首页期刊导航|中华医学杂志（英文版）
期刊信息/Journal information
中华医学杂志（英文版）
中华医学会
中华医学杂志（英文版）

中华医学会

照日格图

半月刊

0366-6999

renlihua@cma.org.cn

010-85158321

100710

北京市东城区东四西大街42号

中华医学杂志（英文版）/Journal Chinese Medical JournalCSCDCSTPCD北大核心SCI
查看更多>>1887年创刊，中华医学会主办。中华医学杂志英文版(Chinese Medical Journal)是中华医学会会刊，是中国惟一被SCI核心版收录、具有百年以上历史的医学期刊。重点报道我国医学各学科最新进展和高水平科研成果，目前已被《科学引文索引（SCI）》、《医学索引（IM）》、Medline等国际著名检索系统收录。2009年SCI影响因子0.952，SCI被引频次3407。2010年被国际医学期刊编辑委员会（ICMJE）吸收为新成员。多次获得国家期刊奖、科协专项基金、自然基金等奖项和资助。实行全文上网 （），网上投稿审稿()。
正式出版
收录年代

    Changing the 3-decade routine of preoperative radiotherapy for locally advanced rectal cancer:New wine for new bottle?

    Ruoxu DouJianwei ZhangJianping WangYanhong Deng...
    1891-1893页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Regulation of fatty acid synthase on tumor and progress in the development of related therapies

    Rilan BaiJiuwei Cui
    1894-1902页
    查看更多>>摘要：Fatty acid synthase(FASN)is an essential molecule in lipid metabolic pathways,which are crucial for cancer-related studies.Recent studies have focused on a comprehensive understanding of the novel and important regulatory effects of FASN on malignant biological behavior and immune-cell infiltration,which are closely related to tumor occurrence and development,immune escape,and immune response.FASN-targeting antitumor treatment strategies are being developed.Therefore,in this review,we focused on the effects of FASN on tumor and immune-cell infiltration and reviewed the progress of related anti-tumor therapy development.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Health outcomes of electronic cigarettes

    Xinmeng LiLingzhi YuanFen Wang
    1903-1911页
    查看更多>>摘要：The usage of electronic cigarettes(e-cigarettes)sparked an outbreak of unidentified vaping-related lung disease in the US during late 2019.With e-cigarettes becoming more and more popular,smokers have more options other than conventional cigarettes.Under these circumstances,a comprehensive evaluation of the general safety of new tobacco and tobacco-related products,represented by e-cigarettes,to human health is necessary.In this review,we summarize the current research on potential negative impacts of e-cigarette exposure on human health.In particular,studies detailing the relationship between e-cigarettes and the digestive system are summarized,with mechanisms mainly including hepatic metabolic dysfunction,impaired gut barrier,and worsened outcomes of inflammatory bowel disease(IBD).Although believed to be safer than traditional cigarettes,e-cigarettes exert adverse effects on systemic health and induce the development of multiple diseases including asthma,cardiovascular disease,and IBD.Moreover,nicotine-containing e-cigarettes have a negative impact on the childhood development and increase the risk of arterial stiffness compared to the non-nicotine e-cigarettes.However,non-nicotine e-cigarette components have detrimental effects including promoting liver damage and metabolic disorders.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Bioinformatic approaches of liquid-liquid phase separation in human disease

    Jun SunYilong ChenRuiye BiYong Yuan...
    1912-1925页
    查看更多>>摘要：Biomolecular aggregation within cellular environments via liquid-liquid phase separation(LLPS)spontaneously forms drop-let-like structures,which play pivotal roles in diverse biological processes.These structures are closely associated with a range of diseases,including neurodegenerative disorders,cancer and infectious diseases,highlighting the significance of understanding LLPS mechanisms for elucidating disease pathogenesis,and exploring potential therapeutic interventions.In this review,we delineate recent advancements in LLPS research,emphasizing its pathological relevance,therapeutic considerations,and the pivotal role of bioinformatic tools and databases in facilitating LLPS investigations.Additionally,we undertook a comprehensive analysis of bioinformatic resources dedicated to LLPS research in order to elucidate their functionality and applicability.By providing comprehensive insights into current LLPS-related bioinformatics resources,this review highlights its implications for human health and disease.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Antibiotic resistance in Helicobacter pylori among children and adolescents in East Asia:A systematic review and meta-analysis

    Yuhang ZhouYanli ZhangShiyu Du
    1926-1938页
    查看更多>>摘要：Background:In East Asia,Helicobacter pylori(H.pylori)infection and related diseases are common,primarily during childhood and adolescence.The rates of primary antibiotic resistance in H.pylori among East Asian children and adolescents have not been extensively explored;few relevant systematic reviews or meta-analyses have been conducted.We evaluated the rates of antibiotic resistance in H.pylori among East Asian children and adolescents,with the goal of facilitating individualized treatment recommendations.Methods:We searched PubMed,Embase,and the Cochrane Library for studies in any language published up to February 2023 that explored antibiotic resistance in H.pylori among East Asian children and adolescents.We used MeSH and non-MeSH terms related to the topic,including terms related to children,adolescents,antibiotic resistance,H.pylori,and nations or regions.Additionally,we reviewed the reference lists of relevant articles.Studies that matched our strict predefined eligibility criteria were included in the screening process.Using established assessment methods,we evaluated the quality of the included studies.Results:We identified 15 observational studies involving 4831 H.pylori isolates,all published between 2001 and 2022.There was substantial primary antibiotic resistance in H.pylori isolates from East Asian children and adolescents.The rates of primary resistance were 51％(95％confidence interval[CI]:40-62％)for metronidazole;37％(95％CI:20-53％)for clarithromycin;19％(95％CI:11-28％)for levofloxacin;and less than 3％each for amoxicillin,tetracycline,and furazolidone.Subgroup analysis revealed a prominent increase in metronidazole resistance over time.Clarithromycin and levofloxacin resistance rates fluctuated between 2005 and 2015,then remained stable;other antibiotic resistance rates were generally stable.Metronidazole,clarithromycin,and levofloxacin resistance rates were significantly higher in the Chinese mainland than in other East Asian regions.The rates of dual and multiple antibiotic resistance were 28％(95％CI:21-36％)and 10％(95％CI:7-14％),highlighting the potential for diverse resistance patterns.Conclusions:H.pylori isolates from East Asian children and adolescents exhibit high levels of metronidazole and clarithromycin resistance,particularly in the Chinese mainland.The non-negligible rates of dual and multiple resistance highlight the complexity of this problem.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Artificial intelligence system for outcome evaluations of human in vitro fertilization-derived embryos

    Ling SunJiahui LiSimiao ZengQiangxiang Luo...
    1939-1949页
    查看更多>>摘要：Background:In vitro fertilization(IVF)has emerged as a transformative solution for infertility.However,achieving favorable live-birth outcomes remains challenging.Current clinical IVF practices in IVF involve the collection of heterogeneous embryo data through diverse methods,including static images and temporal videos.However,traditional embryo selection methods,primarily reliant on visual inspection of morphology,exhibit variability and are contingent on the experience of practitioners.Therefore,an automated system that can evaluate heterogeneous embryo data to predict the final outcomes of live births is highly desirable.Methods:We employed artificial intelligence(AI)for embryo morphological grading,blastocyst embryo selection,aneuploidy prediction,and final live-birth outcome prediction.We developed and validated the AI models using multitask learning for embryo morphological assessment,including pronucleus type on day 1 and the number of blastomeres,asymmetry,and fragmentation of blastomeres on day 3,using 19,201 embryo photographs from 8271 patients.A neural network was trained on embryo and clin-ical metadata to identify good-quality embryos for implantation on day 3 or day 5,and predict live-birth outcomes.Additionally,a 3D convolutional neural network was trained on 418 time-lapse videos of preimplantation genetic testing(PGT)-based ploidy outcomes for the prediction of aneuploidy and consequent live-birth outcomes.Results:These two approaches enabled us to automatically assess the implantation potential.By combining embryo and maternal metrics in an ensemble AI model,we evaluated live-birth outcomes in a prospective cohort that achieved higher accuracy than experienced embryologists(46.1％vs.30.7％on day 3,55.0％vs.40.7％on day 5).Our results demonstrate the potential for AI-based selection of embryos based on characteristics beyond the observational abilities of human clinicians(area under the curve:0.769,95％confidence interval:0.709-0.820).These findings could potentially provide a noninvasive,high-throughput,and low-cost screening tool to facilitate embryo selection and achieve better outcomes.Conclusions:Our study underscores the AI model's ability to provide interpretable evidence for clinicians in assisted reproduc-tion,highlighting its potential as a noninvasive,efficient,and cost-effective tool for improved embryo selection and enhanced IVF outcomes.The convergence of cutting-edge technology and reproductive medicine has opened new avenues for addressing infertility challenges and optimizing IVF success rates.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Reducing language barriers,promoting information absorption,and communication using fanyi

    Difei WangGuannan ChenLin LiShaodi Wen...
    1950-1956页
    查看更多>>摘要：Interpreting genes of interest is essential for identifying molecular mechanisms,but acquiring such information typically involves tedious manual retrieval.To streamline this process,the fanyi package offers tools to retrieve gene information from sources like National Center for Biotechnology Information(NCBI),significantly enhancing accessibility.Additionally,understanding the latest research advancements and sharing achievements are crucial for junior researchers.However,language barriers often restrict knowledge absorption and career development.To address these challenges,we developed the fanyi package,which leverages artificial intelligence(AI)-driven online translation services to accurately translate among multiple languages.This dual functionality allows researchers to quickly capture and comprehend information,promotes a multilingual environment,and fosters innovation in academic community.Meanwhile,the translation functions are versatile and applicable beyond biomedicine research to other domains as well.The fanyi package is freely available at https://github.com/YuLab-SMU/fanyi.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Burden of six major types of digestive system cancers globally and in China

    Yueyang ZhouKai SongYuqing ChenYuelun Zhang...
    1957-1964页
    查看更多>>摘要：Background:Digestive system cancers constitute a significant number of cancer cases,but their burden is not uniform.As Global Cancer Observatory(GLOBOCAN)2022 has recently updated its estimates of cancer burden,we aimed to investigate the burden of six major digestive system cancers both worldwide and in China,along with geographical and temporal variations in cancer-specific incidence and mortality.Methods:We extracted data on primary cancers of the esophagus,stomach,colorectum,liver,pancreas,and gallbladder from the GLOBOCAN database for 2022.Age-standardized incidence and mortality rates were calculated and stratified by sex,country,region,and human development index(HDI).We used the 2022 revision of the World Population Prospects(United Nations)to obtain demographic data for various age groups in China from 1988 to 2012 and used the joinpoint model and the average annual percentage change(AAPC)to analyze cancer incidence trends in China.Results:In 2022,the estimated global incidence of digestive system cancers reached 4,905,882,with an estimated 3,324,774 cancer-related deaths.Colorectal cancer was most prevalent in terms of incidence and mortality.There was a significant correlation between the burden of gastrointestinal cancers and country HDI.From 1988 to 2012,the incidence of esophageal,gastric,and liver cancers declined in China,whereas colorectal and pancreatic cancer incidences continued to increase.By 2050,colorectal and liver cancers are projected to remain the leading cancer types in China in terms of incidence and mortality,respectively.Conclusions:Digestive system cancers remain a significant public health challenge globally and in China.Although progress has been made in the prevention and control of some cancers,the burden of digestive system cancers persists.The implementation of tertiary prevention strategies must be intensified to reduce the incidence and mortality of digestive system cancers,mitigating their impact on public health.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Association between coronary artery stenosis and myocardial injury in patients with acute pulmonary embolism:A case-control study

    Yinjian YangChao LiuJieling MaXijie Zhu...
    1965-1972页
    查看更多>>摘要：Background:The potential impact of pre-existing coronary artery stenosis(CAS)on acute pulmonary embolism(PE)episodes remains underexplored.This study aimed to investigate the association between pre-existing CAS and the elevation of high-sensi-tivity cardiac troponin Ⅰ(hs-cTnⅠ)levels in patients with PE.Methods:In this multicenter,prospective case-control study,88 cases and 163 controls matched for age,sex,and study center were enrolled.Cases were patients with PE with elevated hs-cTnⅠ.Controls were patients with PE with normal hs-cTnⅠ.Coronary artery assessment utilized coronary computed tomographic angiography or invasive coronary angiography.CAS was defined as≥50％stenosis of the lumen diameter in any coronary vessel＞2.0 mm in diameter.Conditional logistic regression was used to evaluate the association between CAS and hs-cTnⅠ elevation.Results:The percentage of CAS was higher in the case group compared to the control group(44.3％[39/88]vs.30.1％[49/163];P=0.024).In multivariable conditional logistic regression model 1,CAS(adjusted odds ratio[OR],2.680;95％confidence interval[CI],1.243-5.779),heart rate＞75 beats/min(OR,2.306;95％CI,1.056-5.036)and N-terminal pro-B type natriuretic peptide(NT-proBNP)＞420 pg/mL(OR,12.169;95％CI,4.792-30.900)were independently associated with elevated hs-cTnI.In model 2,right CAS(OR,3.615;95％CI,1.467-8.909)and NT-proBNP＞420 pg/mL(OR,13.890;95％CI,5.288-36.484)were independently associated with elevated hs-cTnⅠ.Conclusions:CAS was independently associated with myocardial injury in patients with PE.Vigilance towards CAS is warranted in patients with PE with elevated cardiac troponin levels.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    An E2F7/TSC1-based model for predicting the efficacy of sirolimus after liver transplantation for hepatocellular carcinoma beyond the Milan criteria

    Lincheng ZhangWei ZhouShusen ZhengSunbin Ling...
    1973-1975页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据