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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    The 3rd Xihua Chemistry and Biomedicine Forum

    Yahui ZhangZhouyu WangLeyong WangXiaoqi Yu...
    1-2页
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    Professor Hualiang Jiang:A tribute to an esteemed visionary chemist and pharmacist

    Editorial Board of Chinese Chemical Letters
    3页
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    Recent advances in visible light-mediated chemical transformations of enaminones

    Yu HanLiyun ZhouChengyu WangShangti Feng...
    4-15页
    查看更多>>摘要：Enaminones,which possesses both the nucleophilic enamine as well as electrophilic enone structures,are well known versatile building blocks in organic synthesis.Meanwhile,visible light-mediated reac-tions have emerged as useful synthetic strategy with enhanced sustainability.Around the last decade,various photochemical transformations of enaminones have been developed to construct cyclic or acyclic compounds.In this review,we describe the recent advances in visible light-mediated chemical transfor-mations of enaminones.Detailed discussion on the reaction mechanism of the related reactions is given to provide guide to the reader.Finally,a summary on the existing challenges and the future outlook towards the development of practical photocatalytic reactions of enaminones is also presented.
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    Development of porphyrin-based fluorescent sensors and sensor arrays for saccharide recognition

    Yubin DingJiaxin WangRuinan WangYongshu Xie...
    16-23页
    查看更多>>摘要：Saccharide sensing is a very meaningful research topic as saccharides are involved in many biological activities.However,it is challenging to design molecular sensors for saccharides because this family of compounds is hydromimetic in aqueous solutions and shares a similar chemical structure.In this re-view,research progress in the development of porphyrin-based saccharide sensors is described with rep-resentative examples.We focus on using porphyrin as the signal reporter because porphyrins exhibit unique advantages in high chemical stability,long emission wavelength,and multiple structural modifi-cation strategies.Reported literature results have been classified into mainly two sections according to the general working principles of the porphyrin sensor molecules.In the first section,recognition unit,design strategy and sensing performance of traditional porphyrin-based selective saccharide sensors are discussed.While in the second section,development of porphyrin-based sensor arrays for pattern recog-nition of saccharides has been summarized.Looking through the design strategy and sensing performance of reported achievements,it is reasonable to anticipate a bright future for designing practical porphyrin-based saccharide sensors.
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    Recent advances of versatile reagents as controllable building blocks in organic synthesis

    Shaomin ChenLuigi VaccaroYanlong Gu
    24-43页
    查看更多>>摘要：Diversity-oriented synthesis is a powerful and interesting synthetic tool for the rapid construction of structurally complex and privileged scaffolds from readily accessible starting materials.To date,diversity-oriented synthesis mostly relies on the employment of versatile reagents.Versatile reagents can be reg-ulated as controllable and flexible building blocks for multipurpose utilizations.Over the past decade,a variety of multifunctional reagents have been developed.However,most versatile reagents usually need multi-step synthesis,thus restricting their wide application to a large extent.In terms of the practicali-ties and universalities,we prefer to pay more attention to the utilization of simple and practical versatile reagents with multiple reactivities,mainly including atropaldehyde acetals,aryl methyl ketones,vinylene carbonate,vinyl azides,aryldiazonium salts,rongalite,halodifluoromethyl compounds.Most importantly,these versatile reagents can also play different roles simultaneously in the same reaction,in which their different reactivities are converged into the final target products.Such strategy can not only offer more possibilities for the synthesis of several active pharmaceutical ingredients,but also minimize the occur-rence of some side reactions by lessening the varieties of materials.Also,a perspective is given at the end of this review.
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    Synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting

    Yan-Long MaShi YanXiong-Jie XuHua Cao...
    44-56页
    查看更多>>摘要：Due to its simplicity,high efficiency,and chemo-selectivity,bioorthogonal chemistry has shown a great application potential in pre-targeting.Currently,four bioorthogonal pairs as targeting tools,including(strept)avidin/biotin,antibody/antigen,oligonucleotide hybridization and IEDDA tools,have been devel-oped and applied in targeted delivery.Nevertheless,all of these tools still suffer from some limitations,such as difficult modification,biochemical fragility and larger molecular weight for biological associa-tion tools,as well as chemical instability for IEDDA tools.Synthetic host-guest pairs with relatively small molecular sizes not only possess strong chemical stability,but also have the features of fast conjugation rate,tunable binding affinity,easy modification,and high chemo-selectivity.Consequently,they can be used as a novel non-covalent bioorthogonal tool for pre-targeting.In order to further promote the de-velopment of host-guest pairs as novel bioorthogonal tools for pre-targeted delivery,we firstly calculate their conversion rate to make researcher aware of their unique advantages;next,we summarize the re-cent research progress in this area.The future perspectives and limitations of these unique tools will be discussed.This review will provide a systemic overview of the development of synthetic host-guest pairs as novel bioorthogonal tools for pre-targeting,and may serve as a"go for"resort for researchers who are interested in searching for new synthetic tools to improve pre-targeting.
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    Functional nanoemulsions:Controllable low-energy nanoemulsification and advanced biomedical application

    Maojie ZhangQiang CaoYuming YuanXiaohan Guo...
    57-69页
    查看更多>>摘要：Nanoemulsions are widely used as advanced pharmaceutical delivery systems in biomedical field,due to their high encapsulation efficiency and good therapy efficacy.Nanoemulsification techniques that pro-duce nanoemulsions with controllable sizes and compositions are promising for creating advanced na-noemulsion systems for pharmaceutical delivery.This review summarizes recent advances on low-energy emulsification techniques for producing nanoemulsions,and the use of these nanoemulsions as advanced pharmaceutical delivery systems and as templates to create drug-loaded functional particles for biomed-ical application.First,nanoemulsification techniques that utilize elaborate interfacial physics/chemistry and micro-/nano-fluidics,featured with relatively-low energy input,to produce nanoemulsions with con-trollable sizes and compositions,are introduced.Uses of these nanoemulsions to create nanoemulsion-incorporated milli-particles,drug-loaded nanoparticles and nanoparticle-incorporated microparticles with sizes ranging from several millimeters to sub-10nm are emphasized.Flexible and efficient use of the nanoemulsions,functional nanoparticles and milli-/micro-particles integrated with nanoemulsions or nanoparticles for advanced pharmaceutical delivery in biomedical field are highlighted,with focus on how the interplay between their sizes and compositions achieve desired pharmaceutical-delivery perfor-mances.Finally,perspectives on further advances on the controllable production of nanoemulsions are provided.
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    Reducing the voltage loss of Y-series acceptor based organic solar cells via ternary/quaternary strategies

    Pengyu ZhangZhiyang ZhangHeng SunJie Li...
    70-86页
    查看更多>>摘要：In recent years,with the emergence of non-fullerene fused-ring acceptors,power conversion efficiencies(PCEs)of organic solar cells(OSCs)have exceeded 19％.However,compared to inorganic or perovskite photovoltaic cells,a higher voltage loss has become one of the key factors limiting further improvement in the PCEs of OSCs.The ternary/quaternary strategy has been identified as a feasible and effective way to obtain high-efficiency OSCs.In this review,a brief outline is given of the key roles that guest materials played in reducing voltage losses in solar cell devices and a brief look at the future material design and the design of ternary/quaternary systems.
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    Research progress on rare earth up-conversion and near-infrared Ⅱ luminescence in biological applications

    Miao YangHaijiang GongDan YangLili Feng...
    87-96页
    查看更多>>摘要：Rare earth luminescence has attracted widespread attention for several decades,among which near-infrared(NIR)light-related up-conversion luminescence and NIR-Ⅱ luminescence are widely used in the biomedical field.The NIR-related luminescence is widely studied due to the excellent performance,such as good biocompatibility,deep tissue penetration depth,low self-fluorescence and minimal light damage to organisms.In this review,we mainly introduce the mechanism for rare earth up-conversion lumi-nescence,NIR-Ⅱ luminescence and conclude their advantages compared with traditional luminescence.These excellent priorities provide the basis for NIR-related luminescence bioimaging in vivo.Additionally,we hilglight the scheme for the sensitive detection of substances in organisms and various methods for biological therapy.In spite of the existing research,it is outlined that NIR-related luminescence has great potential to be applied in different aspects,expanding perspectives and future challenges of research in related fields.Based on the current scientific achievements,this review can provide reference for research in the areas mentioned above,expand the research direction and arouse a broad interest in different dis-ciplines to pay attention to rare earth luminescence.
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    Harnessing bacteria for tumor therapy:Current advances and challenges

    Lina GuoJinsong DingWenhu Zhou
    97-106页
    查看更多>>摘要：After a century of standstill,bacteria-based tumor therapy has resurged recently benefiting from the revolution of tumor immunotherapy,which provides unique solutions to tackle the obstacles of tradi-tional tumor treatments.Obligate and facultative anaerobes with active tropism can selectively colonize at tumor sites and suppress tumor growth via different mechanisms,serving as attractive tools for tu-mor treatment either as a monotherapy or combining with other therapies for synergistic anti-tumor effects.In this critical review,we introduce the recent advances of bacteria-based tumor therapy from the following aspects.First,the general properties of bacteria are reviewed emphasizing on their struc-tural components related to tumor immunotherapy,and the main bacteria that have been used in tumor therapy are listed.Then,the benefits of bacteria for tumor therapy are illustrated,such as tumor tar-getability,deep penetration,and facile genetic engineering for attenuation,enhanced efficacy,as well as bioimaging.Next,anti-tumor mechanisms of bacteria are summarized,which refer to intrinsic tumori-cidal activities,immune activation,bacteria metabolism,and their capability to regulate gut microbiota homeostasis.Moreover,bacteria could act as carriers to deliver various types of therapeutics to achieve combination therapy with improved efficacy.In addition,several challenges for anti-tumor applications of bacteria are discussed regarding the delivery,efficacy and safety issues,and potential solutions are also provided.Finally,the possible improvements and perspectives are discussed in the end,which provide a guideline for the design of advanced bacteria-based tumor therapeutics in the future.
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