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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    The 2nd Asian Conference on Porphyrins,Phthalocyanines and Related Materials

    Gaojie ZhuZhen YangShijun LiWeihua Zhu...
    1-3页
      原文链接:
    • 万方数据

    Recent process in developing advanced heterogeneous diatomic-site metal catalysts for electrochemical CO2 reduction

    Xueyang ZhaoBangwei DengHongtao XieYizhao Li...
    4-13页
    查看更多>>摘要：Diatomic-site catalysts(DASCs)have emerged as a kind of promising heterogeneous candidate catalysts for electrochemical CO2 reduction(ECR),which is considered to retain the advantage of single-atom cat-alysts(SACs)but also introduce opportunities to exceed the limit of single-atom catalysts.In the past few years,tremendous progress has been achieved in this field.Herein,the recent progress in ECR on DASCs has been summarized.It will start with the classification of DASCs.Then the challenges in the precise fabrication and characterization of DASCs have been emphasized.By introducing the advanced ECR performance on DASCs,superior to that on SACs,the synergistic effects of the dual metal atoms are highlighted,as this origin of the advanced ECR performance on DASCs is comprehensively summa-rized.Finally,the major challenges and perspectives of DASCs have been proposed to shed light on the development of DASCs for ECR application.
      原文链接:
    • 万方数据

    Multivariate chemical analysis:From sensors to sensor arrays

    Xueling YuLixing FuTong WangZhixin Liu...
    14-24页
    查看更多>>摘要：Chemical sensor arrays can obtain more comprehensive analyte information through high-dimensional data.It is of great significance in the analysis of multi-component complex samples.This review summa-rizes the development and status of chemical sensor arrays.We focused on the design of chemical sensor arrays based on various sensing materials.In addition,several pattern recognition methods in chemomet-rics are introduced.And applications of chemical sensor arrays in food monitoring,medical diagnosis,and environmental monitoring are illustrated.Based on the analysis of the limitations of current sensor array technology,the direction of the array is also predicted.This review aims to help the broad readership understand the research state of chemical sensor arrays and their development prospects.
      原文链接:
    • 万方数据
    • 维普

    Detection of SARS-CoV-2 based on artificial intelligence-assisted smartphone:A review

    Yunxin LiJinghui ZhangJisen ChenFeng Zhu...
    25-34页
    查看更多>>摘要：In recent years,the application of smartphone in various fields has received great attention,and it has become a promising tool in virus detection,data processing and data exchange.During the rapid spread of COVID-19 around the world,many traditional detection methods have been combined with smart-phone to assist in the analysis and detection of the novel coronavirus(SARS-CoV-2),including electro-chemistry,fluorescence and colorimetry.With the gradual development of artificial intelligence(AI),the combination of AI and smartphone to analyze SARS-CoV-2 was also the focus of research.Based on the summary of the traditional methods combined with smartphone to detect SARS-CoV-2 virus,in addition to AI-based data processing,AI algorithms are also employed for SARS-CoV-2 detection itself.This review discussed both strategies and focused on the application of the former.The combination of AI algorithm and smartphone to detect SARS-CoV-2 has high accuracy,which is more conducive to meeting the needs of portable detection.In addition,the classification of SARS-CoV-2 virus samples in biological fluids such as blood and saliva was also discussed.Finally,this paper briefly discussed the limitations of using smart-phone analysis to detect SARS-CoV-2,as well as the prospect and future development of virus detection.In conclusion,the detection methods based on smartphone and AI algorithms show great potential in the detection of SARS-CoV-2 and can be a valuable complement to traditional analysis methods.
      原文链接:
    • 万方数据
    • 维普

    Beyond 1,4-addition of in-situ generated(aza-)quinone methides and indole imine methides

    Yan-Li LiZhi-Ming LiKai-Kai WangXiao-Long He...
    35-53页
    查看更多>>摘要：The conjugate addition of in-situ generated(aza-)quinone methides(QMs)and indole imine methides(IIMs)emerged as a powerful protocol to access densely functionalized benzenes and indoles.Hydrox-ybenzyl alcohols,aminobenzhydryl alcohols,and varied indolylmethanols served as most effective pre-cursors for the in-situ generation of such reactive species under acid conditions.The relevant propargylic alcohol has proven to be an elegant precursor to generate the propargylic-QMs and-IIMs via the acid promoted dehydration process,thus enabling diverse challenging remote activation to proceed conjugate 1,6-and 1,8-additions.Moreover,the heteroarene has proven to be workable to transfer the LUMO of the p-QMs and 2-IIMs,thus inducing the remote nucleophilic dearomative additions.The conjugate additions of(aza-)p-QMs and varied IIMs has made significant contribution in the field of remote activation chem-istry in past decade.This review summarizes the latest advances of the remote conjugate additions of the in-situ generated QMs and IIMs.
      原文链接:
    • 万方数据
    • 维普

    Valorization of carbon dioxide with alcohols

    Daheng WenWeiwei FangYongmei LiuTao Tu...
    54-58页
    查看更多>>摘要：Utilizing CO2 for the production of bulky and valuable chemicals presents an attractive solution to ad-dress environmental and fossil energy crises.Among the various approaches,direct carboxylation of alco-hols with CO2 stands out as an eco-friendly process capable of efficiently producing carboxylic acids in a sustainable manner.However,the high dissociation energy of the C-O bond poses a significant challenge in this process.Over the past few decades,several strategies have been developed to activate alcohols and establish efficient catalytic systems for carboxylation with CO2.Nevertheless,the sporadic nature of reported approaches makes it difficult to determine the most effective one.This perspective aims to pro-vide an overview of the current state-of-the-art catalytic protocols for carboxylating alcohols with CO2,encompassing esterification,halogenation,and photocatalysis,while considering their respective advan-tages and limitations.We aim to discern the most promising avenues for future development in this field.The insights presented in this perspective will contribute to the advancement of efficient and sustainable carboxylation methods using CO2,leading to the production of valuable chemicals in future.
      原文链接:
    • 万方数据
    • 维普

    Molecules for COVID-19 treatment

    Zhigang ZengChangzhou LiaoLei Yu
    59-65页
    查看更多>>摘要：COVID-19 is a major event with worldwide influences.Since the beginning of the epidemic,pharmaceu-tical chemists have paid attention to the therapeutic effect of a variety of small molecule medicines on COVID-19 infection.A series of organic molecules are designed and found to be effective in the treatment of COVID-19 infection.In fact,no matter how effective they are,with the development of the COVID-19 epidemic,various small molecule medicines are gradually recognized by people.This is equivalent to a good science popularization of pharmaceutical chemistry.This review aims to introduce the molecules for COVID-19 treatment on the basis of their chemical structures,synthetic methods as well as their effects.
      原文链接:
    • 万方数据
    • 维普

    Indole derivatives as agrochemicals:An overview

    Ping SunYuanqin HuangShunhong ChenXining Ma...
    66-72页
    查看更多>>摘要：Indole is a biologically active compound formed by the fusion of benzene and pyrrole,and it is widely found in natural products and drugs.Due to the unique structure and properties of indole,its deriva-tives often exhibit distinctive physiological activities,which has led to widespread attention in the field of pesticide development.Analyzing the design strategies and structure-activity relationships(SARs)of compounds is a crucial step in developing novel pesticides.This review mainly summarizes indole com-pounds with plant growth regulating,antiviral,fungicidal,herbicidal,and insecticidal activities,with the aim of providing new insights into the discovery and mechanism of action of novel indole-based pesti-cides.
      原文链接:
    • 万方数据
    • 维普

    Vesicular drug delivery systems for oral absorption enhancement

    Linghui ZouMeng ChengKaili HuJianfang Feng...
    73-88页
    查看更多>>摘要：Oral administration is the most acceptable route of drug delivery at this stage due to its convenience,safety,and non-invasiveness.However,drugs given orally are exposed to a complex gastrointestinal en-vironment,causing a tremendous challenge for their successful absorption into the circulation.Over the past decades,researchers have developed various novel pharmaceutical technologies to improve oral ab-sorption,among which the vesicular drug delivery system(like liposomes,niosomes and transfersomes)has received extensive attention.Encouragingly,there have been several investigations confirming the improved effect of vesicular drug delivery systems on oral drug absorption.Nevertheless,the clinical translation of oral vesicular drug delivery systems has been less impressive than implied by the positive results,and few vesicular formulations for oral use have been marketed yet.Against this background,this article provides an overview of the current applications and challenges associated with the vesicular delivery systems available for oral drug delivery,specifically liposomes,niosomes,transfersomes,chito-somes and bilosomes.The composition,formation mechanism,drug delivery advantages and application cases of these carriers in oral drug delivery are summarized.The possible mechanisms by which vesicular carriers enhance oral drug absorption are analyzed in terms of the in vivo process of oral drugs.Further,the challenges that oral vesicular carriers now face,such as safety,undefined in vivo fate,and scale-up production,are summarized,while possible strategies to deal with them are indicated.By reviewing the aforementioned,it can facilitate a more comprehensive knowledge of vesicular systems that can be used for oral drug delivery,providing a theoretical basis and reference for the design of oral formulations.
      原文链接:
    • 万方数据
    • 维普

    Supercritical fluid technology:A game-changer for biomacromolecular nanomedicine preparation and biomedical application

    Yating ZhengYulan HuangJing LuoXuqi Peng...
    89-99页
    查看更多>>摘要：Biomacromolecules are attractive in biomedical applications as therapeutic agents and potential drug car-riers due to their natural active components,good biocompatibility,and high targeting.However,their large relative molecular weight,complex structure,susceptibility to degradation,and poor stability limit their usefulness.Nanotechnology can address these issues by improving the therapeutic value,bioavail-ability,permeability,and absorption of biomacromolecules while regulating their retention time in the body.Especially,compelling evidence has been reported that supercritical fluid(SCF)technology has emerged as an alternative that maintains the integrity of biomacromolecules and reduces environmental contamination.In this review,we highlight a set of unique nanosizing strategies based on SCF technol-ogy for biomacromolecular nanomedicine,and extensively discuss their characteristics and mechanisms.In particular,the protein-based,nucleic acid-based,and polysaccharide-based nanomedicine preparations via SCF technology and their biomedical applications are summarized,and the potential for industrial production of biomacromolecular drugs is also considered.We further provide perspectives on the op-portunities and challenges in this excellent field of biomacromolecular drugs nanotechnology.
      原文链接:
    • 万方数据
    • 维普