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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy

    Zhe LiPing-Zhao LiangLi XuFei-Yu Yang...
    205-210页
    查看更多>>摘要：Photodynamic therapy(PDT)has emerged as a significant cancer therapy option.Currently,cation-based organic small molecule aggregation-induced emission(AIE)photosensitizers(PSs)attract the wide atten-tion of many scientists,due to improved reactive oxygen species(ROS)production after cationization.However,such PSs tend to localize only the mitochondria,limiting the death way of tumor cells(usu-ally apoptosis)during PDT process,which may affect the therapeutic effect under some circumstances.Herein,we designed a novel water-soluble three positive charge PS,TPAN-18F,which could be distributed uniformly in cell cytoplasm and had distribution in different sub-organelles(mitochondria,endoplasmic reticulum,lysosome).The experimental results showed that TPAN-18F-based PDT process can not only disrupt mitochondrial functions(reducing ATP production and destroying mitochondrial membrane po-tential),but also elevate the intracellular lipid peroxides(LPOs)level,which evoke the non-apoptotic death manner of tumor cells.Further,in vivo studies showed that TPAN-18F-based PDT could effectively inhibit tumor growth.Accordingly,we believe that the construction of TPAN-18F is suggestive for tumor non-apoptotic therapy.
      原文链接:
    • 万方数据
    • 维普

    HSA shrinkage optimizes the photostability of embedded dyes fundamentally to amplify their efficiency as photothermal materials

    Yongkang YueZhou XuKaiqing MaFangjun Huo...
    211-216页
    查看更多>>摘要：Focused on the performance promotion of organic small molecular dyes based photothermal agents via non-chemical modification,we found that heat-assisted binding of human serum albumin(HSA)to the dye causes shrinkage of the protein and encapsulate the dye to form nanoparticles.This revolutionizes the photostability of small molecule dyes which further improves their photothermal conversion effi-ciency and tumor ablation performance as photothermal agents significantly.In this work,the obtained photothermal agent named HSA-P2-T could accumulate in tumor and induce 22 ℃ enhancement of the tumor in xenograft models upon ultra-low dose(0.1 W/cm2)laser irradiation,which,as far as we know,is the lowest laser dose used in vivo photothermal therapy.Utilizing HSA-P2-T,we realized tumor ablation upon twice intravenous injections of the nanoparticles and four photothermal treatments.
      原文链接:
    • 万方数据
    • 维普

    A biocompatible Horner-Wadsworth-Emmons(HWE)reaction triggered by a bioorthogonal proximity-induced platform

    Yayue WangHaojie YangJie LiQiao Kong...
    217-220页
    查看更多>>摘要：Here,we present a novel bioorthogonal platform that enables precise positioning of attached moieties in close proximity,thereby facilitating the discovery and optimization of biocompatible reactions.Using this platform,we achieve a Horner-Wadsworth-Emmons(HWE)reaction under physiological conditions,generating a fluorophore in situ with a yield of up to 93％.This proximity platform should facilitate the discovery of various types of biocompatible reactions,making it a versatile tool for biomedical applica-tions.
      原文链接:
    • 万方数据
    • 维普

    Enzymatically controlled DNA tetrahedron nanoprobes for specific imaging of ATP in tumor

    Xiaohong WenMei YangLie LiMingmin Huang...
    221-224页
    查看更多>>摘要：Intracellular ATP is an emerging biomarker for cancer early diagnosis because it is a key messenger for regulating the proliferation and migration of cancer cells.However,the conventional ATP biosensing strat-egy is often limited by the undesired on-target off-tumor interference.Here,we reported a novel strategy to design enzymatically controlled DNA tetrahedron nanoprobes(En-DT)for biosensing and imaging ATP in tumor cells.The En-DT was designed via rational engineering of structure-switching aptamers with the incorporation of an enzyme-activatable site and further conjugation on the DNA tetrahedron.The En-DT could be catalytically activated by apurinic/apyrimidinic endonuclease 1(APE1)in cancer cells,but they did not respond to ATP in normal cells,thereby enabling cancer-specific ATP biosensing and imaging in vitro and in vivo with improved tumor specificity.This strategy would facilitate the precise detection of a broad range of biomarker in tumors and may promote the development of smart probes for cancer diagnosis.
      原文链接:
    • 万方数据
    • 维普

    The dark side of cyclooctatetraene(COT):Photophysics in the singlet states of"self-healing"dyes

    Supphachok ChanmungkalakulSyed Ali Abbas AbediFederico J.HernándezJianwei Xu...
    225-228页
    查看更多>>摘要：Cyclooctatetraene(COT)attachment to fluorophores("self-healing"dyes)is known for quenching reac-tive triplet states via triplet-state energy transfer(TET),enhancing photostability.However,COT's impact on singlet states remains unclear.Quantum calculations reveal that COT induces energy transfer to dark states in deep blue dyes while promoting photoinduced electron transfer(PET)and intersystem crossing(ISC)in visible dyes,potentially compromising brightness and/or photostability.To address this,we pro-pose the use of ΔE descriptor to optimize COT's effects.Our findings uncover COT's multifaceted impact.These insights will guide the development of superior triplet state quenchers and photostable dyes.
      原文链接:
    • 万方数据

    Active molecule-based theranostic agents for tumor vasculature normalization and antitumor efficacy

    Jin WangXiaoyan PanJunyu ZhangQingqing Zhang...
    229-234页
    查看更多>>摘要：Tumor vascular normalization has emerged as a promising strategy for synergistic therapy recently.Based on the strategy of"fluorescence turn on-controllable release",a novel bifunctional candidate was con-structed based on previous developed vascular normalization inducer QDAU5,which could self-assemble to form functional enzyme infrared QDAU5 nanoparticles(FEIRQ NPs).Subsequently,biological evaluation demonstrated that the FEIRQ NPs could induce ferroptosis,endoplasmic reticulum stress,and antigen pre-conditioning and maturation of dendritic cells and CD8+T cells,leading to excellent antitumor efficacy in the absence of cytotoxic drugs.Additionally,FEIRQ NPs show high fluorescence intensity upon expo-sure to the β-galactosidase(β-Gal)enzyme expressed in ovarian cancer,enabling real-time monitoring of therapeutic effects.Overall,our findings suggest a prospering strategy to early diagnosis and efficient therapy for ovarian cancer without cytotoxicity.
      原文链接:
    • 万方数据
    • 维普

    Highly reversible photomodulated hydrosoluble stiff-stilbene supramolecular luminophor induced by cucurbituril

    Guoxing LiuYixin LiChangming TianYongmei Xiao...
    235-239页
    查看更多>>摘要：A photochromic molecular rotor based on stiff-stilbene(SSB-FMR)was handily prepared through coupled reaction,and further self-assembled with cucurbit[8]uril(CB[8])to form a 2:2 quaternary supramolecu-lar complex(SSB-FMR/CB[8]).Significantly,the intervention of CB[8]on SSB-FMR achieved dual functions that assembly-induced emission enhancement and assembly-induced improvement of photoisomerized performance(especially reversibility)of stiff-stilbene molecular photoswitch.The supramolecular strategy further facilitated the assembly as a photoresponsive fluorescence switch with outstanding fatigue resis-tance,which was expediently applied in high-security-level QR code anti-counterfeiting and controllable lysosome targeted imaging.The study unprecedentedly provides a supramolecular method for highly effi-ciently improving photoisomerized performance especially reversibility of molecular photoswitches based on stiff-stilbene,and is of vital significance for the construction of intelligent materials with excellent ca-pability.
      原文链接:
    • 万方数据
    • 维普

    Synthesis and molecular recognition characteristics of a tetrapodal benzene cage

    Caihong MaoYanfeng HeXiaohan WangYan Cai...
    240-244页
    查看更多>>摘要：In this contribution,we describe the preparation and recognition characteristics of a novel tetrapodal benzene cage(1).The cage can express a wide recognition range without losing selectivity for the object of appropriate size and functional groups.The key to obtaining the desired structural isomer of 1 is the synthesis and isolation of the o-bis(bromomethyl)benzene precursor(5).Three distinct guests,F-(ex-tremely small size),D-lactate(appropriate size)and L-Asp(branched shape),were selected as examples to demonstrate the recognition characteristics of 1.By NMR titration studies,they all expressed good binding affinity(K＞105 L/mol)in competitive medium(10％DMSO/THF),indicating that 1 has a wide recognition scope.The highest binding constant was observed for D-lactate,revealing that 1 has good selectivity for D-lactate versus F-and L-Asp.Moreover,the NMR titration study of F-in DMSO indicates 1 can achieve different binding modes(1:1 and 2:1 guest-host)for small-sized guests,which allows for the further development of binary binding properties and thereafter applications in the field of catalysis.
      原文链接:
    • 万方数据
    • 维普

    Site-selection and recognition of aromatic carboxylic acid in response to coronene and pyridine derivative

    Yuanjiao LiuXiaoyang ZhaoSongyao ZhangYi Wang...
    245-249页
    查看更多>>摘要：The self-assembled structures of H3BDA molecule with multiple meta-dicarboxylic groups and their stim-ulus responses to the guest molecules(COR and T4PT)are thoroughly investigated by scanning tunneling microscopy(STM).STM observations display that two kinds of nanostructures are fabricated by H3BDA molecules through intermolecular hydrogen bonds,in which a linear structure is formed at a higher con-centration and a flower-like structure is obtained at a lower concentration.After the addition of COR and T4PT,H3BDA appears different responsiveness resulting in different co-assembled structures,respectively.The linear structure is regulated into a flower-like structure by COR and COR molecules are trapped in the cavities.When the pyridine derivative(T4PT)is introduced,a new bicomponent porous structure emerges via the hydrogen bond formed between the carboxyl group and the pyridine.Furthermore,the deposition of additional COR to the H3BDA/T4PT system results in the breakdown of the porous structure and the generation of H3BDA/COR host-guest system.Combined with density functional theory(DFT)calculations and molecular dynamics(MD)simulations,the transformation phenomenon of bi-component nanostruc-ture induced by guest molecules is formulated.The results are expected to understand the modification effect of guest molecules on the host network,which is of great significance for the design and construc-tion of multi-component nanostructures and crystal engineering.
      原文链接:
    • 万方数据
    • 维普

    Sustainable and practical semi-heterogeneous photosynthesis of 5-amino-1,2,4-thiadiazoles over WS2/TEMPO

    Jia-Cheng HouHong-Tao JiYu-Han LuJia-Sheng Wang...
    250-253页
    查看更多>>摘要：An eco-friendly and practical method for the clean preparation of 5-amino-1,2,4-thiadiazoles was devel-oped.With WS2 as the semiconductor photocatalyst,both TEMPO and O2(in air)as the redox catalysts,a variety of thiadiazoles were semi-heterogeneously formed in high to quantitative yields and could be easily collected by CPME extraction and rinsing.Furthermore,the catalytic system can be reusable for at least 5 reaction runs.
      原文链接:
    • 万方数据