期刊,世界胃肠病学杂志（英文版） 2012年卷36期_国家学术搜索

期刊信息/Journal information

世界胃肠病学杂志（英文版）

主　　编：潘伯荣

出版周期：周刊

国际刊号：1007-9327

电子邮箱：wjg@wjgnet.com

电　　话：010-85381901-628

邮政编码：100025

地　　址：北京市朝阳区东四环中路62号楼远洋国际中心D座903室

世界胃肠病学杂志（英文版）/Journal World Journal of GastroenterologyCSCDCSTPCDSCI

查看更多>>主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。

正式出版

收录年代

Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22

Jia-Ping HuaiXue-Cheng SunMeng-Jun ChenYin Jin...

5122-5128页

查看更多>>摘要：AIM:To investigate whether therapeutic treatment with melatonin could protect rats against acute pancreatitis and its associated lung injury.METHODS:Seventy-two male Sprague-Dawley rats were randomly divided into three groups:the sham operation (SO),severe acute pancreatitis (SAP),and melatonin treatment (MT) groups.Acute pancreatitis was induced by infusion of 1 mL/kg of sodium taurocholate (4％ solution) into the biliopancreatic duct.Melatonin (50 mg/kg) was administered 30 min before pancreatitis was induced,and the severity of pancreatic and pulmonary injuries was evaluated 1,4 and 8 h after induction.Serum samples were collected to measure amylase activities,and lung tissues were removed to measure levels of mRNAs encoding interleukin 22 (IL-22)and T helper cell 22 (Th22),as well as levels of IL-22.RESULTS:At each time point,levels of mRNAs encoding IL-22 and Th22 were significantly higher (P ＜ 0.001)in the MT group than in the SAP group (0.526 ± 0.143vs 0.156 ± 0.027,respectively,here and throughout,after 1 h; 0.489 ± 0.150 vs 0.113 ±0.014 after 4 h;0.524 ± 0.168 vs 0.069 ± 0.013 after 8 h,0.378 ± 0.134vs 0.122 ± 0.015 after 1 h; 0.205 ± 0.041 vs 0.076 ±0.019 after 4 h; 0.302 ± 0.108 vs 0.045 ± 0.013 after 8 h,respectively) and significantly lower (P ＜ 0.001)in the SAP group than in the SO group (0.156 ± 0.027vs 1.000 ± 0.010 after 1 h; 0.113 ± 0.014 vs 1.041 ±0.235 after 4 h; 0.069 ± 0.013 vs 1.110 ± 0.213 after 8 h,0.122 ± 0.015 vs 1.000 ± 0.188 after 1 h; 0.076 ± 0.019 vs 0.899 ± 0.125 after 4 h; 0.045 ± 0.013 vs 0.991± 0.222 after 8 h,respectively).The mean pathological scores for pancreatic tissues in the MT group were significantly higher (P ＜ 0.01) than those for samples in the SO group (1.088 ± 0.187 vs 0.488 ± 0.183 after 1 h;2.450 ± 0.212 vs 0.469 ± 0.242 alter 4 h; 4.994 ± 0.184vs 0.513 ± 0.210 alter 8 h),but were significantly lower (P ＜ 0.01) than those for samples in the SAP group at each time point (1.088 ± 0.187 vs 1.969 ± 0.290 after 1 h; 2.450 ± 0.212 vs 3.344 ± 0.386 after 4 h; 4.994 ±0.184 vs 6.981 ± 0.301 after 8 h).The severity of SAP increased significantly (P ＜ 0.01) over time in the SAP group (1.088 ± 0.187 vs 2.450 ± 0.212 between 1 hand 4 h after inducing pancreatitis; and 2.450 ± 0.212vs 4.994 ± 0.184 between 4 and 8 h after inducing pancreatitis).CONCLUSION:Melatonin protects rats against acute pancreatitis-associated lung injury,probably through the upregulation of IL-22 and Th22,which increases the innate immunity of tissue cells and enhances their regeneration.

原文链接:

NETL
NSTL
万方数据
维普

CpG island methylator phenotype and Helicobacter pylori infection associated with gastric cancer

Ji-Bin LiuXu-Ming WuJin CaiJin-Ye Zhang...

5129-5134页

查看更多>>摘要：AIM:TO investigate the association between the CpG island methylator phenotype (CIMP) and serum Helicobacter pylori (H.pylori) levels for clinical prediction of gastric cancer (GC) progression.METHODS:We analyzed the serum CIMP status of 75 patients with GC using a methylation marker panel and a methylation-specific polymerase chain reaction.Serum samples from 40 healthy persons were examined at the same time.The genes examined were APC,WIF-1,RUNX-3,DLC-1,SFRP-1,DKK and E-cad.H.pylori infection in serum was assayed with an anti-H.pylori immunoglobulin G antibody test and a rapid urease test.RESULTS:The frequencies of high-level methylation in GC tissues for the seven genes were:48％ for APC,57.33％ for WIF-1,56％ for RUNX-3,50.67％ for DLC-1,52％ for SFRP-1,54.67％ for DKK,and 48％ for E-cad.The frequencies in GC serum were 30.67％ for APC,34.67％ for WIF-1,37.33％ for RUNX-3,29.33％ for DLC-1,33.33％ for SFRP-1,32％ for DKK,and 26.67％for E-cad.CIMP+ (defined as ≥ 3 methylated genes)was associated with 47 (62.67％) GC tissue samples and 44 (58.67％) GC serum samples.CIMP+ was not associated with non-neoplastic mucosal tissues or the serum of healthy persons.Of the 75 GC cases,51 (68％)were H.pylori+,and 24 (32％) were H.pylori-.Of the 51 H.pylori+ cases,36 were CIMP+ and 15 were CIMP-.In contrast,for the 24H.pylori-cases,11 were ClMP+,and 13 were CIMP-.The difference was significant between the H.pylori+ and H.pylori-groups (x2=4.27,P ＜ 0.05).Of the 51 H.pylori+ GC patients,34were CIMP+ and 17 were CIMP-,while among the 24 H.pylori-GC cases,10 were CIMP+ and 14 were CIMP-.The difference was significant between the H.pylori+and H.pylori-groups (x2 =4.21,P ＜ 0.05).A 2-year follow-up showed significant difference in the rates of metastasis and recurrence between H.pylori+lCIMP+cases and the H.pylori+/CIMP-cases or CIMP-cases associated with H.pylori assayed in serum (P ＜ 0.05).However,there were no significant differences in survival rates between the two groups.CONCLUSION:H.pylori+/CIMP+ cases are associated with higher rates of metastasis and recurrence than H.pylori+/CIMP-cases.Serum may be useful for examining CIMP status.

原文链接:

NETL
NSTL
万方数据

Use of anti tumor necrosis factor-alpha monoclonal antibody for ulcerative jejunoileitis

Gulseren SevenAdel AssaadThomas BiehlRichard A Kozarek...

5135-5137页

查看更多>>摘要：Ulcerative jejunoileitis is an uncommon clinical syndrome consisting of abdominal pain,weight loss associated with diarrhea,and multiple inflammatory ulcerations and strictures of the small bowel.Ulcerative jejunoileitis can complicate established celiac disease or develop in patients de novo.Increased levels of tumor necrosis factor-alpha (TNF-α) in the small intestine of patients with untreated celiac disease are associated with a role in the immune pathogenesis of this disorder.No specific therapy has been shown to change the course of ulcerative jejunoileitis.We report a case of severe ulcerative jejunoileitis previously unresponsive to traditional therapies,including high dose corticosteroids and cyclosporine.The patient had a dramatic resolution of symptoms and a complete normalization of endoscopic findings after anti-TNF-α monoclonal antibody,infliximab (Remicade(R)).

原文链接:

NETL
NSTL
万方数据
维普

Scrub typhus hepatitis confirmed by immunohistochemical staining

Jong-Hoon ChungSung-Chul LimNa-Ra YunSung-Heui Shin...

5138-5141页

查看更多>>摘要：Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi (O.tsutsugamushi).We report herein the case of a woman who presented with fever and elevated serum levels of liver enzymes and who was definitively diagnosed with scrub typhus by histopathological examination of liver biopsy specimens,serological tests and nested polymerase chain reaction.Immunohistochemical staining using a monoclonal anti-O.tsutsugamushi antibody showed focally scattered positive immunoreactions in the cytoplasm of some hepatocytes.This case suggests that scrub typhus hepatitis causes mild focal inflammation due to direct liver damage without causing piecemeal necrosis or interface hepatitis.Thus,scrub typhus hepatitis differs from acute viral hepatitis secondary to liver damage due to host immune responses,which causes severe Iobular disarray with diffuse hepatocytic degeneration,necrosis and apoptosis as well as findings indicative of hepatic cholestasis,such as hepatic bile plugs or brown pigmentation of hepatocytes.

原文链接:

NETL
NSTL
万方数据
维普

Air in the main pancreatic duct: A case of innocent air

Yun Ji KimHyung Keun KimYoung Seok ChoSung Soo Kim...

5142-5144页

查看更多>>摘要：Air in the main pancreatic duct has been reported only rarely and might be associated with either a spontaneous or a surgically induced alteration of the anatomy of the biliary tract.We report a case of "innocent" air found incidentally in the main pancreatic duct.To our knowledge,this is only the third such case reported.A 54-year-old woman presented with hemoptysis that had lasted for 3 d.She underwent a chest computed tomography scan,which revealed not only focal bronchiectasis in the left lower lobe,but also air in the main pancreatic duct and dilatation of the common bile duct.She was managed conservatively for the hemoptysis and no further problems developed.She had no specific gastrointestinal symptoms and had no history of surgery or medication.Her laboratory parameters were normal.Magnetic resonance cholangiopancreatography also demonstrated air in the main pancreatic duct and a dilated common bile duct (CBD).Duodenoscopy revealed separate biliary and pancreatic oririces with patulous openings and some air bubbles appearing in the pancreatic orifice.Endoscopic retrograde cholangiopancreatography (ERCP) showed the dilated CBD and pancreatic duct with some air bubbles,but no other abnormal lesions.She was discharged with no further problems.Most patients with air in the main pancreatic duct have had a pancreatobiliary disease,or a history of pancreatobiliary disease,pancreatobiliary surgery or sphincterotomy.If the air is innocent,as in our case,ERCP should be performed to evaluate any altered sphincteric function or anatomy such as patuIous openings.

原文链接:

NETL
NSTL
万方数据
维普

Information

后插3-后插8页

原文链接:

NETL
NSTL
万方数据