期刊,中国科学:生命科学（英文版） 2024年卷9期_国家学术搜索

期刊信息/Journal information

中国科学:生命科学（英文版）

主　　编：周光召

出版周期：月刊

国际刊号：1674-7305

电子邮箱：sales@scichina.org

电　　话：010-64019820

邮政编码：100717

地　　址：北京东黄城根北街16号

中国科学:生命科学（英文版）/Journal Science China(Life Sciences)CSCDCSTPCDSCI

查看更多>>《中国科学》是中国科学院主办、中国科学杂志社出版的自然科学专业性学术刊物。《中国科学》任务是反映中国自然科学各学科中的最新科研成果，以促进国内外的学术交流。《中国科学》以论文形式报道中国基础研究和应用研究方面具有创造性的、高水平的和有重要意义的科研成果。在国际学术界，《中国科学》作为代表中国最高水平的学术刊物也受到高度重视。国际上最具有权威的检索刊物SCI，多年来一直收录《中国科学》的论文。1999年《中国科学》夺得国家期刊奖的第一名。

正式出版

收录年代

TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation

Mengjie SunBiying YangGuangwei XinYao Wang...

1957-1969页

查看更多>>摘要：Proper function of the centromeres ensures correct attachment of kinetochores to spindle microtubules and faithful chromosome segre-gation in mitosis.Defects in the integrity and function of centromeres can result in chromosome missegregation and genomic instability.Bub1 is essential for the mitotic centromere dynamics,yet the underlying molecular mechanisms remain largely unclear.Here,we de-monstrate that TIP60 acetylates Bub1 at K424 and K431 on kinetochores in early mitosis.This acetylation increases the kinase activity of Bub1 to phosphorylate centromeric histone H2A at T120(H2ApT120),which recruits Aurora B and Shugoshin 1(Sgo1)to regulate centromere integrity,protect centromeric cohesion,and ensure the subsequent faithful chromosome segregation.Expression of the non-acetylated Bub1 mutant reduces its kinase activity,decreases the level of H2ApT120,and disrupts the recruitment of centromere proteins and chromosome congression,leading to genomic instability of daughter cells.When cells exit mitosis,HDAC1-regulated deacetylation of Bub1 decreases H2ApT120 levels and thereby promotes the departure of centromeric CPC and Sgo1,ensuring timely centromeres dis-assembly.Collectively,our results reveal a molecular mechanism by which the acetylation and deacetylation cycle of Bub1 modulates the phosphorylation of H2A at T120 for recruitment of Aurora B and Sgo1 to the centromeres,ensuring faithful chromosome segregation during mitosis.

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万方数据

LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance,systemic inflammation,and mito-chondrial morphology in a weaned piglet model

Jiayi YuChangbing ZhengQiuping GuoYulong Yin...

1970-1988页

查看更多>>摘要：We previously demonstrated that lipopolysaccharide(LPS)injection-induced immune stress could impair muscle growth in weaned piglets,but the precise mechanisms behind this remain elusive.Here,we found that chronic immune stress induced by LPS resulted in a significant reduction of 36.86％in the total muscle mass of piglets at 5 d post-treatment compared with the control group.At 1 d,prior to muscle mass loss,multiple alterations were noted in response to LPS treatment.These included a reduction in the abundance of Bacteroidetes,an increase in serum concentrations of pro-inflammatory cytokines,compromised mitochondrial morphology,and an upregulation in the expression of dynamin-related protein 1(Drp1),a critical protein involved in mitochondrial fission.We highlight a strong negative correlation between Bacteroidetes abundance and the levels of serum pro-inflammatory cytokines,cor-roborated by in vivo intervention strategies in the musculature of both pig and mouse models.Mechanistically,the effects of Bac-teroidetes on inflammation and muscle mass loss may involve the signaling pathway of the tauro-β-muricholic acid-fibroblast growth factor 15.Furthermore,the induction of overexpression of inflammatory cytokines,achieved without LPS treatment through oral administration of recombinant human IL-6(rhIL-6),led to increased levels of circulating cytokines,subsequently causing a decrease in muscle mass.Notably,pre-treatment with Mdivi-1,an inhibitor of Drp-1,markedly attenuated the LPS-induced elevation in reactive oxygen species levels and rescued the associated decline in muscle mass.Collectively,these data indicate that LPS-induced muscle mass loss was linked to the reduction of Bacteroidetes abundance,increased inflammation,and the disruption of mitochondrial morphology.These insights offer promising avenues for the identification of potential therapeutic targets aimed at mitigating muscle mass loss.

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Unveiling the distinctive traits of functional rye centromeres:minisatellites,retrotransposons,and R-loop formation

Chang LiuShulan FuCongyang YiYang Liu...

1989-2002页

查看更多>>摘要：Centromeres play a vital role in cellular division by facilitating kinetochore assembly and spindle attachments.Despite their conserved functionality,centromeric DNA sequences exhibit rapid evolution,presenting diverse sizes and compositions across species.The functional significance of rye centromeric DNA sequences,particularly in centromere identity,remains unclear.In this study,we comprehensively characterized the sequence composition and organization of rye centromeres.Our findings revealed that these centromeres are primarily composed of long terminal repeat retrotransposons(LTR-RTs)and interspersed minisatellites.We systematically classified LTR-RTs into five categories,highlighting the prevalence of younger CRS1,CRS2,and CRS3 of CRSs(centromeric retrotransposons of Secale cereale)were primarily located in the core centromeres and exhibited a higher association with CENH3 nucleosomes.The minisatellites,mainly derived from retrotransposons,along with CRSs,played a pivotal role in establishing functional centromeres in rye.Additionally,we observed the formation of R-loops at specific regions of CRS1,CRS2,and CRS3,with both rye pericentromeres and centromeres exhibiting enrichment in R-loops.Notably,these R-loops selectively formed at binding regions of the CENH3 nucleosome in rye centromeres,suggesting a potential role in mediating the precise loading of CENH3 to centromeres and contributing to centromere specification.Our work provides insights into the DNA sequence composition,distribution,and potential function of R-loops in rye centromeres.This knowledge contributes valuable information to understanding the genetics and epigenetics of rye centromeres,offering implications for the development of synthetic centromeres in future plant modifications and beyond.

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万方数据

Genomic insights into adaptation to bipedal saltation and desert-like habitats of jerboas

Simin ChaiYujie ChongDaiqing YinQiang Qiu...

2003-2015页

查看更多>>摘要：Jerboas is a lineage of small rodents displaying atypical mouse-like morphology with elongated strong hindlimbs and short forelimbs.They have evolved obligate bipedal saltation and acute senses,and been well-adapted to vast desert-like habitats.Using a newly sequenced chromosome-scale genome of the Mongolian five-toed jerboa(Orientallactaga sibirica),our comparative genomic analyses and in vitro functional assays showed that the genetic innovations in both protein-coding and non-coding regions played an important role in jerboa morphological and physiological adaptation.Jerboa-specific amino acid substitutions,and segment insertions/deletions(indels)in con-served non-coding elements(CNEs)were found in components of proteoglycan biosynthesis pathway(XYLT1 and CHSY1),which plays an important role in limb development.Meanwhile,we found specific evolutionary changes functionally associated with energy or water metabolism(e.g.,specific amino acid substitutions in ND5 and indels in CNEs physically near ROR2)and senses(e.g.,expansion of vo-meronasal receptors and the FAM136A gene family)in jerboas.Further dual-luciferase reporter assay verified that some of the CNEs with jerboa-specific segment indels exerted a significantly different influence on luciferase activity,suggesting changes in their regulatory function in jerboas.Our results revealed the potential molecular mechanisms underlying jerboa adaptation since the divergence from the Eocene-Oligocene transition,and provided more resources and new insights to enhance our understanding of the molecular basis under-lying the phenotypic diversity and the environmental adaptation of mammals.

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万方数据

Global convergence in terrestrial gross primary production response to atmospheric vapor pressure deficit

Chao HuangJingfeng HuangJingfeng XiaoXing Li...

2016-2025页

查看更多>>摘要：Atmospheric vapor pressure deficit(VPD)increases with climate warming and may limit plant growth.However,gross primary production(GPP)responses to VPD remain a mystery,offering a significant source of uncertainty in the estimation of global terrestrial ecosystems carbon dynamics.In this study,in-situ measurements,satellite-derived data,and Earth System Models(ESMs)simulations were analysed to show that the GPP of most ecosystems has a similar threshold in response to VPD:first increasing and then declining.When VPD exceeds these thresholds,atmospheric drought stress reduces soil moisture and stomatal conductance,thereby decreasing the productivity of terrestrial ecosystems.Current ESMs underscore CO2 fertilization effects but predict significant GPP decline in low-latitude ecosystems when VPD exceeds the thresholds.These results emphasize the impacts of climate warming on VPD and propose limitations to future ecosystems productivity caused by increased atmospheric water demand.Incorporating VPD,soil moisture,and canopy conductance in-teractions into ESMs enhances the prediction of terrestrial ecosystem responses to climate change.

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