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药物分析学报（英文）
西安交通大学
药物分析学报（英文）

西安交通大学

双月刊

2095-1779

jpa2011@126.com

029-82655433

710061

西安市雁塔西路76号

药物分析学报（英文）/Journal Journal of Pharmaceutical AnalysisCSCD北大核心SCI
查看更多>>《药物分析学报（英文）》（Journal of Pharmaceutical Analysis，简称JPA），2011年创刊，双月刊，为大16开本，系教育部主管、西安交通大学主办的药物分析专业英文期刊。JPA以搭建高水平的国际学术交流平台、创办具有国际影响力的高水平的专业学术期刊为办刊宗旨。主要报道药物分析新方法、新技术，药品质量控制和用药安全等最新研究成果。创刊之初与Elsevier国际出版集团合作，已组建国际化编委会，采用EVISE投稿审稿系统，开放获取，通过ScienceDirect平台在线向全球读者开放阅读，实现稿源国际化、同行评议国际化、出版国际化和读者国际化。
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    IR-EcoSpectra:Exploring sustainable ex situ and in situ FTIR applications for green chemical and pharmaceutical analysis

    Alina CherniienkoRoman LesykLucjusz ZaprutkoAnna Pawełczyk...
    1255-1266页
    查看更多>>摘要：In various industries,particularly in the chemical and pharmaceutical fields,Fourier transform infrared spectroscopy(FTIR)spectroscopy provides a unique capacity to detect and characterise complex chemicals while minimising environmental damage by minimal waste generation and reducing the need for extensive sample preparation or use of harmful reagents.This review showcases the versatility of ex situ and in situ FTIR applications for substance identification,analysis,and dynamic monitoring.Ex situ FTIR spectroscopy's accuracy in identifying impurities,monitoring crystallisation processes,and regu-lating medication release patterns improves product quality,safety,and efficacy.Furthermore,its quantification capabilities enable more effective drug development,dosage procedures,and quality control practices,all of which are consistent with green analytical principles.On the other hand,in situ FTIR spectroscopy appears to be a novel tool for the real-time investigation of molecular changes during reactions and processes,allowing for the monitoring of drug release kinetics,crystallisation dynamics,and surface contacts,as well as providing vital insights into material behaviour.The combination of ex situ FTIR precision and in situ FTIR dynamic capabilities gives a comprehensive analytical framework for developing green practices,quality control,and innovation in the chemical and pharmaceutical in-dustries.This review presents the wide range of applications of ex situ and in situ FTIR spectroscopy in chemical,pharmaceutical and medical fields as an analytical green chemistry tool.However,further study is required to fully realise FTIR's potential and develop new applications that improve sustain-ability in these areas.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Targeting NTCP for liver disease treatment:A promising strategy

    Xin TanYu XiangJianyou ShiLu Chen...
    1267-1281页
    查看更多>>摘要：The sodium taurocholate co-transporting polypeptide(NTCP),a bile acids transporter,has been identi-fied as a new therapeutic target for the treatment of liver disease.This paper thoroughly investigates the function of NTCP for regulating bile acid regulation,its correlation with hepatitis B and D infections,and its association with various liver diseases.Additionally,in this review we examine recent breakthroughs in creating NTCP inhibitors and their prospective applications in liver disease treatment.While this review emphasizes the promising potential of targeting NTCP,it concurrently underscores the need for broader and more detailed research to fully understand the long-term implications and potential side effects associated with NTCP inhibition.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Emerging role of Jumonji domain-containing protein D3 in inflammatory diseases

    Xiang LiRu-Yi ChenJin-Jin ShiChang-Yun Li...
    1282-1300页
    查看更多>>摘要：Jumonji domain-containing protein D3(JMJD3)is a 2-oxoglutarate-dependent dioxygenase that specif-ically removes transcriptional repression marks di-and tri-methylated groups from lysine 27 on histone 3(H3K27me2/3).The erasure of these marks leads to the activation of some associated genes,thereby influencing various biological processes,such as development,differentiation,and immune response.However,comprehensive descriptions regarding the relationship between JMJD3 and inflammation are lacking.Here,we provide a comprehensive overview of JMJD3,including its structure,functions,and involvement in inflammatory pathways.In addition,we summarize the evidence supporting JMJD3's role in several inflammatory diseases,as well as the potential therapeutic applications of JMJD3 inhibitors.Additionally,we also discuss the challenges and opportunities associated with investigating the functions of JMJD3 and developing targeted inhibitors and propose feasible solutions to provide valuable insights into the functional exploration and discovery of potential drugs targeting JMJD3 for inflammatory diseases.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Targeted delivery of rosuvastatin enhances treatment of hyperhomocysteinemia-induced atherosclerosis using macrophage membrane-coated nanoparticles

    Dayue LiuAnning YangYulin LiZhenxian Li...
    1301-1319页
    查看更多>>摘要：Rosuvastatin(RVS)is an excellent drug with anti-inflammatory and lipid-lowering properties in the aca-demic and medical fields.However,this drug faces a series of challenges when used to treat atherosclerosis caused by hyperhomocysteinemia(HHcy),including high oral dosage,poor targeting,and long-term toxic side effects.In this study,we applied nanotechnology to construct a biomimetic nano-delivery system,macrophage membrane(Møm)-coated RVS-loaded Prussian blue(PB)nanoparticles(MPR NPs),for improving the bioavailability and targeting capacity of RVS,specifically to the plaque lesions associated with HHcy-induced atherosclerosis.In vitro assays demonstrated that MPR NPs effectively inhibited the Toll-like receptor 4(TLR4)/hypoxia-inducible factor-1α(HIF-1α)/nucleotide-binding and oligomerization domain(NOD)-like receptor thermal protein domain associated protein 3(NLRP3)signaling pathways,reducing pyroptosis and inflammatory response in macrophages.Additionally,MPR NPs reversed the abnormal distribution of adenosine triphosphate(ATP)-binding cassette transporter A1(ABCA1)/ATP binding cassette transporter G1(ABCA1)/ATP binding cassette transporter G1(ABCG1)caused by HIF-1α,promoting cholesterol efflux and reducing lipid deposition.In vivo studies using apolipoprotein E knockout(ApoE-/-)mice confirmed the strong efficacy of MPR NPs in treating atherosclerosis with favorable bio-security,and the mechanism behind this efficacy is believed to involve the regulation of serum metabolism and the remodeling of gut microbes.These findings suggest that the synthesis of MPR NPs provides a promising nanosystem for the targeted therapy of HHcy-induced atherosclerosis.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Design of a nanozyme-based magnetic nanoplatform to enhance photodynamic therapy and immunotherapy

    Chen BaiJiajing LiuLuyao BaiDapeng Yao...
    1320-1329页
    查看更多>>摘要：The tumor microenvironment,particularly the hypoxic property and glutathione(GSH)overexpression,substantially inhibits the efficacy of cancer therapy.In this article,we present the design of a magnetic nanoplatform(MNPT)comprised of a photosensitizer(Ce6)and an iron oxide(Fe3O4)/manganese oxide(MnO2)composite nanozyme.Reactive oxygen species(ROS),such as singlet oxygen(1O2)radicals produced by light irradiation and hydroxyl radicals(·OH)produced by catalysis,are therapeutic species.These therapeutic substances stimulate cell apoptosis by increasing oxidative stress.This apoptosis then triggers the immunological response,which combines photodynamic therapy and T-cell-mediated immunotherapy to treat cancer.Furthermore,MNPT can be utilized as a contrast agent in magnetic resonance and fluorescence dual-modality imaging to give real-time tracking and feedback on treatment.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Spatially resolved metabolomics visualizes heterogeneous distribution of metabolites in lung tissue and the anti-pulmonary fibrosis effect of Prismatomeris connate extract

    Haiyan JiangBowen ZhengGuang HuLian Kuang...
    1330-1346页
    查看更多>>摘要：Pulmonary fibrosis(PF)is a chronic progressive end-stage lung disease.However,the mechanisms un-derlying the progression of this disease remain elusive.Presently,clinically employed drugs are scarce for the treatment of PF.Hence,there is an urgent need for developing novel drugs to address such diseases.Our study found for the first time that a natural source of Prismatomeris connata Y.Z.Ruan(Huang Gen,HG)ethyl acetate extract(HG-2)had a significant anti-PF effect by inhibiting the expression of the transforming growth factor beta 1/suppressor of mothers against decapentaplegic(TGF-β1/Smad)pathway.Network pharmacological analysis suggested that HG-2 had effects on tyrosine kinase phosphorylation,cellular response to reactive oxygen species,and extracellular matrix(ECM)disassembly.Moreover,mass spec-trometry imaging(MSI)was used to visualize the heterogeneous distribution of endogenous metabolites in lung tissue and reveal the anti-PF metabolic mechanism of HG-2,which was related to arginine biosyn-thesis and alanine,asparate and glutamate metabolism,the downregulation of arachidonic acid meta-bolism,and the upregulation of glycerophospholipid metabolism.In conclusion,we elaborated on the relationship between metabolite distribution and the progression of PF,constructed the regulatory metabolic network of HG-2,and discovered the multi-target therapeutic effect of HG-2,which might be conducive to the development of new drugs for PF.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    β-elemene promotes miR-127-3p maturation,induces NSCLCs autophagy,and enhances macrophage M1 polarization through exosomal communication

    Xiahui WuJie WuTingting DaiQiangcheng Wang...
    1347-1360页
    查看更多>>摘要：β-elemene has been observed to exert inhibitory effects on a multitude of tumors,primarily through multiple pathways such as the inhibition of cancer cell proliferation and the induction of apoptosis.The present study is designed to elucidate the role and underlying mechanisms of β-elemene in the thera-peutic intervention of non-small cell lung cancer(NSCLC).Both in vitro and in vivo experimental models corroborate the inhibitory potency of β-elemene on NSCLCs.Our findings indicate that β-elemene fa-cilitates the maturation of miR-127-3p by inhibiting CBX8.Functioning as an upstream regulator of MAPK4,miR-127-3p deactivates the Akt/mTOR/p70S6K pathway by targeting MAPK4,thereby inducing autophagy in NSCLCs.Additionally,β-elemene augments the packaging of miR-127-3p into exosomes via SYNCRIP.Exosomal miR-127-3p further stimulates M1 polarization of macrophages by suppressing ZC3H4.Taken together,the detailed understanding of the mechanisms through which β-elemene in-duces autophagy in NSCLCs and facilitates M1 polarization of macrophages provides compelling scientific evidence supporting its potential utility in NSCLC treatment.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Advancing drug safety and mitigating health concerns:High-resolution mass spectrometry in the levothyroxine case study

    Hana ChmelařováMaria Carmen CatapanoJean-Christophe GarriguesFrantišek Švec...
    1361-1371页
    查看更多>>摘要：Levothyroxine is a drug with a narrow therapeutic index.Changing the drug formulation composition or switching between pharmaceutical brands can alter the bioavailability,which can result in major health problems.However,the increased adverse drug reactions have not been fully explained scientifically yet and a thorough investigation of the formulations is needed.In this study,we used a non-targeted analytical approach to examine the various levothyroxine formulations in detail and to reveal possible chemical changes.Ultra-high-performance liquid chromatography coupled with a data-independent acquisition high-resolution mass spectrometry(UHPLC-DIA-HRMS)was employed.UHPLC-DIA-HRMS allowed not only the detection of levothyroxine degradation products,but also the presence of non-expected components in the formulations.Among these,we identified compounds resulting from re-actions between mannitol and other excipients,such as citric acid,stearate,and palmitate,or from re-actions between an excipient and an active pharmaceutical ingredient,such as levothyroxine-lactose adduct.In addition to these compounds,undeclared phospholipids were also found in three formula-tions.This non-targeted approach is not common in pharmaceutical quality control analysis.Revealing the presence of unexpected compounds in drug formulations proved that the current control mecha-nisms do not have to cover the full complexity of pharmaceutical formulations necessarily.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    17β-Estradiol,through activating the G protein-coupled estrogen receptor,exacerbates the complication of benign prostatic hyperplasia in type 2 diabetes mellitus patients by inducing prostate proliferation

    Tingting YangZhen QiuJiaming ShenYutian He...
    1372-1386页
    查看更多>>摘要：Benign prostatic hyperplasia(BPH)is one of the major chronic complications of type 2 diabetes mellitus(T2DM),and sex steroid hormones are common risk factors for the occurrence of T2DM and BPH.The profiles of sex steroid hormones are simultaneously quantified by LC-MS/MS in the clinical serum of patients,including simple BPH patients,newly diagnosed T2DM patients,T2DM complicated with BPH patients and matched healthy individuals.The G protein-coupled estrogen receptor(GPER)inhibitor G15,GPER knockdown lentivirus,the YAP1 inhibitor verteporfin,YAP1 knockdown/overexpression lentivirus,targeted metabolomics analysis,and Co-IP assays are used to investigate the molecular mechanisms of the disrupted sex steroid hormones homeostasis in the pathological process of T2DM complicated with BPH.The homeostasis of sex steroid hormone is disrupted in the serum of patients,accompanying with the proliferated prostatic epithelial cells(PECs).The sex steroid hormone metabolic profiles of T2DM patients complicated with BPH have the greatest degrees of separation from those of healthy individuals.Elevated 17β-estradiol(E2)is the key contributor to the disrupted sex steroid hormone homeostasis,and is significantly positively related to the clinical characteristics of T2DM patients complicated with BPH.Activating GPER by E2 via Hippo-YAP1 signaling exacerbates high glucose(HG)-induced PECs prolifer-ation through the formation of the YAP1-TEAD4 heterodimer.Knockdown or inhibition of GPER-mediated Hippo-YAP1 signaling suppresses PECs proliferation in HG and E2 co-treated BPH-1 cells.The anti-proliferative effects of verteporfin,an inhibitor of YAP1,are blocked by YAP1 overexpression in HG and E2 co-treated BPH-1 cells.Inactivating E2/GPER/Hippo/YAP1 signaling may be effective at delaying the progression of T2DM complicated with BPH by inhibiting PECs proliferation.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    MEOX2 promotes glioma growth and temozolomide chemoresistance

    Tengfei LiKaijun SunWanchun YangMeiling Zhang...
    1387-1389页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据