首页期刊导航|中国化学快报（英文版）
期刊信息/Journal information
中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
正式出版
收录年代

    Chemical isotope labeling-assisted liquid chromatography-mass spectrometry enables sensitive and accurate determination of dipeptides and tripeptides in complex biological samples

    Feng-Qing HuangYu WangJi-Wen WangDai Yang...
    284-289页
    查看更多>>摘要：Small peptides have attracted increasing attention for their unique features and diverse biological func-tions.Achieving rapid separation and accurate quantification,however,remains a challenge because of their low abundance and the co-existence of numerous structural isomers.In this study,we developed a novel approach using isotope chemical labeling for ultrasensitive determination of di/tripeptides in bi-ological samples.We successfully synthesized a novel derivatization reagent,4-(2-(ethoxymethylene)-3-oxobutanamido)-N,N,N-trimethylbenzenaminium iodide(EOTMBA)as well as its deuterium-labeled iso-tope reagent(d3-EOTMBA).A total of 97 small peptides,including 89 dipeptides and 8 tripeptides,could be completely derivatized in methanol within 1.5 h at 60 ℃.After EOTMBA labeling,analysis of these di/tripeptides were achieved within 22 min by LC-MS/MS analysis.The method demonstrated 86.3％-113％accuracy and the limit of quantification ranged from 0.25 fmol/L to 5nmol/L.Using this method,we achieved ultrasensitive and accurate quantification of di/tripeptides in 147 plasma,49 urine and 46 bile samples obtained from healthy individuals and patients with biliary tract diseases.The iden-tified differential di/tripeptide biomarker panels showed promising diagnostic performance for patients with biliary tract cancer with area under the receiver operating curve values from 0.870 to 0.996.Further-more,this method was successfully applied to quantify di/tripeptides in the extract of an animal-derived traditional Chinese medicine,Eupolyphaga sinensis Walker.These findings highlight the possible appli-cation of the analytical method in clinics and for the purposes of quality control of traditional Chinese medicines.
      原文链接:
    • 万方数据
    • 维普

    Universal MOF nanozyme-induced catalytic amplification strategy for label-free electrochemical immunoassay

    Ruixin LiuFeng ShiYanping XiaHaibing Zhu...
    290-293页
    查看更多>>摘要：Label-free immunoassay is confronted with a great challenge that its insufficient sensitivity for low con-centration analytes,which can be assigned to the low catalytic efficiency of modified materials towards electroactive molecules.Herein,a universal MOF nanozyme-induced catalytic amplification strategy was proposed for constructing highly sensitive label-free electrochemical immunoassay.Specifically,the syn-thesized CuFe-MOF nanozyme with superior peroxidase(POD)-like activity,regarding as a MOF nanozyme model,can catalyze hydrogen peroxide to produce hydroxyl radicals(·OH),which can efficiently oxidize electroactive probe(such as 1,2-phenylenediamine(o-PD))accompanying with intense electrochemical signals.Modification of MOF nanozyme on the electrode and capture of antibodies for binding target antigens hinder the catalytic process of MOF nanozyme toward o-PD,resulting in a gradual decrease in electrochemical signal with increasing target antigen concentration,enabling quantitative label-free immunoassay.Thus,a highly sensitive label-free immunosensor using MOF nanozyme-induced catalytic amplification achieved effective detection of Immunoglobulin G(IgG)with a wide linear range of 0.001-50ng/mL and low detection limit of 0.45 pg/mL.This work proposes a promising nanozyme-induced cat-alytic amplification strategy for the development of label-free electrochemical immunoassay.
      原文链接:
    • 万方数据
    • 维普

    Construction of degradable liposome-templated microporous metal-organic frameworks with commodious space for enzymes

    Cheng ChengNasir AliJi LiuJuan Qiao...
    294-298页
    查看更多>>摘要：The construction of enzyme reactors based on metal-organic frameworks(MOFs)as the immobilized matrix is a proven strategy that has achieved the widespread application of enzymes across industries.Although many MOFs and a variety of strategies have been developed,a formidable challenge remains in maintaining the high enzyme activity with excellent recyclability and tolerance for harsh conditions.Herein,using degradable redox stimuli-responsive liposomes as the templates with microporous MOFs(M-MOFs)as the hosts for enzyme encapsulation,a series of enzyme reactors(enzyme@M-MOFs)was designed and created.Based on the premise of enhancing enzyme protection in the harsh environment,this strategy provided a high degree-of-freedom space via removal of liposomes that improved the con-formational freedom of the enzymes,promoted the mass transfer of substrates and products,and greatly boosted the catalytic activity.Importantly,the strategy had good universality and was applied to various liposomes,M-MOFs and enzymes.Additionally,the co-encapsulation of different enzymes with synergis-tic functions was performed using the M-MOFs platform.This study solved the problems of the confor-mation limitation of enzymes and mass transfer resistance of substrates and products using the proposed enzyme@M-MOFs,providing a new approach for the construction of biological cascade reaction devices based on MOFs materials.
      原文链接:
    • 万方数据
    • 维普

    Enhancing self-assembly efficiency of macrocyclic compound into nanotubes by introducing double peptide linkages

    Cheng-Yan WuYi-Nan GaoZi-Han ZhangRui Liu...
    299-303页
    查看更多>>摘要：Constructing more stable self-assembled organic nanotubes has been one of the focuses of scientists in recent decades.Hexakis(m-phenylene ethynylene)(m-PE)benzene macrocycles can form stable tubular self-assemblies in nonpolar or weakly polar solvents through the π-π interaction of the main skeleton and the hydrogen bonding of the side chain amide.We covalently linked two macrocyclic units at the para position of the macrocycles using two oligo(β-alanine)linkers through an efficient synthetic route.UV-visible spectroscopy,fluorescence spectroscopy,and circular dichroism spectroscopy were employed to demonstrate that the incorporation of two peptide chains significantly enhances the stability of the self-assemblies.Meanwhile,the average open time of the ion channel formed by the macrocyclic dimer in the lipid bilayer was significantly better than that of the ion channel formed by a single macrocycle.This study shows that this strategy effectively improves the efficiency of self-assembly and the stability of its formed self-assemblies,providing a feasible strategy for constructing organic self-assembled nanotubes in highly polar solvents.
      原文链接:
    • 万方数据
    • 维普

    A luminescent one-dimensional covalent organic framework for organic arsenic sensing in water

    Chao LiuChao JiaShi-Xian GanQiao-Yan Qi...
    304-308页
    查看更多>>摘要：Roxarsone(ROX)is a commonly used antibacterial and growth-promoting additive to animal feed.The development of an effective method for detecting ROX and its conversion products is of importance be-cause of their potential harm to human health and ecosystem.Herein,we report the designed synthesis of a novel one-dimensional covalent organic framework(1D COF),named EP-COF,and its application as a fluorescent probe for ROX sensing.EP-COF is constructed based on imine linkages,exhibiting high crys-tallinity,strong fluorescence emission,and good dispersibility in water.It displays a remarkable capability to efficiently detect ROX,with an impressive detection limit of 4.5nmol/L.Moreover,EP-COF also offers advantages of excellent selectivity,and high structural stability.This work not only presents a promising approach for the detection of harmful substances like ROX,but also serves as a valuable reference for exploring application of 1D COFs in chemical sensing.
      原文链接:
    • 万方数据
    • 维普

    Supramolecular confinement effect enabling light-harvesting system for photocatalytic α-oxyamination reaction

    Xuanyu WangZhao GaoWei Tian
    309-313页
    查看更多>>摘要：The supramolecular Förster resonance energy transfer(FRET)is seen as a promising approach for or-ganic photocatalysis using dyes as catalysts,because it combines the high efficiency of energy transfer with the dynamic responsiveness based on non-covalent interactions.Here we propose a supramolecu-lar FRET photocatalysis strategy for α-oxyamination reaction based on supramolecular confinement effect.The well-designed benzothiadiazole-based cationic monomer as energy donor and the dyes of Nile Red as acceptor are doped into the amphiphilic surfactants of sodium dodecyl sulfate(SDS).Benefitting from the supramolecular confinement space provided by SDS in aqueous environment,the FRET process between the monomer and Nile Red is effectively achieved(exciton migration rate:3.99 × 1014L mol-1 s-1).On this basis,the supramolecular FRET system is used as an efficient energy source to catalyze α-oxyamination reactions between a series of 1,3-dicarbonyl compounds and 2,2,6,6-tetramethylpiperidine-1-oxyl under white LED light,showing a yield as high as 94％and a turnover frequency value of 3.92 h-1.This photo-catalytic result shows a great enhancement compared to that of Nile Red alone.
      原文链接:
    • 万方数据
    • 维普

    Benzothiadiazole-based water-soluble macrocycle:Synthesis,aggregation-induced emission and selective detection of spermine

    Shuo LiQianfa LiuLijun MaoXin Zhang...
    314-317页
    查看更多>>摘要：Reported here is the synthesis of a new macrocycle bearing anionic carboxylate groups with water-soluble aggregation-induced emission(AIE).The water-soluble macrocycle without typical AIE luminogens is con-structed based on the building block of benzothiadiazole.It exhibits a remarkable AIE effect.This water-soluble macrocycle can selectively bind different types of biogenic amines in aqueous media with the tightest binding towards spermine.The fluorescence enhancement induced by supramolecular encapsu-lation is used to detect spermine.
      原文链接:
    • 万方数据
    • 维普

    Crown aldoxime ethers:Their synthesis,structure,acid-catalyzed/photo-induced isomerization and adjustable guest binding

    Yulin MaoJingyu MaJiecheng JiYuliang Wang...
    318-322页
    查看更多>>摘要：A series of novel crown aldoxime ethers were synthesized,demonstrating notable thermal and hydrolysis stability.The showcased acid-catalyzed and photo-induced cis/trans isomerization,which enables orthog-onal control over both guest complexation and the chiroptical effects of these crown aldoxime ethers,manifesting a regulation of complexation through isomerization at binding heteroatoms.
      原文链接:
    • 万方数据
    • 维普

    Artificial transmembrane channel constructed from shape-persistent covalent organic molecular cages capable of ion and small molecule transport

    Brandon BishopShaofeng HuangHongxuan ChenHaijia Yu...
    323-328页
    查看更多>>摘要：Shape-persistent arylene ethynylene molecular cages have been investigated as transmembrane chan-nels for ions and small molecules.The molecular cages were obtained starting from tetrayne monomers through alkyne metathesis cyclooligomerization.We found these porphyrin-based rigid molecular cages can insert into the lipid bilayer and efficiently transport ions and small molecules(e.g.,calcein).Our study reveals longer hydrophobic alkyl chains on the cage molecule promote the channeling efficiency,while shorter and/or more polar side chains impair such activity.Kinetic analysis shows linear correlation be-tween the rate of proton transport and the concentration of the cage,suggesting the active species is likely a monomeric cage.We found that C70-encapsulated cages are nearly inactive for transmembrane ion transportation,indicating that ions are likely transported through the internal cavity of the cage.Dis-crete shape-persistent organic cages represent highly stable synthetic ion channels or pores,which could have interesting applications in biomimetic signaling and drug delivery.
      原文链接:
    • 万方数据
    • 维普

    Designed assembly of heterometallic cluster organic frameworks based on Th6 cluster

    Xianghe KongXiaoli LiaoZhenkun HuangLei Mei...
    329-333页
    查看更多>>摘要：Four novel compounds based on hexanuclear thorium cluster were synthesized and characterized.Com-pound 1[Th6(HPyC)8(HCOO)4]is formed by replacing formate ligands of preassembled thorium clus-ter[Th6O4(OH)4(H2O)6(HCOO)12]with eight H2PyC(4-pyrazolecarboxylic acid)under solvothermal con-ditions.Each of the HPyC-ligands is coordinated with one Cu2+to form the(4,8)-connected scu-net structure of compound 2[(CuCl2)2Th6(HPyC)8(HCOO)4].In compound 3[(CuCl2)2Th6(HPyC)10(HCOO)4],ten of the formate ligands of preassembled Th6 cluster are replaced by HPyC-ligands.Compared with compound 2,the two extra HPyC-ligands in the equatorial plane of the Th6 cluster in compound 3 are not further connected to copper ions.Therefore,the topology structure of compound 3 is same with that of compound 2.Compound 4[(Cu3Cl2)(CuCl2)Th6(PyC)3(HPyC)4(HCOO)5]contains three kinds of metal nodes,Th6 cluster,Cu3 cluster and mononuclear Cu2+,and exhibits a novel(5,7)-connected net struc-ture,which was first discovered in actinide MOFs.Furthermore,considering the satisfactory stability of compound 4 and its unsaturated metal nodes and Lewis acid sites,the catalysis of cycloaddition of CO2 was further studied.We found that this thorium-copper heterometallic cluster organic framework can be used as a potential actinide functional material for catalyzing the efficient CO2 conversion to value-added products.
      原文链接:
    • 万方数据