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中华生物医学工程杂志
中华生物医学工程杂志

钟南山

双月刊

1674-1927

cjbme@vip.tom.com

020-81340157

510182

广东省广州市东风西路195号广州医学院内28栋1楼

中华生物医学工程杂志/Journal Chinese Journal of Biomedical EngineeringCSTPCD
查看更多>>中华医学会、广州医学院主办。本刊办刊宗旨：密切关注并报道生物医学工程学研究的新理论、新方法、新技术，跟踪生物医学工程学在临床中的最新应用成果，服务广大临床医生，促进生物医学工程学的学科发展。生物医学工程的发展一直是临床医学进步的动力，而临床医学所需要解决的问题则是生物医学工程创新的源泉。临床医生、科学家和产业界工程技术人员的紧密合作将为人类创造更美好的健康长寿的新生活。内容和栏目：（1）编者导读；（2）专论；（3）论著；（4）新技术与临床；（5）新技术研发；（6）生物技术；（7）综述；（8）专题讲座。
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    尿膀胱癌抗原联合尿液核基质蛋白22在膀胱癌诊断中的临床价值

    张运伟沈伟张翔
    77-81页
    查看更多>>摘要：探讨尿膀胱癌抗原（UBC）联合尿液核基质蛋白22（NMP22）在膀胱癌诊断中的价值。研究显示，膀胱癌病人尿液内的NMP22和UBC蛋白浓度水平较非肿瘤病人上升明显，且在膀胱癌不同分级及分期中有均存在差异表达，尿液内的NMP22和UBC蛋白浓度水平联合检测可作为膀胱癌无创诊断的瘤标，值得推广使用。 To explore the value of urinary bladder cancer cancer antigen (UBC) combined with urinary nuclear matrix protein 22 (NMP22) in the diagnosis of bladder cancer. The concentration of NMP22 and UBC protein in the urine of bladder cancer patients increased significantly than that of non tumor patients, and there were different expressions in different grades and stages of bladder cancer. The combined detection of NMP22 and UBC protein concentration in the urine can be used as a tumor marker for non-invasive diagnosis of bladder cancer, and the value should be popularized.

    膀胱癌膀胱癌抗原NMP22诊断

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    2型糖尿病患者下肢血管病变程度与血清指标的相关性

    范枝芳孙萍任毅杜瑞...
    82-85页
    查看更多>>摘要：探究2型糖尿病患者下肢血管病变（PAD）程度与血清生化指标的关系。102例糖尿病患者依据踝肱指数（ABI）分为非下肢血管病变（N-PAD）、轻度（A-PAD）、中度（B-PAD）和重度（C-PAD）下肢血管病变组，30例健康人群为对照组，分析PAD程度与血清生化指标关系。与对照组相比，N-PAD组、A-PAD组、B-PAD组和C-PAD组的空腹血糖（FPG）、TC、TG、LDL-C升高，而HDL-C、25羟维生素D[25-（OH）D]降低（P<0.05）；PAD程度与FPG正相关，与25-（OH）D负相关（P<0.05）。糖尿病患者FPG、25-（OH）D与下肢血管病变发生密切相关。 The purpose of this study was to investigate the relationship between the severity of lower extremity peripheral artery disease (PAD) and serum biochemical indicators in the patients with type 2 diabetes mellitus. A total of 102 diabetic patients were divided into non-lower extremity PAD (N-PAD), mild-lower extremity PAD (A-PAD), moderate-lower extremity PAD (B-PAD) and severe-lower extremity PAD (C-PAD) groups based on ankle-brachial index (ABI), and 30 healthy subjects were included as the control group. The relationship between the severity of PAD and serum biochemical indicators was analyzed, respectively. Compared with the control group, the serum levels of fasting plasma glucose (FPG), total cholesterol (TC), triglycerides (TG), and low-density lipoprotein-C (LDL-C) increased, while the serum levels of high-density lipoprotein cholesterol (HDL-C) and 25 hydroxyvitamin D[25- (OH) D]decreased, in the N-PAD, A-PAD, B-PAD, and C-PAD groups (all P<0.05). The severity of PAD was positively correlated with the serum level of FPG, and negatively correlated with the serum level of 25- (OH) D (bothP<0.05). In conclusion, the serum levels of FPG and 25- (OH) D may be closely associated with the development of lower extremity PAD in diabetic patients.

    2型糖尿病血清25羟维生素D脂蛋白踝肱指数下肢血管病变

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    关节镜在治疗膝关节髌骨骨折及软骨损伤恢复评估的作用研究

    韩冬孙政文马云鹏巩金鹏...
    86-89页
    查看更多>>摘要：回顾分析99例行关节镜下髌骨骨折治疗术（观察组）与104例行传统切开复位术（对照组）的髌骨骨折合并软骨损伤患者的治疗疗效。研究发现关节镜下髌骨骨折治疗能有效实现髌骨解剖复位，减轻关节炎症，手术创伤小，减轻患者治疗痛苦，术后的功能恢复好；二次关节镜的利用能直观地对髌骨软骨修复情况进行评估，并能及时对病损进行二次处理和治疗。 The purpose of this study was to retrospectively determine the curative efficacy of arthroscopic treatment in 99 cases of patellar fractures (study group) vs traditional open reduction in 104 cases of patellar fractures complicated with cartilage injury. The study found that the treatment of patellar fractures under arthroscopy could effectively achieve anatomical reduction of patella, reduce joint inflammation with less surgical trauma, relieve pain for patient, and improve postoperative functional recovery. A second look with secondary arthroscopy favors direct visual evaluation on the repair of patellar cartilage, and enables a redo manipulation and treatment of lesions in due time.

    关节镜髌骨骨折软骨损伤

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    内镜辅助锁孔入路血肿清除术对丘脑出血患者的疗效

    王载忠李力周莎莎刘继东...
    90-93页
    查看更多>>摘要：探究内镜辅助血肿清除术（锁孔入路）治疗丘脑出血（TH）患者的效果。研究发现与MIPHD治疗TH患者相比，应用内镜辅助血肿清除术（锁孔入路）治疗于提高血肿清除率、改善预后、缓解炎性反应、改善神经功能方面更具优势，且安全性更高。 The purpose of this study was to assess the efficacy of endoscope-assisted hematoma evacuation via keyhole approach as a treatment in patients with thalamic hemorrhage (TH). The study findings showed that, compared with minimally invasive puncture hematoma drainage (MIPHD), management of TH using endoscope-assisted hematoma evacuation via keyhole approach was more advantageous in improving the hematoma clearance, prognosis, inflammatory response, and neurological function in the patients, with higher safety profiles.

    炎性因子丘脑出血神经因子血肿清除术

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    肺磨玻璃结节患者CT影像预测肺腺癌浸润程度及对肺结节病理性质的判定

    刘利静张薇张国伟张翔...
    94-97页
    查看更多>>摘要：研究肺磨玻璃结节（GGN）患者CT影像预测肺腺癌浸润程度及对肺结节病理性质的判定价值。研究发现，良性组以及恶性组患者的影像学特征、CT平均值之间的差异存在统计学意义（P<0.001）；不同浸润情况患者的CT平均值差异存在统计学意义（P<0.001）。GGN患者CT影像对于肺腺癌浸润程度及病理性质的判定具有显著的意义。 The purpose of this study was to investigate the value of CT images in predicting the degree of lung adenocarcinoma infiltration and determining the pathological nature of pulmonary nodules in patients with pulmonary ground glass nodules (GGN). The study found statistically significant differences in imaging features and mean CT values between patients with benign and malignant lesions (P<0.001). Patients with varied degree of tumor infiltration differed significantly in mean CT values (P<0.001). In conclusion, CT images can be of remarkably relevance in evaluating the infiltration and pathological nature of lung adenocarcinoma in patients with GGN, and thus is recommendable for widespread use in clinical settings.

    肺结节肺腺癌病理浸润性CT值

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    重症住院中心静脉置管患者并发多重耐药菌感染影响因素及其预测模型

    赵媛媛杜立强彭丽马珍...
    98-101页
    查看更多>>摘要：分析重症住院中心静脉置管（CVC）患者并发多重耐药菌（MDRO）感染的危险因素，并构建预测模型。选择2019年6月到2022年6月重症住院中心收治的316名CVC患者为研究对象，将其分为感染组（80例）和对照组（236例）。采用Logistic回归分析影响CVC患者并发MDRO感染的危险因素，构建预测模型，分析其实际应用价值。Logistic回归分析提示，年龄>60岁、机械通气、抗生素使用时间>10 d、抗生素种类三联及以上、合并糖尿病以及股静脉置管是引起重症住院CVC置管患者发生MDRO感染的独立危险因素。预测模型的AUC=0.945，灵敏度及特异度分别为91.3%和97.5%。基于以上分析构建的预测模型在筛选高危MDRO感染者中的价值良好。 The purpose of this study was to identify the risk factors of multi-drug resistant organism (MDRO) infections in patients with central venous catheterization (CVC) in a critical care medicine center, and accordingly to construct a prediction model. A total of 316 patients with CVC admitted to our critical care medicine center between June 2019 and June 2022 were included as study subjects and assigned to the infection group (n=80) and the control group (n=236). Logistic regression analysis was performed to identify the risk factors affecting comorbidity with MDRO infection in patients with CVC. A prediction model was thereby constructed and validated for its usefulness. Our Logistic regression analysis showed that patient age > 60 years old, use of mechanical ventilation, duration on antibiotics > 10 days, combination use of three or more antibiotics, diabetes mellitus, and femoral vein catheterization were independent risk factors for MDRO infections in patients with CVC who stayed in our critical care medicine center. The prediction model yielded an area under curve (AUC) of 0.945, a sensitivity of 91.3% and a specificity of 97.5%. In conclusion, the prediction model constructed based on our data analyses is considerably valuable in screening patients at high-risk for MDRO infection.

    同时感染导管插入术中心静脉危重病人医疗预测模型

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    随机对照试验与真实世界研究相辅相成：历史之进步

    方积乾张翔
    102-104页
    查看更多>>摘要：本讲座介绍真实世界研究和随机对照试验的来龙去脉，说明如今学术界提倡两者相辅相成乃历史之进步。

    真实世界研究随机对照试验"金标准"

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    肾周脂肪组织与慢性肾脏病的研究现状

    翟璐张红霞刘新艳
    105-110页
    查看更多>>摘要：肾周脂肪组织是一种非典型的内脏脂肪组织，具有完整的血液供应、淋巴液引流和神经系统支配，可通过神经调节对肾功能造成影响；同时具有内分泌功能，可分泌瘦素、脂联素等多种脂肪细胞因子参与肾功能调节。近期有研究提示肾周脂肪厚度是慢性肾脏病的独立危险因素。本文就肾周脂肪组织的解剖学结构、测量技术、对肾脏影响的相关机制及治疗等进行综述，为进一步探讨慢性肾脏病发病机制提供理论支持。

    内脏脂肪组织肾周脂肪组织细胞因子类慢性肾脏病

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    可弯曲支气管镜技术在儿科的临床应用进展

    李忠强吴雪郡刘新艳
    111-116页
    查看更多>>摘要：随着支气管镜设备的研发，出现了适合儿童的小型支气管镜设备，并设置了小尺寸操作孔及配套辅助工具，可弯曲支气管镜（FB）已发展成为儿童呼吸系统疾病诊断及治疗的重要角色。随着儿科医生FB操作熟练程度的提高，FB技术在儿科应用范围也逐渐扩大，包括气道检查、肺泡灌洗、气道异物、经支气管镜活检、球囊扩张、瘘管修补、气管支架应用、激光治疗、微创治疗、引导插管等。文章对目前FB技术在儿科的临床应用进展进行综述。

    支气管镜支气管肺泡灌洗介入治疗儿童

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