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结合医学学报（英文版）
结合医学学报（英文版）

赵伟康

月刊

2095-4964

jcim@163.com

021-81873540

200433

上海市杨浦区翔殷路800号第二军医大学中医系2201室

结合医学学报（英文版）/Journal Journal of Chinese Integrative MedicineCSCDCSTPCD北大核心SCI
查看更多>> 《中西医结合学报》于2003年5月创刊，是中国科技论文统计源期刊、中国科技核心期刊、RCCSE中国权威学术期刊、上海市科协系统优秀科技期刊、全国中医药优秀期刊、美国《医学索引》（Index Medicus/MEDLINE/PubMed）收录期刊。 《中西医结合学报》是开放获取期刊，已被列入《开放获取期刊指南》（Directory of Open Access Journals, DOAJ）,所有被录用的稿件均经过同行评议，同时在纸质印刷版和网络电子版发表。 《中西医结合学报》为月刊，设有院士笔谈、专论、述评、学术探讨、系统评价、临床论著、实验论著、经验交流、医案医话、文献研究、文献综述、学术讲座、医学统计学、中医英译、结合医学概览、医学论文写作、国际动态、会议消息、书评、招聘启事、读者来信等栏目。纸质印刷版于每月15日出版，全球发行；网络电子版与纸质印刷版同步出版。网络电子版具有完善的检索和参考文献链接功能。全球用户可在本刊中英文双语网站无任何限制地检索、阅读和下载全部论文。 《中西医结合学报》在国际最权威的医学文献电子数据库PubMed建有免费全文链接。全球用户可在PubMed免费检索任何一篇论文的摘要和题录，并且可以在PubMed即时链接本刊网站，免费阅读所检索的论文全文。 中西医结合学报杂志社（JCIM Press）是出版者国际链接联合会（Publisher International Linking Association, PILA）和CrossRef的机构会员，与CrossRef成员期刊实现了跨平台链接。《中西医结合学报》的每一篇论文都注册了DOI号，并建有参考文献链接和被引链接。 《中西医结合学报》将以最快的速度，最便捷的方式，最大范围地向世界展示您的研究成果。 我们的办刊方针：坚持学术期刊的导向作用，履行学术期刊的社会责任，倡导科学、严谨、务实、创新的学术风尚。我们的办刊理念：只争朝夕，只求卓越；尽我所能，做到更好。 我们的办刊目的：向世界展示中国中西医结合研究的成果，向中国读者介绍世界结合医学的进展，为全球读者提供一个即时和自由交流的学术平台。 我们的办刊方向：编辑出版国际一流医学期刊，打造国际化精品期刊、品牌期刊。
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    Distribution of licensed acupuncturists and educational institutions in the United States at the start of 2023,during the late stage of the COVID-19 pandemic

    Arthur Yin FanDe-guang HeAnu SangraulaSarah Faggert Alemi...
    379-384页
    查看更多>>摘要：This study was conducted to identify the number and density of active licensed acupuncturists(LAcs),as well as the number of accredited schools in acupuncture and Oriental medicine(AOM),as of January 1,2023,in the United States(U.S.).The number of active LAcs as of January 1,2023 was 34,524,potentially 33,364 after removing license duplication in multiple states,among which the largest three states were California(with 7317 LAcs[21.19％of the total]),New York(5024[14.55％])and Florida(2644[7.66％]).The total number of LAcs decreased by 8.87％from 2018,and fell short of our projected number of LAcs in 2023 by 9037,or 20.75％.The overall LAc density in the U.S.-measured as the number of LAcs per 100,000 population-was 10.36,less than in 2018.There were 56 active,accredited AOM schools which offered a total of 147 programs(121 at the level necessary for licensing[entry-level],12 for an advanced practicing degree[advanced-level],and 14 for certifications).Broken down further,offerings included 50 master's degrees in acupuncture,40 master's degrees in Oriental medicine,31 entry-level doctorate degrees(10 in acupuncture and 21 in acupuncture plus Chinese herbal medicine),and 12 advanced-level doctorate degrees in AOM.The certification programs included one in East-Asian Medical Bodywork and 13 in CHM.Among these schools in 2023,institutions in the West and East Coast states comprised 67.86％(decreased from 77.42％in 2018)of the national total.California,Florida and Illinois represented 39.29％.There were 48 jurisdictions with acupuncture practice laws in place.The data suggests that the acupuncture profession in the U.S.has been significantly impacted during the coronavirus disease 2019 pandemic.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Advancements in nanotechnology for the delivery of phytochemicals

    Divya ChauhanPavan K.YadavNazneen SultanaArun Agarwal...
    385-398页
    查看更多>>摘要：Phytosomes(phytophospholipid complex)are dosage forms that have recently been introduced to increase the stability and therapeutic effect of herbal medicine.Currently,bioactive herbs and the phy-tochemicals they contain are considered to be the best remedies for chronic diseases.One promising approach to increase the efficacy of plant-based therapies is to improve the stability and bioavailability of their bio-active ingredients.Phytosomes employ phospholipids as their active ingredients,and use their amphiphilic properties to solubilize and protect herbal extracts.The unique properties of phospho-lipids in drug delivery and their use in herbal medicines to improve bioavailability results in significantly enhanced health benefits.The introduction of phytosome nanotechnology can alter and revolutionize the current state of drug delivery.The goal of this review is to explain the application of phytosomes,their future prospects in drug delivery,and their advantages over conventional formulations.
      原文链接:
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    Therapeutic potential and pharmacological mechanism of visnagin

    Poonam YadavSumeet Kumar SinghSayantap DattaSaloni Verma...
    399-412页
    查看更多>>摘要：Visnagin is a furanochromone and one of the most important compound in the Ammi visnaga(L.)Lam(a synonym of Visnaga daucoides Gaertn.)plant,which is used to cure various ailments.Many investigations into the bioactive properties of visnagin have been studied to date.The literature on visnagin demon-strates its biological properties,including anti-inflammatory,anti-diabetic,and beneficial effects in car-diovascular and renal diseases.Moreover,visnagin improves sperm quality parameters,stimulates steroidogenesis,and increases serum gonadotropins and testosterone levels,while decreasing pro-inflammatory cytokines,oxidative damage,genomic instability,and it modulates apoptosis.Thus,vis-nagin has emerged as an exciting lead for further research,owing to its potential in various unmet clinical needs.The current review summarized its basic structure,pharmacokinetics,and pharmacological effects,focusing on its mechanisms of action.The review will help to understand the potential of visnagin as an alternative treatment strategy for several diseases and provide insight into research topics that need further exploration for visnagin's safe clinical use.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    From ancient wisdom to modern science:Gut microbiota sheds light on property theory of traditional Chinese medicine

    Ya-nan YangJia-guo ZhanYing CaoChong-ming Wu...
    413-444页
    查看更多>>摘要：The property theory of traditional Chinese medicine(TCM)has been practiced for thousands of years,playing a pivotal role in the clinical application of TCM.While advancements in energy metabolism,chemical composition analysis,machine learning,ion current modeling,and supercritical fluid technol-ogy have provided valuable insight into how aspects of TCM property theory may be measured,these studies only capture specific aspects of TCM property theory in isolation,overlooking the holistic per-spective inherent in TCM.To systematically investigate the modern interpretation of the TCM property theory from multidimensional perspectives,we consulted the Chinese Pharmacopoeia(2020 edition)to compile a list of Chinese materia medica(CMM).Then,using the Latin names of each CMM and gut microbiota as keywords,we searched the PubMed database for relevant research on gut microbiota and CMM.The regulatory patterns of different herbs on gut microbiota were then summarized from the perspectives of the four natures,the five flavors and the meridian tropism.In terms of the four nat-ures,we found that warm-natured medicines promoted the colonization of specific beneficial bacteria,while cold-natured medicines boosted populations of some beneficial bacteria while suppressing patho-genic bacteria.Analysis of the five flavors revealed that sweet-flavored and bitter-flavored CMMs posi-tively influenced beneficial bacteria while inhibiting harmful bacteria.CMMs with different meridian tropism exhibited complex modulative patterns on gut microbiota,with Jueyin(Liver)and Taiyin(Lung)meridian CMMs generally exerting a stronger effect.The gut microbiota may be a biological indi-cator for characterizing the TCM property theory,which not only enhances our understanding of classic TCM theory but also contributes to its scientific advancement and application in healthcare.
      原文链接:
    • NETL
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    Effects of acupuncture on hypothalamic-pituitary-adrenal axis:Current status and future perspectives

    Jia-yuan ZhengJing ZhuYu WangZhan-zhuang Tian...
    445-458页
    查看更多>>摘要：The hypothalamic-pituitary-adrenal(HPA)axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes.Dysregulation of HPA axis function disrupts the neuroendocrine equilibrium,resulting in impaired physiological functions.Acupuncture is recognized as a non-pharmacological type of therapy which has been confirmed to play an important role in modulating the HPA axis and thus favorably targets diseases with abnormal activation of the HPA axis.With numerous studies reporting the promising efficacy of acupuncture for neuroendocrine disorders,a comprehensive review in terms of the underlying molecular mechanism for acupuncture,especially in regulating the HPA axis,is currently in need.This review fills the need and summarizes recent breakthroughs,from the basic principles and the pathological changes of HPA axis dysfunction,to the molecular mechanisms by which acupuncture regulates the HPA axis.These mechanisms include the modulation of multiple neurotransmitters and their receptors,neuropeptides and their receptors,and microRNAs in the paraventricular nucleus,hippocampus,amygdala and pituitary gland,which alleviate the hyperfunctioning of the HPA axis.This review comprehensively summarizes the mechanism of acupuncture in regulating HPA axis dysfunc-tion for the first time,providing new targets and prospects for further exploration of acupuncture.
      原文链接:
    • NETL
    • NSTL
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    Efficacy and safety of electroacupuncture for insomnia:A systematic review and meta-analysis

    Han-yu XuLin-na WuYuan ZhangTe Ba...
    459-472页
    查看更多>>摘要：Background:Electroacupuncture is often used to treat insomnia.Objective:To evaluate the efficacy and safety of electroacupuncture for insomnia.Search strategy:Databases including PubMed,Cochrane Library,Embase,Web of Science,Chinese Biomedical Literature Database,China National Knowledge Infrastructure,Wanfang Data and VIP Full-text e-Journals Database were searched up to January 15,2023.Inclusion criteria:Randomized clinical trials were included if they compared the clinical efficacy and safety of electroacupuncture with sham acupuncture,no treatment or usual care(UC)and general acupuncture.Data extraction and analysis:The full texts of the studies were reviewed to remove ineligible literature.The extracted data included authors,publication year,diagnostic criteria,sample size,population char-acteristics,interventions and outcomes.The above steps were performed independently by two review-ers and the data were cross-checked.Stata15.0 software was used to analyze the extracted outcome data.For continuous data(Pittsburgh Sleep Quality Index[PSQI]score and Insomnia Severity Index score),weighted mean difference(WMD)was calculated and 95％confidence interval(CI)was reported when the same scale was applied.For dichotomous variables(clinical response rate and adverse events),a meta-analysis was performed using risk ratio(RR)as the effect indicator.Results:Thirty-one trials with 2226 subjects were included.The meta-analysis suggested that elec-troacupuncture was more effective in improving insomnia compared with the control group(sham acupuncture,no treatment,UC and general acupuncture)(RR=1.21;95％CI:[1.16,1.27]),significantly reducing the PSQI score in insomnia patients after treatment and at follow-up(WMD=-3.23;95％CI:[-4.29,-2.17];P＜0.001).There was no significant difference in the incidence of adverse events between the EA and control groups(sham acupuncture and no treatment or UC.RR=1.48;95％Cl:[0.91,2.40];P=0.117).In addition,the regression results revealed that receiving electroacupuncture for seven to nine weeks provided the best efficacy(P＜0.05).Conclusion:Electroacupuncture can significantly promote better sleep quality in insomnia patients and is suitable for the treatment of various types of insomnia.However,the articles included were single-center trials with small sample sizes,and some articles were of poor quality.Therefore,further research is still needed to confirm these findings.
      原文链接:
    • NETL
    • NSTL
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    Effectiveness of craniosacral therapy,Bowen therapy,static touch and standard exercise program on sleep quality in fibromyalgia syndrome:A randomized controlled trial

    Reepa Avichal UghrejaPrem VenkatesanDharmanand Balebail GopalakrishnaYogesh Preet Singh...
    473-483页
    查看更多>>摘要：Background:Sleep disturbance is commonly seen in fibromyalgia syndrome(FMS);however,high quality studies involving manual therapies that target FMS-linked poor sleep quality are lacking for the Indian population.Objective:Craniosacral therapy(CST),Bowen therapy and exercises have been found to influence the autonomic nervous system,which plays a crucial role in sleep physiology.Given the paucity of evidence concerning these effects in individuals with FMS,our study tests the effectiveness of CST,Bowen therapy and a standard exercise program against static touch(the manual placebo group)on sleep quality in FMS.Design,setting,participants and intervention:A placebo-controlled randomized trial was conducted on 132 FMS participants with poor sleep at a hospital in Bangalore.The participants were randomly allo-cated to one of the four study groups,including CST,Bowen therapy,standard exercise program,and a manual placebo control group that received static touch.CST,Bowen therapy and static touch treatments were administered in once-weekly 45-minute sessions for 12 weeks;the standard exercise group received weekly supervised exercises for 6 weeks with home exercises until 12 weeks.After 12 weeks,all study participants performed the standard exercises at home for another 12 weeks.Main outcome measures:Sleep quality,pressure pain threshold(PPT),quality of life and fibromyalgia impact,physical function,fatigue,pain catastrophizing,kinesiophobia,and positive-negative affect were recorded at baseline,and at weeks 12 and 24 of the intervention.Results:At the end of 12 weeks,the sleep quality improved significantly in the CST group(P=0.037)and Bowen therapy group(P=0.023),and the PPT improved significantly in the Bowen therapy group(P=0.002)and the standard exercise group(P＜0.001),compared to the static touch group.These improvements were maintained at 24 weeks.No between-group differences were observed for other sec-ondary outcomes.Conclusion:CST and Bowen therapy improved sleep quality,and Bowen therapy and standard exercises improved pain threshold in the short term.These improvements were retained within the groups in the long term by adding exercises.CST and Bowen therapy are treatment options to improve sleep and reduce pain in FMS.
      原文链接:
    • NETL
    • NSTL
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    Efficacy of Huoxue Qianyang Qutan Recipe on essential hypertension:A randomized,double-blind,placebo-controlled trial

    Jun XieYu-long MaMing-tai GuiLei Yao...
    484-492页
    查看更多>>摘要：Background:Hypertension,a prevalent disease,is a significant risk factor for coronary heart disease.Huoxue Qianyang Qutan Recipe(HQQR),a traditional Chinese herbal remedy,has been used for treating hypertension over several years.Objective:This study assesses HQQR's efficacy for controlling blood pressure among patients with hyper-tension related to blood stasis,yang hyperactivity and phlegm.Design,setting,participants and interventions:A randomized controlled trial was conducted at the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,from July 2020 to June 2022.Major components of HQQR were iden-tified using thin-layer chromatography and high-performance liquid chromatography.Participants aged 18-80 years,exhibiting traditional Chinese medicine syndromes of blood stasis,yang hyperactivity or phlegm,along with grades 1 or 2 hypertension,were randomly categorized into two groups.The inter-vention group was given HQQR granules alongside conventional hypertension treatment,while the con-trol group was given placebo granules in addition to conventional treatment for 12 weeks.Main outcome measures:The primary outcome was clinic blood pressure,whereas secondary outcomes included metabolic indices(e.g.,homeostasis model assessment of insulin resistance[HOMA-1R],total cholesterol[TC],low-density lipoprotein cholesterol and triglyceride),target organ damage indices(left ventricular mass index and urinary albumin creatinine ratio[UACR])and inflammation indices(interleukin-6[IL-6]and high-sensitivity C-reactive protein[hs-CRP]).Results:HQQR's primary components were identified as salvianolic acid B,emodin and ferulic acid.Of the 216 participants(108 in each group),compared to the control,the intervention group exhibited signifi-cant improvements(P＜0.001)in clinic systolic blood pressure([136.24±7.63]vs[130.06±8.50]mmHg),clinic diastolic blood pressure([84.34±8.72]vs[80.46±6.05]mmHg),home systolic blood pressure([131.64±8.74]vs[122.36±8.45]mmHg)and home diastolic blood pressure([78.47±9.53]vs[71.79±6.82]mmHg).HQQR demonstrated a reduction in ambulatory blood pressure(24-hour systolic blood pressure:[133.75±10.49]vs[132.46±8.84]mmHg and 24-hour diastolic blood pressure:[84.12±8.01]vs[82.11±7.45]mmHg)and an improvement in HOMA-1R([4.09±1.72]vs[3.98±1.44]),TC([4.66±1.47]vs[3.75±1.81]mmol/L)and UACR(75.94[5.12,401.12]vs 45.61[4.26,234.26]).Moreover,HQQR demonstrated a decrease in hs-CRP(1.46[0.10,10.53]vs 0.57[0.12,3.99]mg/L)and IL-6(6.69[2.00,29.74]vs 5.27[2.00,9.73]pg/mL),with no reported side effects(P＜0.001).Conclusion:This study highlights the therapeutic potential of HQQR use in ameliorating blood pressure,glycolipid metabolism,and inflammation in patients with hypertension.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Berberine alleviates ovarian tissue damage in mice with hepatolenticular degeneration by suppressing ferroptosis and endoplasmic reticulum stress

    Qian-zhuo LiuHui HanXin-ru FangLu-yao Wang...
    493-502页
    查看更多>>摘要：Objective:Hepatolenticular degeneration(HLD)is an autosomal recessive disorder that manifests as mul-tiorgan damage due to impaired copper(Cu)metabolism.Female patients with HLD often experience reproductive impairments.This study investigated the protective effect of berberine against ovarian dam-age in toxic-milk(TX)mice,a murine model for HLD.Methods:Mice were categorized into control group,HLD TX group(HLD group),penicillamine(Cu chelator)-treated TX group and berberine-treated TX group.Body weight,ovary weight and the number of ovulated eggs were recorded.Follicular morphology and cellular ultrastructure were examined.Total iron,ferrous iron(Fe2+)and trivalent iron(Fe3+)levels,as well as malondialdehyde(MDA),glutathione(GSH)and oxidized glutathione(GSSG),were measured in the ovaries.Western blot analysis was used to analyze the expression of proteins related to ferroptosis and endoplasmic reticulum(ER)stress.Results:Ovarian tissue damage was evident in the HLD group,with a significant increase in ferroptosis and ER stress compared to the control group.This damage was inhibited by treatment with penicillamine,a Cu chelator.Compared with the HLD group,berberine increased the number of ovulations,and improved ovarian morphology and ultrastructure.Further,we found that berberine reduced total iron,Fe2+,MDA and GSSG levels,elevated GSH levels,decreased the expression of the ferroptosis marker pro-tein prostaglandin-endoperoxide synthase 2(PTGS2),and increased glutathione peroxidase 4(GPX4)expression.Furthermore,berberine inhibited the expression of ER stress-associated proteins mediated by the protein kinase RNA-like ER kinase(PERK)pathway.Conclusion:Ferroptosis and ER stress are involved in Cu-induced ovarian damage in TX mice.Berberine ameliorates ovarian damage in HLD TX mice by inhibiting ferroptosis and ER stress.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Cycloastragenol induces apoptosis and protective autophagy through AMPK/ULK1/mTOR axis in human non-small cell lung cancer cell lines

    Li-hua ZhuYu-pei LiangLian YangFeng Zhu...
    503-514页
    查看更多>>摘要：Objective:Studies have demonstrated that cycloastragenol induces antitumor effects in prostate,colorec-tal and gastric cancers;however,its efficacy for inhibiting the proliferation of lung cancer cells is largely unexplored.This study explores the efficacy of cycloastragenol for inhibiting non-small cell lung cancer(NSCLC)and elucidates the underlying molecular mechanisms.Methods:The effects of cycloastragenol on lung cancer cell proliferation were assessed using an adeno-sine triphosphate monitoring system based on firefly luciferase and clonogenic formation assays.Cycloastragenol-induced apoptosis in lung cancer cells was evaluated using dual staining flow cytometry with an annexin V-fluorescein isothiocyanate/propidium iodide kit.To elucidate the role of cycloas-tragenol in the induction of apoptosis,apoptosis-related proteins were examined using Western blots.Immunofluorescence and Western blotting were used to determine whether cycloastragenol could induce autophagy in lung cancer cells.Genetic techniques,including small interfering RNA technology,were used to investigate the underlying mechanisms.The effects against lung cancer and biosafety of cycloastragenol were evaluated using a mouse subcutaneous tumor model.Results:Cycloastragenol triggered both autophagy and apoptosis.Specifically,cycloastragenol promoted apoptosis by facilitating the accumulation of phorbol-12-myristate-13-acetate-induced protein 1(NOXA),a critical apoptosis-related protein.Moreover,cycloastragenol induced a protective autophagy response through modulation of the adenosine 5'-monophosphate-activated protein kinase(AMPK)/unc-51-like autophagy-activating kinase(ULK1)/mammalian target of rapamycin(mTOR)pathway.Conclusion:Our study sheds new light on the antitumor efficacy and mechanism of action of cycloas-tragenol in NSCLC.This insight provides a scientific basis for exploring combination therapies that use cycloastragenol and inhibiting the AMPK/ULK1/mTOR pathway as a promising approach to combating lung cancer.
      原文链接:
    • NETL
    • NSTL
    • 万方数据