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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    Pd-catalyzed asymmetric carbonyl alkynylation:Synthesis of axial chiral ynones

    Long JinJian HanDongmei FangMin Wang...
    293-297页
    查看更多>>摘要：Ynones are important skeletons in bioactive molecules and valuable building blocks for organic synthe-sis,thus great efforts have been devoted to their preparation.While,introducing prochiral substrates to construct ynones bearing a chiral framework is unrealized to date.Herein,we reported the first example of Pd/SOP-catalyzed asymmetric carbonylative alkynylation via a non-classical carbonylative Sonogashira-type approach(acyl-Pd(Ⅱ)species generated from nucleophiles).By using cyclic diaryliodonium salts as prochiral substrates,various axial chiral ynones with good functional group tolerance(39 examples),sat-isfied yields(71％-96％)and excellent enantioselectivities(generally 94％-99％ee)were produced.Synthesis of bioactive compounds,scale-up experiment and useful transformations were also conducted to demon-strate the utility of this process.
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    Could π-aromaticity cross an unsaturated system to a fully saturated one?

    Shicheng DongJun Zhu
    298-302页
    查看更多>>摘要：The classification of π-/σ-aromaticity depends on the electrons with the dominating contributions.Tra-ditionally,π-and σ-aromaticity are used to describe the unsaturated and saturated systems,respectively.Thus,it is rarely reported that π-aromaticity is dominated in a saturated system.Here we demonstrate that π-aromaticity could be dominating in several fully saturated four-membered rings(4MRs),sup-ported by various aromaticity indices including ΔBL,NICS,EDDB,MCI,and AdNDP.The origin of suchπ-aromaticity in saturated rings could be attributed to an introduction of two additional electrons into the π-type LUMO of the parent neutral species.Our findings represent a novel approach to achieve π-aromaticity into a fully saturated system which has traditionally been dominated by σ-aromaticity.
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    Photo-induced tunable luminescence from an aggregated amphiphilic ethylene-pyrene derivative in aqueous media

    Junying ZhangRuochen LiHaihua WangWenbing Kang...
    303-306页
    查看更多>>摘要：An amphiphilic derivative with a large Stokes shift by introducing flexible hydrophilic long chains into a rigid ethylene-pyrene compound have been successfully synthesized.The alkylated compound exhibited a notable change in charge distribution,facilitating cation-π interactions.Through the process of am-phiphilic self-assembly,the formation of highly ordered aggregates enabled effective photo-dimerization under 449 nm LED irradiation.Notably,this photo-responsive technology not only exhibited advanced multi-color emission effects,including white light emission but also exhibited environmentally friendly behavior in the aqueous phase.
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    Merging non-covalent and covalent crosslinking:En route to single chain nanoparticles

    Yifei ZhangYuncong XueLaiwei GaoRui Liao...
    307-311页
    查看更多>>摘要：Single-chain nanoparticles represent an emerging class of nanomaterials designed to mimic protein's fold-ing paradigm.Intrachain covalent crosslinking toward the formation of single-chain nanoparticles encoun-ters complex energy landscapes,leading to the potential occurrence of misfolding issues.While non-covalent crosslinking can circumvent this issue,the resulting single-chain nanoparticles exhibit lower structural stability compared to their covalently crosslinked counterparts.In this study,we present a novel approach for the synthesis of single-chain nanoparticles,achieved through the combination of non-covalent and covalent intramolecular crosslinking.Cyanostilbenes grafted onto the linear polymer form intrachain non-covalent stacks aided by hydrogen bonds,leading to the formation of non-covalently crosslinked single-chain nanoparticles.These nanoparticles undergo conversion to covalently crosslinked nanostructures through subsequent photo-irradiation using[2+2]photocycloaddition,a process facili-tated by the supramolecular confinement effect.Consequently,the resulting single-chain nanoparticles demonstrate both intrachain folding efficiency and substantial stability,offering significant potential for advancing applications across diverse fields.
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    The effects of in ovo feeding of selenized glucose on liver selenium concentration and antioxidant capacity in neonatal broilers

    Jiahui LiQiao ShiYing XueMingde Zheng...
    312-315页
    查看更多>>摘要：Selenium is an essential trace element for humans and animals.As the active center of selenoproteins,the addition of selenium is beneficial to enhance the antioxidant ability.However,the high cost limits the application of organic Se in agriculture animal production.Selenized glucose(SeGlu)is a newly invented organoselenium material with good stability,low toxicity and low cost.This assay found that SeGlu was able to increase selenium deposition in liver of newborn broilers,and enhance the antioxidant capacity of liver by elevating the activities of antioxidant enzymes such as total superoxide dismutase and glu-tathione peroxidase.This paper as the first example clarifying the mechanism of SeGlu to enhance the antioxidant ability of chicks,shows that SeGlu can be used as an organic selenium enrichment additive for early nutrition of poultry.As a cross-discipline study involving chemistry,biology and agriculture an-imal science,the work may be beneficial for studies in related fields and prompt the development of the selenium science.
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    Tryptophan-specific peptide modification through metal-free photoinduced N-H alkylation employing N-aryl glycines

    Jianhui YinWenjing HuangChangyong GuoChao Liu...
    316-319页
    查看更多>>摘要：Tryptophan(Trp)carries a unique heteroaromatic indole side chain and plays a critical role in peptide or protein modification.Herein,we have reported a metal-free photoinduced N-H alkylation strategy us-ing N-aryl glycines for specific modification of tryptophan-containing peptides.The robustness of our approach is demonstrated by its wide substrate scope,excellent isolated yields,as well as almost unob-servable side effects.Using this highly efficiently metal-free condition,alkylated Trp-containing peptides can be smoothly assembled.This study provides a reliable and practical tool for the chemo-selective modification of various tryptophan containing oligopeptides.
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    Pd(Ⅰ)-catalyzed ring-opening arylation of cyclopropyl-α-aminoamides:Access to α-ketoamide peptidomimetics

    Yue SunLiming YangYaohang ChengGuanghui An...
    320-326页
    查看更多>>摘要：We report the unprecedent Pd(Ⅰ)catalyzed ring-opening arylation of cyclopropyl-α-aminoamides.This protocol allows facile access to biologically important α-ketoamide-containing oligopeptides and even more challenging peptide-natural product conjugates.Site selectivity was achieved by introduction of special unnatural amino acids,which also meets the requisite of bioorthogonal chemistry.Mechanism investigations reveals a distinct domino radical ring-opening process through Pd(l)catalysis.
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    Supporting-electrolyte-free electrochemical[2+2+1]annulation of benzo[d]isothiazole 1,1-dioxides,N-arylglycines and paraformaldehyde

    Hai-Yang SongJun JiangYu-Hang SongMin-Hang Zhou...
    327-330页
    查看更多>>摘要：The H-bond promoted electrochemical[2+2+1]annulation of benzo[d]isothiazole 1,1-dioxides,N-arylglycines and paraformaldehyde for the synthesis of various benzo[d]imidazo[1,5-b]isothiazole 5,5-dioxide derivatives under redox mediator,catalyst and electrolyte-free conditions was developed.
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    Photoinduced copper-catalyzed alkoxyl radical-triggered ring-expansion/aminocarbonylation cascade

    Jing-Qi TaoShuai LiuTian-Yu ZhangHong Xin...
    331-336页
    查看更多>>摘要：A photoinduced copper-catalyzed alkoxyl triggered C-C bond cleavage/aminocarbonylation cascade is presented.Through adjusting the structure of alkoxyl radical precursors,functionalized lactones and keto-amides were synthesized with good yields and excellent functional group tolerance under redox-neutral conditions.Notably,this protocol enables the integration of lactone fragments with many amine drugs and drug fragments.
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    Size-controlled synthesis and near-infrared photothermal response of Cp* Rh-based metalla[2]catenanes and rectangular metallamacrocycles

    Ying ZhaoYin-Hang ChaiTian ChenJie Zheng...
    337-343页
    查看更多>>摘要：A variety of research reports on novel supramolecular topologies have been published over the last years.However,it is still a great challenge to tap into the inner functional properties of these complexes.Herein,two tetranuclear metallamacrocycles 1 and 2 and four octonuclear[2]catenanes 3-6 were constructed successfully via a coordination-driven self-assembly strategy,by conscious design and use of the tetram-ethyl bidentate pyridine ligand L1,and the appropriate selection of six binuclear half-sandwich rhodium building units with different longitudinal dimensions.The complexes have been fully characterized by single crystal X-ray diffraction analysis and NMR spectroscopy.Furthermore,near-infrared photothermal studies of the obtained[2]catenanes reveal different photothermal response in solid and solution states,which may be attributed to a strong fluorescence quenching effect of the half-sandwich organometallic fragment and different conjugated effect of Cp*Rh based building blocks in the interlocking structures.The photothermal conversion efficiencies of[2]catenanes 4-6 fall in the range 30.5％-16.5％respectively.This contribution aims to play a key role in the experimental development of Cp*-based photothermal materials.
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