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世界胃肠病学杂志（英文版）
世界胃肠病学杂志（英文版）

潘伯荣

周刊

1007-9327

wjg@wjgnet.com

010-85381901-628

100025

北京市朝阳区东四环中路62号楼远洋国际中心D座903室

世界胃肠病学杂志（英文版）/Journal World Journal of GastroenterologyCSCDCSTPCDSCI
查看更多>>主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。
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    Risk modification of colorectal cancer susceptibility by interleukin-8-251T＞A polymorphism in Malaysians

    Mohd Aminudin MustaphaSiti Nurfatimah Mohd ShahpudinAhmad Aizat Abdul AzizRavindran Ankathil...
    2668-2673页
    查看更多>>摘要：AIM:To investigate the allele and genotype frequencies and associated risk of interleukin (IL)-8-251T＞A polymorphism on colorectal cancer (CRC) susceptibility risk.METHODS:Peripheral blood samples of 255 normal controls and 255 clinically and histopathologically confirmed CRC patients were genotyped for IL-8-251T＞A polymorphism employing allele-specific polymerase chain reaction.The relative association of variant allele and genotypes with CRC susceptibility risk was determined by calculating the odds ratios (ORs).Corresponding x2 tests on the CRC patients and controls were carried out and 95％ confidence intervals (CIs) were determined using Fisher's exact test.The allele frequencies and its risk association were calculated using FAMHAP,haplotype association analysis software.RESULTS:On comparing the frequencies of genotypes of patients and controls,the homozygous variant AA was significantly higher in CRC patients (P =0.002)compared to controls.Investigation on the association of the polymorphic genotypes with CRC susceptibility risk,showed that the homozygous variant IL-8-251AA had a significantly increased risk with OR 3.600 (95％CI:1.550-8.481,P =0.001).In the case of allele frequencies,variant allele A of IL-8-251 showed a significantly increased risk of CRC predisposition with OR 1.32(95％ CI:1.03-1.69,P =0.003).CONCLUSION:Variant allele and genotype of IL-8 (-251T＞A) was significantly associated with CRC susceptibility risk and could be considered as a high-risk variant for CRC predisposition.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Eradication of Helicobacter pylori increases childhood growth and serum acylated ghrelin levels

    Yao-Jong YangBor-Shyang SheuHsiao-Bai YangCheng-Chan Lu...
    2674-2681页
    查看更多>>摘要：AIM:To determine whether Helicobacterpylori (H.pylorl)-infected children have reduced body weight (BW) and height (BH) growth,and if H.pylori eradication may restore growth while improving serum acylated ghrelin.METHODS:This longitudinal cohort study with oneyear follow-up enrolled 1222 children aged 4 to 12 years old into an observation cohort (18 with and 318 without H.pylori) and intervention cohort (75 with and 811 without).The 7-d triple therapy was used for eradication in the intervention cohort.The net increases of BW and BH as well serum acylated ghrelin after oneyear follow-up were compared between successful eradicated H.pylori-infected children and controls.RESULTS:In the observation cohort,the H.pyloriinfected children had lower z score of BW (-1.11 ± 0.47vs 0.35± 0.69,P =0.01) and body mass index (BMI)(0.06 ± 0.45 vs 0.44± 0.73,P =0.02) at enrollment and lower net BW gain after one-year follow-up (3.3 ±2.1 kg vs 4.5 ± 2.4 kg,P =0.04) than the non-infected controls.In the intervention cohort,the H.pyloriinfected children had lower z score of BMI (0.25 ± 1.09vs 0.68 ± 0.87,P =0.009) and serum acylated ghrelin levels (41.8 ± 35.6 pg/mL vs 83.6 ± 24.2 pg/mL,P ＜0.001) than the non-infected controls.In addition to restoring decreased serum ghrelin levels (87.7 ± 38.0pg/mL vs 44.2 ± 39.0 pg/mL,P ＜ 0.001),the H.pyloriinfected children with successful eradication had higher net gains (P ＜ 0.05) and increase of z scores (P ＜ 0.05)of both BW and BH as compared with non-infected controls after one-year follow-up.CONCLUSION:H.pylori-infected children are associated with low serum acylated ghrelin and growth retardation.Successful eradication of H.pylori restores ghrelin levels and increases growth in children.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Colorectal cancer screening: Comparison of transferrin and immuno fecal occult blood test

    Ji-Gui ChenJuan CaiHuan-Lei WuHua Xu...
    2682-2688页
    查看更多>>摘要：AIM:To evaluate the sensitivity and specificity of transfesrrin dipstick test (Tf) in colorectal cancer (CRC)screening and precancerous lesions screening.METHODS:Eight hundreds and sixty-one individuals at high-risk for CRC were recruited.Six hundreds and eleven subsequently received the three fecal occult blood tests and colonoscopy with biopsy performed as needed.Fecal samples were obtained on the day before colonoscopy.Tf,immuno fecal occult blood test (IFOBT)and guaiac fecal occult blood test (g-FOBT) were performed simultaneously on the same stool.To minimize false-negative cases,all subjects with negative samples were asked to provide an additional stool specimen for a second test even a third test.If the results were all negative after testing three repeated samples,the subject was considered a true negative.The performance characteristics of Tf for detecting CRC and precancerous lesions were examined and compared to those of IFOBT and the combination of Tf,IFOBT and g-FOBT.RESULTS:A total of six hundreds and eleven subjects met the study criteria including 25 with CRC and 60 with precancerous lesions.Sensitivity for detecting CRC was 92％ for Tf and 96％ for IFOBT,specificities of Tf and IFOBT were both 72.0％ (95％ CI:68.2％-75.5％;x2 =0.4,P ＞ 0.05); positive likelihood ratios of those were 3.3 (95％ CI:2.8-3.9) and 3.4 (95％ CI:2.9-4.0),respectively.In precancerous lesions,sensitivities for Tf and IFOBT were 50％ and 58％,respectively (x2 =0.8,P ＞ 0.05); specificities of Tf and IFOBT were 71.5％ (95％ CI:67.6％-75.1％) and 72.2％ (95％ CI:68.4％-75.8％); positive likelihood ratios of those were 1.8 (95％ CI:1.3-2.3) and 2.1 (95％ CI:1.6-2.7),respectively; compared to IFOBT,g-FOBT+ Tf+ IFOBT had a significantly higher positive rate for precancerous lesions (83％ vs 58％,respectively; x2 =9.1,P ＜ 0.05).In patients with CRC and precancerous lesions,the sensitivities of Tf and IFOBT were 62％ and 69％ (x2 =0.9,P ＞ 0.05); specificities of those were 74.5％ (95％ CI:70.6％-78.1％) and 75.5％ (95％ CI:71.6％-79.0％);positive likelihood ratios of those were 2.5 (95％ CI:2.0-3.1) and 2.8 (95％ CI:2.3-3.5).Compared to IFOBT alone,combining g-FOBT,IFOBT and Tf led to significantly increased sensitivity for detecting CRC and cancerous lesions (69％ vs 88％,respectively; x2 =9.0,P ＜ 0.05).CONCLUSION:Tf dipstick test might be used as an additional tool for CRC and precancerous lesions screening in a high-risk cohort.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Health-related quality of life evaluated by tumor node metastasis staging system in patients with hepatocellular carcinoma

    Cui-Xia QiaoXiao-Feng ZhaiChang-Quan LingQing-Bo Lang...
    2689-2694页
    查看更多>>摘要：AIM:To investigate and evaluate the change in healthrelated quality of life (HRQoL) by tumor node metastasis (TNM) staging system in patients with hepatocellular carcinoma (HCC).METHODS:A total of 140 patients diagnosed with HCC between June 2008 and April 2009 in our department were enrolled to this study.One hundred and thirty-five (96.5％) patients had liver cirrhosis secondary to hepatitis B virus (HBV) infection,73 (54.07％) of them being HBV DNA positive; the other etiologies of liver cirrhosis were alcoholic liver disease (1.4％),hepatitis C (1.4％)or cryptogenic (0.7％).All subjects were fully aware of their diagnosis and provided informed consent.HRQoL was assessed before treatment using the functional assessment of cancer therapy-hepatobiliary (FACTHep) questionnaire.Descriptive statistics were used to evaluate demographics and disease-specific characteristics of the patients.One-way analysis of variance and independent samples t tests were used to compare the overall FACT-Hep scores and clinically distinct TNM stages.Scores for all FACT-Hep items were analyzed by frequency analyses.The mean scores obtained from the FACT-Hep in different Child-Pugh classes were also evaluated.RESULTS:The mean FACT-Hep scores were reduced significantly from TNM Stage Ⅰ to Stage Ⅱ,Stage ⅢA,Stage ⅢB group (687 ± 39.69 vs 547 ± 42.57 vs 387 ± 51.24 vs 177 ± 71.44,P =0.001).Regarding the physical and emotional well-being subscales,scores decreased gradually from Stage Ⅰ to Stage ⅢB (P =0.002 vs Stage Ⅰ ; P =0.032 vs Stage Ⅱ; P =0.033 vs Stage ⅢA).Mean FACT-Hep scores varied by Child-Pugh class,especially in the subscales of physical well-being,functional well-being and the hepatobiliary cancer (P =0.001 vs Stage Ⅰ; P =0.036 vs Stage Ⅱ ; P =0.032 vs Stage ⅢA).For the social and family well-being subscale,only Stage ⅢB scores were significantly lower as compared with Stage Ⅰ scores (P =0.035).For the subscales of functional well-being and hepatobiliary cancer,there were significant differences for Stages Ⅱ Ⅰ,ⅢA and ⅢB (P =0.002 vs Stage Ⅰ).CONCLUSION:HRQoL of patients with HCC worsens gradually with progression of TNM stages.The most impaired subscales of HRQoL,as measured by FACTHep,were physical and emotional well-being.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Effect of intensive vs conventional insulin therapy on perioperative nutritional substrates metabolism in patients undergoing gastrectomy

    Han-Cheng LiuYan-Bing ZhouDong ChenZhao-Jian Niu...
    2695-2703页
    查看更多>>摘要：AIM:To investigate the effect of intensive vs conventional insulin therapy on perioperative nutritional substrates metabolism in patients undergoing radical distal gastrectomy.METHODS:Within 24 h of intensive care unit management,patients with gastric cancer were enrolled after written informed consent and randomized to the intensive insulin therapy (IIT) group to keep glucose levels from 4.4 to 6.1 mmol/L or the conventional insulin therapy (CIT) group to keep levels less than 10 mmol/L.Resting energy expenditure (REE),respiratory quotient (RQ),resting energy expenditure per kilogram (REE/kg),and the lipid oxidation rate were monitored by the indirect calorimeter of calcium citrate malate nutrition metabolism investigation system.The changes in body composition were analyzed by multi-frequency bioimpedance analysis.Blood fasting glucose and insulin concentration were measured for assessment of Homeostasis model assessment of insulin resistance.RESULTS:Sixty patients were enrolled.Compared with preoperative baseline,postoperative REE increased by over 22.15％ and 11.07％; REE/kg rose up to 27.22 ± 1.33 kcal/kg and 24.72 ± 1.43 kcal/kg; RQ decreased to 0.759 ± 0.034 and 0.791 ± 0.037; the lipid oxidation ratio was up to 78.25％ ± 17.74％ and 67.13％ ± 12.76％ supported by parenteral nutrition solutions from 37.56％ ± 11.64％ at the baseline; the level of Ln-HOMA-IR went up dramatically (P ＜ 0.05,respectively) on postoperative days 1 and 3 in the IIT group.Meanwhile the concentration of total protein,albumin and triglyceride declined significantly on postoperative days 1 and 3 compared with pre-operative levels (P ＜ 0.05,respectively).Compared with the CIT group,IIT reduced the REE/kg level (27.22 ± 1.33 kcal/kg vs 29.97 ± 1.47 kcal/kg,P =0.008; 24.72 ± 1.43 kcal/kg vs 25.66 ± 1.63 kcal/kg,P =0.013); and decreased the Ln-HOMA-IR score (P =0.019,0.028) on postoperative days 1 and 3; IIT decreased the level of CRP on postoperative days 1 and 3 (P =0.017,0.006); the total protein and albumin concentrations in the IIT group were greater than those in the CIT group (P =0.023,0.009).Postoperative values of internal cell fluid (ICF),fat mass,protein mass (PM),muscle mass,free fat mass and body weight decreased obviously on postoperative 7th day compared with the preoperative baseline in the CIT group (P ＜ 0.05,respectively).IIT reduced markedly consumption of fat mass,PM and ICF compared with CIT (P =0.009 to 0.026).CONCLUSION:There were some benefits of IIT in decreasing the perioperative insulin resistance state,reducing energy expenditure and consumption of proteins and lipids tissue in patients undergoing gastrectomy.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    GABA stimulates human hepatocellular carcinoma growth through overexpressed GABAA receptor theta subunit

    Yue-Hui LiYan LiuYan-Dong LiYan-Hong Liu...
    2704-2711页
    查看更多>>摘要：AIM:To investigate the function of gamma-aminobutyric acid (GABA) and gamma-aminobutyric acid A receptor θ subunit (GABRQ) in hepatocellular carcinoma (HCC).METHODS:Semiquantitative polymerase chain reaction was used for detecting the expression of GABRQ receptor among HCC cell line HepG2,normal liver cell line L-02,non-malignant Chang's liver cells,8 samples of HCC tissues and paired non-cancerous tissues.HepG2 cells were treated with GABA at serial concentrations (0,1,10,20,40 and 60 μmol/L),and their proliferating abilities were analyzed with the methyl thiazolyl tetrazolium assay,cell cycle analysis and tumor implanted in nude mice.Small interfering RNA was used for knocking down the endogenous GABRQ in HepG2.Proliferating abilities of these cells treated with or without GABA were analyzed.RESULTS:We identified the overexpression of GABRQ in HCC cell lines and half of the tested HCC tissues.Knockdown of endogenous GABRQ expression in HepG2 attenuated HCC cell growth,suggesting its role in HCC cell viability.We studied the effect of GABA in the proliferation of GABRQ-positive cell lines in vitro and in vivo,and found that GABA increased HCC growth in a dosedependent manner.Notably,the addition of GABA into the cell culture medium promoted the proliferation of GABRQ-expressing HepG2 cells,but not GABRQ-knockdown HepG2 cells,which means that GABA stimulates HepG2 cell growth through GABRQ.CONCLUSION:GABRQ play important roles in HCC development and progression and could be a promising molecular target for the development of new diagnostic and therapeutic strategies of HCC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Phosphatase and tensin homolog expression related to cetuximab effects in colorectal cancer patients: A meta-analysis

    Yue ShenJian YangZhi XuDong-Ying Gu...
    2712-2718页
    查看更多>>摘要：AIM:To investigate the correlation between expression of phosphatase and tensin homolog (PTEN) and cetuximab effects in colorectal cancer.METHODS:We searched PubMed,EMBASE and ASCO to identify eligible studies.Finally,8 randomized control studies were included in the meta-analysis.STATA 10.0 Software was used to investigate heterogeneity among individual studies and to summarize all the studies.Risk ratios (RRs) and hazard ratios (HRs) with 95％ confidence intervals (CIs) were used to assess the strength of the association.RESULTS:Compared with 20 of 266 patients with loss of PTEN,206 of 496 patients with intact PTEN protein expression had a better objective response rate to cetuximab-based therapy (RR,4.75; 95％ CI,2.59-8.72;P ＜ 0.001).PTEN positivity was associated with better progression-free survival (PFS) (HR,0.675; 95％ CI,0.473-0.964; P =0.031) but not with better overall survival (OS) (HR,0.608; 95％ CI,0.411-0.899; P =0.013).In patients with KRAS wild-type status,PTEN positivity did not predict a longer PFS or OS (PFS:HR,0.707;95％ CI,0.440-1.138; P =0.154; OS:HR,0.943; 95％CI,0.646-1.377; P =0.761).CONCLUSION:Expression of PTEN is related to the effect of cetuximab in colorectal cancer patients and should be considered in treatment with cetuximab.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Aberrant methylation and downregulation of sall3 in human hepatocellular carcinoma

    Xue-Xi YangJing-Zhe SunFen-Xia LiYing-Song Wu...
    2719-2726页
    查看更多>>摘要：AIM:To investigated whether sall3 transcription was regulated by promoter CpG island hypermethylation in hepatocellular carcinoma (HCC).METHODS:The cell lines Huh7,HepG2,SK-HEP1,SMMC7721,Bel7402,QGY7703 and a cohort of 38 HCC tissue specimens and corresponding nontumorous tissues were subjected to analysis for sall3 promoter CpG island methylation and mRNA transcription.sall3 promoter CpG island methylation levels were determined using the MassARRAY platform and mRNA transcription levels of the gene were detected by quantitative realtime polymerase chain reaction.RESULTS:The levels of sall3 mRNA were decreased by more than twofold in 33 of 38 tumor tissues compared to adjacent noncancerous tissues.Among these 33 tumor tissues with lower levels of sall3 mRNA,24 showed higher levels of methylation.Based on these results,we hypothesized that the decrease in sall3 mRNA transcription level was likely due to promoter CpG island hypermethylation.Changes in sall3 mRNA transcription and promoter CpG island methylation were determined in the above six cell lines after treatment with 0,0.1,0.5 and 2.5 μmol 5-aza-2-deoxycytidine,a demethylating agent.Promoter CpG island methylation levels decreased in a dose-dependent manner in all six cell lines,while the mRNA transcription level increased dosedependently in Huh7,HepG2,SK-HEP1 and SMMC7721 cells and irregularly in Bel7402 and QGY7703 cells.CONCLUSION:These results indicated that promoter CpG island hypermethylation contributes to the downregulation of sall3 mRNA transcription in HCC.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    A pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release

    Giovanni Di NardoSalvatore OlivaMarina AloiFederica Ferrari...
    2727-2729页
    查看更多>>摘要：Pediatric Menetrier's disease (MD) is an uncommon,acute,self-limited hypertrophic gastropathy characterized by enlarged gastric folds associated with epithelial hyperplasia and usually accompanied by protein losing gastropathy.Gastric cytomegalovirus infection is found in one third of MD children and its treatment is often associated with remission.Diagnosis often requires fullthickness biopsy due to inability to detect typical histological findings with conventional endoscopic biopsy.We report an uncommon case of non self-limited pediatric MD needing endoscopic mucosal resection for diagnosis which was then successfully treated with octreotide long-acting release (LAR).To the best of our knowledge,this is the first pediatric MD case successfully treated with octreotide LAR.Our experience suggests octreotide LAR as treatment for refractory MD before gastrectomy.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普

    Infliximab stopped severe gastrointestinal bleeding in Crohn's disease

    Satimai AniwanSurasak EakpongpaisitBoonlert ImrapornSurachai Amornsawadwatana...
    2730-2734页
    查看更多>>摘要：To report the result of rapid ulcer healing by infliximab in Crohn's patients with severe enterocolic bleeding.During 2005 and 2010,inflammatory bowel disease database of King Chulalongkorn Memorial and Samitivej hospitals were reviewed.There were seven Crohn's disease (CD) patients (4 women and 3 men; mean age 52 ± 10.4 years; range:11-86 years).Two of the seven patients developed severe gastrointestinal bleeding (GIB) as a flare up of CD whereas the other five patients presented with GIB as their first symptom for CD.Their mean hemoglobin level dropped from 12 ± 1.3 g/dL to 8.7 ± 1.3 g/dL in a 3-d period.Median packed red blood cells units needed for resuscitation was 4 units.Because of uncontrolled bleeding,surgical resection was considered.However,due to the poor surgical candidacy of these patients (n =3) and/or possible development of short bowel syndrome (n =6),surgery was not pursued.Likewise angiographic embolization was not considered in any due to the risk of large infarction.All severe GIBs successfully stopped by one or two doses of intravenous infliximab.Our data suggests that infliximab is an alternative therapy for CD with severe GIB when surgery has limitation or patient is a high risk.
      原文链接:
    • NETL
    • NSTL
    • 万方数据
    • 维普