查看更多>>摘要:In this study,the co-culture of Nigrospora oryzae and Beauveria bassiana,the pathogenic endophytes in the seeds of Dendrobium officinale,were examined for their antagonistic relationship by the production of metabolite.One new chlorotetralone(1)and five known compounds,murranoic acid A(2),9,12,13-trihydroxy-10-octadecenoic acid(3),3,3'-methylenebis(4-hydroxy-6-methyl-2H-pyran-2-one)(4),sclerin(5),and(4S)-4,6,8-trihydroxy-3,4-dihydro-1(2H)-naphthalen-1-one(6),were isolated.Compounds 1-5 showed antifungal activity against B.bassiana with MICs of 256,128,2,32,and 64 μg/mL,and N.oryzae with MICs of 64,256,256,256,and 64 μg/mL.Compound 4 showed significant antifungal activity against co-culture of B.bassiana and N.oryzae with MIC at 1 μg/mL.