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科学通报（英文版）
科学通报（英文版）

周光召

旬刊

1001-6538

csb@scichina.com

010-64036120

100717

北京东黄城根北街16号

科学通报（英文版）/Journal Chinese Science BulletinEISCI
查看更多>>《科学通报》创刊于1950年，是中国科学院主办、中国科学杂志社承办的自然科学综合性学术刊物，报道自然科学各学科基础理论和应用研究方面具有创新性和和高水平的、具有重要意义的最新研究成果，要求文章的可读性强，能在一个比较宽范的学术领域产生深刻的影响。我们的目标是：成为国内外读者了解中国乃至世界范围的自然科学各研究领域最新成果的主要窗口之一。《科学通报》进入了国际上主要检索系统，如CA，EI，日本《科技速报》和美国科学信息研究所（ISI）的以下系统：Science Citation Index(SCI-CDE)，SCISearch，Current Contents(PC&E)和Research Alert。
正式出版
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    Spatiotemporal patterns of the pregnancy microbiome and links to reproductive disorders

    Liwen XiaoTian ZhouZhenqiang ZuoNingxia Sun...
    1275-1285页
    查看更多>>摘要：The microbiome of females undergoes extensive remodeling during pregnancy,which is likely to have an impact on the health of both mothers and offspring.Nevertheless,large-scale integrated investigations characterizing microbiome dynamics across key body habitats are lacking.Here,we performed an exten-sive meta-analysis that compiles and analyzes microbiome profiles from＞10,000 samples across the gut,vagina,and oral cavity of pregnant women from diverse geographical regions.We have unveiled unex-pected variations in the taxonomic,functional,and ecological characteristics of microbial communities throughout the course of pregnancy.The gut microbiota showed distinct trajectories between Western and non-Western populations.The vagina microbiota exhibited fluctuating transitions at the genus level across gestation,while the oral microbiota remained relatively stable.We also identified distinctive microbial signatures associated with prevalent pregnancy-related disorders,including opposite varia-tions in the oral and gut microbiota of patients with gestational diabetes and disrupted microbial net-works in preterm birth.This study establishes a comprehensive atlas of the pregnancy microbiome by integrating multidimensional datasets and offers foundational insights into the intricate interplay between microbes and host factors that underlie reproductive health.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Adavosertib-encapsulated metal-organic frameworks for p53-mutated gallbladder cancer treatment via synthetic lethality

    Shijie LiSarun JuengpanichWin TopatanaTianao Xie...
    1286-1301页
    查看更多>>摘要：Adavosertib(ADA)is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer(GBC).However,drug resistance due to DNA damage response compensation pathways and high toxicity limits further applications.Herein,estrone-targeted ADA-encapsulated metal-organic frame-works(ADA@MOF-EPL)for GBC synthetic lethal treatment by inducing conditional factors are developed.The high expression of estrogen receptors in GBC enables ADA@MOF-EPL to quickly enter and accumulate near the cell nucleus through estrone-mediated endocytosis and release ADA to inhibit WEE1 upon enter-ing the acidic tumor microenvironment.Ultrasound irradiation induces ADA@MOF-EPL to generate reac-tive oxygen species(ROS),which leads to a further increase in DNA damage,resulting in a higher sensitivity of p53-mutated cancer cells to WEE1 inhibitor and promoting cell death via conditional syn-thetic lethality.The conditional factor induced by ADA@MOF-EPL further enhances the antitumor efficacy while significantly reducing systemic toxicity.Moreover,ADA@MOF-EPL demonstrates similar antitumor abilities in other p53-mutated solid tumors,revealing its potential as a broad-spectrum antitumor drug.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Regional variations in management and outcomes of patients with acute coronary syndrome in China:Evidence from the National Chest Pain Center Program

    Shuduo ZhouYan ZhangXuejie DongJunxiong Ma...
    1302-1312页
    查看更多>>摘要：Regional variations in acute coronary syndrome(ACS)management and outcomes have been an enor-mous public health issue.However,studies have yet to explore how to reduce the variations.The National Chest Pain Center Program(NCPCP)is the first nationwide,hospital-based,comprehensive,con-tinuous quality improvement program for improving the quality of care in patients with ACS in China.We evaluated the association of NCPCP and regional variations in ACS healthcare using generalized linear mixed models and interaction analysis.Patients in the Western region had longer onset-to-first medical contact(FMC)time and time stay in non-percutaneous coronary intervention(PCI)hospitals,lower rates of PCI for ST-elevation myocardial infarction(STEMI)patients,and higher rates of medication usage.Patients in Central regions had relatively lower in-hospital mortality and in-hospital heart failure rates.Differences in the door-to-balloon time(DtoB)and in-hospital mortality between Western and Eastern regions were less after accreditation(β=-8.82,95％confidence interval(CI)-14.61 to-3.03;OR=0.79,95％CI 0.70 to 0.91).Similar results were found in differences in DtoB time,primary PCI rate for STEMI between Central and Eastern regions.The differences in PCI for higher-risk non-ST-segment elevation acute coronary syndrome(NSTE-ACS)patients among different regions had been smaller.Additionally,the differences in medication use between Eastern and Western regions were higher after accreditation.Regional variations remained high in this large cohort of patients with ACS from hospitals participating in the NCPCP in China.More comprehensive interventions and hospital internal system optimizations are needed to further reduce regional variations in the management and outcomes of patients with ACS.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Long-term PM1 exposure and hypertension hospitalization:A causal inference study on a large community-based cohort in South China

    Yuqin ZhangShirui ChenJing WeiJie Jiang...
    1313-1322页
    查看更多>>摘要：Limited evidence exists on the effect of submicronic particulate matter(PM1)on hypertension hospital-ization.Evidence based on causal inference and large cohorts is even more scarce.In 2015,36,271 par-ticipants were enrolled in South China and followed up through 2020.Each participant was assigned single-year,lag0-1,and lag0-2 moving average concentration of PM1 and fine inhalable particulate mat-ter(PM2.5)simulated based on satellite data at a 1-km resolution.We used an inverse probability weight-ing approach to balance confounders and utilized a marginal structural Cox model to evaluate the underlying causal links between PM1 exposure and hypertension hospitalization,with PM2.5-hypertension association for comparison.Several sensitivity studies and the analyses of effect modifica-tion were also conducted.We found that a higher hospitalization risk from both overall(HR:1.13,95％CI:1.05-1.22)and essential hypertension(HR:1.15,95％CI:1.06-1.25)was linked to each 1 pg/m3 increase in the yearly average PM1 concentration.At lag0-1 and lag0-2,we observed a 17％-21％higher risk of hypertension associated with PM1.The effect of PM1 was 6％-1 1％higher compared with PM2.5.Linear concentration-exposure associations between PM1 exposure and hypertension were identified,without safety thresholds.Women and participants that engaged in physical exercise exhibited higher suscepti-bility,with 4％-22％greater risk than their counterparts.This large cohort study identified a detrimental relationship between chronic PM1 exposure and hypertension hospitalization,which was more pro-nounced compared with PM2.5 and among certain groups.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Cenozoic Indo-Pacific warm pool controlled by both atmospheric CO2 and paleogeography

    Ran ZhangZhonghui LiuDabang JiangYongqiang Yu...
    1323-1331页
    查看更多>>摘要：The Indo-Pacific warm pool(IPWP)is crucial for regional and global climates.However,the development of the IPWP and its effect on the regional climate during the Cenozoic remain unclear.Here,using a com-pilation of sea surface temperature(SST)records(mainly since the middle Miocene)and multimodel paleoclimate simulations,our results indicated that the extent,intensity and warmest temperature posi-tion of the IPWP changed markedly during the Cenozoic.Specifically,its extent decreased,its intensity weakened,and its warmest temperature position shifted from the Indian to western Pacific Ocean over time.The atmospheric CO2 dominated its extent and intensity,while paleogeography,by restricting the distribution of the Indian Ocean and the width of the tropical seaways,controlled the shift in its warmest temperature position.In particular,the eastward shift to the western Pacific Ocean from the middle to late Miocene inferred from compiled SST records likely resulted from the constriction of trop-ical seaways.Furthermore,by changing the atmospheric thermal structure and atmospheric circulation,the reduced extent and intensity of the IPWP decreased the annual precipitation in the western Indian Ocean,eastern Asia and Australia,while the shift in the warmest temperature position from the Indian to western Pacific Ocean promoted aridification in Australia.Qualitative model-data agreements are obtained for both the IPWP SST and regional climate.From the perspective of past warm climates with high concentrations of atmospheric CO2,the expansion and strengthening of the IPWP will occur in a warmer future and favor excessive precipitation in eastern Asia and Australia.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Importance of soil moisture conservation in mitigating climate change

    Zhiyan ZuoLiang QiaoRenhe ZhangDeliang Chen...
    1332-1341页
    查看更多>>摘要：A troubling feedback loop,where drier soil contributes to hotter climates,has been widely recognized.This study,drawing on climate model simulations,reveals that maintaining current global soil moisture levels could significantly alleviate 32.9％of land warming under low-emission scenarios.This action could also postpone reaching critical warming thresholds of 1.5 ℃ and 2.0 ℃ by at least a decade.Crucially,preserving soil moisture at current levels could prevent noticeable climate change impacts across 42％of the Earth's land,a stark deviation from projections suggesting widespread impacts before the 2060s.To combat soil drying,afforestation in mid-to-low latitude regions within the next three decades is pro-posed as an effective strategy to increase surface water availability.This underscores the substantial potential of nature-based solutions for managing soil moisture,benefiting both climate change mitiga-tion and ecological enhancement.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Adjustment methods of Schottky barrier height in one-and two-dimensional semiconductor devices

    Jianping MengChengkuo LeeZhou Li
    1342-1352页
    查看更多>>摘要：The Schottky contact which is a crucial interface between semiconductors and metals is becoming increasingly significant in nano-semiconductor devices.A Schottky barrier,also known as the energy bar-rier,controls the depletion width and carrier transport across the metal-semiconductor interface.Controlling or adjusting Schottky barrier height(SBH)has always been a vital issue in the successful oper-ation of any semiconductor device.This review provides a comprehensive overview of the static and dynamic adjustment methods of SBH,with a particular focus on the recent advancements in nano-semiconductor devices.These methods encompass the work function of the metals,interface gap states,surface modification,image-lowering effect,external electric field,light illumination,and piezotronic effect.We also discuss strategies to overcome the Fermi-level pinning effect caused by interface gap states,including van der Waals contact and 1D edge metal contact.Finally,this review concludes with future perspectives in this field.
      原文链接:
    • NETL
    • NSTL
    • 万方数据