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中华医学杂志（英文版）
中华医学会
中华医学杂志（英文版）

中华医学会

照日格图

半月刊

0366-6999

renlihua@cma.org.cn

010-85158321

100710

北京市东城区东四西大街42号

中华医学杂志（英文版）/Journal Chinese Medical JournalCSCDCSTPCD北大核心SCI
查看更多>>1887年创刊，中华医学会主办。中华医学杂志英文版(Chinese Medical Journal)是中华医学会会刊，是中国惟一被SCI核心版收录、具有百年以上历史的医学期刊。重点报道我国医学各学科最新进展和高水平科研成果，目前已被《科学引文索引（SCI）》、《医学索引（IM）》、Medline等国际著名检索系统收录。2009年SCI影响因子0.952，SCI被引频次3407。2010年被国际医学期刊编辑委员会（ICMJE）吸收为新成员。多次获得国家期刊奖、科协专项基金、自然基金等奖项和资助。实行全文上网 （），网上投稿审稿()。
正式出版
收录年代

    Cerebellar involvement in Parkinson's disease:Pathophysiology and neuroimaging

    Tao QiuMeichen LiuXinhui QiuTianbai Li...
    2395-2403页
    查看更多>>摘要：Parkinson's disease(PD)is a neurodegenerative disease characterized by various motor and non-motor symptoms.The com-plexity of its symptoms suggests that PD is a heterogeneous neurological disorder.Its pathological changes are not limited to the substantia nigra-striatal system,but gradually extending to other regions including the cerebellum.The cerebellum is connected to a wide range of central nervous system regions that form essential neural circuits affected by PD.In addition,altered dopaminergic activity and α-synuclein pathology are found in the cerebellum,further suggesting its role in the PD progression.Furthermore,an increasing evidence obtained from imaging studies has demonstrated that cerebellar structure,functional connectivity,and neural metabolism are altered in PD when compared to healthy controls,as well as among different PD subtypes.This review provides a comprehensive summary of the cerebellar pathophysiology and results from neuroimaging studies related to both motor and non-motor symptoms of PD,highlighting the potential significance of cerebellar assessment in PD diagnosis,differential diagnosis,and disease monitoring.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Tuberculosis in infertility and in vitro fertilization-embryo transfer

    Xiaoyan GaiHongbin ChiRong LiYongchang Sun...
    2404-2411页
    查看更多>>摘要：Tuberculosis(TB)is a prominent infectious disease globally that imposes a substantial health burden.Genital TB(GTB),an extrapul-monary manifestation,leads to complications such as tubal adhesions,blockage,and diminished ovarian function,culminating in infertility,and is recognized as a prevalent cause of infertility in nations with high-burden TB.In regions with low TB rates,infertility and active TB during pregnancy have been reported to be most common among female immigrants from countries with high-burden TB.In the context of TB,pregnant women often exhibit exacerbated symptoms after in vitro fertilization-embryo transfer(IVF-ET),heightening the risk of dissemination.Miliary pulmonary TB and tuberculous meningitis pose a serious threat to maternal and fetal health.This article integrates recent epidemiological data and clinical research findings,delineating the impact of TB on infertility and assisted reproduction and particularly focusing on the diagnosis and treatment of GTB,underscored by the imperative of TB screening before IVF-ET.Our objective is to increase awareness among respiratory and reproductive health professionals,promoting multidisciplinary management to enhance clinical vigilance.This approach seeks to provide patients with judicious reproductive plans and scientifically rigorous pregnancy management,thereby mitigating adverse pregnancy outcomes related to TB activity.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Curbing alcohol-associated liver disease by increasing alcohol excise taxes

    Feiyu ZhangPeng XiaoYali LiuTao Liu...
    2412-2414页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Single-cell RNA sequencing reveals the process of CA19-9 production and dynamics of the immune microenvironment between CA19-9(+)and CA19-9(-)PDAC

    Deyu ZhangFang CuiKailian ZhengWanshun Li...
    2415-2428页
    查看更多>>摘要：Background:Pancreatic ductal adenocarcinoma(PDAC)is one of the main types of malignant tumor of the digestive system,and patient prognosis is affected by difficulties in early diagnosis,poor treatment response,and a high postoperative recurrence rate.Carbohydrate antigen 19-9(CA19-9)has been widely used as a biomarker for the diagnosis and postoperative follow-up of PDAC patients.Nevertheless,the production mechanism and potential role of CA19-9 in PDAC progression have not yet been elucidated.Methods:We performed single-cell RNA sequencing on six samples pathologically diagnosed as PDAC(three CA19-9-positive and three CA19-9-negative PDAC samples)and two paracarcinoma samples.We also downloaded and integrated PDAC samples(each from three CA19-9-positive and CA19-9-negative patients)from an online database.The dynamics of the proportion and potential function of each cell type were verified through immunofluorescence.Moreover,we built an in vitro coculture cellular model to confirm the potential function of CA19-9.Results:Three subtypes of cancer cells with a high ability to produce CA19-9 were identified by the markers TOP2A,AQP5,and MUC5AC.CA19-9 production bypass was discovered on antigen-presenting cancer-associated fibroblasts(apCAFs).Importantly,the proportion of immature ficolin-1 positive(FCN1+)macrophages was high in the CA19-9-negative group,and the proportion of mature M2-like macrophages was high in the CA19-9-positive group.High proportions of these two macrophage subtypes were associated with an unfavourable clinical prognosis.Further experiments indicated that CA19-9 could facilitate the transfor-mation of M0 macrophages into M2 macrophages in the tumor microenvironment.Conclusions:Our study described CA19-9 production at single-cell resolution and the dynamics of the immune atlas in CA19-9-positive and CA19-9-negative PDAC.CA19-9 could promote M2 polarization of macrophage in the pancreatic tumor microenvironment.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Incidence,mortality,and disability-adjusted life years of female breast cancer in China,2022

    Kexin SunBailin ZhangShaoyuan LeiRongshou Zheng...
    2429-2436页
    查看更多>>摘要：Background:Breast cancer is ranked among the most prevalent malignancies in the Chinese female population.However,compre-hensive reports detailing the latest epidemiological data and attributable disease burden have not been extensively documented.Methods:In 2018,high-quality cancer surveillance data were recorded in 700 population-based cancer registries in China.We extracted data on female breast cancers(International Classification of Diseases,Tenth Revision[ICD-10]:C50)and estimated the incidence and mortality in 2022 according to the baseline data and corresponding trends from 2010 to 2018.Pathological types were classified according to the ICD for Oncology,3rd Edition codes.Disability-adjusted life years(DALYs)were calculated as the sum of the years of life lost(YLLs)and years lived with disability(YLDs).Results:In 2022,approximately 357,200 new female breast cancer cases and 75,000 deaths occurred in China,accounting for 15.59％and 7.94％of total new cancer cases and deaths,respectively.The age-standardized incidence rate(ASIR)was 33.04 per 100,000.When analyzed by pathological type,the ASIRs for papillary neoplasms,invasive breast carcinoma,rare and salivary gland-type tumors,and other types were 1.13,29.79,0.24,and 1.88 per 100,000,respectively.The age-standardized mortality rate(ASMR)was 6.10 per 100,000.A total of 2,628,000 DALYs were found to be attributable to female breast cancer in China,comprising 2,278,300 YLLs and 349,700 YLDs.The ASIR,ASMR,and age-standardized rate(ASR)for DALYs in urban areas were consistently higher than those in rural areas.We observed a four-fold increase in the ASIR and ASR for DALYs and an eight-fold increase in the ASMR among females over 55 years compared with those aged under 55 years.Conclusion:These data provide invaluable insights into the latest epidemiology of female breast cancer in China and highlight the urgency for disease prevention and control strategy formulation.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Targeting NUF2 suppresses gastric cancer progression through G2/M phase arrest and apoptosis induction

    Bo LongHuinian ZhouLixia XiaoXiangyan Jiang...
    2437-2451页
    查看更多>>摘要：Background:Gastric cancer(GC),a malignant tumor with poor prognosis,is one of the leading causes of cancer-related deaths worldwide;consequently,identifying novel therapeutic targets is crucial for its corresponding treatment.NUF2,a component of the NDC80 kinetochore complex,promotes cancer progression in multiple malignancies.Therefore,this study aimed to explore the potential of NUF2 as a therapeutic target to inhibit GC progression.Methods:Clinical samples were obtained from patients who underwent radical resection of GC at Lanzhou University Second Hospital from 2016 to 2021.Cell count assays,colony formation assays,and cell-derived xenotransplantation(CDX)models were used to determine the effects of NUF2 on GC progression.Flow cytometry was used to detect the effect of NUF2 or quercetin on cell cycle progression and apoptosis.A live-cell time-lapse imaging assay was performed to determine the effect of NUF2 on the regulation of mitotic progression.Transcriptomics was used to investigate the NUF2-associated molecular mechanisms.Virtual docking and microscale thermophoresis were used to identify NUF2 inhibitors.Finally,CDX,organoid,and patient-derived xenograft(PDX)models were used to examine the efficacy of the NUF2 inhibitor in GC.Results:NUF2 expression was significantly increased in GC and was negatively correlated with prognosis.The deletion of NUF2 suppressed GC progression both in vivo and in vitro.NUF2 significantly regulated the mitogen-activated protein kinase(MAPK)pathway,promoted G2/M phase transition,and inhibited apoptosis in GC cells.Additionally,quercetin was identified as a selec-tive NUF2 inhibitor with low toxicity that significantly suppressed tumor growth in GC cells,organoids,CDX,and PDX models.Conclusions:Collectively,NUF2-mediated G2/M phase transition and apoptosis inhibition promoted GC progression;addition-ally,NUF2 inhibitors exhibited potent anti-GC activity.This study provides a new strategy for targeting NUF2 to suppress GC progression in clinical settings.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Mortality,morbidity,and care practices for 1750 very low birth weight infants,2016-2021

    Yang HeMeng ZhangJun TangWanxiu Liu...
    2452-2460页
    查看更多>>摘要：Background:Very low birth weight(VLBW)infants are the key populations in neonatology,wherein morbidity and mortality remain major challenges.The study aimed to analyze the clinical characteristics of VLBW infants.Methods:A retrospective cohort study was conducted in West China Second Hospital between January 2016 and December 2021.Neonates with a birth weight of＜1500 g were included.Mortality,care practices,and major morbidities were analyzed,and compared with those of previous 7 years(2009-2015).Results:Of the total 1750 VLBW,1386 were infants born with birth weight between 1000-1499 g and 364 infants were born with weight below 1000 g;42.9％(751/1750)required delivery room resuscitation;53.9％(943/1750)received non-invasive ventilation only;38.2％(669/1750)received invasive ventilation;1517 VLBW infants received complete treatment.Among them,60.1％(912/1517)of neonates had neonatal respiratory distress syndrome(NRDS),28.7％(436/1517)had bronchopulmo-nary dysplasia(BPD),22.0％(334/1517)had apnea,11.1％(169/1517)had culture-confirmed sepsis,8.4％(128/1517)had pulmonary hemorrhage,7.6％(116/1517)had severe intraventricular hemorrhage(IVH)/periventricular leukomalacia(PVL),5.7％(87/1517)had necrotizing enterocolitis(NEC),and 2.0％(31/1517)had severe retinopathy of prematurity.The total and in-hospital mortality rates were 9.7％(169/1750)and 3.0％(45/1517),respectively.The top three diagnoses of death among those who had received complete treatment were sepsis,NRDS,and NEC.In 2009-2015,1146 VLBW were enrolled and 895 infants received complete treatment.The proportions of apnea,IVH,and IVH stage ≥3/PVL,were higher in 2009-2015 compared with those in 2016-2021,while the proportions of NRDS and BPD were characterized by significant increases in 2016-2021.The total and in-hospital mortality rates were 16.7％(191/1146)and 5.6％(50/895)respectively in 2009-2015.Conclusion:Among VLBW infants born in 2016-2021,the total and in-hospital mortality rates were lower than those of neonates born in 2009-2015.Incidences of NRDS and BPD increased in 2016-2021,which affected the survival rates and long-term prognosis of VLBW.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    A novel intracoronary hypothermia device reduces myocardial reperfusion injury in pigs

    Zhiqiang PeiJin QiuYongchao ZhaoShuai Song...
    2461-2472页
    查看更多>>摘要：Background:Hypothermia therapy has been suggested to attenuate myocardial necrosis;however,the clinical implementation as a valid therapeutic strategy has failed,and new approaches are needed to translate into clinical applications.This study aimed to assess the feasibility,safety,and efficacy of a novel selective intracoronary hypothermia(SICH)device in mitigating myocardial reperfusion injury.Methods:This study comprised two phases.The first phase of the SICH was performed in a normal porcine model for 30 minutes(n=5)to evaluate its feasibility.The second phase was conducted in a porcine myocardial infarction(MI)model of myocardial ischemia/reperfusion which was performed by balloon occlusion of the left anterior descending coronary artery for 60 minutes and maintained for 42 days.Pigs in the hypothermia group(n=8)received hypothermia intervention onset reperfusion for 30 minutes and controls(n=8)received no intervention.All animals were followed for 42 days.Cardiac magnetic resonance analysis(five and 42 days post-MI)and a series of biomarkers/histological studies were performed.Results:The average time to lower temperatures to a steady state was 4.8±0.8 s.SICH had no impact on blood pressure or heart rate and was safely performed without complications by using a 3.9 F catheter.Interleukin-6(IL-6),tumor necrosis factor-α,C-reactive protein(CRP),and brain natriuretic peptide(BNP)were lower at 60 min post perfusion in pigs that underwent SICH as compared with the control group.On day 5 post MI/R,edema,intramyocardial hemorrhage,and microvascular obstruction were reduced in the hypothermia group.On day 42 post MI/R,the infarct size,IL-6,CRP,BNP,and matrix metalloproteinase-9 were reduced,and the ejection fraction was improved in pigs that underwent SICH.Conclusions:The SICH device safely and effectively reduced the infarct size and improved heart function in a pig model of MI/R.These beneficial effects indicate the clinical potential of SICH for treatment of myocardial reperfusion injury.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Population pharmacokinetics of Ainuovirine and exposure-response analysis in human immunodeficiency virus-infected individuals

    Xiaoxu HanJin SunYihang ZhangTaiyi Jiang...
    2473-2482页
    查看更多>>摘要：Background:Ainuovirine(ANV)is a new generation of non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus(HIV)type 1 infection.This study aimed to evaluate the population pharmacokinetic(PopPK)profile and exposure-response relationship of ANV among people living with HIV.Methods:Plasma concentration-time data from phase 1 and phase 3 clinical trials of ANV were pooled for developing the PopPK model.Exposure estimates obtained from the final model were used in exposure-response analysis for virologic responses and safety responses.Results:ANV exhibited a nonlinear pharmacokinetic profile,which was best described by a two-compartment model with first-or-der elimination.There were no significant covariates correlated to the pharmacokinetic parameters of ANV.The PopPK parameter estimate(relative standard error[％])for clearance adjusted for bioavailability(CL/F)was 6.46(15.00)L/h,and the clearance of ANV increased after multiple doses.The exposure-response model revealed no significant correlation between the virologic response(HIV-RNA＜50 copies/mL)at 48 weeks and the exposure,but the incidence of adverse events increased with the increasing exposure(P value of steady-state trough concentration and area under the steady-state curve were 0.0177 and 0.0141,respectively).Conclusions:Our PopPK model supported ANV 150 mg once daily as the recommended dose for people living with HIV,requiring no dose adjustment for the studied factors.Optimization of ANV dose may be warranted in clinical practice due to an increasing trend in adverse reactions with increasing exposure.
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据

    Effect and safety of different doses of desloratadine citrate disodium in patients with chronic spontaneous urticaria in Chinese Han population

    Ke XueMengmeng LiLei WangYi Sun...
    2483-2485页
      原文链接:
    • 国家科技期刊平台
    • NETL
    • NSTL
    • 万方数据