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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    Asperochones A and B,two antimicrobial aromatic polyketides from the endophytic fungus Aspergillus sp.MMC-2

    Hong ZhangCui-Ping LiLi-Li WangZhuo-Da Zhou...
    206-209页
    查看更多>>摘要：Two novel fungal metabolites,asperochones A and B,were obtained from an Aspergillus sp.Their struc-tures were determined by 1D/2D nuclear magnetic resonance(NMR)spectroscopy,high resolution elec-trospray ionization mass spectroscopy(HRESIMS),and single-crystal X-ray diffraction analysis.Aspero-chone A possesses an intriguing skeleton bearing 5/6/6/6/7/5/5/5 octacyclic ring system,and asperochone B also exhibits an unusual carbon skeleton with five stereochiral centers.Their structures were proposed as heterotrimeric and heterodimeric products of aromatic polyketides.In addition,asperochone A ex-hibited a potential anti-tuberculosis effect since it showed a moderate potency against Mycobacterium smegmatis.
      原文链接:
    • 万方数据
    • 维普

    (+)/(-)-Mycosphatide A,a pair of highly oxidized polyketides with lipid-lowering activity from the mangrove endophytic fungus Mycosphaerella sp.SYSU-DZG01

    Qi TanRun-Zhu FanWencong YangGe Zou...
    210-213页
    查看更多>>摘要：(±)-Mycosphatide A(1a/1b),a pair of highly oxidized enantiomeric polyketides featuring a unique 5/5/6/5-fused tetracyclic ring system,were isolated from the mangrove endophytic fungus Mycosphaerella sp.SYSU-DZG01.Their structures were established by extensive spectroscopic analyses,single crystal X-ray diffraction,and experimental electronic circular dichroism(ECD)spectra comparison.The plausible biosynthetic pathway of 1 was proposed,which involved the generation of a key spiro[4.5]decane scaf-fold.Compounds(+)-1a and(-)-1b exhibited significant lipid-lowering activity in 3T3-L1 adipocytes model,with EC50 values of 7.85±1.56 and 8.87±0.80 μmol/L,respectively.
      原文链接:
    • 万方数据
    • 维普

    Hydrophobic tagging-induced degradation of NAMPT in leukemia cells

    Menglu GuoYing-Qi SongJunfei ChengGuoqiang Dong...
    214-218页
    查看更多>>摘要：Nicotinamide phosphoribosyl transferase(NAMPT)is considered as a promising target for cancer ther-apy to its crucial role in cancer metabolism.Despite the therapeutic potential of NAMPT enzymatic in-hibitors,their effectiveness is limited by dose-related toxicity and the inability to suppress nonenzymatic functions of extracellular NAMPT(eNAMPT).Herein,we designed and synthesized the first hydrophobic tagging NAMPT degraders.Among them,compound NH-11 selectively degraded NAMPT in leukemia cells through the ubiquitin-proteasome system.Compound NH-11 effectively induced apoptosis and showed low toxicity to normal cells,representing a promising anti-leukemia lead compound.
      原文链接:
    • 万方数据
    • 维普

    Employing pH-responsive RNA triplex to control CRISPR/Cas9-mediated gene manipulation in mammalian cells

    Yan LiuYang WangJiayi ZhuXuxian Su...
    219-222页
    查看更多>>摘要：The clustered regularly interspersed short palindromic repeats/CRISPR-associated protein 9(CRISPR/Cas9)system is an RNA-guided platform for highly efficient and specific genome targeting in diverse organisms,which has been exploited for various applications in gene manipulation.Compared with the constantly active CRISPR/Cas9 function,conditional control of its activity can improve the performance of the system with reduced side effects and high spatiotemporal precision.The pH-responsive triplex RNA was success-ful used in CRISPR-derived RNA/trans-activating crRNA(crRNA/tracrRNA)of CRISPR/Cas9,thus affecting RNA/dead Cas9(dCas9)complex to target DNA in vitro and in vivo.This design of triplex RNA opens a new window towards the broad involvement of eukaryotic cells for conditional control of CRISPR/Cas9 function.
      原文链接:
    • 万方数据
    • 维普

    Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

    Gongcheng MaQihang DingYuding ZhangYue Wang...
    223-226页
    查看更多>>摘要：Carbon monoxide(CO)is a vital intracellular gas messenger known for its cytoprotective and homeostatic properties.It plays a pivotal role in a myriad of biological processes.Therefore,the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease diagnosis.We herein introduce NFCOP,a state-of-the-art near-infrared(NIR)turn-on fluorescence(FL)probe that has been meticulously designed for highly sensitive,swift and se-lective imaging of CO.The NFCOP response occurred rapidly with CO,within just 10 s,and the calculated detection limit for CO was determined to be 0.32 μmol/L.Further investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.
      原文链接:
    • 万方数据
    • 维普

    Achieving tunable long persistent luminescence in metal organic halides based on pyridine solvent

    Jun-Ting MoZheng Wang
    227-231页
    查看更多>>摘要：The research of long persistent luminescence(LPL)materials has yield brilliant results in many fields.However,the efforts are still needed for the regulation of the LPL performance.In this work,a series of LPL metal organic halides with rich halogen-bond interactions,Py-CdX2(X=Cl,Br,I)were synthesized through self-assembly by CdX2 and pyridine solvent.The steady-state emission redshifted and phospho-rescence lifetime declined as the halogen atoms are aggravated.Three halides exhibit adjustable emission from blue to green and multiple phosphorescence from green to yellow at room temperature by changing the excitation wavelengths.Surprisingly,Py-CdX2 can emit the visible color-tunable LPL from green to yel-low after removing different excitation sources at ambient conditions.Combing the results of theoretical calculation and experimental analysis,it is found that heavy atom effect and the rich intermolecular halo-gen bond help realize LPL and multiple triplet states originated from the pyridine ring and the halogens.
      原文链接:
    • 万方数据
    • 维普

    Photoluminescence and photothermal conversion in boric acid derived carbon dots for targeted microbial theranostics

    Yiqiao ChenAo LiuBiwen YangZhenzhen Li...
    232-237页
    查看更多>>摘要：Theranostic carbon dots(CDs)have attracted widespread attention recently due to their tunable optical properties and diverse bioactivities.Beyond fluorescent imaging application,the photothermal property endows CDs with the potential for microbial inactivation.However,realization of the effective conver-sion between fluorescence and heat in one CD system has rarely been reported.Herein,we provide a simple strategy for targeted microbial theranostics based on 4-carboxyphenylboronic acid-derived CDs(PCBA-CDs)which possess concentration-dependent photoluminescence/photothermal features.At lower concentrations,PCBA-CDs show bright and stable fluorescent signals ranging from blue to green.The fluorescence intensity gradually decreases with increasing concentration,while on the contrary,the pho-tothermal effect of PCBA-CDs ascends progressively due to the rearrangement of electronic transitions in aggregated CDs.PCBA-CDs also demonstrate high affinity to the polysaccharide structures on the surface of microbe which allows rapid microbial fluorescence imaging as well as specific photothermal ablation of pathogens in skin wounds using PCBA-CDs at lower and higher concentrations,respectively.This study supplies a facile nanotheranostic strategy for just-in-time microbial management using bioactive CDs.
      原文链接:
    • 万方数据
    • 维普

    Regulation of the multi-emission centers in carbon dots via a bottom-up synthesis approach

    Bohan ZhangBingzhe WangGuichuan XingZikang Tang...
    238-242页
    查看更多>>摘要：Understanding the luminescence mechanisms and regulating the emission centers of carbon dots(CDs)are important for advancing their related applications.In this work,we systematically investigate the formation processes of multi-emission centers in CDs synthesized through a bottom-up approach by con-trolling the solvothermal reaction temperature.CDs synthesized at a lower temperature(140 ℃,140-CDs)exhibit smaller particle sizes(3-4 nm)with dominant green-yellow emission,while CDs synthesized at a higher temperature(180 ℃,180-CDs)exhibit larger particle sizes(8-9 nm)with enhanced red emis-sion and emerging near-infrared(NIR)emission.The green-yellow emission and red emission originate from the core state and the surface-related state,respectively,and the emissions could be regulated by temperature-controlled dehydration and carbonization processes.The clear NIR emission center in 180-CDs is attributable to the increased content of radical defects in the cores during the increased dehydra-tion and carbonization processes during higher-temperature solvothermal treatment.
      原文链接:
    • 万方数据
    • 维普

    Gold mineralized"hybrid nanozyme bomb"for NIR-Ⅱ triggered tumor effective permeation and cocktail therapy

    Ji LiuDongsheng HeTianjiao HaoYumin Hu...
    243-249页
    查看更多>>摘要：Lung cancer is one of the most common malignant tumors with the fastest increase in the incidence rate and mortality.Even after maximum tumor resection assistance with a radiotherapy and chemotherapy combination,the recurrence of non-small cell lung cancer is still inevitable.In addition,low targeting efficiency and poor permeability of drug delivery systems strongly affect the therapeutic efficiency of anti-cancer drugs on non-small cell lung cancer.Here we designed a gemcitabine(GEM)loaded arginine-glycine-aspartic acid-cysteine(RGDc)-modified gold mineralization"hybrid nanozyme bomb"(RGTG)to overcome those obstacles.RGDc modification improved the active targeting of liposomes to the tumor tissues with the second near-infrared(NIR-Ⅱ)-triggered gold-shell disruption and GEM release.The col-lapsed gold-shell particles with a smaller size could penetrate the tumor solid barrier and act as pho-tothermal therapy(PTT)agents to improve PTT therapy and starvation therapy via generating gluconic acid and reactive oxygen species(ROS).Moreover,the resting reversal effect of gold particles on tumor fibroblasts can achieve accelerating tumor penetration of gold particles and GEM.Compared to monother-apy,RGTG showed significant improvement in tumor inhibition,with a tumor volume reduction of 83％compared to the control group,which provides a promising tumor treatment platform for non-small cell lung cancer(NSCLC).
      原文链接:
    • 万方数据

    Accurate expression of neck motion signal by piezoelectric sensor data analysis

    Neng ShiHaonan JiaJixiang ZhangPengyu Lu...
    250-256页
    查看更多>>摘要：The development of high-precision sensors using flexible piezoelectric materials has the advantages of high sensitivity,high stability,good durability,and lightweight.The main problem with sensing equip-ment is low sensitivity,which is due to the mismatch between materials and analysis methods,resulting in the inability to effectively eliminate noise.To address this issue,we developed the denoising analysis method to motion signals captured by a flexible piezoelectric sensor fabricated from poly(L-lactic acid)(PLLA)and polydimethylsiloxane(PDMS)materials.Experimental results demonstrate that this improved denoising method effectively removes noise components from neck muscle motion signals,thus obtaining high-quality,low-noise motion signal waveforms.Wavelet decomposition and reconstruction is a signal processing technique that involves decomposing a signal into different scales and frequency components using wavelets and then selectively reconstructing the signal to emphasize specific features or eliminate noise.The study employed the sym8 wavelet basis for wavelet decomposition and reconstruction.In the denoised signals,a high degree of stability and periodic peaks are distinctly manifested,while ampli-tude and frequency differences among different types of movements also become noticeably visible.As a result of this study,we are enabled to accurately analyze subtle variations in neck muscle motion sig-nals,such as nodding,shaking the head,neck lateral flexion,and neck circles.Through temporal and frequency domain analysis of denoised motion signals,differentiation among various motion states can be achieved.Overall,this improved analytical approach holds broad application prospects across various types of piezoelectric sensors,such as healthcare monitoring,sports biomechanics.
      原文链接:
    • 万方数据
    • 维普