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中华内分泌代谢杂志
中华内分泌代谢杂志

宁光

月刊

1000-6699

cjem@vip.163.com

021-64315587

200025

上海市瑞金二路197号

中华内分泌代谢杂志/Journal Chinese Journal of Endocrinology and MetabolismCSCD北大核心CSTPCD
查看更多>>1985年创刊，中华医学会主办。本刊是反映我国当代及与国外合作的，在内分泌代谢病学领域内临床与科研最新成果的高级学术刊物。在强调刊文的先进性、科学性与新颖性的同时，也十分重视临床的实用性和论文的可读性。本刊设指南与共识、述评、专论、论坛、临床研究、基础研究、综述、讲座、临诊应对、当年学术进展与动态、临床经验交流、新药研究、学术争鸣及国外期刊论文评论等栏目。本刊的读者对象主要为各级从事临床和基础内分泌代谢病学工作的医、教、研人员及研究生，以及内、外、儿、妇科以及神经、泌尿、老年、营养等相关科室的人员。
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    肢端肥大症合并妊娠一例并文献复习

    鞠姜华朱惠娟王林杰阳洪波...
    68-72页
    查看更多>>摘要：本文报道1例肢端肥大症患者妊娠期服用溴隐亭并成功分娩的诊治经过。回顾性总结了该患者2次妊娠前后的临床资料及治疗结局。该患者第2次妊娠期间口服溴隐亭，妊娠期病情较稳定，并足月剖宫产1女婴。本文提示肢端肥大症患者在病情稳定后妊娠可获得良好结局，妊娠期服用多巴胺受体激动剂没有增加围产期不良事件。 This article reports the diagnosis and treatment of a case of acromegaly in a pregnant patient who took bromocriptine during pregnancy and delivered successfully. A retrospective summary of the clinical data and treatment outcomes before and after two pregnancies of the patient is provided. The patient took bromocriptine during the second pregnancy, and her condition remained stable. A baby girl was delivered by caesarean section at full term. The article suggests that pregnancy in acromegaly patients, after the stabilization of the condition, can lead to favorable outcomes. The use of dopamine receptor agonists during pregnancy does not increase adverse events during the perinatal period.

    肢端肥大症妊娠多巴胺受体激动剂安全性

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    72页
    查看更多>>摘要：本刊2023年第39卷第12期刊登的文章《低钠血症的中国专家共识》的作者需要对第1002页的图2进行更正。
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    甲状腺类器官研究进展

    姚金玉卢庆苗鲁一兵周丽斌...
    73-76页
    查看更多>>摘要：类器官作为来源于原代组织或干细胞的三维培养的细胞聚集体，可以自我组织，形成器官型结构，模拟组织的细胞微环境，并代表组织生理学。甲状腺滤泡组织是甲状腺激素生物合成的重要结构，虽目前来源于成体组织及多能干细胞的甲状腺滤泡已在体外实现长期扩增，但甲状腺类器官技术的发展依然面临许多挑战，建立更贴近人体真实情况的复合型甲状腺类器官依然是亟待解决的研究难点。现就甲状腺的发育过程、现有甲状腺类器官模型的相关应用及其构建方法的研究进展作一综述。 As cell aggregates in three-dimensional culture derived from primary tissues or stem cells, organoids possess the ability to self-organize into organotypic structures, mimic the cellular microenvironment, and represent tissue physiology. The thyroid′s follicular tissue plays a crucial role in thyroid hormone biosynthesis. Despite prolonged in vitro expansion of thyroid follicles from adult tissues and pluripotent stem cells have been expanded for a long time, the development of thyroid organoid technology still encounters numerous challenges. Establishing a comprehensive thyroid organoid that closely mimics the human body′s actual conditions remains a research challenge. This article reviews the development process of thyroid, the related applications of existing thyroid organoid models and the methods employed in the construction.

    类器官甲状腺三维培养

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    多囊卵巢综合征的发病机制和治疗新进展

    周丽斌
    77-85页
    查看更多>>摘要：多囊卵巢综合征(PCOS)的主要特征是雄激素过多和排卵障碍。PCOS不仅影响育龄期女性的生殖健康，而且作为一种代谢性疾病增加患者的长期健康风险。PCOS的发病机制尚不完全明确。早发现、早诊断、早治疗对于PCOS患者的预后非常重要。近期，BMJ Medicine就这一问题发表了1篇题为《多囊卵巢综合征：病理生理学和治疗机遇》的综述[Dong J, Rees DA. Polycystic ovary syndrome: pathophysiology and therapeutic opportunities. BMJ Medicine, 2023，2(1): e000548]。该文为开放获取文章，本文对其进行了中文编译。该综述汇总相关文献，就PCOS关键病理生理过程进行了深入的阐释和探讨，对目前现有药物进行总结，并对新兴药物的治疗进行了回顾与展望。 Polycystic ovary syndrome(PCOS) is characterized by excessive androgen levels and ovulatory dysfunction. Beyond its impact on the reproductive wellness of women of reproductive age, PCOS poses long-term health risks as a metabolic disease. The pathogenesis of PCOS is not fully understood. Early detection, diagnosis, and treatment are crucial for the prognosis of patients with PCOS. A review "Polycystic ovary syndrome: pathophysiology and therapeutic opportunities" was recently published in BMJ Medicine [Dong J, Rees DA. Polycystic ovary syndrome: pathophysiology and therapeutic opportunities. BMJ Medicine, 2023, 2(1): e000548]. This open-access article has been translated into Chinese. The review consolidates relevant literature, offers a comprehensive exploration of the key pathophysiology of PCOS, evaluates existing treatment modalities, and concludes by highlighting therapeutic opportunities presented by emerging drugs.

    多囊卵巢综合征病理生理学治疗

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    2023年 Journal of Diabetes第12期中文导读

    周丽斌
    86-90页
    查看更多>>摘要：论著/Original Article
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