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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    A strained π-extended[10]cycloparaphenylene carbon nanoring

    Kang WeiJiayu LiWen ZhangBing Yuan...
    171-174页
    查看更多>>摘要：Herein,we report the facile synthesis of a highly strained hexabenzocoronene-containing carbon nanor-ing,cyclo[4]-paraphenylene[2]-2,11-hexabenzocoronenylene([4,2]CPHBC),as the segment of a[10,10]single-walled carbon nanotube([10,10]SWNT).[4,2]CPHBC was synthesized based on the platinum-mediated assembly of diborylbiphenyl and diborylhexabenzocoronene,forming a tetranuclear platinum complex,followed by reductive elimination.This nanoring molecule was confirmed by NMR and HR-MS,and its photophysical properties were studied using steady-state and time-resolved spectroscopies.Moreover,the selective supramolecular host-guest interaction between[4,2]CPHBC and C60 was also in-vestigated.
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    taBOX:A water-soluble tetraanionic rectangular molecular container for conjugated molecules and taste masking for berberine and palmatine

    Qihan LinJiabin XingYue-Yang LiuGang Wu...
    175-178页
    查看更多>>摘要：A water-soluble macrocycle that bears four carboxylate anions has been designed and prepared,which forms a rectangular cavity that can efficiently encapsulate discrete electron-deficient aromatic com-pounds,including berberine and palmatine.This macrocycle is revealed to be highly biocompatible and able to inhibit the bitter taste of the two drugs.
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    Differentiated self-assembly through orthogonal noncovalent interactions towards the synthesis of two-dimensional woven supramolecular polymers

    Zhenzhu WangChenglong LiuYunpeng GeWencan Li...
    179-182页
    查看更多>>摘要：Molecular weaving is a powerful approach to make molecularly woven materials that have showed un-precedented characteristics and properties intrinsically distinct to those of non-woven materials.We here report a facile and efficient approach for the synthesis of 2D woven supramolecular polymers by differen-tiated self-assembly through orthogonal noncovalent interactions.Importantly,the difference in binding strength of two orthogonal noncovalent interactions can be used to control the process of molecular weaving.Consequently,single-layered 2D woven supramolecular polymers were synthesized and fully characterized by various techniques.This study demonstrates a controllable method for molecular weav-ing,and will significantly hasten the development of molecularly woven materials.
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    Ultracycles consisting of macrocycles

    Wen-Hui MiTeng-Yu HuangYu-Fei AoXu-Dong Wang...
    183-188页
    查看更多>>摘要：Presented here is a one-pot strategy starting from rationally designed macrocyclic precursors for the di-verse construction of sophisticated ultracycles.The type and amount of the base were found to signifi-cantly influence the macrocyclization outcome.The use of 4.0 equiv.CsF resulted in ultracycles of both types A and B while the presence of CsF larger than 6.0 equiv.produced only type B ultracycles.Existence of anion template increased the total yields and affected the distribution of the ultracycles.The ultracy-cles can accommodate large organic dicarboxylates anions via multiple anion-π and hydrogen bonds,and show selectivity to the size-matched heptanedioate(C72-).Based on all possible species and rele-vant equilibrium constants as well as material and charge balances,a numerical iterative algorithm was developed and applied to fit the association constants of B2H with dicarboxylates from glutarate(C52-)to octanedioate(C82-),which gave association constants up to 103 L/mol.
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    Solar cells based on doubly concerted companion dyes with the efficiencies modulated by inserting an ethynyl group at different positions

    Yuqing WangZhemin LiQingjun LuQizhao Li...
    189-192页
    查看更多>>摘要：To develop efficient sensitizers for dye-sensitized solar cells(DSSCs),we recently reported doubly con-certed companion(DCC)dye XW83 with a wrapped porphyrin sub-dye unit linked to an organic sub-dye unit through a flexible chain,which exhibits panchromatic absorption and excellent anti-aggregation abil-ity.To further improve the absorption,we herein report XW87 and XW88 by inserting an ethynyl group into the organic sub-dye unit of XW83 near the donor and acceptor,respectively.For the corresponding organic dyes Z3 and Z4,the introduced ethynyl group improves their absorption,but induces aggravated charge recombination,leading to lowered power conversion efficiencies(PCEs).Similar to the organic dyes,the introduced ethynyl group improves the absorption of DCC dyes XW87 and XW88 as well.In addition,the ethynyl group near the acceptor of the organic sub-dye unit can be well protected by the long wrapping chains from the porphyrin unit.As a result,XW88 affords the highest Jsc(21.84 mA/cm2),Voc(782 mV)and PCE(12.2％)among the DCC dyes.These results provide an effective method for devel-oping efficient DSSC dyes by inserting an ethynyl group at a suitable position of a DCC dye.
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    Site-specific incorporation of reduction-controlled guest amino acids into proteins for cucurbituril recognition

    Zhen DaiLinzhi TanYeyu SuKerui Zhao...
    193-196页
    查看更多>>摘要：Protein recognition using host-guest recognition approach is of great interest but has been limited mainly to the protein N-terminal residues.Here,we site-specific incorporated two novel non-canonical amino acids containing supramolecular guest motifs into protein via an expanded genetic code.Through Staudinger reduction reactions,the encoded unnatural residues on protein becoming activated and can be specifically recognized by cucurbit[7]uril(CB[7])and cucurbit[8]uril(CB[8]).We demonstrated that enzyme containing guest amino acid incorporated near the active site can be reversibly regulated by CB[7]recognition,and CB[8]recognition induces protein dimerization.These amino acids will make use-ful addition to the supramolecular toolbox for protein targeting using molecular recognition approaches.
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    N-Glycosylated type Ⅱ collagen peptides as therapeutic saccharide vaccines for rheumatoid arthritis

    Dake LiuShuyan LiuFanlei HuZhongtang Li...
    197-200页
    查看更多>>摘要：The interaction among type Ⅱ collagen(CⅡ),human DR4 major histocompatibility complex type Ⅱmolecule(MHC Ⅱ)and T-cell receptor(TCR)is associated with the development of rheumatoid arthri-tis(RA).The activation of T cells can be reduced through exposure to modified CⅡ(263-272)glycopeptide fragment via competitive inhibition with self-antigen.In this work,30 peptides based on the sequence of CⅡ(263-272)were prepared and evaluated for their binding to DR4 protein by surface plasmon reso-nance(SPR)assay.The effect on the secretion of pro-inflammatory factors by the spleen cells in collagen induced rheumatoid arthritis(CIA)mouse was also investigated.Two N-glycosylated CⅡ peptides were identified to have strong binding to the human recombinant DR4 protein and weak proinflammatory effect.These glycopeptides could be developed as therapeutic saccharide vaccines for the treatment of rheumatoid arthritis(RA).
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    Chemical construction and anti-HCoV-OC43 evaluation of novel 10,12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1

    Yulong ShiFenbei ChenMengyuan WuXin Zhang...
    201-206页
    查看更多>>摘要：Thirty-one new 10,12-disubstituted aloperine derivatives were subtly constructed through a selective oxi-dation on the 10-α-C-H induced by sulfonyl and a nucleophilic substitution with the stereoselectivity and scalability.Of them,compound 6b displayed a moderate anti-human coronavirus OC43(HCoV-OC43)po-tency and blocked the viral entry stage through a host mechanism of action.Using chemoproteomic tech-niques,both transmembrane serine protease 2(TMPRSS2)and scavenger receptor class B type 1(SR-B1)proteins,which act as host cofactors of viral entry,were identified to be the direct targets of 6b against HCoV-OC43.Furthermore,6b may deactivate the TMPRSS2 by inducing a change in protein conformation,rather than binding to its catalytic center,thus suppressing the viral membrane fusion.Accordingly,our study provided key scientific data for the development of aloperine derivatives into a new class of antivi-ral candidates against human β-coronavirus,including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).
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    F?rster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect

    Xiaoyao MaJinling ZhangGe FangHe Gao...
    207-212页
    查看更多>>摘要：The clinical benefit of combination therapy is significant,but it is not easy to define the mechanism of complexity and diversity.Previous studies illustrate that phillygenin(Phi)binds in the allosteric inhibit pocket of protein kinase B(AKT),and swertiamarin(Swe)acts on the pleckstrin homology(PH)domain of AKT.However,the combined synergistic effect of relieving the inflammatory response has yet to be elucidated.Based on high sensitivity,specificity and fast-responsibility fluorescent sensors,the Förster resonance energy transfer(FRET)technique offers a route to provide clear insights into physiological and pathological processes.In the study,molecular docking,the fluorescent probes of Phi and Swe for FRET were designed and synthesized.FRET analysis shown that Swe and Phi concurrently acted on the PH do-main and allosterically inhibited pocket of AKT,respectively.The combination of Swe and Phi significantly increased the heat stability of AKT and decreased protease-induced degeneration.In lipopolysaccharides(LPS)-induced mice and cells,the combination arrested AKT activation,nuclear factor kappa-B(NF-κB)phosphorylation,and the expression of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-8.In conclusion,FRET revealed Phi and Swe concurrently targeted AKT on different domains and the combi-nation of Phi and Swe enhanced the anti-inflammatory effect.
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    AbnI:An α-ketoglutarate-dependent dioxygenase involved in brassicicene C-H functionalization and ring system rearrangement

    Wenling YuanFengli LiZhe ChenQiaoxin Xu...
    213-217页
    查看更多>>摘要：We reported the characterization of a novel brassicicene diterpene biosynthetic gene cluster,which con-tains a unique α-ketoglutarate-dependent dioxygenase(αKGD)enzyme,AbnI.Our findings revealed that AbnI demonstrates remarkable substrate promiscuity and is capable of activating multiple sites on both 5-8-5 and 5-9-5 brassicicene skeletons,resulting in skeleton modifications and an unexpected ring sys-tem rearrangement.These results suggested the potential utility of AbnI as an enzymatic tool for terpene C-H functionalization.In addition,the catalytic mechanism of AbnI and its potential ecological implica-tions were discussed.
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