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遗传学报
遗传学报

薛勇彪

月刊

1673-8527

jgg@genetics.ac.cn

010-64889354

100101

北京市朝阳区北辰西路1号院2号,遗传与发育生物学研究所

遗传学报/Journal Journal of Genetics and GenomicsCSCD北大核心CSTPCDSCI
查看更多>>本刊是中国遗传学会和中国科学院遗传与发育生物学研究所主办、科学出版社出版的高级学术刊物，全国优秀期刊、中国自然科学核心期刊、中国期刊方阵双百期刊，最近入围国家期刊奖重点期刊行列。已被美国化学文摘（CA）、生物学文摘（BA）和医学索引（MED）等国内外30余种重要检索系统和数据库收录。
正式出版
收录年代

    Grow rice under sunshine of Xizang/Tibet:promise and challenges

    Chunkun FanXiaoming ZhengQingbo YuanTao Wang...
    265-267页
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Emerging roles and therapeutic potentials of sphingolipids in pathophysiology:emphasis on fatty acyl heterogeneity

    Jinming MuSin Man LamGuanghou Shui
    268-278页
    查看更多>>摘要：Sphingolipids not only exert structural roles in cellular membranes,but also act as signaling molecules in various physiological and pathological processes.A myriad of studies have shown that abnormal levels of sphingolipids and their metabolic enzymes are associated with a variety of human diseases.Moreover,blood sphingolipids can also be used as biomarkers for disease diagnosis.This review summarizes the biosynthesis,metabolism,and pathological roles of sphingolipids,with emphasis on the biosynthesis of ceramide,the precursor for the biosynthesis of complex sphingolipids with different fatty acyl chains.The possibility of using sphingolipids for disease prediction,diagnosis,and treatment is also discussed.Tar-geting endogenous ceramides and complex sphingolipids along with their specific fatty acyl chain to promote future drug development will also be discussed.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Protein post-translational modifications in auxin signaling

    Xiankui CuiJunxia WangKe LiBingsheng Lv...
    279-291页
    查看更多>>摘要：Protein post-translational modifications(PTMs),such as ubiquitination,phosphorylation,and small ubiq-uitin-like modifier(SUMO)ylation,are crucial for regulating protein stability,activity,subcellular localization,and binding with cofactors.Such modifications remarkably increase the variety and complexity of pro-teomes,which are essential for regulating numerous cellular and physiological processes.The regulation of auxin signaling is finely tuned in time and space to guide various plant growth and development.Accu-mulating evidence indicates that PTMs play critical roles in auxin signaling regulations.Thus,a thorough and systematic review of the functions of PTMs in auxin signal transduction will improve our profound comprehension of the regulation mechanism of auxin signaling and auxin-mediated various processes.This review discusses the progress of protein ubiquitination,phosphorylation,histone acetylation and methyl-ation,SUMOylation,and S-nitrosylation in the regulation of auxin signaling.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Potential and progress of studying mountain biodiversity by means of butterfly genetics and genomics

    Shuting WangMarco GirardelloWei Zhang
    292-301页
    查看更多>>摘要：Mountains are rich in biodiversity,and butterflies are species-rich and have a good ecological and evolutionary research foundation.This review addresses the potential and progress of studying mountain biodiversity using butterflies as a model.We discuss the uniqueness of mountain ecosystems,factors influencing the distribution of mountain butterflies,representative genetic and evolutionary models in butterfly research,and evolutionary studies of mountain biodiversity involving butterfly genetics and ge-nomics.Finally,we demonstrate the necessity of studying mountain butterflies and propose future per-spectives.This review provides insights for studying the biodiversity of mountain butterflies as well as a summary of research methods for reference.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    The genome-wide meiotic recombination landscape in ciliates and its implications for crossover regulation and genome evolution

    Lu FuChen GuKazufumi MochizukiJie Xiong...
    302-312页
    查看更多>>摘要：Meiotic recombination is essential for sexual reproduction and its regulation has been extensively studied in many taxa.However,genome-wide recombination landscape has not been reported in ciliates and it re-mains unknown how it is affected by the unique features of ciliates:the synaptonemal complex(SC)-in-dependent meiosis and the nuclear dimorphism.Here,we show the recombination landscape in the model ciliate Tetrahymena thermophila by analyzing single-nucleotide polymorphism datasets from 38 hybrid progeny.We detect 1021 crossover(CO)events(35.8 per meiosis),corresponding to an overall CO rate of 9.9 cM/Mb.However,gene conversion by non-crossover is rare(1.03 per meiosis)and not biased towards G or C alleles.Consistent with the reported roles of SC in CO interference,we find no obvious sign of CO interference.CO tends to occur within germ-soma common genomic regions and many of the 44 identified CO hotspots localize at the centromeric or subtelomeric regions.Gene ontology analyses show that CO hotspots are strongly associated with genes responding to environmental changes.We discuss these re-sults with respect to how nuclear dimorphism has potentially driven the formation of the observed recombination landscape to facilitate environmental adaptation and the sharing of machinery among meiotic and somatic recombination.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    HvMPK4 phosphorylates HvWRKY1 to enhance its suppression of barley immunity to powdery mildew fungus

    Pengya XueLing ZhangRenchun FanYanan Li...
    313-325页
    查看更多>>摘要：Mitogen-activated protein kinase(MAPK)cascades play important roles in disease resistance in model plant species.However,the functions of MAPK signaling pathways in crop disease resistance are largely unknown.Here we report the function of HvMKK1-HvMPK4-HvWRKY1 module in barley immune system.HvMPK4 is identified to play a negative role in barley immune response against Bgh,as virus-induced gene silencing of HvMPK4 results in enhanced disease resistance whilst stably overexpressing HvMPK4 leads to super-susceptibility to Bgh infection.Furthermore,the barley MAPK kinase HvMKK1 is found to specifically interact with HvMPK4,and the activated HvMKK1DD variant specifically phosphorylates HvMPK4 in vitro.Moreover,the transcription factor HvWRKY1 is identified to be a downstream target of HvMPK4 and phosphorylated by HvMPK4 in vitro in the presence of HvMKK1DD.Phosphorylation assay coupled with mutagenesis analyses identifies S122,T284,and S347 in HvWRKY1 as the major residues phosphorylated by HvMPK4.HvWRKY1 is phosphorylated in barley at the early stages of Bgh infection,which enhances its suppression on barley immunity likely due to enhanced DNA-binding and transcriptional repression activity.Our data suggest that the HvMKK1-HvMPK4 kinase pair acts upstream of HvWRKY1 to negatively regulate barley immunity against powdery mildew.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Genetic and lipidomic analyses reveal the key role of lipid metabolism for cold tolerance in maize

    Lei GaoHaifang JiangMinze LiDanfeng Wang...
    326-337页
    查看更多>>摘要：Lipid remodeling is crucial for cold tolerance in plants.However,the precise alternations of lipidomics during cold responses remain elusive,especially in maize(Zea mays L.).In addition,the key genes responsible for cold tolerance in maize lipid metabolism have not been identified.Here,we integrate lip-idomic,transcriptomic,and genetic analysis to determine the profile of lipid remodeling caused by cold stress.We find that the homeostasis of cellular lipid metabolism is essential for maintaining cold tolerance of maize.Also,we detect 210 lipid species belonging to 13 major classes,covering phospholipids,glyc-erides,glycolipids,and free fatty acids.Various lipid metabolites undergo specific and selective alterations in response to cold stress,especially mono-/di-unsaturated lysophosphatidic acid,lysophosphatidylcho-line,phosphatidylcholine,and phosphatidylinositol,as well as polyunsaturated phosphatidic acid,monogalactosyldiacylglycerol,diacylglycerol,and triacylglycerol.In addition,we identify a subset of key enzymes,including ketoacyl-acyl-carrier protein synthase Ⅱ(KAS Ⅱ),acyl-carrier protein 2(ACP2),male sterility33(Ms33),and stearoyl-acyl-carrier protein desaturase 2(SAD2)involved in glycerolipid biosynthetic pathways are positive regulators of maize cold tolerance.These results reveal a comprehensive lipidomic profile during the cold response of maize and provide genetic resources for enhancing cold tolerance in crops.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Sex-biased single-cell genetic landscape in mice with autism spectrum disorder

    Qian ZhangYongjie WangJie TaoRuixue Xia...
    338-351页
    查看更多>>摘要：Autistic spectrum disorder(ASD)is a male-biased,heterogeneous neurodevelopmental disorder that af-fects approximately 1%-2%of the population.Prenatal exposure to valproic acid(VPA)is a recognized risk factor for ASD,but the cellular and molecular basis of VPA-induced ASD at the single-cell resolution is unclear.Here,we aim to compare the cellular and molecular differences in the hippocampus between male and female prenatal mice with ASD at the single-cell transcriptomic level.The transcriptomes of more than 45,000 cells are assigned to 12 major cell types,including neurons,glial cells,vascular cells,and immune cells.Cell type-specific genes with altered expression after prenatal VPA exposure are analyzed,and the largest number of differentially expressed genes(DEGs)are found in neurons,choroid plexus epithelial cells,and microglia.In microglia,several pathways related to inflammation are found in both males and females,including the tumor necrosis factor(TNF),nuclear factor kappa B(NF-KB),toll-like receptor(TLR),and mitogen-activated protein kinase(MAPK)signaling pathways,which are important for the induction of autistic-like behavior.Additionally,we note that several X-linked genes,including Bex1,Bex3,and Gria3,were among the male-specific DEGs of neurons.This pioneering study describes the landscape of the transcriptome in the hippocampus of autistic mice.The elucidation of sexual differences could provide innovative strategies for the prevention and treatment of ASD.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    ORPA:a fast and efficient phylogenetic analysis method for constructing genome-wide alignments of organelle genomes

    Guiqi BiXinxin LuanJianbin Yan
    352-358页
    查看更多>>摘要：Creating a multi-gene alignment matrix for phylogenetic analysis using organelle genomes involves aligning single-gene datasets manually,a process that can be time-consuming and prone to errors.The HomBlocks pipeline has been created to eliminate the inaccuracies arising from manual operations.The processing of a large number of sequences,however,remains a time-consuming task.To conquer this challenge,we develop a speedy and efficient method called Organelle Genomes for Phylogenetic Analysis(ORPA).ORPA can quickly generate multiple sequence alignments for whole-genome comparisons by parsing the result files of NCBI BLAST,completing the task just in 1 min.With increasing data volume,the efficiency of ORPA is even more pronounced,over 300 times faster than HomBlocks in aligning 60 high-plant chloroplast genomes.The phylogenetic tree outputs from ORPA are equivalent to HomBlocks,indicating its outstanding efficiency.Due to its speed and accuracy,ORPA can identify species-level evolutionary conflicts,providing valuable insights into evolutionary cognition.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish

    Ao ZhangJingao LuShachuan FengHuapeng Yu...
    359-362页
      原文链接:
    • NETL
    • NSTL
    • 万方数据