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中国化学快报（英文版）
中国化学快报（英文版）

梁晓天

月刊

1001-8417

cclbj@imm.ac.cn

010-63165638

100050

北京市先农坛街1号

中国化学快报（英文版）/Journal Chinese Chemical LettersCSCDCSTPCD北大核心SCI
查看更多>>本刊是由中国科协主管、中国化学会主办、中国医学科学院药物所承办的学术期刊，是由著名化学家梁晓天院士主编。是中国化学界通向世界的窗口，内容覆盖化学全领域。本刊的办刊宗旨是“新、快、准”，我们将坚持这个宗旨，力求及时反映化学研究中各个相关领域内的最新进展及热点问题，主要读者群是科研人员、研究生、大学教师。现已被国内外多家数据库收录，如SCI　Search、Chemical Abstract、Research Alert、Chemistry Citation Index、《日本科技文献速报》、万方数据数字化期刊群、中国学术期刊过刊全文数据库、中国学术期刊（光盘版）、中国学术期刊文摘、中文期刊全文数据库、俄罗斯Рж期刊源等。
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    C14-HSL limits the mycelial morphology of pathogen Trichosporon cells but enhances their aggregation:Mechanisms and implications

    Xin LuHaoran SunXiaomeng LiChunrui Li...
    398-403页
    查看更多>>摘要：The biosecurity hazards caused by pathogenic fungus have been widely concerned.Given the long-term coexistence of eukaryotic pathogens and quorum sensing bacteria in different habitats in environments,we hypothesized that they have social interactions via signal molecules.In this work,we firstly discovered the well-known bacterial signal molecules play an adverse role in the cell morphology and metabolism in a model pathogen Trichosporon asahii.N-Tetradecanoyl-L-homoserine lactone(C14-HSL)was discovered to increase pathogen hazards of T.asahii,which limited mycelium by 52％,but enhanced cell aggregation by 93％.Higher fluorescence intensity of tryptophan(59％)and aromatic protein(2-fold)contents after the treatment of C14-HSL,indicating that aromatic proteins helped aggregate Trichosporon and showed hydrophobicity.Transcriptome analysis revealed that C14-HSL upregulated the shikimate pathway(above 1-fold)located in downstream of tricarboxylic acid cycle,which contributed to the synthesis of more aro-matic proteins and the formation of larger flocs.The limited mycelial growth of T.asahii attributed to the up-regulated expressions of cell cycle process.The fungal transboundary response to bacterial C14-HSL was controlled by signal transduction pathways.This study provides new insights into the co-evolution of bacterial and pathogenic fungi in microecosystems.
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    Carbon dots anchored NiAl-LDH@In2O3 hierarchical nanotubes for promoting selective CO2 photoreduction into CH4

    Xiuzheng DengChanghai LiuXiaotong YanJingshan Fan...
    404-408页
    查看更多>>摘要：The efficient conversion of CO2 into hydrocarbon fuels(CH4)with high selectivity is considered as a great challenge in photocatalysis owing to the multiple-electron transfer pathway and competitive H2 generation.Herein,we developed carbon dots(CDs)-modulated S-scheme heterojunction of CDs/NiAl-LDH@ln2O3(C-DH@IN)through a facile in-situ hydrothermal method.Thanks to the multi-shell nanotube structure,the C-DH@IN shows an enhanced CH4 evolution rate of 10.67 pmol h-1 g-1 and higher se-lectivity of CH4(85.70％)compared with In2O3 and NiAI-LDH@In2O3 binary catalyst in the pure water without sacrificial agent.Electron spin resonance(ESR)and in situ Fourier transform infrared spectra ver-ify that the constructed S-scheme heterojunction can possess the strong redox capability and the HCOO and CH3O-as critical intermediates play an important role in selective CO2 reduction to generate CH4.Furthermore,CDs with superior photoabsorption can boost the electron transfer and absorb H+,thus im-proving the integration of H+and CO2 molecule.Therefore,this work emphasizes a facile strategy to achieve efficient CO2-to-CH4 conversion based on construction of CDs-based heterojunction catalysts.
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    A novel and promising engineering application of carbon dots:Enhancing the chloride binding performance of cement

    Wu-Jian LongYang YuChuang He
    409-416页
    查看更多>>摘要：Corrosion of reinforcement induced by chloride invasion is extensively considered as the dominating deterioration mechanism of reinforced concrete(RC)structures,leading to serious safety hazards and tremendous economic losses.However,it still lacks well dispersive and cost-efficient nanomaterials to improve the anti-chloride-corrosion ability of RC structures.Herein,specific carbon dots(CDs)with high dispersity and low cost are deliberately designed,successfully prepared by hydrothermal processing,and then firstly applied to immensely enhance chloride binding performance of cement,thereby contributing to suppressing the corrosion of reinforcement.Specifically,the tailored CDs are composed of the carbon core with highly crystalline sp2 C structures and oxygen-containing groups connecting on the carbon core;The typical equilibrium test confirms that with respect to that of the blank cement paste,the chloride binding capacity of cement paste involving 0.2 wt％(by weight of cement)CDs is increased by 109％after 14-day exposure to 3mol/L NaCl solution;according to comprehensive analyses of phase compositions,the chloride binding mechanism of CDs-modified cement is rationally attributed to the fact that the incorporation of CDs advances the formation of calcium silicate hydrate(C-S-H)gels and Friedel's salt(Fs),thus enormously enhancing the physically adsorbed and chemically bound chloride ions of cement pastes.This work not only firstly provides a novel high-dispersity and low-cost nanoma-terial toward the durability enhancement of RC structures,but also broadens the application of CDs in the field of engineering,conducing to stimulating their industrialization development.
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    A highly sensitive fluorescent HClO probe for discrimination between cancerous and normal cells/tissues

    Linfang WangJing LiuMinghao RenWei Guo...
    417-420页
    查看更多>>摘要：Elevated level of hypochlorous acid(HClO)is closely associated with cancer development.Identifying HClO level in cancer cells would provide important evidence in either early-stage cancer diagnostics or monitoring of its treatment efficiency.In this work,a new pyronine-based fluorescent probe for rapid and sensitive detection of HClO was developed by condensing meso-formyl pyronine(PyCHO)with 2-hydrazinopyridine to form meso-pyridylhydrazone-functionalized pyronine PyHP,PyHP is nonfluorescent due to the excited-state C=N isomerization nonradiative decay,whereas the HClO-triggered formation of meso-triazolopyridyl pyronine PyTP abolishes the C=N isomerization and thus greatly enhances the fluorescence.With the probe,the cancer cells/tumor were distinguished with high-contrast from normal ones by laser confocal fluorescence imaging,and the tumor-to-normal(T/N)ratios obtained exceed the clinically acceptable threshold of 2.0.Moreover,its capability of in vivo imaging tumor was also demon-strated.These results indicate the potential of PyHP as an effective tool in the early clinical diagnosis of cancers.
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    Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy

    Qiang LiJiangbo FanHongkai MuLin Chen...
    421-426页
    查看更多>>摘要：Carbon dots(CDs)with precise targeting function show great potential in the field of drug delivery thera-peutics.In this study,the functionalized nucleus-targeting orange-emissive CDs with nuclear localization sequence(NLS)were loaded with adriamycin(DOX)to obtain a nucleus-targeting orange-emissive CDs drug delivery system(CDs-NLS-DOX),which delivered DOX to tumor cell nuclei to enhance its anti-tumor activity.The drug carrier orange-emissive CDs showed excitation-independent behavior,stable and en-hanced imaging capability and good biocompatibility in vitro and in vivo.Meanwhile,the CDs-NLS could target the nuclei efficiently,and the CDs-NLS-DOX complexes had a high drug loading rate(59.4％)after loading DOX,exhibiting pH-dependent DOX release behavior through breaking acylhydrazone bond in a weak acidic environment.In addition,the CDs-NLS-DOX complexes exhibited an enhanced killing activity against human hepatoma cells(HepG2).The in vivo therapeutic effects on HepG2 nude mice transplanted tumors indicated the CDs-NLS-DOX had a stronger ability to inhibit tumor growth compared to free DOX.In short,CDs-NLS-DOX is expected to be a precise and efficient nucleus-targeting nano-drug delivery sys-tem for tumor treatment.
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    Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy

    Yihan ZhouDuo GaoYaying WangLi Liang...
    427-432页
    查看更多>>摘要：Local delivery of nanoparticles holds promise for colorectal cancer(CRC)therapy.However,the pres-ence of the mucus layer on the epithelium poses a significant challenge to drug delivery,thereby ad-versely affecting treatment efficiency.It is crucial to develop efficient drug delivery carriers that can effectively overcome mucus barriers to treat colorectal cancer.Herein,we utilized poly(1,4-butadiene)-b-poly(ethylene oxide)polymers to prepare four distinct geometries of polymeric micelles,namely linear micelles(LMs),worm-like micelles(WLMs),large spherical micelles(LSMs),and small spherical micelles(SSMs)to investigate the influence of shape effects on overcoming colonic mucosal barrier.We found that the carriers exhibited diverse shapes while maintaining comparable physicochemical properties.Of these,WLMs had an aspect ratio similar to segmented filamentous bacteria,which exhibited superior mucus penetration ability,leading to prolonged drug release kinetics and faster entry into epithelial cells com-pared to LSMs.Furthermore,rectally administrated 10-hydroxycamptothecin-loaded WLMs traversed the colorectal mucus in orthotopic CRC nude mice model,penetrated and accumulated within tumor tissue,and effectively aggregated within cancer cells,thereby inducing significantly robust antitumor outcomes in vivo.These findings underscore the significance of shape design in overcoming colonic mucosal absorp-tion barriers,offering a novel approach for the development of drug delivery carriers tailored for effective tumor therapy.
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    Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging

    Boran ChengLei CaoChen LiFang-Yi Huo...
    433-438页
    查看更多>>摘要：As a type of new carbon-based nanomaterials,carbon dots(CDs)possess exceptional optical properties,making them highly desirable for use in fluorescent sensors.However,the CDs with deep-red(DR)or near-infrared(NIR)emission have rarely been reported.In this work,we prepared deep-red emissive fluorine-doped carbon quantum dots(F-CDs)by introducing a precursor simultaneously containing fluo-rine and amidogen.The synergistic effect of nitrogen doping and D-π-A pattern production contributed to the maximum emission of F-CDs at 636 nm with an absolute quantum yield of 36.00％±0.68％.More-over,we designed an F-CDs-based fluorescence assay to determine the content of hypochlorite(ClO-),with a limit of detection(LOD)as low as 15.4nmol/L,indicating the high sensitivity of F-CDs to ClO-.In real samples,the F-CDs-based fluorescent sensor exhibited excellent sensitivity and selectivity in the detection of ClO-,with an error below 2％,suggesting their great potential in daily life.In cancer cell imaging,the F-CDs not only demonstrated high sensitivity to ClO-but also exhibited excellent mitochon-dria targeting,as evidenced by the high Pearson's correlation coefficient(PCC)of 0.93 in colocalization analysis.The work presented here suggests the great potential of replacing commercial dyes with F-CDs for highly specific mitochondria labeling and cell imaging.
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    Developing a fluorescence substrate for HRP-based diagnostic assays with superiorities over the commercial ADHP

    Zhichao ZhouFuqian ChenXiaotong XiaDong Ye...
    439-444页
    查看更多>>摘要：The combination of horseradish peroxidase(HRP)and a fluorescence substrate has been attract-ing great interests in developing sensitive biochemical analysis and immunoassays.10-Acetyl-3,7-dihydroxyphenoxazine(ADHP or Amplex red)is the most sensitive fluorogenic substrate known for HRP in current market,however,it suffers from some drawbacks,such as non-specific reactivity to carboxylesterase and limited fluorescence stability.In the present study,a novel HRP substrate 10-cyclopropylcarbonyl-dichloro-dihydroxyphenoxazine(AR-2),has been prepared,which exhibited im-proved sensitivity than ADHP in sensing HRP.Moreover,the fluorescence of AR-2/HRP demonstrated im-proved tolerance to physiological relevant pH fluctuation as compared to ADHP/HRP.Successful detec-tion of uric acid/urate oxidase reaction indicated excellent application prospect of AR-2/HRP for monitor-ing H2O2-generating biochemical reactions.More interestingly,an enzyme-linked immunosorbent assay(ELISA)using AR-2 as the fluorescence reporter has been successfully used in detecting IgG against se-vere acute respiratory syndrome coronavirus 2(SARS-CoV-2)from human serum samples.Overall,AR-2 exhibits improved performances over the commercial ADHP,which will be an ideal alternative to ADHP in HRP-based fluorescence biochemical analysis and immunoassays.
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    Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy

    Leichen WangAnqing MeiNa LiXiaohong Ruan...
    445-450页
    查看更多>>摘要：Introducing heavy halogen atoms into organic small molecules is a practical strategy for efficient sin-glet oxygen(1O2)generation.Generally,bromine or iodine atoms are introduced on the aza-boron-dipyrromethene(aza-BODIPY)core,rather than on the periphery aryl rings for efficient 1O2 generation.Herein,an aza-BODIPY dye NBDPBr with unexpected bromination on the periphery aryl rings was synthe-sized for photoacoustic(PA)imaging-guided synergistic photothermal therapy(PTT)and photodynamic therapy(PDT)in tumor cells.Owing to unexcepted bromination at the periphery aryl rings,NBDPBr demonstrated an outstanding singlet oxygen quantum yield(ΦΔ)of 66％which was superior to simi-lar brominated photosensitizers previously reported.After encapsulation with amphiphilic polymer F-127,hydrophilic NBDPBr nanoparticles(NPs)were fabricated and exhibited an excellent photothermal conver-sion efficiency(η)of 43.0％under 660 nm photoirradiation.In vivo PA imaging results demonstrated that NBDPBr NPs could specifically accumulate at tumor sites and realized the maximum tumor retention at 7 h post-injection.All the in vitro and in vivo results indicated the significant potence of NBDPBr with unexpected bis-bromination for PA imaging-guided synergetic PDT/PTT.
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    A multi-enzymatic cascade reaction for the synthesis of bioactive C-oligosaccharides

    Kebo XieQian ZhangFei YeJungui Dai...
    451-455页
    查看更多>>摘要：C-Oligosaccharides are rare in nature and possess diverse bioactivities.However,their chemical synthesis faces many challenges.In this work,enzymatic introduction of C-linked sugar chains to target aglycones was successfully achieved by multi-enzymatic cascade reactions.A C-glycosyltransferase from Aloe bar-badensis was employed to introduce the first C-linked glucose and then a cyclomaltodextrin glucanotrans-ferase from Bacillus licheniformis was used to extend the sugar chain.A total of twenty C-oligosaccharides with 2-6 sugars were synthesized from scale-up reactions and exhibited good water solubility and sodium-dependent glucose transporter 2(SGLT2)inhibitory activity.Furthermore,a glucoamylase was used to control the length of the sugar chain and the C-maltosides were efficiently synthesized.These findings not only expanded the structural diversity of C-oligosaccharides,but also provided a strategy for the modification of C-glycoside drugs to improve the druggability.
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