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遗传学报
遗传学报

薛勇彪

月刊

1673-8527

jgg@genetics.ac.cn

010-64889354

100101

北京市朝阳区北辰西路1号院2号,遗传与发育生物学研究所

遗传学报/Journal Journal of Genetics and GenomicsCSCD北大核心CSTPCDSCI
查看更多>>本刊是中国遗传学会和中国科学院遗传与发育生物学研究所主办、科学出版社出版的高级学术刊物，全国优秀期刊、中国自然科学核心期刊、中国期刊方阵双百期刊，最近入围国家期刊奖重点期刊行列。已被美国化学文摘（CA）、生物学文摘（BA）和医学索引（MED）等国内外30余种重要检索系统和数据库收录。
正式出版
收录年代

    Journal of Genetics and Genomics in 2023:progresses and beyond

    Xiu-Fen SongXiaoxuan GuoJing ZhaoYutian Zhang...
    1-2页
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    The evolving views of hematopoiesis:from embryo to adulthood and from in vivo to in vitro

    Yifan ZhangFeng Liu
    3-15页
    查看更多>>摘要：The hematopoietic system composed of hematopoietic stem and progenitor cells(HSPCs)and their differentiated lineages serves as an ideal model to uncover generic principles of cell fate transitions.From gastrulation onwards,there successively emerge primitive hematopoiesis(that produces specialized he-matopoietic cells),pro-definitive hematopoiesis(that produces lineage-restricted progenitor cells),and definitive hematopoiesis(that produces multipotent HSPCs).These nascent lineages develop in several transient hematopoietic sites and finally colonize into lifelong hematopoietic sites.The development and maintenance of hematopoietic lineages are orchestrated by cell-intrinsic gene regulatory networks and cell-extrinsic microenvironmental cues.Owing to the progressive methodology(e.g.,high-throughput lineage tracing and single-cell functional and omics analyses),our understanding of the developmental origin of hematopoietic lineages and functional properties of certain hematopoietic organs has been updated;meanwhile,new paradigms to characterize rare cell types,cell heterogeneity and its causes,and comprehensive regulatory landscapes have been provided.Here,we review the evolving views of HSPC biology during developmental and postnatal hematopoiesis.Moreover,we discuss recent advances in the in vitro induction and expansion of HSPCs,with a focus on the implications for clinical applications.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Insights into plant salt stress signaling and tolerance

    Huapeng ZhouHaifan ShiYongqing YangXixian Feng...
    16-34页
    查看更多>>摘要：Soil salinization is an essential environmental stressor,threatening agricultural yield and ecological security worldwide.Saline soils accumulate excessive soluble salts which are detrimental to most plants by limiting plant growth and productivity.It is of great necessity for plants to efficiently deal with the adverse effects caused by salt stress for survival and successful reproduction.Multiple determinants of salt tolerance have been identified in plants,and the cellular and physiological mechanisms of plant salt response and adaption have been intensely characterized.Plants respond to salt stress signals and rapidly initiate signaling pathways to re-establish cellular homeostasis with adjusted growth and cellular metabolism.This review summarizes the advances in salt stress perception,signaling,and response in plants.A better under-standing of plant salt resistance will contribute to improving crop performance under saline conditions using multiple engineering approaches.The rhizosphere microbiome-mediated plant salt tolerance as well as chemical priming for enhanced plant salt resistance are also discussed in this review.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Reconstructing cell lineage trees with genomic barcoding:approaches and applications

    Zizhang LiWenjing YangPeng WuYuyan Shan...
    35-47页
    查看更多>>摘要：In multicellular organisms,developmental history of cell divisions and functional annotation of terminal cells can be organized into a cell lineage tree(CLT).The reconstruction of the CLT has long been a major goal in developmental biology and other related fields.Recent technological advancements,especially those in editable genomic barcodes and single-cell high-throughput sequencing,have sparked a new wave of experimental methods for reconstructing CLTs.Here we review the existing experimental approaches to the reconstruction of CLT,which are broadly categorized as either image-based or DNA barcode-based methods.In addition,we present a summary of the related literature based on the biological insight pro-vided by the obtained CLTs.Moreover,we discuss the challenges that will arise as more and better CLT data become available in the near future.Genomic barcoding-based CLT reconstructions and analyses,due to their wide applicability and high scalability,offer the potential for novel biological discoveries,especially those related to general and systemic properties of the developmental process.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    LSM14B coordinates protein component expression in the P-body and controls oocyte maturation

    Huiru ZhangTao ZhangXiang WanChang Chen...
    48-60页
    查看更多>>摘要：The generation of mature and healthy oocytes is the most critical event in the entire female reproductive process,and the mechanisms regulating this process remain to be studied.Here,we demonstrate that Smith-like(LSM)family member 14B(LSM14B)regulates oocyte maturation,and the loss of LSM14B in mouse ovaries leads to abnormal oocyte Mil arrest and female infertility.Next,we find the aberrant tran-scriptional activation,indicated by abnormal non-surrounded nucleolus and surrounded nucleolus oocyte proportions,and abnormal chromosome assembly and segregation in Lsm14b-deficient mouse oocytes.The global transcriptome analysis suggests that many transcripts involved in cytoplasmic processing body(P-body)function are altered in Lsm14b-deficient mouse oocytes.Deletion of Lsm14b results in the expression and/or localization changes of P-body components(such as LSM14A,DCP1A,and 4E-T).Notably,DDX6,a key component of the P-body,is downregulated and accumulates in the nuclei in Lsm14b-deficient mouse oocytes.Taken together,our data suggest that LSM14B links mouse oocyte maturation to female fertility through the regulation of the P-body.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Thyroid-stimulating hormone-thyroid hormone signaling contributes to circadian regulation through repressing clock2/npas2 in zebrafish

    Cheng JiYue OuWangjianfei YuJiaxin Lv...
    61-74页
    查看更多>>摘要：Thyroid-stimulating hormone(TSH)is important for the thyroid gland,development,growth,and meta-bolism.Defects in TSH production or the thyrotrope cells within the pituitary gland cause congenital hy-pothyroidism(CH),resulting in growth retardation and neurocognitive impairment.While human TSH is known to display rhythmicity,the molecular mechanisms underlying the circadian regulation of TSH and the effects of TSH-thyroid hormone(TH)signaling on the circadian clock remain elusive.Here we show that TSH,thyroxine(T4),triiodothyronine(T3),and tshba display rhythmicity in both larval and adult zebrafish and tshba is regulated directly by the circadian clock via both E'-box and D-box.Zebrafish tshba-/-mutants manifest congenital hypothyroidism,with the characteristics of low levels of T4 and T3 and growth retar-dation.Loss or overexpression of tshba alters the rhythmicity of locomotor activities and expression of core circadian clock genes and hypothalamic-pituitary-thyroid(HPT)axis-related genes.Furthermore,TSH-TH signaling regulates clock2/npas2 via the thyroid response element(TRE)in its promoter,and tran-scriptome analysis reveals extensive functions of Tshba in zebrafish.Together,our results demonstrate that zebrafish tshba is a direct target of the circadian clock and in tum plays critical roles in circadian regulation along with other functions.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus

    Boxun ZhangXuan ZhangZhen LuoJixiang Ren...
    75-86页
    查看更多>>摘要：Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are lacking.Here,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to DM.Analysis of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT groups.In addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacte-rium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Mega-spaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Ancient mitochondrial genome depicts sheep maternal dispersal and migration in Eastern Asia

    Liu YangXing ZhangYaning HuPiao Zhu...
    87-95页
    查看更多>>摘要：Sheep have been one of the most important groups of animals since ancient times.However,the knowl-edge of their migration routes and genetic relationships is still poorly understood.To investigate sheep matemal migration histories alongside Eurasian communications routes,in this study,we obtain mito-chondrial genomes(mitogenomes)from 17 sheep remains in 6 Chinese sites and 1 Uzbekistan site dated 4429-3100 years before present(BP).By obtaining the mitogenomes from the sheep(4429-3556 BP)found in the Tongtian Cave site in Xinjiang,Altai region of northwest China,our results support the emer-gence of haplogroup C sheep in Xinjiang as early as 4429-3556 BP.The combined phylogenetic analyses with extant ancient and modem sheep mitogenomes suggest that the Uzbekistan-Altai region may have been a migration hub for early sheep in eastern Asia.At least two migration events have taken place for sheep crossing Eurasia to China,one passing by Uzbekistan and Northwest China to the middle and lower reaches of the Yellow River at approximately 4000 BP and another following the Altai region to middle Inner Mongolia from 4429 BP to 2500 BP.Overall,this study provides further evidence for early sheep utilization and migration patterns in Eastern Asia.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    The nodule-specific transcriptional repressor Top Hub 4 regulates nodule structure and nitrogen fixation capacity in soybean

    Kui GeQi LvShengcai ChenZhenhao Guo...
    96-99页
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Multi-omics analyses of G6PD deficiency variants in Chinese population

    He JiJiahuan ChenPeide HuangZhimin Feng...
    100-104页
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普