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结合医学学报（英文版）
结合医学学报（英文版）

赵伟康

月刊

2095-4964

jcim@163.com

021-81873540

200433

上海市杨浦区翔殷路800号第二军医大学中医系2201室

结合医学学报（英文版）/Journal Journal of Chinese Integrative MedicineCSCDCSTPCD北大核心SCI
查看更多>> 《中西医结合学报》于2003年5月创刊，是中国科技论文统计源期刊、中国科技核心期刊、RCCSE中国权威学术期刊、上海市科协系统优秀科技期刊、全国中医药优秀期刊、美国《医学索引》（Index Medicus/MEDLINE/PubMed）收录期刊。 《中西医结合学报》是开放获取期刊，已被列入《开放获取期刊指南》（Directory of Open Access Journals, DOAJ）,所有被录用的稿件均经过同行评议，同时在纸质印刷版和网络电子版发表。 《中西医结合学报》为月刊，设有院士笔谈、专论、述评、学术探讨、系统评价、临床论著、实验论著、经验交流、医案医话、文献研究、文献综述、学术讲座、医学统计学、中医英译、结合医学概览、医学论文写作、国际动态、会议消息、书评、招聘启事、读者来信等栏目。纸质印刷版于每月15日出版，全球发行；网络电子版与纸质印刷版同步出版。网络电子版具有完善的检索和参考文献链接功能。全球用户可在本刊中英文双语网站无任何限制地检索、阅读和下载全部论文。 《中西医结合学报》在国际最权威的医学文献电子数据库PubMed建有免费全文链接。全球用户可在PubMed免费检索任何一篇论文的摘要和题录，并且可以在PubMed即时链接本刊网站，免费阅读所检索的论文全文。 中西医结合学报杂志社（JCIM Press）是出版者国际链接联合会（Publisher International Linking Association, PILA）和CrossRef的机构会员，与CrossRef成员期刊实现了跨平台链接。《中西医结合学报》的每一篇论文都注册了DOI号，并建有参考文献链接和被引链接。 《中西医结合学报》将以最快的速度，最便捷的方式，最大范围地向世界展示您的研究成果。 我们的办刊方针：坚持学术期刊的导向作用，履行学术期刊的社会责任，倡导科学、严谨、务实、创新的学术风尚。我们的办刊理念：只争朝夕，只求卓越；尽我所能，做到更好。 我们的办刊目的：向世界展示中国中西医结合研究的成果，向中国读者介绍世界结合医学的进展，为全球读者提供一个即时和自由交流的学术平台。 我们的办刊方向：编辑出版国际一流医学期刊，打造国际化精品期刊、品牌期刊。
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    Stimuli-evoked NOergic molecules and neuropeptides at acupuncture points and the gracile nucleus contribute to signal transduction of propagated sensation along the meridian through the dorsal medulla-thalamic pathways

    Sheng-xing Ma
    515-522页
    查看更多>>摘要：Numerous studies from different international groups have demonstrated that sensations can be propa-gated along acupuncture channel pathways.The propagated sensation along the channel pathway(PSCP)can be elicited by electroacupuncture(EA),transcutaneous electrical nerve stimulation(TENS),manual acupuncture(MA),and heat applied to distal acupuncture points(acupoints).Nitric oxide(NO)levels were reported to be elevated in the gracile nucleus and skin regions near to the EA sites,with higher levels at acupoints associated with an enhanced expression of NO synthase and transient receptor poten-tial vanilloid type 1.The stimuli,EA,MA,TENS,and heat,have been used to elicit axonal reflexes,which increase local release of NO and neuropeptides such as calcitonin gene related peptide.Furthermore,the sensation of PSCP along the body surface occurs only ipsilaterally to the stimulated acupoints in various human studies,which does not support the involvement of the spinal-thalamic pathway,which would involve cross over transmission of the signals.The gracile nucleus receives ascending input from the sci-atic nerve and responds to somatosensory stimulation mainly on the ipsilateral side via the dorsal col-umn pathway.EA at Zusanli(ST36)increases NO release and expression of NO synthase mainly in the ipsilateral side of the gracile nucleus,while the cardiovascular effects and analgesic responses to EA at ST36 are changed by influences of L-arginine-derived NO synthesis in the ipsilateral gracile nucleus in rats.The stimuli-induced release of NOergic molecules and neuropeptides exist high levels in the acu-points,which contain rich neuronal components and blood vessels.Enhanced NOergic molecules at acu-points cause axon reflexes during the stimuli,which elevate cutaneous blood flow.Elevated NOergic molecules and local blood flow may spread over acupoints one after another along the meridian lines dif-fering from nerve pathways following the stimuli to induce PSCP.The same types of stimulation also elicit NO release in the gracile nucleus,which contributes to the somatosensory signal transduction of PSCP through the dorsal medulla-thalamic pathways.Other substances such as serotonin and catecholamines are proposed to mediate responses and certain effects of acupuncture-like stimulation but their mecha-nisms are poorly-understood.In this review we summarize the current understanding of the neurobio-logical processes of PSCP research with an emphasis on recent developments of NO mediating stimulation-evoked axon reflexes and somatosensory signal transduction for PSCP perceptions through the dorsal medulla-thalamic pathways.
      原文链接:
    • 万方数据
    • 维普

    Unlocking the potential:How acupuncture reshapes the liver-centered lipid metabolism pattern to fight obesity

    Shu-rui YangLi ChenDan LuoYa-yuan Wang...
    523-532页
    查看更多>>摘要：Obesity,a widespread global health issue,is frequently linked to disrupted lipid metabolism,resulting in excessive accumulation of adipose tissue and associated health complications.Acupuncture,a traditional Chinese medical modality,has exhibited potential as a viable intervention for addressing obesity.The underlying mechanism proposed involves the stimulation of specific acupoints to exert a regulatory influ-ence on hepatic function.The liver has a central role in lipid metabolism,including processes such as lipid synthesis,storage and distribution.Acupuncture is believed to enhance the liver's efficiency in processing lipids,thereby reducing lipid accumulation and improving metabolic functions.Research indicates that acupuncture can influence the expression of certain genes and proteins involved in lipid metabolism in the liver.This includes upregulating genes that promote lipid breakdown and oxidation,and downreg-ulating those involved in lipid synthesis.Additionally,acupuncture has been shown to improve insulin sensitivity,which is crucial for the regulation of lipid metabolism.Furthermore,the potential anti-inflammatory effects of acupuncture may play a significant role in its efficacy for the treatment of obesity.The presence of chronic inflammation has been strongly associated with metabolic disorders such as obe-sity.Through its ability to mitigate inflammation,acupuncture can potentially aid in the restoration of lipid metabolism and the reduction of body weight.Moreover,the amelioration of hepatic oxidative stress represents another mechanism by which acupuncture may contribute to the reduction of lipid deposition.Notably,the liver,being the primary site of lipid metabolism,maintains communication with various organs including the brain,adipose tissue,skeletal muscle and intestines.This perspective opens new avenues for the treatment of obesity,emphasizing the importance of holistic approaches in manag-ing complex metabolic disorders.
      原文链接:
    • 万方数据
    • 维普

    Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias-the PrePoP guidelines

    Alexander L.TournierLeoni V.BonaminSusann Buchheim-SchmidtSteven Cartwright...
    533-544页
    查看更多>>摘要：Objective:Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrative medicine.The physicochemical properties and biological activity of these preparations are often investigated in preclinical research,yet no guidelines for experimental research currently exist in this area.The present PrePoP guidelines aim to provide recommendations to promote high-quality,statistically sound,and reproducible preclinical research on potentised preparations.Methods:Input was gathered from researchers nominated by the relevant scientific societies using a simplified Delphi consensus approach covering the most relevant aspects of basic research methodology in the field including appropriate controls,sample preparation and handling,and statistics.After three rounds of feedback,a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised preparations.Results:We present a series of recommendations on a range of topics including experimental controls,system stability,blinding and randomisation,environmental influences,and procedures for the prepara-tion of potentised samples and controls,and we address some specific challenges of this research field.Conclusion:This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and provides a valuable framework that will inform and improve the quality of subsequent research in this emerging field.
      原文链接:
    • 万方数据
    • 维普

    Efficacy and safety of Tianqi Pingchan Granule,a compound Chinese herbal medicine,for levodopa-induced dyskinesia in Parkinson's disease:A randomized double-blind placebo-controlled trial

    Yu ZhangXiao-bo ZhuYang ZhaoGui-yun Cui...
    545-551页
    查看更多>>摘要：Background:Patients with Parkinson's disease(PD)undergoing long-term levodopa therapy are prone to develop levodopa-induced dyskinesia(LID).Amantadine is the main drug recommended for the treat-ment of LID by current guidelines,but it is far from meeting clinical needs.Tianqi Pingchan Granule(TPG),a compound Chinese herbal medicine,has been developed to relieve symptom of LID.Objective:This randomized controlled trial evaluated the efficacy and safety of the combination of TPG and amantadine for LID.Design,setting,participants and interventions:This is a randomized double-blind placebo-controlled trial,conducted from January 2020 to August 2021 at 6 sites in Jiangsu,Zhejiang and Shanghai,China.One hundred PD patients with ≥ 0.5 h of LID were randomly assigned to either the TPG plus amantadine group(TPG group)or the placebo plus amantadine group(placebo group),and treated for a period of 12 weeks.To ensure unbiased results,all study participants,investigators and sponsors were unaware of group allocations.Additionally,the data analysts remained blinded until the analysis was finalized.Main outcome measures:The primary outcome was assessed using the Unified Dyskinesia Rating Scale(UDysRS)(Range 0-104).The key secondary end point was improvement of motor and non-motor symp-toms.Safety analyses included all enrolled patients.Results:One hundred patients were enrolled and randomized into the two treatment groups.The changes in UDysRS at week 12 were-11.02 for the TPG group and-4.19 for the placebo group(treatment difference-6.83[-10.53 to-3.12];P=0.0004).Adverse events were reported for 2 of 50 patients(4.0％)in each of the groups.Conclusion:This study indicated that a 12-week treatment of amantadine plus TPG effectively reduced UDysRS scores and was well tolerated,demonstrating the efficacy and safety of TPG for the treatment of LID in PD.
      原文链接:
    • 万方数据

    Hongjin Xiaojie Capsule,a Chinese patent medicine,for treating moderate to severe cyclical breast pain:A single-blind randomized controlled trial

    Qiong ZhangYing-yi FanXue-qing WuYan-dan Huo...
    552-560页
    查看更多>>摘要：Background:Moderate to severe breast pain has major effects on the quality of life for patients.Patent Chinese medicines are widely used in the treatment of breast pain due to their stable dosage form and good efficacy.Objective:To evaluate the beneficial effects and safety of Hongjin Xiaojie Capsule(HJXJC),a Chinese patent medicine,for the treatment of cyclical breast pain.Design,setting,participants and intervention:This is a multicenter,single-blind randomized controlled trial conducted in 3 medical centers in China from 2019 to 2021.Patients with moderate to severe cyclic breast pain were randomly divided into the intervention group(who took HJXJC,four capsules per dose,three times a day for 12 weeks)and the control group(waiting for the treatment)in a 1∶1 ratio.Main outcome measures:The primary outcome was pain duration,and the patients recorded measure-ments at baseline and at the end of weeks 4,8,12 and 16 on a patient log card.Results:The full analysis set(FAS)population included 298 participants(intervention group,n=150;control group,n=148),while the per-protocol analysis set(PPS)included 274 participants.After 12 weeks,the duration of breast pain was significantly shorter in the intervention group(FAS:mean dif-ference,-6.69;95％CI,-7.58 to-5.80;P＜0.01,vs control.PPS:mean difference,-7.09;95％CI,-8.01 to-6.16;P＜0.01,vs control).The Short-form McGill Pain Questionnaire(SF-MPQ)scores were significantly lower in the intervention group(FAS:mean difference,-12.55;95％CI,-13.90 to-11.21;P＜0.01,vs con-trol.PPS:mean difference,-13.07;95％Cl,-14.48 to-11.66;P＜0.01,vs control).The above indicators continued to be significantly different through week 16.Moreover,in the intervention group,breast lumps shrank after 12 weeks and the size of breast lumps was statistically smaller than that in the control group(P＜0.05),whereas the sizes of breast nodules and uterine fibroid showed no statistically signifi-cant difference compared with the control group(P＞0.05).At weeks 8 and 12,the dysmenorrhea scores in the intervention group were lower than those in the control group(P＜0.05).No obvious adverse reac-tions were observed in any group.Conclusion:HJXJC can significantly shorten the duration of breast pain,reduce breast pain,reduce the size of breast lumps,and relieve dysmenorrhea.However,it has no significant effect on the size of breast nodules or uterine fibroid.
      原文链接:
    • 万方数据
    • 维普

    Efficacy and safety of Qingfei Huatan formula in the treatment of acute exacerbation of chronic obstructive pulmonary disease:A multi-centre,randomised,double-blind,placebo-controlled trial

    Hui-zhi ZhuCheng-yi LiLiang-ji LiuJia-bing Tong...
    561-569页
    查看更多>>摘要：Background:Chronic obstructive pulmonary disease(COPD),a common respiratory disease,can be effec-tively treated by traditional Chinese medicine(TCM).Qingfei Huatan,a TCM formula,has been reported to effectively alleviate the clinical symptoms of COPD patients.However,there is a lack of multi-centre,randomised,double-blind,controlled clinical trials documenting the clinical efficacy and safety of this formula in the treatment of acute exacerbation of COPD(AECOPD).Objective:This study evaluated the efficacy and safety of Qingfei Huatan formula in the treatment of AECOPD,thereby providing high-quality clinical evidence.Design,setting,participants and interventions:A total of 276 patients with AECOPD were included in this multi-centre,randomised,double-blind,placebo-controlled trial and were randomised into treatment and control groups at a ratio of 1:1.Patients in the treatment and control groups took Qingfei Huatan granules or simulated Qingfei Huatan granules twice a day,for 14 days,in addition to Western medicine treatment.All patients were followed up for 3 months.Main outcome measures:The primary outcome was time taken to symptom stabilisation.The secondary outcomes included duration of antibiotic use,clinical symptom and sign score,TCM syndrome score,dys-pnoea score,and quality of life(QOL)score.Meanwhile,the safety of the formula was assessed through routine urine and stool tests,electrocardiograms,liver and kidney function tests,and the observation of adverse events throughout the trial.Results:The time taken for effective stabilisation(P＜0.05)and obvious stabilisation(P＜0.01),and the duration of antibiotic use(P＜0.05)were significantly shorter in the treatment group than in the control group.On days 6,9,12 and 14 of treatment,clinical symptom and sign score decreased in both groups,particularly in the treatment group(P＜0.01).On days 9,12 and 14 of treatment,the TCM syndrome scores of both groups were reduced(P＜0.01),with more significant reductions in the treatment group.At 3 months after the end of treatment,the treatment group continued to have lower clinical symptom and sign score and TCM syndrome score than the control group(P＜0.01).On days 6,9,12 and 14 of treat-ment,dyspnoea and QOL scores were markedly reduced in the two groups(P＜0.05 and P＜0.01,respec-tively),especially in the treatment group.At 3 months after the end of treatment,dyspnoea and QOL scores were lower in the treatment group than those in the control group(P＜0.01).No serious adverse events were observed in either group.Conclusion:The Qingfei Huatan formula can effectively shorten the duration of AECOPD and antibiotic use,significantly relieve clinical symptoms,and increase QOL for AECOPD patients,with a favourable safety profile.These results suggest that this formula can be used as a complementary treatment for AECOPD patients.
      原文链接:
    • 万方数据
    • 维普

    A survey on the real-world clinical utilization of a traditional acupuncture in Republic of Korea:Sa-am acupuncture

    Ji-Yeun ParkYe-Seul LeeHi-Joon ParkSeungmin Kathy Lee...
    570-578页
    查看更多>>摘要：Objective:This study investigated the clinical details and usage of Sa-am acupuncture in Korean medicine clinics and explored how practicing Korean medicine doctors(KMDs)think about Sa-am acupuncture.Methods:We conducted a questionnaire-based survey of KMDs who utilize Sa-am acupuncture in their practice.The study comprehensively investigated issues related to clinical application of Sa-am acupunc-ture,needling techniques used during treatment,training methods,and directions for its future improve-ment.Results:We analyzed 572 responses.An average of 50％of the patients visiting Korean medicine clinics were receiving Sa-am acupuncture.The most prevalent indication for Sa-am acupuncture use was digestive dis-orders.The patients'appetite level and digestive function were most frequently used indicators for select-ing acupuncture points.Regarding prescription compositions,Jung-Gyuk formulas were more frequently used than Seung-Gyuk formulas.Inserting the needle along the flow of the channel or against the flow of the channel was most popular.The acupuncture style most frequently used in combination with Sa-am acupuncture was Ashi point acupuncture.Strengths of Sa-am acupuncture included its versatility,easy application,and good outcomes.Limitations included the lack of rigorous education and training programs,difficulty in applying the principles for beginners,and insufficient clinical research evidence.Conclusion:In clinics where Sa-am acupuncture is available,KMDs were providing Sa-am acupuncture to about half of their patients.Practitioners were not using all of the tonification and sedation techniques which may be due to time constraints or simply a lack of necessity.Sa-am acupuncture demonstrated high utility in clinical practice and high satisfaction based on the efficacy and safety.More training programs and high-quality research are needed to help expand the use of Sa-am acupuncture.
      原文链接:
    • 万方数据
    • 维普

    Delphi study for developing a checklist of adverse events associated with acupotomy

    Hyungsun JunHaebeom LeeSang-Hoon YoonChan-Young Kwon...
    579-587页
    查看更多>>摘要：Background:Acupotomy,a more invasive procedure than acupuncture,involves the use of a thicker nee-dle with an integrated knife at the tip,necessitating safety research.We aimed to define relevant adverse events(AEs)and create a standardized form of the ACUPOtomy-related AEs CHECKlist(ACUPOCHECK).Methods:Before conducting the Delphi process,a systematic review and pilot prospective study were conducted to gather information on previously reported AEs.Using these data,pilot versions of the ACUPOCHECK and Delphi questionnaires were developed.The Delphi questionnaire involved selecting types of AE for inclusion,establishing separate criteria for acupotomy-related AEs,and achieving a con-sensus on AE assessment.Thirteen Korean doctors with experience in acupotomy or AE research were recruited to participate in each Delphi round.Consensus was considered to have been reached if the crit-ical value for the content validity ratio met or exceeded 0.538.Results:The final ACUPOCHECK was developed using four rounds of the Delphi method and one face-to-face consensus meeting.It included 12 local AEs(pain,hemorrhage,bruise,hematoma,edema,pruritus,rash,infection,nerve damage,dysesthesia,movement impairment,and pneumothorax)and 14 systemic AEs(disease aggravation,needle fatigue,sleepiness,procedural nausea,procedural vomiting,procedural headache,procedural dizziness,sweating,procedural shock,syncope,dyspnea,procedural pain,sleep dis-order,and postprocedural infection).Separate criteria were established for pain,hemorrhage and bruis-ing:pain was defined as pain that occurrs during daily activities and persists for longer than 72 h,hemorrhage as bleeding that continues for ≥ 3 min despite pressure application,and bruising as having a bruise with a diameter of ≥ 3 cm.Open-ended descriptions were allowed for AEs not covered by the checklist,and severity and causality were assessed using the Common Terminology Criteria for Adverse Events and modified World Health Organization-Uppsala Monitoring Center criteria.Conclusion:ACUPOCHECK provides a standardization framework that can help research on traditional practices as well as new tools and techniques that are more invasive and may cause more severe AEs.Subsequent studies will use ACUPOCHECK to develop rational safety guidelines for acupotomy tech-niques.
      原文链接:
    • 万方数据
    • 维普

    Electroacupuncture activates AMPKα1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer's disease by regulating hippocampal mitochondrial dynamics

    Wei-wei JiaHua-wei LinMin-guang YangYa-ling Dai...
    588-599页
    查看更多>>摘要：Objective:Studies have shown that electroacupuncture(EA)can alleviate cognitive impairments from Alzheimer's disease(AD)by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK),but the specific mechanism involved remains to be elucidated.Therefore,this study explores the potential mechanism by which EA improves cognitive function from the perspective of mito-chondrial dynamics.Methods:The four-month-old transgenic mice with amyloid precursor protein(APP)/presenilin 1(PS1)and AMPKα1-subunit conditional knockout(AMPKα1-cKO)were used for experiments.To evaluate the effects of EA treatment on cognitive function,the T-maze and Morris water maze were used.In addition,chemical exchange saturation transfer,thioflavin staining,transmission electron microscopy,mitochon-drial membrane potential,and Western blotting were used to examine the potential mechanisms under-lying the effects of EA on APP/PS1 mice.Results:Both APP/PS1 mice and AMPKα1-cKO mice exhibited dysfunction in mitochondrial dynamics accompanied by learning and memory impairment.Inactivation of the AMPK/peroxisome proliferator-activated receptor-γ coactivator-1α(PGC-1 α)pathway increased pathological amyloid-β(Aβ)deposition and aggravated the dysfunction in mitochondrial dynamics.In addition,EA rescued learning and memory deficits in APP/PS1 mice by activating the AMPK/PGC-1α pathway,specifically by reducing pathological Aβ deposition,normalizing energy metabolism,protecting the structure and function of mitochondria,increasing the levels of mitochondrial fusion proteins,and downregulating the expression of fission pro-teins.However,the therapeutic effect of EA on cognition in APP/PS1 mice was hindered by AMPKα1 knockout.Conclusion:The regulation of hippocampal mitochondrial dynamics and reduction in Aβ deposition via the AMPK/PGC-1α pathway are critical for the ability of EA to ameliorate cognitive impairment in APP/PS1 mice.
      原文链接:
    • 万方数据

    Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice

    Mijung YeomSora AhnDae-Hyun HahmSun-Young Jang...
    600-613页
    查看更多>>摘要：Objective:Atopic dermatitis(AD)is a chronic inflammatory skin disease that may be linked to changes in the gut microbiome.Acupuncture has been proven to be effective in reducing AD symptoms without seri-ous adverse events,but its underlying mechanism is not completely understood.The purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut microbiota-dependent.Methods:AD-like skin lesions were induced by applying MC903 topically to the cheek of the mouse.Acupuncture was done at the Gok-Ji(LI11)acupoints.AD-like symptoms were assessed by lesion scores,scratching behavior,and histopathological changes;intestinal barrier function was measured by fecal output,serum lipopolysaccharide levels,histopathological changes,and mRNA expression of markers involved in intestinal permeability and inflammation.Gut microbiota was profiled using 16S rRNA gene sequencing from fecal samples.Results:Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening,and also significantly altered gut microbiota structure as revealed by β-diversity indices and analysis of similarities.These beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated mice.Interestingly,AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability,atrophy of the mucosal structure(reduced villus height and crypt depth),decreased expression of tight junctions and mucus synthesis genes,and increased expression of inflammatory mediators in the ileum.Acupuncture attenuated these abnormalities,which was gut microbiota-dependent.Conclusion:Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier,providing new per-spective for non-pharmacological strategies for modulating gut microbiota to prevent and treat AD.
      原文链接:
    • 万方数据
    • 维普