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世界胃肠病学杂志（英文版）
世界胃肠病学杂志（英文版）

潘伯荣

周刊

1007-9327

wjg@wjgnet.com

010-85381901-628

100025

北京市朝阳区东四环中路62号楼远洋国际中心D座903室

世界胃肠病学杂志（英文版）/Journal World Journal of GastroenterologyCSCDCSTPCDSCI
查看更多>>主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。
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    Role of taxanes in pancreatic cancer

    Carmen BelliStefano CeredaMichele Reni
    4457-4465页
    查看更多>>摘要：Pancreatic cancer is one of the most deadly cancers and is characterized by a poor prognosis.Single agent gemcitabine,despite its limited activity and modest impact on disease outcome,is considered as the standard therapy in pancreatic cancer.Most of the combination regimens used in the treatment of this disease,also including the targeted agents,did not improve the outcome of patients.Also,taxanes have been tested as single agent and in combination chemotherapy,both in first line and as salvage chemotherapy,as another possible option for treating pancreatic cancer.The inclusion of taxanes in combination with gemcitabine as upfront therapy obtained promising results.Accordingly,taxanes,and above all,new generation taxanes,appear to be suitable candidates for further testing to assess their role against pancreatic cancer in various clinical settings.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Confounding factors affect the pathophysiology of eosinophilic esophagitis

    Yoram Elitsur
    4466-4469页
    查看更多>>摘要：Eosinophilic esophagitis is a newly diagnosed esophageal disease in adult and children.The clinical and pathological characteristics of this disease have been established and were recently summarized in the expert clinical guideline published in 2011.In spite of the wide knowledge accumulated on this disease,there are many areas where scientific data are missing,especially in regard to the disease's pathophysiology.Recent publications have suggested that other confounding factors modify the disease and may affect its clinicalphenotypic presentation.Those factors may include place of living,air pollution,race,genetic factors and other.In the present report we discussed and review those confounding factors,the new developments,and what direction we should go to further advance our knowledge of this disease.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Diagnostic criteria for autoimmune hepatitis in children:A challenge for pediatric hepatologists

    Priscila Menezes FerriAlexandre Rodrigues FerreiraDébora Marques MirandaAna Cristina Sim(o)es e Silva...
    4470-4473页
    查看更多>>摘要：Autoimmune hepatitis (AIH) is a progressive inflammatory liver disorder that is rare in children and adolescents.AIH has a broad clinical spectrum and a quick response to treatment with corticosteroids and immunosuppressive medication.The available diagnosis criteria have limitations and should be evaluated in pediatric populations.Recently,some studies reported that the 2008 simplified diagnostic criteria for AIH could be used in children with high sensibility and specificity.In addition,the authors reported that globulin and immunoglobulin G levels can be used interchangeably for diagnostic purposes.They also demonstrated that the 2008 simplified criteria fail in identifying patients with fulminant hepatic failure.Here,we discuss the limitations of the use of these criteria in pediatric patients and the requirement of more studies to improve the diagnosis of AIH in children.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Asymptomatic pancreatic lesions: New insights and clinical implications

    Martin LoosChristoph W MichalskiJ(o)rg Kleeff
    4474-4477页
    查看更多>>摘要：Despite great efforts in experimental and clinical research,the prognosis of pancreatic cancer (PC) has not changed significantly for decades.Detection of pre-invasive lesions or early-stage PC with small resectable cancers in asymptomatic individuals remains one of the most promising approaches to substantially improve the overall outcome of PC.Therefore,screening programs have been proposed to identify curable lesions especially in individuals with a familial or genetic predisposition for PC.In this regard,Canto et al recently contributed an important article comparing computed tomography,magnetic resonance imaging,and endoscopic ultrasound for the screening of 216 asymptomatic high-risk individuals (HRI).Pancreatic lesions were detected in 92 of 216 asymptomatic HRI (42.6％).The high diagnostic yield in this study raises several questions that need to be answered of which two will be discussed in detail in this commentary:First:which imaging test should be performed? Second and most importantly:what are we doing with incidentally detected pancreatic lesions? Which ones can be observed and which ones need to be resected?
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Opposite fates of fructose in the development of metabolic syndrome

    Marta AlegretJuan C Laguna
    4478-4480页
    查看更多>>摘要：This short review comments on the recently published work of Ishimoto et al regarding the opposing effects of fructokinase C and A isoforms on fructoseinduced metabolic syndrome in mice.The framework for the commentary is the preexisting background of epidemiological and experimental data regarding the association between ingestion of fructose,as present in sweetened beverages,and the development of metabolic syndrome.The work of Ishimoto etal clearly confirms the negative effect of fructose on lipid and glucose metabolism,independently from the amount of energy provided by the ingested sugar.It also confirms the absolute requirement of liver fructose metabolism,driven by fructokinase activity,in order to develop the full spectrum of metabolic syndrome alterations.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Entry of hepatitis C virus into the cell: A therapeutic target

    José Antonio Del Campo(A)ngela RojasManuel Romero-Gómez
    4481-4485页
    查看更多>>摘要：Several receptors have been identified as implicated on viral entry into the hepatocyte; and,this interaction between the virus and potential receptors could modulate infection,spontaneous viral clearance,persistence of the infection and the widespread of the virus as outbreak.Nevertheless,the playing role of each of them remains controversial.The NiemannPick type C1 like 1 gene (NPC1L1) receptor has been recently implicated on hepatitis C virus (HCV) entry into the cell and ezetimibe,an anti-cholesterol drug seems to block that,emerging the idea to control hepatitis C outbreak modulating lipid-related receptors.Hepatitis C infection seems to modulate lipid metabolism according to host genetic background.Indeed,it circulates like a lipoviroparticle.The main aim of this field of vision would be to discuss the role of hepatocyte receptors implicated on virus entry,especially NPC1L1 and the therapeutic options derived from the better knowledge about HCV-lipids-receptors interaction.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Early administration of branched-chain amino acid granules

    Toru Ishikawa
    4486-4490页
    查看更多>>摘要：The effect of malnutrition on survival in patients with decompensated liver cirrhosis has not been well defined.Nutritional intervention with branched-chain amino acid (BCAA) can increase serum albumin concentration in patients with decompensated cirrhosis but its effects on survival are unclear.The BCAA to tyrosine ratio (BTR) is a surrogate marker (the normal range of BTR is between 4.41 and 10.05,and a Fischer's ratio of 1.8 corresponds to a BTR of 3.5) in patients with decompensated liver cirrhosis,and BCAA inhibits hepatic carcinogenesis in patients with compensated cirrhosis.This review discusses data regarding the effect of early administration of BCAA granules based on the ratio of BCAA to BTR on prognosis in patients with cirrhosis.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Donation after cardio-circulatory death liver transplantation

    Hieu Le DinhArnaud de RooverAbdour KabaSéverine Lauwick...
    4491-4506页
    查看更多>>摘要：The renewed interest in donation after cardio-circulatory death (DCD) started in the 1990s following the limited success of the transplant community to expand the donation after brain-death (DBD) organ supply and following the request of potential DCD families.Since then,DCD organ procurement and transplantation activities have rapidly expanded,particularly for nonvital organs,like kidneys.In liver transplantation (LT),DCD donors are a valuable organ source that helps to decrease the mortality rate on the waiting lists and to increase the availability of organs for transplantation despite a higher risk of early graft dysfunction,more frequent vascular and ischemia-type biliary lesions,higher rates of re-listing and re-transplantation and lower graft survival,which are obviously due to the inevitable warm ischemia occurring during the declaration of death and organ retrieval process.Experimental strategies intervening in both donors and recipients at different phases of the transplantation process have focused on the attenuation of ischemia-reperfusion injury and already gained encouraging results,and some of them have found their way from pre-clinical success into clinical reality.The future of DCD-LT is promising.Concerted efforts should concentrate on the identification of suitable donors (probably Maastricht category Ⅲ DCD donors),better donor and recipient matching (high risk donors to low risk recipients),use of advanced organ preservation techniques (oxygenated hypothermic machine perfusion,normothermic machine perfusion,venous systemic oxygen persufflation),and pharmacological modulation (probably a multi-factorial biologic modulation strategy) so that DCD liver allografts could be safely utilized and attain equivalent results as DBD-LT.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Surveillance for gastrointestinal malignancies

    Ashish K TiwariHeather S Laird-FickRamesh K WaliHemant K Roy...
    4507-4516页
    查看更多>>摘要：Gastrointestinal (GI) malignancies are notorious for frequently progressing to advanced stages even in the absence of serious symptoms,thus leading to delayed diagnoses and dismal prognoses.Secondary prevention of GI malignancies through early detection and treatment of cancer-precursor/premalignant lesions,therefore,is recognized as an effective cancer prevention strategy.In order to efficiently detect these lesions,systemic application of screening tests (surveillance) is needed.However,most of the currently used non-invasive screening tests for GI malignancies (for example,serum markers such as alpha-fetoprotein for hepatocellular carcinoma,and fecal occult blood test,for colon cancer) are only modestly effective necessitating the use of highly invasive endoscopy-based procedures,such as esophagogastroduodenoscopy and colonoscopy for screening purposes.Even for hepatocellular carcinoma where non-invasive imaging (ultrasonography) has become a standard screening tool,the need for repeated liver biopsies of suspicious liver nodules for histopathological confirmation can't be avoided.The invasive nature and high-cost associated with these screening tools hinders implementation of GI cancer screening programs.Moreover,only a small fraction of general population is truly predisposed to developing GI malignancies,and indeed needs surveillance.To spare the average-risk individuals from superfluous invasive procedures and achieve an economically viable model of cancer prevention,it's important to identify cohorts in general population that are at substantially high risk of developing GI malignancies (riskstratification),and select suitable screening tests for surveillance in these cohorts.We herein provide a brief overview of such high-risk cohorts for different GI malignancies,and the screening strategies that have commonly been employed for surveillance purpose in them.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Management of chronic hepatitis B in pregnancy

    Guo-Rong HanChuan-Lu XuWei ZhaoYong-Feng Yang...
    4517-4521页
    查看更多>>摘要：Pregnancy associated with chronic hepatitis B (CHB)is a common and important problem with unique challenges.Pregnant women infected with CHB are different from the general population,and their special problems need to be considered:such as the effect of hepatitis B virus (HBV) infection on the mother and fetus,the effect of pregnancy on replication of the HBV,whether mothers should take HBV antiviral therapy during pregnancy,the effect of these treatments on the mother and fetus,how to carry out immunization of neonates,whether it can induce hepatitis activity after delivery and other serious issues.At present,there are about 350 million individuals with HBV infection worldwide,of which 50％ were infected during the perinatal or neonatal period,especially in HBV-endemic countries.Currently,the rate of HBV infection in the child-bearing age group is still at a high level,and the infection rate is as high as 8.16％.Effective prevention of mother-to-child transmission is an important means of reducing the global burden of chronic HBV infection.Even after adopting the combined immunization measures,there are still 5％-10％ of babies born with HBV infection in hepatitis B e antigen positive pregnant women.As HBV perinatal transmission is the main cause of chronic HBV infection,we must consider how to prevent this transmission to reduce the burden of HBV infection.In this population of chronic HBV infected women of childbearing age,specific detection,intervention and follow-up measures are particularly worthy of attention and discussion.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普