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世界胃肠病学杂志（英文版）
世界胃肠病学杂志（英文版）

潘伯荣

周刊

1007-9327

wjg@wjgnet.com

010-85381901-628

100025

北京市朝阳区东四环中路62号楼远洋国际中心D座903室

世界胃肠病学杂志（英文版）/Journal World Journal of GastroenterologyCSCDCSTPCDSCI
查看更多>>主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。
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    Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells

    Khanitta SrimuangwongChainarong TocharusPornphrom Yoysungnoen ChintanaApichart Suksamrarn...
    2383-2389页
    查看更多>>摘要：AIM:To investigate the ability of hexahydrocurcumin (HHC) to enhance 5-fluorouracil (5-FU) in inhibiting the growth of HT-29 cells by focusing on cyclooxygenase (COX)-2 expression.METHODS:Antiproliferative effects of HHC and 5-FU,alone and in combination,on growth of HT-29 human colon cancer cells were assessed using 5-diphenyltetrazolium bromide (MTT) reduction assay.In combination treatment,low doses of 5-FU were used combined with various concentrations of HHC to minimize the toxicity and side effects of 5-FU.The therapeutic effects of these drugs on down-regulation of COX-2 mRNA and protein expression were examined using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting analysis.RESULTS:MTT reduction assay indicated that HHC alone markedly decreased the viability of HT-29 human colon cancer cells compared to control.Semi-quantitative RT-PCR analysis indicated that HHC is a selective COX-2 inhibitor.This finding was supported by the observation that HHC significantly down-regulates COX-2 mRNA expression compared to the control (control:100.05％ ± 0.03％ vs HHC:61.01％ ± 0.35％,P ＜ 0.05)but does not alter COX-1 mRNA.In combined treatment,addition of HHC to a low dose of 5-FU exerts a synergistic effect against the growth of HT-29 cells by markedly reducing cell viability to a greater degree than monotherapy.Semi-quantitative RT-PCR indicated that 5-FU at the concentration of 5 μmol/L in combination with HHC at the concentration of 25 μmol/L significantly down-regulates COX-2 mRNA expression when compared with values in cells treated with 5-FU or HHC alone (HHC + 5-FU:31.93％ ± 5.69％,5-FU:100.66％± 4.52％ vs HHC:61.01％ ± 0.35％,P ＜ 0.05).CONCLUSION:HHC together with 5-FU exerts a synergistic effect and may prove chemotherapeutically useful in treating human colon cancer.
      原文链接:
    • NETL
    • NSTL
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    • 维普

    A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease

    Abdallah A KobeissyJana G HashashFaek R JamaliAssaad M Skoury...
    2390-2395页
    查看更多>>摘要：AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease (NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole (group A) vs ranitidine (group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease (GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A (n =44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B (n =39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life (QoL)questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients (40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups (71.4％ vs 65.4％,respectively; P =0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups (rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P =0.582).There was no significant difference in the mean number of pills used (rabeprazole 35.70 ± 29.75vs ranitidine 32.86 ± 26.98; P =0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life.
      原文链接:
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    Poorly expandable common bile duct with stones on endoscopic retrograde cholangiography

    Chi-Liang ChengYung-Kuan TsouCheng-Hui LinJui-Hsiang Tang...
    2396-2401页
    查看更多>>摘要：AIM:To describe characteristics of a poorly expandable (PE) common bile duct (CBD) with stones on endoscopic retrograde cholangiography.METHODS:A PE bile duct was characterized by a rigid and relatively narrowed distal CBD with retrograde dilatation of the non-PE segment.Between 2003 and 2006,endoscopic retrograde cholangiography (ERC) images and chart reviews of 1213 patients with newly diagnosed CBD stones were obtained from the computer database of Therapeutic Endoscopic Center in Chang Gung Memorial Hospital.Patients with characteristic PE bile duct on ERC were identified from the database.Data of the patients as well as the safety and technical success of therapeutic ERC were collected and analyzed retrospectively.RESULTS:A total of 30 patients with CBD stones and characteristic PE segments were enrolled in this study.The median patient age was 45 years (range,20 to 92 years); 66.7％ of the patients were men.The diameters of the widest non-PE CBD segment,the PE segment,and the largest stone were 14.3 ± 4.9 mm,5.8 ± 1.6 mm,and 11.2 ± 4.7 mm,respectively.The length of the PE segment was 39.7±15.4 mm (range,12.3 mm to 70.9 mm).To remove the CBD stone(s) completely,mechanical lithotripsy was required in 25 (83.3％) patients even though the stone size was not as large as were the difficult stones that have been described in the literature.The stone size and stone/PE segment diameter ratio were associated with the need for lithotripsy.Post-ERC complications occurred in 4 cases:pancreatitis in 1,cholangitis in 2,and an impacted Dormia basket with cholangitis in 1.Two (6.7％)of the 28 patients developed recurrent CBD stones at follow-up (50 ± 14 mo) and were successfully managed with therapeutic ERC.CONCLUSION:Patients with a PE duct frequently require mechanical lithotripsy for stones extraction.To retrieve stones successfully and avoid complications,these patients should be identified during ERC.
      原文链接:
    • NETL
    • NSTL
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    • 维普

    Prognosis of HER2 over-expressing gastric cancer patients with liver metastasis

    Hai-Zhen DangYang YuShun-Chang Jiao
    2402-2407页
    查看更多>>摘要：AIM:To study the risk factors for liver metastasis and the prognosis in patients with human epidermal growth factor receptor 2 (HER2) over-expressing gastric cancer (GC).METHODS:A total of 84 GC patients recruited from the General Hospital of the People's Liberation Army (PLA) between 2003 and 2010 were randomly enrolled in this study.HER2 expression was detected by immunohistochemistry in 84 GC patients with liver metastases.The study group consisted of 66 men and 18 women,with an average age of 54 years (range:19-74years).Liver metastasis was diagnosed by magnetic resonance imaging or computed tomography.Patients were followed-up and predictive factors of liver metastasis were evaluated.RESULTS:The median follow-up period was 47 mo (range:6-85 mo).The characteristics of 35 (25.7％)patients with HER2 over-expression of liver metastatic GC are presented.HER2 over-expression was detected in 23 out of 49 (46.9％) patients with intestinal GC,and 9 out of 35 (25.7％) patients with diffuse GC.29 out of 59 (49.2％) patients aged ＜ 60 years were HER2-positive,while 8 out of 25 (32％) patients aged ≥ 60were HER2-positive; a significant difference (P ＜ 0.05).Univariate analysis (log-rank test) showed that HER2 over-expression,sex,Lauren classification,differentiation and disease-free interval were correlated with poor survival (P ＜ 0.05).Survival analysis with a survival curve showed that HER2 over-expression was significantly relevant,with a reduced survival time in GC patients with liver metastases (P ＜ 0.01).2-year survival was not associated with the patient's age.A diseasefree survival longer than 12 mo has a significant association with extended overall survival (OS) in GC patients with liver metastases.The median survival time after the diagnosis of liver metastases was 18 mo [95％ confidence interval (CI):9.07-26.94] among HER2 positive GC patients with liver metastases.In comparison,for 49 (69.4％) out of 84 HER2 negative patients with liver metastatic GC,the median survival time was 47 mo (95％ CI:19.37-74.63).In patients with HER2 positive liver metastatic GC,the median OS was significantly shorter than in HER2 negative patients (median,20.32 mo; 95％ CI:16.51-24.13 vs median,50.14 mo; 95％CI:37.83-62.45; P ＜ 0.01).CONCLUSION:HER2 over-expressing GC patients with liver metastases have a poor prognosis.Overall survival was significantly lower in HER2 positive patients.HER2-overexpression is correlated with a lower survival rate.
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    • NETL
    • NSTL
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    • 维普

    Glypican-3 expression and its relationship with recurrence of HCC after liver transplantation

    Yu-Liang WangZhi-Jun ZhuDa-Hong TengZhi Yao...
    2408-2414页
    查看更多>>摘要：AIM:To investigate the diagnostic value of glypican-3 (GPC3) and its relationship with hepatocellular carcinoma (HCC) recurrence after liver transplantation.METHODS:HCC tissue samples (n =31) obtained from patients who had undergone liver transplantation were analyzed.GPC3 mRNA and protein expression were analyzed by TaqMan real-time reverse transcription-polymerase chain reaction and immunohistochemistry.Correlation between the GPC3 expression and clinicopathological features was analyzed.The potential prognostic value of GPC3 was investigated by comparing recurrence-free survival between HCC patients with and without GPC3 expression.RESULTS:Using a cutoff value of 3.5 × 10-2,20 of 31 cancerous tissues had expression values of ＞ 3.5 ×10-2,whereas 3 of 31 adjacent non-neoplastic parenchyma and 0 of 20 control liver tissues had expression values of ＞ 3.5 × 10-2 (P ＜ 0.001).GPC3 protein was immunoexpressed in 68％ of cancerous tissues,but not in adjacent non-neoplastic parenchyma and control liver tissues.Vascular invasion was significantly related to GPC3 expression (P ＜ 0.05).Recurrence-free survival was significantly longer for patients without GPC3 mRNA overexpression (＞ 3.5 × 102) and those without vascular invasion (P ＜ 0.05 for both).CONCLUSION:GPC3 expression may serve as a valuable diagnostic marker for HCC.GPC3 mRNA overexpression may be an adverse indicator for HCC patients after liver transplantation.
      原文链接:
    • NETL
    • NSTL
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    • 维普

    Salvage liver transplantation in the treatment of hepatocellular carcinoma: A Meta-analysis

    Hong-Yu LiYong-Gang WeiLv-Nan YanBo Li...
    2415-2422页
    查看更多>>摘要：AIM:To evaluate survival and recurrence after salvage liver transplantation (SLT) for the treatment of hepatocellular carcinoma (HCC) compared with primary liver transplantation (PLT) using a meta-analysis.METHODS:Literature on SLT versus PLT for the treatment of HCC published between 1966 and July 2011 was retrieved.A meta-analysis was conducted to estimate pooled survival and disease-free rates.A fixed or random-effect model was established to collect the data.RESULTS:The differences in overall survival and disease-free survival rates at 1-year,3-year and 5-year survival rates were not statistically significant between SLT group and PLT group (P ＞ 0.05).After stratifying the various studies by donor source and Milan criteria,we found that:(1) Living donor liver transplantation recipients had significantly higher 1-year survival rate,lower 3-year and 5-year survival rates compared with deceased-donor liver transplantation (DDLT) recipients.And in DDLT recipients they had better 1-year and 5-year disease-free survival rate in SLT group; and (2)No difference was seen in 1-year,3-year and 5-year survival rates between two groups who beyond Milan criteria at the time of liver transplantation.CONCLUSION:SLT can be effectively performed for patients with recurrence or deterioration of liver function after hepatectomy for HCC.It does not increase the perioperative mortality and has a similar long-term survival rates compared to PLT.
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    Reduced Popdc3 expression correlates with high risk and poor survival in patients with gastric cancer

    Deng LuoMing-Liang LuGong-Fang ZhaoHua Huang...
    2423-2429页
    查看更多>>摘要：AIM:To investigate the expression of Popeye domain containing 3 (Popdc3) and its correlation with clinicopathological features and prognosis of gastric cancer.METHODS:The method of immunohistochemistry was used to investigate the expression of Popdc3 in 306 cases of human gastric cancer and 84 noncancerous gastric tissues.Simultaneously,the relationship between Popdc3 expression and the survival of the patients was retrospectively analyzed.RESULTS:Popdc3 was detected in 72 (85.71％) of 84 human nontumor mucosa.High expression of Popdc3 protein was detected in 78 (25.49％) of 306 human gastric cancer cases,and low expression was detected in 228 (74.51％).Low expression of Popdc3 correlated with depth of invasion (P ＜ 0.0001),regional lymph nodes (P ＜ 0.0001) and distant metastasis (P =0.02),and tumor,nodes,metastasis (TNM) stages (P＜ 0.0001).On multivariate analysis,only the patient's gender,regional lymph node metastasis,distant metastasis,TNM stages,and the expression of Popdc3 were independent prognostic factors in patients with gastric cancer.The Kaplan-Meier plot showed that low Popdc3 expression had a much more significant effect on the survival of those patients with early-stage tumors (x2 =104.741,P ＜ 0.0001),with a ＞ 51.9％ reduction in the three-year survival compared with high Popdc3 expression.In late stages,the difference was also significant (x2 =5.930,P =0.015),with a 32.6％ reduction in the three-year survival.CONCLUSION:Reduced expression of Popdc3 may play a significant role in the carcinogenesis and progression of gastric cancer.Popdc3 may be an independent prognostic factor.
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    Giardia infection: Protein-losing enteropathy in an adult with immunodeficiency

    Alexandre Khodr FurtadoVirginia Lucia Ribeiro CabralThiago Nunes SantosEli Mansour...
    2430-2433页
    查看更多>>摘要：The case of a 52-year-old woman with a past history of thymoma resection who presented with chronic diarrhea and generalized edema is the focal point of this article.A diagnosis of Giardia lamblia infection was established,which was complicated by protein-losing enteropathy and severely low serum protein level in a patient with no urinary protein loss and normal liver function.After anti-helmintic treatment,there was recovery from hypoalbuminemia,though immunoglobulins persisted at low serum levels leading to the hypothesis of an immune system disorder.Good's syndrome is a rare cause of immunodeficiency characterized by the association of hypogammaglobulinemia and thymoma.This primary immune disorder may be complicated by severe infectious diarrhea secondary to disabled humoral and cellular immune response.This is the first description in the literature of an adult patient with an immunodeficiency syndrome who presented with protein-losing enteropathy secondary to giardiasis.
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    An unusual enteropathy-associated T-cell lymphoma with MYC translocation arising in a Japanese patient: A case report

    Kenji OkumuraMasahiko IkebeTatsuro ShimokamaMorishige Takeshita...
    2434-2437页
    查看更多>>摘要：Enteropathy-associated T-cell lymphoma (EATL) is a rare peripheral T-cell lymphoma classified into 2 types,with or without celiac disease,based on histology.Type 2 EATL is less commonly associated with celiac disease,in which cells are characterized by being monomorphic and small-to medium-sized.Cells are characterized by CD8 and CD56 expression and c-MYC oncogene locus gain.We present an atypical case of type 2 EATL in the jejunum,with human T-lymphotropic virus-1 that was CD4-CD8+ CD56-CD30-CD25-TIA-1+ and granzyme B+ on immunohistological staining.It also displayed translocation of chromosome 8p24 (c-MYC),as determined by fluorescent in situ hybridization.Mucosal spreading and intraepithelial invasion by lymphoma with villous atrophy were detected adjacent to the mucosal layer.The lymphoma may be derived from intraepithelial CD8+ T cells,similar to celiac disease.
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    Spontaneous perforation of an intramural rectal hematoma:Report of a case

    Zhu-Lin LiZhen-Jun WangJia-Gang Han
    2438-2440页
    查看更多>>摘要：Spontaneous hematomas are rare and most occur secondary to hematologic disorders or during anticoagulant therapy.Most spontaneous hematomas occur above the sigmoid colon,and rarely in the rectum.Herein we present the case of a patient with a spontaneous perforating hematoma of the rectum who presented with severe abdominal pain after a bloody stool.The hemoglobin level decreased by 33 g/L within 20 h.An abdominal sonogram showed a hydrops in the lower abdomen with a maximum depth of 7.0 cm.A hematoma,8 cm × 6 cm × 5 cm in size,was noted intra-operatively in the rectosigmoid junction,with a 1.5-cm perforation in the hematoma and active hemorrhage.Thus,a partial rectectomy and sigmoidostomy were performed.Three months later,a second operative procedure to re-establish intestinal continuity was performed.The patient is in good condition 12 mo after the last surgery.In addition to this case,the causes of spontaneous perforating hematomas and the treatment are discussed.
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