期刊,中华医学杂志（英文版） 2024年卷2期_国家学术搜索

期刊信息/Journal information

中华医学杂志（英文版）

中华医学会

主办单位：中华医学会

主　　编：照日格图

出版周期：半月刊

国际刊号：0366-6999

电子邮箱：renlihua@cma.org.cn

电　　话：010-85158321

邮政编码：100710

地　　址：北京市东城区东四西大街42号

中华医学杂志（英文版）/Journal Chinese Medical JournalCSCDCSTPCD北大核心SCI

查看更多>>1887年创刊，中华医学会主办。中华医学杂志英文版(Chinese Medical Journal)是中华医学会会刊，是中国惟一被SCI核心版收录、具有百年以上历史的医学期刊。重点报道我国医学各学科最新进展和高水平科研成果，目前已被《科学引文索引（SCI）》、《医学索引（IM）》、Medline等国际著名检索系统收录。2009年SCI影响因子0.952，SCI被引频次3407。2010年被国际医学期刊编辑委员会（ICMJE）吸收为新成员。多次获得国家期刊奖、科协专项基金、自然基金等奖项和资助。实行全文上网（），网上投稿审稿()。

正式出版

收录年代

Chinese consensus on the diagnosis and treatment of immunoglobulin light-chain cardiac amyloidosis

Kaini ShenZhuang TianYajuan GaoYining Wang...

127-129页

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Molecular classification of small cell lung cancer subtypes:Characteristics,prognostic factors,and clinical translation

Hanfei GuoWenqian LiYe GuoNaifei Chen...

130-139页

查看更多>>摘要：Small cell lung cancer(SCLC)is a highly malignant tumor with a very poor prognosis;therefore,more effective treatments are urgently needed for patients afflicted with the disease.In recent years,emerging molecular classifications based on key transcription factors of SCLC have provided more information on the tumor pathophysiology,metastasis,immune microenvironment,and acquired therapeutic resistance and reflected the intertumoral heterogeneity of the various SCLC phenotypes.Additionally,advances in genomics and single-cell sequencing analysis have further revealed the high intratumoral heterogeneity and plasticity of the disease.Herein,we review and summarize these recent lines of evidence and discuss the possible pathogenesis of SCLC.

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Current assessment and management of measurable residual disease in patients with acute lymphoblastic leukemia in the setting of CAR-T-cell therapy

Minghao LinXiaosu ZhaoYingjun ChangXiangyu Zhao...

140-151页

查看更多>>摘要：Chimeric antigen receptor(CAR)-modified T-cell therapy has achieved remarkable success in the treatment of acute lymphoblastic leukemia(ALL).Measurable/minimal residual disease(MRD)monitoring plays a significant role in the prognostication and management of patients undergoing CAR-T-cell therapy.Common MRD detection methods include flow cytometry(FCM),polymerase chain reaction(PCR),and next-generation sequencing(NGS),and each method has advantages and limitations.It has been well documented that MRD positivity predicts a poor prognosis and even disease relapse.Thus,how to perform prognostic evaluations,stratify risk based on MRD status,and apply MRD monitoring to guide individual therapeutic decisions have important implications in clinical practice.This review assesses the common and novel MRD assessment methods.In addition,we emphasize the critical role of MRD as a prognostic biomarker and summarize the latest studies regarding MRD-directed combination therapy with CAR-T-cell therapy and allogeneic hematopoietic stem cell transplantation(allo-HSCT),as well as other therapeutic strategies to improve treatment effect.Furthermore,this review discusses current challenges and strategies for MRD detection in the setting of disease relapse after targeted therapy.

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Prognostic and clinical value of circPRKCI expression in diverse human cancers

Zhongyue LiuXiaolei RenZhimin YangLin Mei...

152-161页

查看更多>>摘要：Background:Highly expressed in various human cancers,circular RNA Protein Kinase C Iota(circPRKCI)has been reported to play an important role in cancer development and progression.Herein,we sought to reveal the prognostic and clinical value of circPRKCI expression in diverse human cancers.Methods:We searched the Pubmed,Web of Science,and the Cochrane Library databases from inception until May 16,2021.The relationship between circPRKCI expression and cancer patients'survival,including overall survival(OS)and disease-free survival(DFS),was assessed by pooled hazard ratios(HR)with corresponding 95％confidence interval(CI).The correlation between circPRKCI expression and clinical outcomes was evaluated using odds ratios(OR)with corresponding 95％CI.The data were analyzed by STATA software(version 12.0)or Review Manager(RevMan 5.3).Results:A total of 15 studies with 1109 patients were incorporated into our meta-analysis.The results demonstrated that high circPRKCI expression was significantly related to poor OS(HR=1.96,95％CI:1.61,2.39,P＜0.001)when compared with low circPRKCI expression in diverse human cancers.However,elevated circPRKCI expression was not associated with DFS(HR=1.34,95％CI:0.93,1.95,P=0.121).Furthermore,the patient with a higher circPRKCI expression was prone to have a larger tumor size,advanced clinical stage,and lymph node metastasis,but it was not significantly correlated with age,gender,and distant metastasis.Conclusion:Elevated circPRKCI expression was correlated with worse OS and unfavorable clinical features,suggesting a novel prognostic and predictive role of circPRKCI in diverse human cancers.

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Alterations in nasal microbiota of patients with amyotrophic lateral sclerosis

Kaixiong LiuQifu GuoYing DingLi Luo...

162-171页

查看更多>>摘要：Background:Links between alterations in gut microbiota composition and amyotrophic lateral sclerosis(ALS)have previously been reported.This study aimed to examine the microbiota in the nasal cavity of ALS.Methods:Sixty-six ALS patients and 40 healthy caregivers who live in close proximity with patients were enrolled.High throughput metagenomic sequencing of the 16S ribosomal deoxyribonucleic acid(rDNA)gene V3-V4 region of nasal microbiota was used to characterize the alpha and beta diversity and relative abundance of bacterial taxa,predict function,and conduct correlation analysis between specific taxa and clinical features.Results:The nasal microbiome of ALS patients showed lower alpha diversity than that of corresponding healthy family members.Genera Gaiella,Sphingomonas,Polaribacter_1,Lachnospiraceae_NK4A136_group,Klebsiella,and Alistipes were differentially enriched in ALS patients compared to controls.Nasal microbiota composition in ALS patients significantly differed from that in healthy subjects(unweighted UniFrac P=0.001),while Linear discriminant analysis Effect Size(LEfSe)analysis indicated that Bacteroidetes and Firmicutes dominated healthy nasal communities at the phylum level,whereas Actinobacteria was the predominant phylum and Thermoleophilia was the predominant class in ALS patients.Genus Faecalibacterium and Alistipes were positively correlated with ALS functional rating scale revised(ALSFRS-R;rs=0.349,P=0.020 and rs=0.393,P=0.008),while Prevotella-9 and Bacteroides operational taxonomic units(OTUs)were positively associated with lung function(FVC)in ALS patients(rs=0.304,P=0.045,and rs=0.300,P=0.048,respectively).Prevotella-1 was positively correlated with white blood cell counts(WBC,rs=0.347,P=0.021),neutrophil percentage(Neu％,rs=0.428,P=0.004),and neutrophil-to-lymphocyte ratio(NLR,rs=0.411,P=0.006),but negatively correlated with lymphocyte percentage(Lym％,rs=-0.408,P=0.006).In contrast,Streptococcus was negatively associated with Neu％(rs=-0.445,P=0.003)and NLR(rs=-0.436,P=0.003),while positively associated with Lym％(rs=0.437,P=0.003).No significant differences in nasal microbiota richness and evenness were detected among the severe and mild ALS patients.Conclusions:ALS is accompanied by altered nasal microbial community composition and diversity.The findings presented here highlight the need to understand how dysbiosis of nasal microbiota may contribute to the development of ALS.

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Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation

Jing LinDeyong LongChenxi JiangCaihua Sang...

172-180页

查看更多>>摘要：Background:Oral anti-coagulants(OAC)are the intervention for the prevention of stroke,which consistently improve clinical outcomes and survival among patients with atrial fibrillation(AF).The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in China.Methods:Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation(CCC-AF)registry,guide-line-recommended OAC use in eligible patients was assessed.Results:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low risk.On admission,only 20.0％(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking OAC.The use of pre-hospital OAC on admission was associated with a lower risk of new-onset ischemic stroke/transient ischemic attack among the diagnosed AF population(adjusted odds ratio:0.54,95％confidence interval:0.43-0.68;P＜0.001).At discharge,the prescription rate of OAC was 45.2％(16,757/37,087)in eligible patients with high stroke risk and 60.7％(2778/4578)in eligible patients with low stroke risk.OAC utilization in patients with high stroke risk on admission or at discharge both increased largely over time(all P＜0.001).Multivariate analysis showed that OAC utilization at discharge was positively associated with in-hospital rhythm control strategies,including catheter ablation(adjusted odds ratio[OR]11.63,95％confidence interval[CI]10.04-13.47;P＜0.001),electronic cardioversion(adjusted OR 2.41,95％CI 1.65-3.51;P＜0.001),and anti-arrhythmic drug use(adjusted OR 1.45,95％CI 1.38-1.53;P＜0.001).Conclusions:In hospitals participated in the CCC-AF project,＞70％of AF patients were at a high risk of stroke.Although poor performance on guideline-recommended OAC use was found in this study,over time the CCC-AF project has made progress in stroke prevention in the Chinese AF population.

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Corrigendum:Role of glutamine in the mediation of E-cadherin,p120-catenin and inflammation in ventilator-induced lung injury

180页

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Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis

Fangming LiuYuting WuBaohui ZhangShuhui Yang...

181-189页

查看更多>>摘要：Background:Liver cancer is largely resistant to chemotherapy.This study aimed to identify the effective chemotherapeutics for p-catenin-activated liver cancer which is caused by gain-of-function mutation of catenin beta 1(CTNNB1),the most frequently altered proto-oncogene in hepatic neoplasms.Methods:Constitutive p-catenin-activated mouse embryonic fibroblasts(MEFs)were established by deleting exon 3(β-catenin△(ex3)/+),the most common mutation site in CTNNB1 gene.A screening of 12 widely used chemotherapy drugs was conducted for the ones that selectively inhibited β-catenin△(ex3)/+but not for wild-type MEFs.Untargeted metabolomics was carried out to examine the alterations of metabolites in nucleotide synthesis.The efficacy and selectivity of methotrexate(MTX)on p-catenin-activated human liver cancer cells were determined in vitro.Immuno-deficient nude mice subcutaneously inoculated with p-catenin wild-type or mutant liver cancer cells and hepatitis B virus(HBV);β-cateninlox(ex3)/+mice were used,respectively,to evaluate the efficacy of MTX in the treatment of p-catenin mutant liver cancer.Results:MTX was identified and validated as a preferential agent against the proliferation and tumor formation of p-catenin-activated cells.Boosted nucleotide synthesis was the major metabolic aberration in β-catenin-active cells,and this alteration was also the target of MTX.Moreover,MTX abrogated hepatocarcinogenesis of HBV;β-cateninlox(ex3)+mice,which stimulated concurrent Ctnnb1-activated mutation and HBV infection in liver cancer.Conclusion:MTX is a promising chemotherapeutic agent for p-catenin hyperactive liver cancer.Since repurposing MTX has the advantages of lower risk,shorter timelines,and less investment in drug discovery and development,a clinical trial is warranted to test its efficacy in the treatment of p-catenin mutant liver cancer.

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LONP1 ameliorates liver injury and improves gluconeogenesis dysfunction in acute-on-chronic liver failure

Muchen WuJing WuKai LiuMinjie Jiang...

190-199页

查看更多>>摘要：Background:Acute-on-chronic liver failure(ACLF)is a severe liver disease with complex pathogenesis.Clinical hypoglycemia is common in patients with ACLF and often predicts a worse prognosis.Accumulating evidence suggests that glucose metabolic disturbance,especially gluconeogenesis dysfunction,plays a critical role in the disease progression of ACLF.Lon protease-1(LONP1)is a novel mediator of energy and glucose metabolism.However,whether gluconeogenesis is a potential mechanism through which LONP1 modulates ACLF remains unknown.Methods:In this study,we collected liver tissues from ACLF patients,established an ACLF mouse model with carbon tetrachloride(CCl4),lipopolysaccharide(LPS),and D-galactose(D-gal),and constructed an in vitro hypoxia and hyperammonemia-triggered hepatocyte injury model.LONP1 overexpression and knockdown adenovirus were used to assess the protective effect of LONP1 on liver injury and gluconeogenesis regulation.Liver histopathology,biochemical index,mitochondrial morphology,cell viability and apoptosis,and the expression and activity of key gluconeogenic enzymes were detected to explore the underlying protective mechanisms of LONP1 in ACLF.Results:We found that LONP1 and the expressions of gluconeogenic enzymes were downregulated in clinical ACLF liver tissues.Furthermore,LONP1 overexpression remarkably attenuated liver injury,which was characterized by improved liver histo-pathological lesions and decreased serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in ACLF mice.Moreover,mitochondrial morphology was improved upon overexpression of LONP1.Meanwhile,the expression and activity of the key gluconeogenic enzymes were restored by LONP1 overexpression.Similarly,the hepatoprotective effect was also observed in the hepatocyte injury model,as evidenced by improved cell viability,reduced cell apoptosis,and improved gluconeogenesis level and activity,while LONP1 knockdown worsened liver injury and gluconeogenesis disorders.Conclusion:We demonstrated that gluconeogenesis dysfunction exists in ACLF,and LONP1 could ameliorate liver injury and improve gluconeogenic dysfunction,which would provide a promising therapeutic target for patients with ACLF.

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Efficacy and safety of CM310 in moderate-to-severe atopic dermatitis:A multicenter,randomized,double-blind,placebo-controlled phase 2b trial

Yan ZhaoJianzhong ZhangBin YangJingyi Li...

200-208页

查看更多>>摘要：Background:Atopic dermatitis(AD)affects approximately 10％of adults worldwide.CM310 is a humanized monoclonal antibody targeting interleukin-4 receptor alpha that blocks interleukin-4 and interleukin-13 signaling.This trial aimed to evaluate the efficacy and safety of CM310 in Chinese adults with moderate-to-severe AD.Methods:This multicenter,randomized,double-blind,placebo-controlled,phase 2b trial was conducted in 21 medical institutions in China from February to November 2021.Totally 120 eligible patients were enrolled and randomized(1∶1∶1)to receive subcutaneous injections of 300 mg CM310,150 mg CM310,or placebo every 2 weeks for 16 weeks,followed by an 8-week follow-up period.The primary endpoint was the proportion of patients achieving ≥75％improvement in the Eczema Area and Severity Index(EASI-75)score from baseline at week 16.Safety and pharmacodynamics were also studied.Results:At week 16,the proportion of EASI-75 responders from baseline was significantly higher in the CM310 groups(70％[28/40]for high-dose and 65％[26/40]for low-dose)than that in the placebo group(20％[8/40]).The differences in EASI-75 response rate were 50％(high vs.placebo,95％CI 31％-69％)and 45％(low vs.placebo,95％CI 26％-64％),with both P values＜0.0001.CM310 at both doses also significantly improved the EASI score,Investigator's Global Assessment score,daily peak pruritus Numerical Rating Scale,AD-affected body surface area,and Dermatology Life Quality Index compared with placebo.CM310 treatment reduced levels of thymus and activation-regulated chemokine,total immunoglobulin E,lactate dehydrogenase,and blood eosinophils.The incidence of treatment-emergent adverse events(TEAEs)was similar among all three groups,with the most common TEAEs reported being upper respiratory tract infection,atopic dermatitis,hyperlipidemia,and hyperuricemia.No severe adverse events were deemed to be attributed to CM310.Conclusion:CM310 at 150 mg and 300 mg every 2 weeks demonstrated significant efficacy and was well-tolerated in adults with moderate-to-severe AD.

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