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世界胃肠病学杂志（英文版）
世界胃肠病学杂志（英文版）

潘伯荣

周刊

1007-9327

wjg@wjgnet.com

010-85381901-628

100025

北京市朝阳区东四环中路62号楼远洋国际中心D座903室

世界胃肠病学杂志（英文版）/Journal World Journal of GastroenterologyCSCDCSTPCDSCI
查看更多>>主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。
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    Similar fecal immunochemical test results in screening and referral colorectal cancer

    Sietze T van TurenhoutLeo GM van RossumFrank A OortRobert JF Laheij...
    5397-5403页
    查看更多>>摘要：AIM:To improve the interpretation of fecal immunochemical test (FIT) results in colorectal cancer (CRC)cases from screening and referral cohorts.METHODS:In this comparative observational study,two prospective cohorts of CRC cases were compared.The first cohort was obtained from 10 322 average risk subjects invited for CRC screening with FIT,of which,only subjects with a positive FIT were referred for colonoscopy.The second cohort was obtained from 3637subjects scheduled for elective colonoscopy with a positive FIT result.The same FIT and positivity threshold (OC sensor; ≥ 50 ng/mL) was used in both cohorts.Colonoscopy was performed in all referral subjects and in FIT positive screening subjects.All CRC cases were selected from both cohorts.Outcome measurements were mean FIT results and FIT scores per tissue tumor stage (T stage).RESULTS:One hundred and eighteen patients with CRC were included in the present study:28 cases obtained from the screening cohort (64％ male; mean age 65 years,SD 6.5) and 90 cases obtained from the referral cohort (58％ male; mean age 69 years,SD 9.8).The mean FIT results found were higher in the referral cohort (829 ± 302 ng/mL vs 613 ± 368 ng/mL,P =0.02).Tissue tumor stage (T stage) distribution was different between both populations [screening population:13 (46％) T1,eight (29％) T2,six (21％) T3,one (4％)T4 carcinoma; referral population:12 (13％) T1,22(24％) T2,52 (58％) T3,four (4％) T4 carcinoma],and higher T stage was significantly associated with higher FIT results (P ＜ 0.001).Per tumor stage,no significant difference in mean F1T results was observed (screening vs referral:T1 498 ± 382 ng/mL vs 725 ± 374 ng/mL,P =0.22; T2 787 ± 303 ng/mL vs 794 ± 341 ng/mL,P=0.79; T3 563 ± 368 ng/mL vs 870 ± 258 ng/mL,P =0.13; T4 not available).Alter correction for T stage in logistic regression analysis,no significant differences in mean FIT results were observed between both types of cohorts (P =0.10).CONCLUSION:Differences in T stage distribution largely explain differences in FIT results between screening and referral cohorts.Therefore,FIT results should be reported according to T stage.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Different risk factors influence peptic ulcer disease development in a Brazilian population

    Rodrigo Buzinaro SuzukiRodrigo Faria ColaLarissa Tranquilino Bardela ColaCamila Garcia Ferrari...
    5404-5411页
    查看更多>>摘要：AIM:To investigate age,sex,histopathology and Helicobacter pylori (H.pylori) status,as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.METHODS:From all 1466 consecutive dyspeptic patients submitted to upper gastroscopy at Hospital das Clinicas of Marilia,antral biopsy specimens were obtained and subjected to histopathology and H.pylori diagnosis.All patients presenting chronic gastritis (CG)and peptic ulcer (PU) disease localized in the stomach,gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study.Gastric biopsies (n =668) positive for H.pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA) medium (m) region mosaicism by polymerase chain reaction.Logistic regression analysis was performed to verify the association of age,sex,histopathologic alterations,H.pylori diagnosis and vacA m region mosaicism with the incidence of DU,GU and CG in patients.RESULTS:Of 1466 patients submitted to endoscopy,1060 (72.3％) presented CG [male/female =506/554;mean age (year) ± SD =51.2 ± 17.81],88 (6.0％)presented DU [male/female =54/34; mean age (year)± SD =51.4 ± 17.14],and 75 (5.1％) presented GU[male/female =54/21; mean age (year) ± SD =51.3± 17.12] and were included in the comparative analysis.Sex and age showed no detectable effect on CG incidence (overall x2 =2.1,P =0.3423).Sex [Odds ratios (OR) =1.8631,P =0.0058] but not age (OR =0.9929,P =0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall x2 =30.5,P ＜ 0.0001).The histopathological results showed a significant contribution of ageing for both atrophy (OR =1.0297,P ＜ 0.0001) and intestinal metaplasia (OR =1.0520,P ＜ 0.0001).Presence of H.pylori was significantly associated with decreasing age (OR =0.9827,P ＜ 0.0001) and with the incidence of DU (OR =3.6077,P ＜ 0.0001).The prevalence of ml in DU was statistically significant (OR =2.3563,P =0.0018) but not in CG (OR =2.678,P =0.0863) and GU (OR =1.520,P=0.2863).CONCLUSION:In our population,male gender was a risk factor for PU; ageing for GU,atrophy and metapla
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Argon plasma coagulation for superficial esophageal squamous-cell carcinoma in high-risk patients

    Kumiko TaharaSatoshi TanabeKenji IshidoKatsuhiko Higuchi...
    5412-5417页
    查看更多>>摘要：AIM:To evaluate the usefulness and safety of argon plasma coagulation (APC) for superficial esophageal squamous-cell carcinoma (SESC) in high-risk patients.METHODS:We studied 17 patients (15 men and 2 women,21 lesions) with SESC in whom endoscopic mucosal resection (EMR),endoscopic submucosal dissection (ESD),and open surgery were contraindicated from March 1999 through February 2009.None of the patients could tolerate prolonged EMR/ESD or open surgery because of severe concomitant disease (e.g.,liver cirrhosis,cerebral infarction,or ischemic heart disease) or scar formation after EMR/ESD and chemoradiotherapy.After conventional endoscopy,an iodine stain was sprayed on the esophageal mucosa to determine the lesion margins.The lesion was then ablated by APC.We retrospectively studied the treatment time,number of APC sessions per site,complications,presence or absence of recurrence,and time to recurrence.RESULTS:The median duration of follow-up was 36 mo (range:6-120 mo).All of the tumors were macroscopically classified as superficial and slightly depressed type (0-Ⅱ c).The preoperative depth of invasion was clinical T1a (mucosal cancer) for 19 lesions and clinical T1b (submucosal cancer) for 2.The median treatment time was 15 min (range:10-36 min).The median number of treatment sessions per site was 2 (range:1-4).The median hospital stay was 14 d (range:5-68d).Among the 17 patients (21 lesions),2 (9.5％) had recurrence and underwent additional APC with no subsequent evidence of recurrence.There were no treatment-related complications,such as bleeding or perforation.CONCLUSION:APC is considered to be safe and effective for the management of SESC that cannot be resected endoscopically because of underlying disease,as well as for the control of recurrence after EMR and local recurrence after chemoradiotherapy.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Hepatitis B virus pre-S2 start codon mutations in Indonesian liver disease patients

    Andi UtamaMarlinang Diarta SiburianIsmail FananyMariana Destila Bayu Intan...
    5418-5426页
    查看更多>>摘要：AIM:To identify the prevalence of pre-S2 start codon mutations and to assess their association with liver disease progression.METHODS:The mutations were identified by direct sequencing from 73 asymptomatic carriers,66 chronic hepatitis (CH),66 liver cirrhosis (LC) and 63 hepatocellular carcinoma (HCC) patients.Statistical significances were determined using Fisher's exact test,x2 test,and t-test analyses whenever appropriate.Pre-S mutation as a risk factor for advanced liver disease was estimated by unconditional logistic regression model adjusted with age,sex,and hepatitis B e antigen (HBeAg).P ＜0.05 was considered significant.RESULTS:Mutation of the hepatitis B virus (HBV)pre-S2 start codon was found in 59 samples from 268subjects (22.0％),with higher prevalence in patients with cirrhosis 27/66 (40.9％) followed by HCC 18/63(28.6％),chronic hepatitis 12/66 (18.2％) and asymptomatic carriers 2/73 (2.7％) (P ＜ 0.001).Logistic regression analysis showed that pre-S2 start codon mutation was an independent factor for progressive liver disease.Other mutations,at T130,Q132,and A138,were also associated with LC and HCC,although this was not statistically significant when adjusted for age,sex,and HBeAg.The prevalence of pre-S2 start codon mutation was higher in HBV/B than in HBV/C (23.0％vs 19.1％),whilst the prevalence of T130,Q132,and A138 mutation was higher in HBV/C than in HBV/B.The prevalence of pre-S2 start codon mutation was higher in LC (38.9％) and HCC (40.0％) than CH (5.6％)in HBeAg(+) group,but it was similar between CH,LC and HCC in HBeAg(-) group.CONCLUSION:Pre-S2 start codon mutation was higher in Indonesian patients compared to other Asian countries,and its prevalence was associated with advanced liver disease,particularly in HBeAg(+) patients.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Oxaliplatin-induced severe anaphylactic reactions in metastatic colorectal cancer: Case series analysis

    Jui-Ho WangTai-Ming KingMin-Chi ChangChao-Wen Hsu...
    5427-5433页
    查看更多>>摘要：AIM:To investigate oxaliplatin-induced severe anaphylactic reactions (SAR) in metastatic colorectal cancer in a retrospective case series analysis and to conduct a systemic literature review.METHODS:During a 6-year period from 2006 to 2011 at Kaohsiung Veterans General Hospital,a total of 412 patients exposed to oxaliplatin-related chemotherapy were retrospectively reviewed.Relevant Englishlanguage studies regarding life-threatening SAR following oxaliplatin were also reviewed in MEDLINE（R） and PubMed（R） search.RESULTS:Eight patients (1.9％,8 of 412 cases) were identified.Seven patients were successful resuscitated without any sequelae and one patient expired.We changed the chemotherapy regimen in five patients and rechallenged oxaliplatin use in patient 3.Twenty-three relevant English-language studies with 66 patients were reported.Patients received a median of 10 cycles of oxaliplatin (range,2 to 29).Most common symptoms were respiratory distress (60％),fever (55％),and hypotension (54％).Three fatal events were reported (4.5％).Eleven patients (16％) of the 66 cases were rechallenged by oxaliplatin.CONCLUSION:SAR must be considered in patients receiving oxaliplatin-related chemotherapy,especially in heavily pretreated patients.Further studies on the mechanism,predictors,preventive methods and management of oxaliplatin-related SAR are recommended.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Myofibrillogenesis regulator-1 overexpression is associated with poor prognosis of gastric cancer patients

    Jing GuoBin DongJia-Fu JiAi-Wen Wu...
    5434-5441页
    查看更多>>摘要：AIM:To investigate the expression of myofibrillogenesis regulator-1 (MR-1) in relation to clinicopathological parameters and postoperative survival in a group of Chinese patients with gastric cancer.METHODS:In our previous study of human wholegenome gene expression profiling,the differentially expressed genes were detected in the gastric cancer and its adjacent noncancerous mucosa.We found that MR-1 was associated with the location and differentiation of tumors.In this study,MR-1 protein expression was determined by immunohistochemistry in specimens of primary cancer and the adjacent noncancerous tissues from gastric cancer patients.A set of real-time quantitative polymerase chain reaction assays based on the Universal ProbeLibrary-a collection of 165 presynthesized,fluorescence-labeled locked nucleic acid hydrolysis probes-was designed specifically to detect the expression of MR-1 mRNA.The correlation was analyzed between the expression of MR-1 and other tumor characteristics which may influence the prognosis of gastric cancer patients.A retrospective cohort study on the prognosis was carried out and clinical data were collected from medical records.RESULTS:MR-1 mRNA and protein could be detected in gastric cancer tissues as well as in matched noncancerous tissues.MR-1 was up-regulated at both mRNA (5.459 ± 0.639 vs 1.233 ± 0.238,P ＜ 0.001) and protein levels (34.2％ vs 13.2％,P =0.003) in gastric cancer tissues.Correlation analysis demonstrated that high expression of MR-1 in gastric cancer was significantly correlated with clinical stage (P =0.034).Kaplan-Meier analysis showed that the postoperative survival of the MR-1 positive group tended to be poorer than that of the MR-1 negative group,and the difference was statistically significant (P =0.002).Among all the patients with stage Ⅰ-Ⅳ carcinoma,the 5-year survival rates of MR-1 positive and negative groups were 50.40％ and 12.70％,respectively,with respective median survival times of 64.27 mo (95％CI:13.41-115.13) and 16.77mo (95％CI:8.80-24.74).Univariate and multivariate analyses were performed to compare the impact of MR-1 expression and other clinicopathological parameters on prognosis.In a univariate analysis on all 70specimens,6 factors were found to be significantly associated with the overall survival statistically:including MR-1 expression,depth of invasion,distant metastasis,lymph node metastasis,vascular invasion and the tumor node metastasis (TNM) stage based on the 7th edition of the International Union against Cancer TNM classification.To avoid the influence caused by univariate analysis,the expressions of MR-1 as well as other parameters were examined in multivariate Cox analysis.Clinicopathological variables that might affect the prognosis of gastric cancer patients were analyzed by Cox regression analysis,which showed that MR-1 expression and TNM stage were independent predictors of postoperative survival.The best mathematical multivariate Cox regression model consisted of two factors:MR-1 expression and TNM stage.Our results indicated that MR-1 protein could act as an independent marker for patient overall survival [Hazard ratio (HR):2.215,P =0.043].CONCLUSION:4R-1 is an important variable that can be used to evaluate the outcome,prognosis and targeted therapy of gastric cancer patients.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma

    Wen WangLan Juan ZhaoYe Xiong TanHao Ren...
    5442-5453页
    查看更多>>摘要：AIM:To identify the differentially expressed miRNAs and their targets in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC).METHODS:Six hundred and sixty seven human miR-NAs were quantitatively analyzed by Taqman lowdensity miRNA array (TLDA) in HBV-HCC tissues.Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were used to analyze the significant function and pathway of the differentially expressed miRNAs in HBV-HCC.TargetScan software was used to predict the targets of deregulated miRNAs.Western blotting and luciferase assay were performed to verify the targets of these miRNAs.RESULTS:Ten up-regulated miRNAs (miR-217,miR-518b,miR-517c,miR-520g,miR-519a,miR-522,miR-518e,miR-525-3p,miR-512-3p,and miR-518a-3p)and 11 down-regulated miRNAs (miR-138,miR-214,miR-214#,miR-199a-5p,miR-433,miR-511,miR-592,miR-483-3p,miR-483-5p,miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues.GO and KEGG pathway analysis revealed that "regulation of actin cytoskeleton" and "pathway in cancer" are most likely to play critical roles in HCC tumorigenesis.MiR-519a and ribosomal protein S6 kinase polypeptide 3 (RPS6KA3) were predicted as the most significant candidates by miRNA-mRNA network.In addition,cyclin D3 (CCND3) and clathrin heavy chain (CHC),usually up-regulated in HCC tissues,were validated as the direct target of miR-138 and miR-199a-5p,respectively.CONCLUSION:Our data suggest an importance of miR-138 and miR-199a-5p as well as their targets CCND3 and CHC in HCC tumorigenesis,and may provide more evidence for reliability of integrative bioinformatics analysis.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Correlation between circulating myeloid-derived suppressor cells and Th17 cells in esophageal cancer

    Zhi-Jun JiaoJing-Jing GaoSheng-Hao HuaDe-Yu Chen...
    5454-5461页
    查看更多>>摘要：AIM:To perform a comprehensive investigation into the potential correlation between circulating myeloidderived suppressor cells (MDSCs) and Th17 cells in esophageal cancer (ECA).METHODS:A total of 31 patients newly diagnosed with ECA and 26 healthy subjects were included in the current study.The frequencies of MDSCs and Th17 cells in peripheral blood were determined by flow cytometry.The mRNA expression of cytokines,arginase 1 (Arg1)and inducible NO synthase (iNOS) in peripheral blood mononuclear cells (PBMCs) and plasma Arg1 were assessed by real-time polymerase chain reaction and enzyme-linked immunosorbent assay,respectively.RESULTS:There was an increased prevalence of MDSCs in the peripheral blood from ECA patients (15.21％± 2.25％) when compared with healthy control (HC)(1.10％ ± 0.12％,P ＜ 0.0001).The plasma levels of Arg1 in ECA patients were significantly higher than those in HC (28.28 ± 4.10 ng/mL vs 9.57 ± 1.51 ng/mL,P =0.0003).iNOS mRNA levels in the peripheral blood of ECA patients also showed a threefold increase compared with HC (P =0.0162).The frequencies of Th17 cells (CD4+IL-17A+) were significantly elevated in ECA patients versus HC (3.50％ ± 0.33％ vs 1.82％ ±0.19％,P =0.0001).Increased mRNA expression of IL-17 and ROR-γt was also observed in ECA patients compared with HC (P =0.0041 and P =0.0004,respectively),while the mRNA expression of IL-6 and tumor necrosis factor-α (TNF-α) showed significant decreases (P =0.0049 and P ＜ 0.0001,respectively).No obvious correlations were found between the frequencies of MDSCs and Th17 cells in the peripheral blood from ECA patients(r =-0.1725,P =0.3534).Arg1 mRNA levels were positively correlated with levels of IL-6 (r =0.6404,P =0.0031) and TNF-α (r =0.7646,P =0.0001).Similarly,iNOS mRNA levels were also positively correlated with levels of IL-6 (r =0.6782,P =0.0007) and TNF-α (r =0.7633,P ＜ 0.0001).CONCLUSION:This study reveals the relationship between circulating MDSCs and Th17 cells,which may lead to new immunotherapy approaches for ECA based on the associated metabolites and cytokines.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Effect of the ginsenoside Rb1 on the spontaneous contraction of intestinal smooth muscle in mice

    Lei XuSui-Ping Huang
    5462-5469页
    查看更多>>摘要：AIM:To investigate the effect and the possible mechanism of ginsenoside Rb1 on small intestinal smooth muscle motility in mice.METHODS:Intestinal smooth muscle strips were isolated from male ICR mice (5 wk old),and the effect of ginsenoside Rb1 on spontaneous contraction was recorded with an electrophysiolograph.The effect of ginsenoside Rb1 on ion channel currents,including the voltage-gated K+ channel current (IKv),calcium-activated potassium channel currents (IKCa),spontaneous transient outward currents and ATP-sensitive potassium channel current (IKATP),was recorded on freshly isolated single cells using the whole-cell patch clamp technique.RESULTS:Ginsenoside Rb1 dose-dependently inhibited the spontaneous contraction of intestinal smooth muscle by 21.15％ ± 3.31％,42.03％ ± 8.23％ and 67.23％ ± 5.63％ at concentrations of 25 μmol/L,50μmol/L and 100 μmol/L,respectively (n =5,P ＜ 0.05).The inhibitory effect of ginsenoside Rb1 on spontaneous contraction was significantly but incompletely blocked by 10 mmol/L tetraethylammonium or 0.5mmol/L 4-aminopyridine,respectively (n =5,P ＜ 0.05).However,the inhibitory effect of ginsenoside Rb1 on spontaneous contraction was not affected by 10 μmol/Lglibenclamide or 0.4 μmol/L tetrodotoxin.At the cell level,ginsenoside Rb1 increased outward potassium currents,and Ikv was enhanced from 1137.71 ± 171.62pA to 1449.73 ± 162.39 pA by 50 μmol/L Rb1 at +60mV (n =6,P ＜ 0.05).Ginsenoside Rb1 increased IKCa and enhanced the amplitudes of spontaneous transient outward currents from 582.77 ± 179.09 mV to 788.12± 278.34 mV (n =5,P ＜ 0.05).However,ginsenoside Rb1 (50 μmol/L) had no significant effect on IKATP (n =3,P ＜ 0.05).CONCLUSION:These results suggest that ginsenoside Rb1 has an inhibitory effect on the spontaneous contraction of mouse intestinal smooth muscle mediated by the activation of Ikv and IKCa,but the KATP channel was not involved in this effect.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach

    Hong-Mei WangChang-Ming HuangChao-Hui ZhengPing Li...
    5470-5475页
    查看更多>>摘要：AIM:To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach.METHODS:We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004.Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size,which was measured as maximum tumor diameter.Based on this cutoff value,patients were divided into two groups:those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs).The correlations between other clinicopathologic factors and tumor size were investigated,and the 5-year overall survival (OS)rate was compared between the two groups.Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's proportional hazard model analysis.The 5-year OS rates in the two groups were compared according to pT stage and pN stage.RESULTS:The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7％.The mean ± SD tumor size was 4.9 ±1.9 cm,and the median tumor size was 5.0 cm.ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8cm were 80.0％ and 68.2％,respectively (AUC =0.795,95％CI:0.751-0.839,P =0.000).Using this cutoff value,222 patients (51.6％) had LSTs (tumor size ≥ 4.8cm) and 208 (48.4％) had SSTs (tumor size ＜ 4.8 cm).Tumor size was significantly correlated with histological type (P =0.039),Borrmann type (P =0.000),depth of tumor invasion (P =0.000),lymph node metastasis (P=0.000),tumor-nodes metastasis stage (P =0.000),mean number of metastatic lymph nodes (P =0.000)and metastatic lymph node ratio (P =0.000).Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1％ vs 63.3％,P =0.000).Univariate analysis showed that depth of tumor invasion (x2 =69.581,P =0.000),lymph node metastasis (x2=138.815,P =0.000),tumor size (x2 =78.184,P =0.000) and metastatic lymph node ratio (x2 =139.034,P =0.000) were significantly associated with 5-year OS rate.Multivariate analysis revealed that depth of tumor invasion (P =0.000),lymph node metastasis (P =0.019) and tumor size (P =0.000) were independent prognostic factors.Gastric cancers were divided into 12 subgroups:pT2N0; pT2N1; pT2N2; pT2N3; pT3N0;pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2;and pT4aN3.In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors,5-year OS rates were significantly lower for LSTs than for SSTs (P ＜0.05 each),but there were no significant differences in the 5-year OS rates in LST and SST patients with pT2-3N0-2 stage tumors (P ＞ 0.05).CONCLUSION:Using a tumor size cutoff value of 4.8cm,tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普