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中华实用儿科临床杂志
中华实用儿科临床杂志

郭学鹏

半月刊

2095-428X

syqk@xxmu.edu.cn

0373-3029144，3831456

453003

河南省新乡市新乡医学院

中华实用儿科临床杂志/Journal Journal of Applied Clinical PediatricsCSCD北大核心CSTPCD
查看更多>>本刊创刊20年来，严格遵守国家的出版法规及条例，执行出版编辑规范，始终坚持突出实用为主，理论联系实践，注重基础与临床相结合，报道儿科领域新的科研成果、新理论、新技术、新进展，为促进我国儿科医学领域的学术交流服务为办刊宗旨。2005年本刊的总被引频次1417，在18种妇、儿科医学类期刊中列第4位，在1606种中国科技论文统计源期刊中列第79位；影响因子0.659，在18种妇、儿科医学类期刊中列第6位，在1606种中国科技论文统计源期刊中列第221位；即年指标0.155,在8种儿科学类期刊中仅次于《中华儿科杂志》，位居第2位，其他学术期刊指标均较去年明显提高。目前已连续四次进入北京大学图书馆主编的《中文核心期刊要目总览》、列入中国科技论文统计源期刊（中国科技核心期刊），2003年被俄罗斯《文摘杂志》收录,2005年又被美国《化学文摘》收录。2004年被评为河南省优秀期刊。我刊已被中国生物医学文献数据库（CBMdisc）、Quick全文资料管理系统（FTME）、中文科技期刊数据库、中国学术期刊（光盘版）、万方数据库和美国《化学文摘》、俄罗斯《文摘杂志》、《中国医学文摘：儿科学分册》等多种权威性数据库与文摘期刊作为固定收录对象。
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收录年代

    忆往昔硕果累累，畅未来再展宏图

    李建华王家勤郭学鹏
    1页
    查看更多>>摘要：2023年是全面落实党的二十大精神的开局之年，是全面建设社会主义现代化国家新征程的起步之年。这一年，中国国际科技期刊影响力进一步提高，进入本学科前列的中国国际科技期刊数量上升明显；这一年，中国科技核心期刊影响力持续提升，面向国家重大需求吸引高水平论文的能力不断加强。
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    不容忽视的儿童侵袭性真菌感染

    李琰冰徐英春张丽单卫华...
    2-6页
    查看更多>>摘要：近年来随着免疫缺陷人群的不断扩大，真菌感染成为威胁人类健康的重要因素。同样，儿童中由于血液病、恶性肿瘤使用免疫抑制剂和广谱抗菌药物等而处于免疫抑制状态的患儿数量增多，使得儿童真菌感染总体死亡率仍较高，且显示出非白念珠菌和曲霉菌感染高发的趋势，真菌感染是导致危重症儿童死亡的重要原因之一。现介绍总结儿童侵袭性真菌感染的流行病学特征、诊断和治疗策略，以期使儿童真菌感染得到临床更多的重视，减少儿童侵袭性真菌感染的发生及改善预后。 With the increasing number of people with immune deficiency in recent years， fungal infections become an important factor threatening human health。Likewise， the number of children who are immunosuppressed due to hematological diseases， malignancies， use of immunosuppressants and spectrum antibacterial drugs has increased， leading to a high mortality of fungal infections。Moreover， infections of the non-candida albicans and aspergillu are prevalent， serving as important causes for the death of critically ill children。 Therefore， this review aims to introduce and summarize the epidemiological characteristics， diagnosis and treatment of pediatric invasive fungal infections， thus yielding the concern of pediatric invasive fungal infections， reducing the occurrence of pediatric fungal infections and improving the prognosis。

    儿童侵袭性真菌病流行病学诊断治疗

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    中国真菌感染管理政策解读

    冯佳佳孔维华林丽开李建华...
    7-9页
    查看更多>>摘要：侵袭性真菌病的发病呈现上升趋势，真菌耐药问题也逐渐引起了全球关注。2022年世界卫生组织制定了第1份真菌病原体清单，鼓励各国提高其真菌学诊断能力，管理真菌感染并进行监测。我国作为全球最早发布和实施遏制细菌耐药国家行动计划的国家之一，始终高度重视包括真菌在内的微生物耐药控制问题和抗菌药物管理，在完善真菌病防治相关法律法规体系、加强抗真菌药物临床应用管理、提升真菌病诊疗能力和诊疗规范化水平、建立健全真菌感染及耐药监测和评估体系等方面开展了一系列工作，取得了阶段性成效。未来，我国在新一轮遏制微生物耐药国家行动计划的指引下，将进一步提高真菌病诊疗水平，减少真菌病的发生及真菌耐药性的传播。 Fungal infections are a growing public health threat， especially as the at-risk population for invasive fungal disease expanding and antifungal resistance emerging。In 2022， the World Health Organization released the first fungal priority pathogens list， aiming to encourage countries to strengthen the response to fungal infections。As one of the first countries to issue and implement the National Action Plan to Contain Antimicrobial Resistance in the world， China has attached great importance to the management of fungal infections。A series of actions and efforts have been made， including improving the legal and regulatory system related to the prevention and treatment of fungal infections， strengthening the management of clinical application of antifungal drugs， improving the diagnosis and treatment ability of fungal infections and the standardization of diagnosis and treatment， establishing a monitoring and evaluation system for fungal infections and drug resistance。Initial results have been achieved。In the future， under the guidance of the new national action plan to contain antimicrobial resistance， the level of diagnosis and treatment of fungal infections will be further improved to reduce the occurrence of fungal infections and the spread of antifungal resistance。

    真菌感染抗真菌药物政策

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    儿童真菌感染的诊断进展

    施婷婷卢根范艳芬
    10-15页
    查看更多>>摘要：真菌感染发病率逐年增高，特别是儿童侵袭性真菌病(IFDs)可引起高死亡率，尽早并准确做出真菌感染诊断对降低病死率至关重要。真菌感染的诊断，特别是IFDs的诊断，仍基于三大要素：宿主因素、临床证据(特别是影像学表现)及真菌病原学依据。为加强儿童真菌病尤其是IFDs诊断的理解，现就其诊断进展进行阐述，以提高临床医务人员诊断真菌病的能力。 The morbidity of fungal infections increased year by year。Notably， the invasive fungal diseases (IFDs) in children lead to a high mortality。It is important to make the diagnosis of IFDs in early stage， thus reducing the mortality。The diagnosis of fungal infection is based on three factors， including host factors， clinical evidences (such as imaging findings) and the evidence of fungal etiology。This review described the progress in the diagnosis of IFDs in children， thus improving the ability of physicians to diagnose the fungal infection。

    真菌感染儿童诊断治疗

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    真菌耐药机制与现状

    胡雨凡徐保平廉珍珍
    15-19页
    查看更多>>摘要：真菌感染正在逐渐引起全球公共卫生的关注，其中念珠菌、曲霉、隐球菌是常见的真菌感染病原。随着抗真菌药物的广泛使用，真菌耐药逐渐增加，明确真菌的耐药情况和耐药机制有助于真菌感染的合理治疗。 Fungal infections gradually attract global public health attention。Candida， Aspergillus， and Cryptococcus are the most common pathogens of fungal infections。With the widespread use of antifungal drugs， fungal resistance is gradually increasing。Clarifying the current status of antifungal drug resistance and the mechanism is helpful for rational treatment of fungal infections。

    真菌真菌耐药儿童侵袭性真菌病

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    真菌感染的免疫治疗

    苟渊胡艳玲王文建单卫华...
    20-25页
    查看更多>>摘要：侵袭性真菌感染是威胁人类健康的一个重要因素，近年来易感人群逐年增加，导致人类真菌疾病负担大幅增加。2022年世界卫生组织发布了一份重点真菌病原体清单，以推动全球对真菌感染和抗真菌耐药性的研究和投资。目前抗真菌药物仍是真菌感染的治疗选择，但是抗真菌药物的毒副作用及耐药影响了临床疗效，改善受损的宿主免疫反应成为提高抗真菌药物有效性的合理途径。现简述真菌感染的流行病学，总结宿主如何通过启动先天和适应性免疫反应来介导清除真菌，同时讨论支持免疫调节疗法治疗侵袭性真菌感染的前景及临床证据。 Invasive fungal infections play an important factor threatening human health。In recent years， the number of the susceptible population of invasive fungal infections has increased rapidly， leading to a significant increase in the disease burden of human fungi。In 2022， the World Health Organization released a list of key fungal pathogens， aiming to promote global research and investment in fungal infection and antifungal resistance。At present， antifungal drugs are preferred for anti-fungal infection treatment， although the efficacy is limited by the adverse events and drug resistance。Improving the damaged host immune response is a reasonable way to improve the effectiveness of antifungal drugs。This article briefly described the epidemiology of fungal infections， summarized how hosts mediate the clearance of fungi by initiating innate and adaptive immune responses， and discussed the prospects and clinical evidence supporting immunomodulatory therapy for invasive fungal infections。

    真菌感染免疫疗法细胞因子治疗细胞免疫治疗

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    儿童过敏性真菌气道疾病诊治进展

    韩鹏申昆玲廉珍珍
    25-30页
    查看更多>>摘要：真菌是过敏性疾病常见的致敏原之一，可影响儿童过敏性气道疾病的易感性、严重程度以及疾病控制情况。与真菌致敏相关的一系列呼吸系统疾病被描述为过敏性真菌气道疾病(AFAD)，包括真菌致敏相关重度哮喘、变应性支气管肺曲霉菌病、雷暴哮喘及过敏性真菌性鼻－鼻窦炎等。糖皮质激素、生物制剂、抗真菌治疗及免疫治疗可减少AFAD的气道炎症、真菌负担以及组织损伤。现对真菌、真菌致敏的机制和检测以及儿童AFAD的范围和治疗进行介绍，以期提高儿科医师对AFAD的认识。 Fungus is one of common allergens in allergic disease that affects the susceptibility， severity， and disease control of allergic airway disease in children。A spectrum of respiratory diseases associated with fungal sensitization has been described as allergic fungal airway disease (AFAD)， including severe asthma with fungal sensitization， allergic bronchopulmonary aspergillosis， thunderstorm asthma， and allergic fungal rhinosinusitis。Glucocorticoids， biologics， antifungal therapy， and immunotherapy can reduce the airway inflammation， fungal burden， and tissue damage associated with AFAD。This review introduced fungus， the mechanism of fungal sensitization and the detection， as well as the scope and treatment of AFAD in children， aiming to improve the understanding of AFAD among pediatricians。

    真菌致敏儿童过敏性真菌气道疾病

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    儿童消化道真菌感染

    李倩王朝霞申玉美
    31-34页
    查看更多>>摘要：儿童消化道真菌感染可以由多种真菌引起，其中最常见的是念珠菌和曲霉。侵袭性真菌感染的发生取决于许多因素，包括地理位置和暴露途径，以及宿主因素，如易感条件、高风险药物，或影响机体免疫功能的基础疾病。随着DNA和核糖体RNA测序和血清学检测的进展，促进了肠道真菌微生物群的识别和诊断，现简要阐述儿童胃肠道真菌感染的常见病原菌、危险因素、临床表现、诊断和治疗。 Fungal infections of the digestive tract in children can be caused by a variety of fungi， the most common of which are Candida and Aspergillus。Occurrence of invasive fungal infections is dependent on numerous factors including geographic location and routes of exposure， and host factors， such as predisposing conditions， high-risk medications， or underlying medical comorbidities that modulate overall immune function。However， advances in DNA and ribosomal RNA sequencing and serologic testing have led to shifts in how gut fungal microbiota are identified and in diagnosing opportunistic infections。This article will briefly expound the common pathogens， risk factors， clinical manifestations， diagnosis， and treatment of gastrointestinal fungal infections in children。

    儿童消化道真菌感染

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    儿童皮肤浅部真菌感染诊疗进展

    肖媛媛马琳廉珍珍梁栋...
    35-39页
    查看更多>>摘要：皮肤浅部真菌感染由只侵犯完全角化组织，例如角质层、毛发和甲的真菌引起。临床上，儿童皮肤浅部真菌感染最常见的为头癣，而体/股癣、手/足癣、甲真菌病及花斑糠疹的发病率相对较低，现就儿童皮肤浅部真菌感染的临床表现、诊断及治疗进展进行阐述。 Superficial cutaneous fungal infections are caused by fungi infections that only invade fully keratinized tissues， such as the stratum corneum， hair， and nails。In clinical practice， tinea capitis is the most prevalent superficial cutaneous fungal infections in children， whereas the incidence of tinea corporis/cruris， tinea manuum/pedis， onychomycosis， and pityriasis versicolor is relatively low。This article aims to comprehensively discuss the clinical manifestations， diagnosis， and advancements in the treatment of superficial cutaneous fungal infections in children， focusing on each specific infection individually。

    儿童皮肤癣菌头癣体/股癣手/足癣甲真菌病花斑糠疹诊断治疗

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    儿童耳真菌病的诊疗进展

    贾得声王欣潘宏光申玉美...
    39-43页
    查看更多>>摘要：儿童耳真菌病的发病率逐渐上升，多重耐药耳念珠菌广泛流行。然而儿童耳真菌病早期诊断相对困难，容易导致误诊和漏诊。本综述基于国内外相关研究，从儿童耳真菌病的流行病学、疾病诱因与危险因素、病原微生物、诊断与治疗等方面对该病进行综合评述，以提高对儿童耳真菌病的认识。 The incidence of pediatric otomycosis is gradually increasing， with a widespread prevalence of multidrug-resistant Candida auris。However， its early diagnosis remains challenging， leading to misdiagnosis and underdiagnosis。This review aims to provide a comprehensive overview of pediatric otomycosis based on relevant domestic and international studies。This article reviewed the epidemiology， etiology， risk factors， pathogenic microorganisms， diagnosis， and treatment of pediatric otomycosis， aiming to enhance the understanding of pediatric otomycosis among healthcare professionals。

    儿童耳真菌病诊断治疗

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