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中华医学杂志（英文版）
中华医学会
中华医学杂志（英文版）

中华医学会

照日格图

半月刊

0366-6999

renlihua@cma.org.cn

010-85158321

100710

北京市东城区东四西大街42号

中华医学杂志（英文版）/Journal Chinese Medical JournalCSCDCSTPCD北大核心SCI
查看更多>>1887年创刊，中华医学会主办。中华医学杂志英文版(Chinese Medical Journal)是中华医学会会刊，是中国惟一被SCI核心版收录、具有百年以上历史的医学期刊。重点报道我国医学各学科最新进展和高水平科研成果，目前已被《科学引文索引（SCI）》、《医学索引（IM）》、Medline等国际著名检索系统收录。2009年SCI影响因子0.952，SCI被引频次3407。2010年被国际医学期刊编辑委员会（ICMJE）吸收为新成员。多次获得国家期刊奖、科协专项基金、自然基金等奖项和资助。实行全文上网 （），网上投稿审稿()。
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    Genotype-phenotype correlations and treatment innovation of neurofibromatosis type 1(NF1):Current understanding and perspective

    Beiyao ZhuWei WangYihui GuChengjiang Wei...
    1639-1641页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    2023 Chinese national clinical practice guideline on diagnosis and management of ulcerative colitis

    Inflammatory Bowel Disease Group,Chinese Society of Gastroenterology,Chinese Medical AssociationInflammatory Bowel Disease Quality Control Center of ChinaKaichun WuMinhu Chen...
    1642-1646页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    2023 Chinese national clinical practice guideline on diagnosis and management of Crohn's disease

    Inflammatory Bowel Disease Group,Chinese Society of Gastroenterology,Chinese Medical AssociationInflammatory Bowel Disease Quality Control Center of ChinaMinhu ChenKaichun Wu...
    1647-1650页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Iron metabolism and arthritis:Exploring connections and therapeutic avenues

    Dachun ZhuoWenze XiaoYulong TangShuai Jiang...
    1651-1662页
    查看更多>>摘要：Iron is indispensable for the viablility of nearly all living organisms,and it is imperative for cells,tissues,and organisms to acquire this essential metal sufficiently and maintain its metabolic stability for survival.Disruption of iron homeostasis can lead to the development of various diseases.There is a robust connection between iron metabolism and infection,immunity,inflammation,and aging,suggesting that disorders in iron metabolism may contribute to the pathogenesis of arthritis.Numerous studies have focused on the significant role of iron metabolism in the development of arthritis and its potential for targeted drug therapy.Targeting iron metabolism offers a promising approach for individualized treatment of arthritis.Therefore,this review aimed to investigate the mechanisms by which the body maintains iron metabolism and the impacts of iron and iron metabolism disorders on arthritis.Furthermore,this review aimed to identify potential therapeutic targets and active substances related to iron metabolism,which could provide promising research directions in this field.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Role of triggering receptor expressed on myeloid cells-1 in kidney diseases:A biomarker and potential therapeutic target

    Yuxi FanYe XuZhi HuoHedong Zhang...
    1663-1673页
    查看更多>>摘要：Triggering receptor expressed on myeloid cells-1(TREM-1)is a member of the immunoglobulin superfamily.As an amplifier of the inflammatory response,TREM-1 is mainly involved in the production of inflammatory mediators and the regulation of cell survival.TREM-1 has been studied in infectious diseases and more recently in non-infectious disorders.More and more studies have shown that TREM-1 plays an important pathogenic role in kidney diseases.There is evidence that TREM-1 can not only be used as a biomarker for diagnosis of disease but also as a potential therapeutic target to guide the development of novel therapeutic agents for kidney disease.This review summarized molecular biology of TREM-1 and its signaling pathways as well as immune response in the progress of acute kidney injury,renal fibrosis,diabetic nephropathy,immune nephropathy,and renal cell carcinoma.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Gallbladder polypoid lesions:Current practices and future prospects

    Kun WangQingpeng XuLu XiaJianing Sun...
    1674-1683页
    查看更多>>摘要：Gallbladder polypoid lesions(GPLs)refer to any elevated lesion of the mucosal surface of the gallbladder wall,and the prevalence is estimated to be between 0.9％and 12.1％.GPLs include benign polyps and malignant polyps.Benign polyps are further classified as non-neoplastic polyps and neoplastic polyps.Cholesterol polyps are the most common benign polyps and adenocarcinoma is the main type of malignant polyp.Hepatitis B virus infection,liver function abnormalities,dyslipidemia,and obesity are the main risk factors for GPLs.Studies of biological mechanisms have focused on malignant gallbladder polyps,the development of which is regulated by hormone levels in vivo,gut microbiota,inflammation,oxidative stress,Salmonella typhimurium,and related molecules.Diagnostic modalities include chemical examination and imaging examination,with imaging examination currently being the mainstay.Treatment of patients with GPLs is based on the presence or absence of symptoms,age,size of the polyps,tendency of the polyp to increase,and risk factors for symptomatic malignancy to determine whether surgery should be performed.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    A systematic review of the role of TREM2 in Alzheimer's disease

    Yunsi YinHanchen YangRuiyang LiGuangshan Wu...
    1684-1694页
    查看更多>>摘要：Background:Given the established genetic linkage between triggering receptors expressed on myeloid cells 2(TREM2)and Alzheimer's disease(AD),an expanding research body has delved into the intricate role of TREM2 within the AD context.However,a conflicting landscape of outcomes has emerged from both in vivo and in vitro investigations.This study aimed to elucidate the multifaceted nuances and gain a clearer comprehension of the role of TREM2.Methods:PubMed database was searched spanning from its inception to January 2022.The search criteria took the form of("Alzheimer's disease"OR"AD")AND("transgenic mice model"OR"transgenic mouse model")AND("Triggering receptor expressed on myeloid cells"OR"TREM2").Inclusion criteria consisted of the following:(1)publication of original studies in English;(2)utilization of transgenic mouse models for AD research;and(3)reports addressing the subject of TREM2.Results:A total of 43 eligible articles were identified.Our analysis addresses four pivotal queries concerning the interrelation of TREM2 with microglial function,Aβ accumulation,tau pathology,and inflammatory processes.However,the diverse inquiries posed yielded inconsistent responses.Nevertheless,the inconsistent roles of TREM2 within these AD mouse models potentially hinge upon factors such as age,sex,brain region,model type,and detection methodologies.Conclusions:This review substantiates the evolving understanding of TREM2's disease progression-dependent impacts.Further-more,it reviews the interplay between TREM2 and its effects across diverse tissues and temporal stages.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Portable spirometer-based pulmonary function test willingness in China:A nationwide cross-sectional study from the"Happy Breathing Program"

    Weiran QiKe HuangQiushi ChenLirui Jiao...
    1695-1704页
    查看更多>>摘要：Background:Understanding willingness to undergo pulmonary function tests(PFTs)and the factors associated with poor uptake of PFTs is crucial for improving early detection and treatment of chronic obstructive pulmonary disease(COPD).This study aimed to understand willingness to undergo PFTs among high-risk populations and identify any barriers that may contribute to low uptake of PFTs.Methods:We collected data from participants in the"Happy Breathing Program"in China.Participants who did not follow physicians'recommendations to undergo PFTs were invited to complete a survey regarding their willingness to undergo PFTs and their reasons for not undergoing PFTs.We estimated the proportion of participants who were willing to undergo PFTs and exam-ined the various reasons for participants to not undergo PFTs.We conducted univariable and multivariable logistic regressions to analyze the impact of individual-level factors on willingness to undergo PFTs.Results:A total of 8475 participants who had completed the survey on willingness to undergo PFTs were included in this study.Out of these participants,7660(90.4％)were willing to undergo PFTs.Among those who were willing to undergo PFTs but actually did not,the main reasons for not doing so were geographical inaccessibility(n=3304,43.1％)and a lack of trust in primary healthcare institutions(n=2809,36.7％).Among the 815 participants who were unwilling to undergo PFTs,over half(n=447,54.8％)believed that they did not have health problems and would only consider PFTs when they felt unwell.In the multivariable regression,individuals who were ≤54 years old,residing in rural townships,with a secondary educational level,with medical reimbursement,still working,with occupational exposure to dust,and aware of the abbreviation"COPD"were more willing to undergo PFTs.Conclusions:Willingness to undergo PFTs was high among high-risk populations.Policymakers may consider implementing strategies such as providing financial incentives,promoting education,and establishing community-based programs to enhance the utilization of PFTs.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Non-alcoholic fatty liver degree and long-term risk of incident inflammatory bowel disease:A large-scale prospective cohort study

    Qian ZhangSi LiuJing WuShengtao Zhu...
    1705-1714页
    查看更多>>摘要：Background:Non-alcoholic fatty liver disease(NAFLD)and inflammatory bowel disease(IBD)have shown similar worsening epidemic patterns globally and shared various overlapping pathophysiological mechanisms.However,evidence on the relationship between NAFLD and IBD risk is lacking.We aimed to investigate the associations between long-term risk of incident IBD and NAFLD in a large prospective cohort.Methods:Participants from the United Kingdom Biobank cohort(https://biobank.ndph.ox.ac.uk/)who were free of IBD and alcoholic liver disease at baseline were enrolled.Baseline non-alcoholic fatty liver degree was measured by the well-established fatty liver index(FLI).The outcomes of interest included incident IBD,ulcerative colitis(UC),and Crohn's disease(CD).Multivariable Cox proportional hazard regression was used to calculate hazard ratios(HRs)and 95％confidence intervals(CIs).Results:Among 418,721 participants(mean FLI:48.11±30.11),160,807(38.40％)participants were diagnosed as NAFLD at baseline.During a median of 12.4 years'follow-up,2346 incident IBD cases(1545 UC,653 CD,and 148 IBD-unclassified)were identified.Due to limited events,those IBD-unclassified were combined in UC or CD when examining the associated risk of UC or CD,separately.Compared with the lowest quartile of FLI,the highest quartile showed a separately 36.00％,25.00％,and 58.00％higher risk of incident IBD(HRQ4 vs.Q1=1.36,95％CI:1.19-1.55,P trend＜0.001),UC(HR Q4 vs.Q1=1.25,95％CI:1.07-1.46,P trend=0.047),and CD(HR Q4 vs Q1=1.58,95％CI:1.26-1.97,P trend＜0.001)after multivariable adjustment.Q1=1.58,95％CI:1.26-1.97,P trend＜0.001)after multivariable adjustment.Compared with non-NAFLD,NAFLD participants had a significantly higher risk of incident IBD(HR=1.13,95％CI:1.04-1.24)and CD(HR=1.36,95％CI:1.17-1.58).Conclusions:Higher degree of non-alcoholic fatty liver is associated with increased risk of incident IBD.Interventions aimed at improving NAFLD may be a potential targeted strategy for the detection and treatment of IBD.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Precise capture of circulating endometrial cells in endometriosis

    Shang WangHongyan ChengHonglan ZhuXiaoming Yu...
    1715-1723页
    查看更多>>摘要：Background:Endometriosis(EM)is a complex benign gynecological disease,but it has malignant biological behavior and can invade any part of the body.Clinical manifestations include pelvic pain,dysmenorrhea,infertility,pelvic nodules,and masses.Our previous study successfully detected circulating endometrial cells(CECs)in the peripheral blood of patients with EM.The purpose of this study is to overcome the limitation of cell size in the previous microfluidic chip method,to further accurately capture CECs,understand the characteristics of these cells,and explore the relationship between CECs and the clinical course characteristics of patients with EM.Methods:Human peripheral venous blood used to detect CECs and circulating vascular endothelial cells(CVECs)was taken from EM patients(n=34)hospitalized in the Peking University People's Hospital.We used the subtraction enrichment and immunostaining fluorescence in situ hybridization(SE-iFISH)method to exclude the interference of red blood cells,white blood cells,and CVECs,so as to accurately capture the CECs in the peripheral blood of patients with EM.Then we clarified the size and ploidy number of chromosome 8 of CECs,and a second grouping of patients was performed based on clinical characteristics to determine the relationship between CECs and clinical course characteristics.Results:The peripheral blood of 34 EM patients and 12 non-EM patients was evaluated by SE-iFISH.Overall,34 eligible EM patients were enrolled.The results showed that the detection rates of CECs were 58.8％in EM patients and 16.7％in the control group.However,after classification according to clinical characteristics,more CECs could be detected in the peripheral blood of patients with rapidly progressive EM,with a detection rate of 94.4％(17/18).In total,63.5％(40/63)of these cells were small cells with diameters below 5 μm,and 44.4％(28/63)were aneuploid cells.No significant association was found between the number of CECs and EM stage.Conclusion:The number and characteristics of CECs are related to the clinical course characteristics of patients with EM,such as pain and changes in lesion size,and may be used as biomarkers for personalized treatment and management of EM in the future.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据