials investigating the role of EVs in bone aging and suggested future research directions.These include the potential for personalized medicine using EVs and the integration of EV research with advanced technologies to enhance the management of age-related bone health.This analysis emphasized the transformative potential of EVs in understanding and managing bone aging,thereby marking a significant advancement in skeletal health research.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Guide for Authors

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      原文链接:
    • NETL
    • NSTL
    • 万方数据