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世界胃肠病学杂志（英文版）
世界胃肠病学杂志（英文版）

潘伯荣

周刊

1007-9327

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世界胃肠病学杂志（英文版）/Journal World Journal of GastroenterologyCSCDCSTPCDSCI
查看更多>>主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。
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    Antimicrobial management of intra-abdominal infections:Literature's guidelines

    Massimo SartelliFausto CatenaFederico CoccoliniAntonio Daniele Pinna...
    865-871页
    查看更多>>摘要：Antimicrobial management of severe intra-abdominal infections (IAIs) involves a delicate balance of optimizing empirical therapy,which has been shown to improve clinical outcomes,while simultaneously reducing unnecessary antimicrobial use.Two sets of guidelines for the management of intra-abdominal infections were recently published.In 2010,the Surgical Infection Society and the Infectious Diseases Society of America (SIS-IDSA)created guidelines for the diagnosis and management of complicated IAIs.The new SIS-IDSA guidelines replace those previously published in 2002 and 2003.The World Society of Emergency Surgery (WSES) guidelines represent additional contributions,made by specialists worldwide,to the debate regarding proper antimicrobial drug methodology.These guidelines represent the conclusions of the consensus conference held in Bologna,Italy,in July 2010 during the first congress of the WSES.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Evaluation of inflammatory activity in Crohn's disease and ulcerative colitis

    Eduardo Garcia VilelaHenrique Osvaldo da Gama TorresFabiana Paiva MartinsMaria de Lourdes de Abreu Ferrari...
    872-881页
    查看更多>>摘要：Crohn's disease and ulcerative colitis evolve with a relapsing and remitting course.Determination of infiammatory state is crucial for the assessment of disease activity and for tailoring therapy.However,no simple diagnostic test for monitoring intestinal inflammation is available.Noninvasive markers give only indirect assessments of disease activity.Histopathological or endoscopical examinations accurately assess inflammatoryactivity,but they are invasive,time consuming and expensive and therefore are unsuitable for routine use.Imaging procedures are not applicable for ulcerative colitis.The usefulness of ultrasound and Doppler imaging in assessing disease activity is still a matter of discussion for Crohn's disease,and an increased interest in computed tomography enterograph (CTE) has been seen,mainly because it can delineate the extent and severity of bowel wall inflammation,besides detecting extraluminal findings.Until now,the available data concerning the accuracy of magnetic resonance enterography in detecting disease activity is less than CTE.Due to this,clinical activity indices are still commonly used for both diseases.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    DNA methylation and microRNAs in cancer

    Xiang-Quan LiYuan-Yuan GuoWei De
    882-888页
    查看更多>>摘要：DNA methylation is a type of epigenetic modification in the human genome,which means that gene expression is regulated without altering the DNA sequence.Methylation and the relationship between methylation and cancer have been the focus of molecular biology researches.Methylation represses gene expression and can influence embryogenesis and tumorigenesis.In different tissues and at different stages of life,the level of methylation of DNA varies,implying a fundamental but distinct role for methylation.When genes are repressed by abnormal methylation,the resulting effects can include instability of that gene and inactivation of a tumor suppressor gene.MicroRNAs have some aspects in common with this regulation of gene expression.Here we reviewed the influence of gene methylation on cancer and analyzed the methods used to profile methylation.We also assessed the correlation between methylation and other epigenetic modifications and microRNAs.About 55 845 research papers have been published about methylation,and one-fifth of these are about the appearance of methylation in cancer.We conclude that methylation does play a role in some cancer types.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Endoscopic ultrasound-guided elastography in the nodal staging of oesophageal cancer

    Stuart PatersonFraser DuthieAdrian J Stanley
    889-895页
    查看更多>>摘要：AIM:To assess quantitative endoscopic ultrasound (EUS)-guided elastography in the nodal staging of oesophagogastric cancers.METHODS:This was a single tertiary centre study assessing 50 patients with established oesophago-gastric cancer undergoing EUS-guided fine needle aspiration biopsy (FNAB) of lymph nodes between July 2007 and July 2009.EUS-guided elastography of lymph nodes was performed before EUS-FNAB.Standard EUS characteristics were also described.Cytological determination of whether a lymph node was malignant or benign was used as the gold standard for this study.Comparisons of elastography and standard EUS characteristics were made between the cytologically benign and malignant nodes.The main outcome measure was the accuracy of elastography in differentiating between benign and malignant lymph nodes in oesophageal cancers.RESULTS:EUS elastography and FNAB were performed on 53 lymph nodes.Cytological malignancy was found in 23 nodes,one was indeterminate,one was found to be a gastrointestinal stromal tumor and 25 of the nodes were negative for malignancy.On 3 occasions insufficient material was obtained for analysis.The area under the curve for the receiver operating characteristic curve for elastography strain ratio was 0.87 (P ＜ 0.0001).Elastography strain ratio had a sensitivity 83％,specificity 96％,positive predictive value 95％,and negative predictive value 86％ for distinguishing between malignant and benign nodes.The overall accuracy of elastography strain ratio was 90％.Elastography was more sensitive and specific in determining malignant nodal disease than standard EUS criteria.CONCLUSION:EUS elastography is a promising modality that may complement standard EUS and help guide EUS-FNAB during staging of upper gastrointestinal tract cancer.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Histotype-based prognostic classification of gastric cancer

    Anna Maria ChiaravalliCatherine KlersyAlessandro VanoliAndrea Ferretti...
    896-904页
    查看更多>>摘要：AIM:To test the efficiency of a recently proposed histotype-based grading system in a consecutive series of gastric cancers.METHOIS:Two hundred advanced gastric cancers operated upon in 1980-1987 and followed for a median 159 mo were investigated on hematoxylin-eosinstained sections to identify low-grade [muconodular,well differentiated tubular,diffuse desmoplastic and high lymphoid response (HLR)],high-grade (anaplastic and mucinous invasive) and intermediate-grade (ordinarycohesive,diffuse and mucinous) cancers,in parallel with a previously investigated series of 292 cases.In addition,immunohistochemical analyses for CD8,CD11 and HLA-DR antigens,pancytokeratin and podoplanin,as well as immunohistochemical and molecular tests for microsatellite DNA instability and in situ hybridization for the Epstein-Barr virus (EBV) EBER1 gene were performed.Patient survival was assessed with death rates per 100 person-years and with Kaplan-Meier or Cox model estimates.RESULTS:Collectively,the four low-grade histotypes accounted for 22％ and the two high-grade histotypes for 7％ of the consecutive cancers investigated,while the remaining 71％ of cases were intermediate-grade cancers,with highly significant,stage-independent,survival differences among the three tumor grades (P =0.004 for grade 1 vs 2 and P =0.0019 for grade 2 vs grade 3),thus confirming the results in the original series.A combined analysis of 492 cases showed an improved prognostic value of histotype-based grading compared with the Lauren classification.In addition,it allowed better characterization of rare histotypes,particularly the three subsets of prognostically different mucinous neoplasms,of which 10 ordinary mucinous cancers showed stage-inclusive survival worse than that of 20 muconodular (P =0.037) and better than that of 21 high-grade (P ＜ 0.001) cases.Tumors with high-level microsatellite DNA instability(MSI-H) or EBV infection,together with a third subset negative for both conditions,formed the T8 cell-rich HLR group,the largest group among low-grade histotypes.Coexisting HLR proved to be a factor in improved prognosis in tumors with microsatellite instability (P =0.0015 vs HLR-/MSI-H tumors) or DR type human leukocyte antigen expression (P =0.033 vs HLR-/HLA-DR+ tumors).CONCLUSION:Identification of low-and high-grade histotypes can improve the prognostic assessment of a substantial proportion of gastric cancers in routine diagnostic practice.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Low-dose steroid pretreatment ameliorates the transient impairment of liver regeneration

    Toshihito ShibataToru MizuguchiYukio NakamuraMasaki Kawamoto...
    905-914页
    查看更多>>摘要：AIM:To determine if liver regeneration (LR) could be disturbed following radiofrequency (RF) ablation and whether modification of LR by steroid administration occurs.METHOIDS:Sham operation,partial hepatectomy (PH),and partial hepatectomy with radiofrequency ablation (PHA) were performed on adult Fisher 344 rats.We investigated the recovery of liver volume,DNA synthetic activities,serum cytokine/chemokine levels and signal transducers and activators of transcription 3 DNA-binding activities in the nucleus after the operations.Additionally,the effects of steroid (dexamethasone) pretreatment in the PH group (S-PH) and the PHA group (S-PHA) were compared.RESULTS:The LR after PHA was impaired,with high serum cytokine/chemokine induction compared to PH,although the ratio of the residual liver weight to body weight was not significantly different.Steroid pretreatment disturbed LR in the S-PH group.On the other hand,low-dose steroid pretreatment improved LR and suppressed tumor necrosis factor (TNF)-α elevation in the S-PHA group,with recovery of STAT3 DNA-binding activity.On the other hand,low-dose steroid pretreatment improved LR and suppressed TNF-α elevation in the S-PHA group,with recovery of STAT3 DNA-binding activity.CONCLUSION:LR is disturbed after RF ablation,with high serum cytokine/chemokine induction.Low-dose steroid administration can improve LR after RF ablation with TNF-α suppression.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    S100A4 silencing blocks invasive ability of esophageal squamous cell carcinoma cells

    Dong ChenXue-Feng ZhengZe-You YangDong-Xiao Liu...
    915-922页
    查看更多>>摘要：AIM:To investigate a potential role of S100A4 in esophagus squamous cell carcinoma metastasis (ESCCs).METHODS:Expression of S100A4 and E-cadherin were analyzed in frozen sections from ESCCs (metastasis,n =28; non-metastasis,n =20) by reverse transcription-polymerase chain reaction,quantitative polymerase chain reaction and immunohistochemistry.To explore the influence of S100A4 on esophageal cancer invasion and metastasis,S100A4 was overexpressed or silenced by S100A4 siRNA in TE-13 or Eca-109 cells in vitro and in vivo.RESULTS:We found the mRNA and protein levels of S100A4 expression in ESCCs was significantly upregulated,and more importantly,that expression of S100A4 and E cadherin are strongly negatively correlated in patients who had metastasis.It was indicated that overexpression of S100A4 in TE-13 and Eca-109 cells downregulates the expression of E-cadherin,leading to increased cell migration in vitro,whereas knockdown of S100A4 inhibited cell migration and upregulation of E-cadherin expression.Moreover,the loss of cell metastatic potential was rescued by overexpression of E-cadherin completely.In addition,nude mice inoculated with S100A4 siRNA-transfected cells exhibited a significantly decreased invasion ability in vivo.CONCLUSION:S100A4 may be involved in ESCC progression by regulate E-cadherin expression,vectorbased RNA interference targeting S100A4 is a potential therapeutic method for human ESCC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids

    Lotta K StenmanReetta HolmaRiitta Korpela
    923-929页
    查看更多>>摘要：AIM:To investigate whether high-fat-feeding is associated with increased intestinal permeability via alterations in bile acid metabolism.METHODS:Male C57B1/6J mice were fed on a high-fat (n =26) or low-fat diet (n =24) for 15 wk.Intestinal permeability was measured from duodenum,jejunum,ileum and colon in an Ussing chamber system using 4 kDa FITC-labeled dextran as an indicator.Fecal bile acids were analyzed with gas chromatography.Segments of jejunum and colon were analyzed for the expression of farnesoid X receptor (FXR) and tumor necrosis factor (TNF).RESULTS:Intestinal permeability was significantly increased by high-fat feeding in jejunum (median 0.334 for control vs 0.393 for high-fat,P =0.03) and colon (0.335 for control vs 0.433 for high-fat,P =0.01),but not in duodenum or ileum.The concentration of nearly all identified bile acids was significantly increased by high-fat feeding (P ＜ 0.001).The proportion of ursodeoxycholic acid (UDCA) in all bile acids was decreased (1.4％ ± 0.1％ in high-fat vs 2.8％ ± 0.3％ in controls,P ＜ 0.01) and correlated inversely with intestinal permeability (r =-0.72,P =0.01).High-fat feeding also increased jejunal FXR expression,as well as TNF expression along the intestine,especially in the colon.CONCLUSION:High-fat-feeding increased intestinal permeability,perhaps by a mechanism related to bile acid metabolism,namely a decreased proportion of fecal UDCA and increased FXR expression.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control

    Stefano Ginanni CorradiniFlaminia FerriMichela MordentiLuigi Iuliano...
    930-937页
    查看更多>>摘要：AIM:To investigate the effect of drinking sulphate-bicarbonate-calcium thermal water (TW) on risk factors for atherosclerosis and cholesterol gallstone disease.METHODS:Postmenopausal women with functional dyspepsia and/or constipation underwent a 12 d cycle of thermal (n =20) or tap (n =20) water controlled drinking.Gallbladder fasting volume at ultrasound,blood vitamin E,oxysterols (7-β-hydroxycholesterol.and 7-ketocholesterol),bile acid (BA),triglycerides,total/low density lipoprotein and high density lipoprotein cholesterol were measured at baseline and at the end of the study.Food consumption,stool frequency and body weight were recorded daily.RESULTS:Blood lipids,oxysterols and vitamin E were not affected by either thermal or tap water consumption.Fasting gallbladder volume was significantly (P ＜0.005) smaller at the end of the study than at baseline in the TW (15.7 ± 1.1 mL vs 20.1 ± 1.7 mL) but not in the tap water group (19.0 ± 1.4 mL vs 19.4 ± 1.5 mL).Total serum BA concentration was significantly (P ＜0.05) higher at the end of the study than at baseline in the TW (5.83-1.24 μmol vs 4.25 ± 1.00 μmol) but not in the tap water group (3.41 ± 0.46 μmol vs 2.91 ± 0.56 μmol).The increased BA concentration after TW consumption was mainly accounted for by glycochenodeoxycholic acid.The number of pasta (P ＜ 0.001),meat (P ＜ 0.001) and vegetable (P ＜ 0.005) portions consumed during the study and of bowel movements per day (P ＜ 0.05) were significantly higher in the TW than in the tap water group.Body weight did not change at the end of the study as compared to baseline in both groups.CONCLUSION:Sulphate-bicarbonate-calcium water consumption has a positive effect on lithogenic risk and intestinal transit and allows maintenance of a stable body weight despite a high food intake.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Duodenal stenting for malignant gastric outlet obstruction:Prospective study

    Eduardo Guimar(a)es Hourneaux MouraFlávio Coelho FerreiraSpencer ChengDiogo Turiani Hourneaux Moura...
    938-943页
    查看更多>>摘要：AIM:To evaluate the results of duodenal stenting for palliation of gastroduodenal malignant obstruction by using a gastric outlet obstruction score (GOOS).METHODS:A prospective,non-randomized study was performed at a tertiary center between August 2005 and April 2010.Patients were eligible if they had malignant gastric outlet obstruction (GOO) and were not candidates for surgical treatment.Medical history and patient demographics were collected at baseline.Scheduled interviews were made on the day of the procedure and 15,30,90 and 180 d later or unscheduled as necessary.RESULTS:Fifteen patients (6 male,9 female; median age 61 years) with GOO who had undergone duodenal stenting were evaluated.Ten patients had metastasis at baseline (66.6％) and 14 were unable to accept oral intake (93.33％),including 7 patients who were using a feeding tube.Laboratory data showed biliary obstruction in eight cases (53.33％); all were submitted to biliary drainage.Two patients developed obstructive symptoms due to tumor ingrowth after 30 d and another due to tumor overgrowth after 180 d.Two cases of stent migration occurred.A good response to treatment was observed,with a mean time of approximately 1 d (19 h) until toleration of a liquid diet and slightly more than 2 d for both soft solids (51 h) and a solid food/normal diet (55 h).The mean time to first failure to maintain liquid intake (GOOS ≥ 1) was 93 d.During follow-up,the mean time to first failure to maintain the previously achieved GOOS of 2-3 (solid/semi-solid food),considered technical failure,was 71 d.On the basis of oral intake a GOOS is defined:0 for no oral intake; 1 for liquids only; 2 for soft solids only; 3 for lowresidue or full diet.CONCLUSION:Enteral stenting to alleviate gastroduodenal malignant obstruction improves quality of life in patients with limited life expectancy,which can be evaluated by using a GOO scoring system.
      原文链接:
    • NETL
    • NSTL
    • 万方数据