查看更多>>摘要：The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer treatment.Herein,a smart hydrogel with self-adaptable size and dual responsive cargos release was fab-ricated to treat breast cancer via accurate tumor elimination,on-demand adipose tissue regeneration and effective infection inhibition.The hydrogel consisted of thiol groups ended polyethylene glycol(SH-PEG-SH)and doxorubicin encapsulated mesoporous silica nanocarriers(DOX@MSNs)double crosslinked hyaluronic acid(HA)after loading of antibacterial peptides(AP)and adipose-derived stem cells(ADSCs).A pH-cleavable unsaturated amide bond was pre-introduced between MSNs and HA frame to perform the tumor-specific acidic environment dependent DOX@MSNs release,meanwhile an esterase degradable glyceryl dimethacrylate cap was grafted on MSNs,which contributed to the selective chemotherapy in tumor cells with over-expressed esterase.The bond cleavage between MSNs and HA would also cause the swelling of the hydrogel,which not only provide sufficient space for the growth of ADSCs,but allows the hydrogel to fully fill the irregular defects generated by surgery and residual tumor atrophy,resulting in the on-demand regeneration of adipose tissue.Moreover,the sustained release of AP could be simul-taneously triggered along with the size change of hydrogel,which further avoided bacterial infection to promote tissue regeneration.
查看更多>>摘要：Due to the limitations of conventional chemotherapy including side effects,poor prognosis,and drug resistance,there is an urgent need for the development of a novel multi-functional combined therapy strategy.Dopamine-modified oxaliplatin prodrug(OXA-DA)was successfully synthesized in this study to ameliorate the organ distribution of oxaliplatin for improving the drug efficacy and reducing toxic side effects,and OXA-DA was applied to develop a porous oxaliplatin cross-linked polydopamine nanoparti-cle for loading siPD-L1 to construct multifunctional nanoplatform.The multifunctional nanoplatform was modified with poly(2-ethyl-2-oxazoline)(PEOz),which occurred charge reversal in the tumor microenvi-ronment,and exerted the lysosomal escape effect in tumor cells to improve the bioavailability of small interfering RNA targeting programmed cell death-ligand 1(siPD-L1).The pH-responsive charge reversal,photothermal,biodegradation,lysosomal escape ability,PD-L1 protein degradation,toxicity properties and multiple antitumor effects were comprehensively evaluated in vitro and in vivo experiments.The findings indicated that OXA-DA-siPD-L1@PDA-PEOz excellently induced tumor cell necrosis and apoptosis as a re-sult of the synergistic effect of chemo-photothermal therapy,and upregulated CD8+T cells produced interferon-γ(IFN-y)to further attack the tumor cells.In conclusion,the novel nanoplatform-mediated chemo/photothermal/immunotherapy has promising clinical applications in the treatment of malignant tumors.
查看更多>>摘要：Inflammatory bowel disease(IBD)is a refractory chronic intestinal inflammatory disease caused by a mal-function of immune system.As the key immune cells in the intestine,macrophages play an important role in maintaining intestinal homeostasis and tissue repair of the IBD.Pharmacological modulation of macrophage function exhibits the promising therapeutic effect for IBD.In this study,mannose-modified liposomes(MAN-LPs)are prepared for macrophage targeting to improve therapeutic efficiency.Rosiglita-zone(ROSI)as an agonist of peroxisome proliferators-activated receptor y(PPAR-y)is used as the model drug to fabricate different sized liposomes.The impacts of mannose modification and particle size for macrophage targeting are investigated in cells,zebrafish,and mouse models and the therapeutic effects of the MAN-LPs are evaluated on dextran sulfate sodium(DSS)-induced IBD mouse.Compared to un-modified liposome,MAN-LPs display higher uptake by RAW 264.7 cells and better co-localization with macrophage in zebrafish model.Furthermore,MAN-LPs could effectively accumulate in the inflamma-tory intestinal sites in IBD mouse model.Most importantly,the targeting ability of MAN-LPs is obvi-ously enhanced with the increasing of particle size,whereas the largest MAN-LPs particles achieve the best anti-inflammatory effect in cells,and a higher therapeutic efficiency in IBD mouse model.Therefore,mannose-modified liposome is a promising strategy for macrophage-targeting in IBD treatment.Particle size of MAN-LPs will affect macrophage targeting ability,as well as the therapeutic effect in-vivo.
查看更多>>摘要：Radiation damage can cause a series of gastrointestinal(GI)tract diseases.The development of safe and effective GI tract radioprotectants still remains a great challenge clinically.Here,we firstly re-port an oral radioprotectant Gel@GYY that integrates a porous gelatin-based(Gel)hydrogel and a pH-responsive hydrogen sulfide(H2S)donor GYY4137(morpholin-4-ium 4 methoxyphenyl(morpholino)phos-phinodithioate).Gel@GYY has a remarkable adhesion ability and long retention time,which not only en-ables responsive release of low-dose H2S in stomach and subsequently sustained release of H2S in the whole intestinal tract especially in the colon,but also ensures a close contact between H2S and GI tract.The released H2S can effectively scavenge free radicals induced by X-ray radiation,reduce lipid peroxida-tion level,repair DNA damage and recover vital superoxide dismutase and glutathione peroxidase activi-ties.Meanwhile,the released H2S inhibits radiation-induced activation of nuclear factor κB(NF-κB),thus reducing inflammatory cytokines levels in GI tract.After treatment,Gel@GYY displays efficient excretion from mice body due to its biodegradability.This work provides a new insight for therapeutic application of intelligent H2S-releasing oral delivery system and potential alternative to clinical GI physical damage protectant.
查看更多>>摘要：A series of photoinduced palladium-catalyzed 1,3-diene-selective fluoroalkylamination derivatives was ra-tionally synthesized based on diversity-oriented synthesis via cross coupling of 1,3-dienes,amines and fluoroalkyl iodides.The reaction featured good function group tolerance and a broad substrate scope,which could be extended to the late-stage modification of bioactive molecules.Bactericidal activity of all the compounds against Xanthomonas oryzae pv.oryzae(Xoo)was evaluated.Among them,compound E14 showed significant activity against Xanthomonas oryzae pv.oryzae(Xoo)with half maximal effective con-centration(EC50)value of 6.61μmol/mL.In pot experiments,the results showed that E14 could control rice bacterial blight with protective and curative efficiencies of 37.5％and 63.2％at 200μg/mL,respec-tively.Additionally,a plausible mechanism for antibacterial behavior of E14 was proposed by electron microscopy,flow cytometry,reactive oxygen species detection,and biofilm assay.In current work,it can promote the development of photoinduced palladium-catalyzed 1,3-diene-selective fluoroalkyl amination compounds as prospective antibacterial agent bearing an intriguing mode of action.
查看更多>>摘要：Polystyrene resins(PS)have been practical ion exchangers for radionuclides removal from water.How-ever,nonspecific effects of ion exchange groups continue to be a major obstacle for emergency treatment with coexisting ions of high concentrations.The selectivity for Cs+enables zirconium phosphate(ZrP)to be the most promising inorganic sorbent for radioactive cesium extraction,despite being difficult to synthesize and causing excessive pressure loss in fixed-bed reactors due to fine powder.Herein,through facile confined crystallization in host macropores,we prepared PS confined α-ZrP nanocrystalline(ZrP-PS).Size-screen sorption of layered α-ZrP and sulfonic acid group preconcentration of PS synergis-tically enable a considerably higher Cs+affinity of ZrP-PS than PS,as confirmed by X-ray photoelectron spectroscopy(XPS)analysis.ZrP-PS demonstrated remarkable cesium sequestration performance in both batch and continuous experiments,with a high adsorption capacity of 269.58 mg/g,a rapid equilibrium within 80 min,and a continuous effluent volume of 2300 L/kg sorbents.Given the excellent selectivity for Cs+and flexibility to separate from treated water,ZrP-PS holds great promise as purification packages for the emergency treatment of radioactively contaminated water.
查看更多>>摘要：In this study,magnesium and coconut shell carbon(CSC)were prepared by a ball milled process and used for water disinfection with adsorbing tiny amounts of copper(Ⅱ).Dissolved oxygen(DO)was reduced to hydrogen peroxide(H2O2)via a two-electron pathway by Mg corrosion.Cu(Ⅱ)in the wastewater will be enriched on the CSC surface and efficiently catalyzes H2O2 for inactivating E.coli.The results show that E.coli with an initial concentration of approximately 106 CFU/mL was under the detection limit(＜4 CFU/mL)within 15 min.All of the Cu(Ⅱ)could be adsorbed by the composite and catalyzed H2O2 to different active species.The quenching experiments,electron spin resonance(ESR)capture measurements and the UV-vis spectroscopy detection confirmed the present of the hydroxyl radicals(·OH),superoxide radicals(·O2-)and Cu(Ⅲ).Different with tradition Fenton like process,Cu(Ⅲ),rather than radicals,played the major role during the Mg-CSC/Cu(ll)process.In addition to the cellular membrane damage,most of the bacterial genomic DNA was also be degraded and the bacterial reactivation was avoided.The Mg-CSC/Cu(Ⅱ)process also showed a satisfied disinfection performance in real wastewater treatment.Overall,this study provides a new strategy for water disinfection.
查看更多>>摘要：Photocatalytic activation of peroxymonosulfate(PMS)has garnered a lot of interest in the field of wastew-ater treatment.Herein,a plasmonic Ag nanoparticles decorated MIL-101(Fe)hybrid was synthesized through a photodeposition process.Upon light irradiation,the Ag/MIL-101(Fe)exhibit reinforced pho-tocatalytic activities for elimination of bisphenol A(BPA)with PMS.The optimized 2.0％Ag/MIL-101(Fe)composite presented the highest photocatalytic activity with kinetic constant k of 0.102 min-1,which was about 10-fold of the pristine MIL-101(Fe).Loading of plasmonic Ag into MIL-101(Fe)boosts photoinduced carrier separation and accelerates PMS activation to generate strong oxidative radicals.Photoelectrochem-ical tests and multiple spectroscopic studies confirmed the promoted charge carrier separation and trans-fer capability of Ag/MIL-101(Fe).Combining the results of radical trapping experiments and electron spin resonance(ESR),the formed SO4·-,·OH,·O2-and1O2had a significant role in the photocatalytic process.According to intermediate study,the degradation pathway was studied,and the possible mechanism was proposed.
查看更多>>摘要：New pollutant pharmaceutical and personal care products(PPCPs),especially antiviral drugs,have re-ceived increasing attention not only due to their increase in usage after the outbreak of COVID-19 epi-demics but also due to their adverse impacts on water ecological environment.Electro-Fenton technol-ogy is an effective method to remove PPCPs from water.Novel particle electrodes(MMT/rGO/Fe3O4)were synthesized by depositing Fe3O4 nanoparticles on reduced graphene oxide modified montmorillonite and acted as catalysts to promote oxidation performance in a three-dimensional electro-Fenton(3D-EF)sys-tem.The electrodes combined the catalytic property of Fe3O4,hydrophilicity of montmorillonite and elec-trical conductivity of graphene oxides,and applied for the degradation of Acyclovir(ACV)with high ef-ficiency and ease of operation.At optimal condition,the degradation rate of ACV reached 100％within 120 min,and the applicable pH range could be 3 to 11 in the 3D-EF system.The stability and reusability of MMT/rGO/Fe3O4 particle electrodes were also studied,the removal rate of ACV remained at 92％after 10 cycles,which was just slightly lower than that of the first cycle.Potential degradation mechanisms were also proposed by methanol quenching tests and FT-ICR-MS.
查看更多>>摘要：To achieve a lower detection limit has always been a goal of analytical chemists.Herein,we demonstrate the first picomolar level detection capability for Fe3+ion via luminescence detection technology.The re-sults of structural analysis and theoretical calculation show that Fe3+ions are adsorbed on the central node of Eu-DBM(DBM=dibenzoylmethane)sensor in the form of single ion at ultralow concentration.Subsequently,the pathways of photo-induced charge and energy transfer of the obtained Eu-DBM@Fe3+material have been changed,from the initial DBM-to-Eu3+before Fe3+adsorption to the ultimate DBM-to-Fe3+after adsorption process,which quenches the luminescence of Eu3+ion.This work not only ob-tains the highly sensitive luminescence detection ability,but also innovatively proposes the single-ion adsorption mechanism,both of which have important scientific and application values for the develop-ment of more efficient detection agents in the future.
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