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期刊信息/Journal information
中国天然药物
中国天然药物

吴晓明 孙汉董

双月刊

1672-3651

cjnm@cpu.edu.cn

025-83271565、83271568

210009

南京童家巷24号

中国天然药物/Journal Chinese Journal of Natural MedicinesCSCD北大核心CSTPCDSCI
查看更多>>本刊以刊登国家重大基金项目、国际合作项目的原创性成果为特色，旨在为具有独特优势的中药、草药、海洋药物、生化药物、微生物药物、民族药物、民间药物的创新研究提供有效载体。全面反映天然药物各学科研究与发展前沿，刊登来源于天然的药物资源与质量、药物化学、药理学、毒理学、药剂学、药物分析学、生物化学、微生物学、分子生物学、药物与临床、药事法规等及其相关学科研究原著，报道天然药物研究热点、难点及新技术、新方法的应用。解析新机理，提供新思路。内容突出创新性、前瞻性、科学性、实用笥。力求反映天然药物研究的最高水平。
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    Pinelliae Rhizoma:a systematic review on botany,ethnopharmacology,phytochemistry,preclinical and clinical evidence

    Zuanji LiangJinchao WeiSioi ChanSiyuan Zhang...
    1-20页
    查看更多>>摘要：Pinelliae Rhizoma(PR),known as Banxia in Chinese,Hange in Japanese,and Banha in Korean,is a renowned herbal medicine in East Asia derived from the dry tuber of Pinellia ternata(Thunb.)Breit.(PT).It is extensively utilized in dispensing granules,classical prescriptions,and herbal formulas to treat various conditions,including cough,infection,phlegm,nausea,asthma,and inflammation.Despite numerous studies on PR and its classical prescriptions over recent decades,a comprehensive synthesis of available evidence regarding its multifunc-tional roles and therapeutic potential is lacking.This review aims to address this gap by ex-amining emerging evidence from metabonomics,preclinical studies,and clinical trials,while exploring potential trends and prospects for future research.A systematic literature search was conducted across six electronic databases,including PubMed,Web of Science,Scopus,ScienceDirect,Wanfang,and China National Knowledge Infrastructure,to identify relevant articles on PR published until March 2023.PR contains 107 compounds with diverse pharma-cological activities,including anti-inflammatory,immune regulatory,anti-viral,anti-cancer,anti-asthma,antitussive and expectorant,antioxidant,anti-obesity,anti-atherosclerosis,anti-microbial,emetic and anti-emetic,anti-convulsant and anti-epileptic,sedative and hypnotic,learning and memory enhancement,and anti-depressant effects.Metabonomic studies sug-gest that raw PR may exhibit cardiotoxicity and pregnancy toxicity while showing no appar-ent hepatorenal toxicity.However,limited pharmacokinetic investigations on PR constrain its clinical translation.Furthermore,clinical safety data on PR is scarce,with only four clinical trials assessing its positive effects in pediatric epilepsy,nausea and vomiting,soft tissue in-jury,and chronic sinus tract.This review aims to enhance understanding of PR and provide valuable information and recommendations for further research and development of herbal medicine.
      原文链接:
    • NETL
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    Research progress of small-molecule natural medicines for the treatment of ischemic stroke

    Kui LiuLing WangTao Pang
    21-30页
    查看更多>>摘要：Stroke is the second leading cause of disability and mortality worldwide,imposing a substan-tial socioeconomic burden on individuals and healthcare systems.Annually,approximately 14 million people experience stroke,with ischemic stroke comprising nearly 85％of cases,of which 10％to 20％involve large vessel occlusions.Currently,recombinant tissue plasmino-gen activator(tPA)remains the only approved pharmacological intervention.However,its utility is limited due to a narrow therapeutic window and low recanalization rates,making it applicable to only a minority of patients.Therefore,there is an urgent need for novel thera-peutic strategies,including pharmacological advancements and combinatory treatments.Small-molecule natural medicines,particularly those derived from traditional Chinese herbs,have demonstrated significant therapeutic potential in ischemic stroke management.These compounds exert multiple neuroprotective effects,such as antioxidation,anti-inflammatory action,and inhibition of apoptosis,all of which are critical in mitigating stroke-induced cereb-ral damage.This review comprehensively examines the pathophysiology of acute ischemic stroke(AIS)and highlights the recent progress in the development of small-molecule natural medicines as promising therapeutic agents for cerebral ischemic stroke.
      原文链接:
    • NETL
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    Recent advances,strategies,and future perspectives of peptide-based drugs in clinical applications

    Qimeng YangZhipeng HuHongyu JiangJialing Wang...
    31-42页
    查看更多>>摘要：Peptide-based therapies have attracted considerable interest in the treatment of cancer,dia-betes,bacterial infections,and neurodegenerative diseases due to their promising therapeut-ic properties and enhanced safety profiles.This review provides a comprehensive overview of the major trends in peptide drug discovery and development,emphasizing preclinical strategies aimed at improving peptide stability,specificity,and pharmacokinetic properties.It assesses the current applications and challenges of peptide-based drugs in these diseases,il-lustrating the pharmaceutical areas where peptide-based drugs demonstrate significant po-tential.Furthermore,this review analyzes the obstacles that must be overcome in the future,aiming to provide valuable insights and references for the continued advancement of peptide-based drugs.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Stem-leaf saponins of Panax notoginseng attenuate experimental Par-kinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway

    Hui WuChenyang NiYu ZhangYingying Song...
    43-53页
    查看更多>>摘要：Stem-leaf saponins from Panax notoginseng(SLSP)comprise numerous PPD-type saponins with diverse pharmacological properties;however,their role in Parkinson's disease(PD),characterized by microglia-mediated neuroinflammation,remains unclear.This study evalu-ated the effects of SLSP on suppressing microglia-driven neuroinflammation in experimental PD models,including the 1-methyl-4-phenylpyridinium(MPTP)-induced mouse model and lipopolysaccharide(LPS)-stimulated BV-2 microglia.Our findings revealed that SLSP mitig-ated behavioral impairments and excessive microglial activation in models of PD,including MPTP-treated mice.Additionally,SLSP inhibited the upregulation of inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX2)and attenuated the phosphorylation of PI3K,protein kinase B(AKT),nuclear factor-KB(NFKB),and inhibitor of NFκB protein α(IKBα)both in vivo and in vitro.Moreover,SLSP suppressed the production of inflammatory markers such as interleukin(IL)-1β,IL-6,and tumor necrosis factor alpha(TNF-α)in LPS-stimulated BV-2 cells.Notably,the P2Y2R agonist partially reversed the inhibitory effects of SLSP in LPS-treated BV-2 cells.These results suggest that SLSP inhibit microglia-mediated neuroinflam-mation in experimental PD models,likely through the P2Y2R/PI3K/AKT/NFκB signaling pathway.These novel findings indicate that SLSP may offer therapeutic potential for PD by at-tenuating microglia-mediated neuroinflammation.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Astragali Radix-Notoginseng Radix et Rhizoma medicine pair prevents cardiac remodeling by improving mitochondrial dynamic balance

    Pingping LinHong ChenZekun CuiBoyang Yu...
    54-63页
    查看更多>>摘要：Astragali Radix(AR)and Notoginseng Radix et Rhizoma(NR)are frequently employed in car-diovascular disease treatment.However,the efficacy of the AR-NR medicine pair(AN)in im-proving cardiac remodeling and its underlying mechanism remains unclear.This study aimed to evaluate AN's cardioprotective effect and potential mechanism on cardiac remodeling us-ing transverse aortic constriction(TAC)in mice and angiotensin Ⅱ(Ang Ⅱ)-induced neonatal rat cardiomyocytes(NRCMs)and fibroblasts in vitro.High-performance liquid chromato-graphy-quadrupole-time of flight tandem mass spectrometry(HPLC-Q-TOF-MS/MS)charac-terized 23 main components of AN.AN significantly improved cardiac function in the TAC-in-duced mice.Furthermore,AN considerably reduced the serum levels of N-terminal pro-B-type natriuretic peptide(NT-proBNP),cardiac troponin T(CTn-T),and interleukin-6(IL-6)and mitigated inflammatory cell infiltration.Post-AN treatment,TAC-induced heart size ap-proached normal.AN decreased cardiomyocyte cross-sectional area and attenuated the up-regulation of cardiac hypertrophy marker genes(ANP,BNP,and MYH7)in vivo and in vitro.Concurrently,AN alleviated collagen deposition in TAC-induced mice.AN also reduced the ex-pression of fibrosis-related indicators(COL1A1 and COL3A1)and inhibited the activation of the transforming growth factor-β1(TGF-β1)/mothers against decapentaplegic homolog 3(Smad3)pathway.Thus,AN improved TAC-induced cardiac remodeling.Moreover,AN down-regulated p-dynamin-related protein(Drp1)(Ser616)expression and upregulated mitogen 2(MFN-2)and optic atrophy 1(OPA1)expression in vivo and in vitro,thereby restoring mito-chondrial fusion and fission balance.In conclusion,AN improves cardiac remodeling by regu-lating mitochondrial dynamic balance,providing experimental data for the rational applica-tion of Chinese medicine prescriptions with AN as the main component in clinical practice.
      原文链接:
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    • NSTL
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    Exploring the mechanism of Xiaoaiping Injection inhibiting autophagy in prostate cancer based on proteomics

    Qiuping ZhangQiuju HuangZhiping ChengWei Xue...
    64-76页
    查看更多>>摘要：Xiaoaiping(XAP)Injection demonstrates the anti-prostate cancer(PCa)effects,yet the under-lying mechanism remains unclear.This study aims to investigate the impact of XAP on PCa and elucidate its mechanism of action.PCa cell proliferation was evaluated using a cell count-ing kit-8(CCK-8)assay.Cell apoptosis was assessed through Hoechst staining and Western blotting assays.Proteomics technology was employed to identify key molecules and signific-ant signaling pathways modulated by XAP in PCa cells.To further validate potential key genes and important pathways,a series of assays were conducted,including acridine orange(AO)staining,transmission electron microscopy,and immunofluorescence assays.The molecular mechanism of XAP against PCa in vivo was examined using a PC3 xenograft mouse model.Res-ults demonstrated that XAP significantly inhibited cell proliferation in multiple PCa cell lines.In C4-2 and prostate cancer cell line-3(PC3)cells,XAP induced cellular apoptosis,evidenced by reduced B-cell lymphoma 2(Bcl-2)levels and elevated Bcl-2-associated X(Bax)levels.Pro-teomic,immunofluorescence,and quantitative reverse transcription-polymerase chain reac-tion(qRT-PCR)investigations revealed a strong correlation between forkhead box O3a(FoxO3a)autophagic degradation and the anti-PCa action of XAP.XAP hindered autophagy by reducing the expression levels of autophagy-related protein 5(Atg5)/autophagy-related pro-tein 12(Atg12)and enhancing FoxO3a expression and nuclear translocation.Furthermore,XAP exhibited potent anti-PCa action in PC3 xenograft mice and triggered FoxO3a nuclear translocation in tumor tissue.These findings suggest that XAP induces PCa apoptosis via in-hibition of FoxO3a autophagic degradation,potentially offering a novel perspective on XAP in-jection as an effective anticancer therapy for PCa.
      原文链接:
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    • NSTL
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    Zhongfeng Xingnao Liquid ameliorates post-stroke cognitive impair-ment through sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)pathway

    Wenqin YangWen WenHao ChenHaijun Zhang...
    77-89页
    查看更多>>摘要：The activation of the sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)pathway has been shown to mitigate oxidative stress-induced apoptosis and mitochondrial damage by reducing reactive oxygen species(ROS)levels.Clinical trials have demonstrated that Zhongfeng Xingnao Liquid(ZFXN)ameliorates post-stroke cognitive impairment(PSCI).However,the underlying mechanism,particularly whether it involves protecting mitochondria and inhibiting apoptosis through the SIRT1/Nrf2/HO-1 pathway,re-mains unclear.This study employed an oxygen-glucose deprivation(OGD)cell model using SH-SY5Y cells and induced PSCI in rats through modified bilateral carotid artery ligation(2VO).The effects of ZFXN on learning and memory,neuroprotective activity,mitochondrial func-tion,oxidative stress,and the SIRT1/Nrf2/HO-1 pathway were evaluated both in vivo and in vitro.Results indicated that ZFXN significantly increased the B-cell lymphoma 2(Bc12)/Bc12-associated X(Bax)ratio,reduced terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling(TUNEL)+cells,and markedly improved cognition,synaptic plasticity,and neur-onal function in the hippocampus and cortex.Furthermore,ZFXN exhibited potent antioxid-ant activity,evidenced by decreased ROS and malondialdehyde(MDA)content and increased superoxide dismutase(SOD),catalase(CAT),and glutathione(GSH)levels.ZFXN also demon-strated considerable enhancement of mitochondrial membrane potential(MMP),Tom20 fluorescence intensity,adenosine triphosphate(ATP)and energy charge(EC)levels,and mi-tochondrial complex Ⅰ and Ⅲ activity,thereby inhibiting mitochondrial damage.Additionally,ZFXN significantly increased SIRT1 activity and elevated SIRT1,nuclear Nrf2,and HO-1 levels.Notably,these effects were substantially counteracted when SIRT1 was suppressed by the in-hibitor EX-527 in vitro.In conclusion,ZFXN alleviates PSCI by activating the SIRT1/Nrf2/HO-1 pathway and preventing mitochondrial damage.
      原文链接:
    • NETL
    • NSTL
    • 万方数据

    Buqi-Tongluo Decoction inhibits osteoclastogenesis and alleviates bone loss in ovariectomized rats by attenuating NFATc1,MAPK,NF-κB sig-naling

    Yongxian LiJinbo YuanWei DengHaishan Li...
    90-101页
    查看更多>>摘要：Osteoporosis is a prevalent skeletal condition characterized by reduced bone mass and strength,leading to increased fragility.Buqi-Tongluo(BQTL)decoction,a traditional Chinese medicine(TCM)prescription,has yet to be fully evaluated for its potential in treating bone diseases such as osteoporosis.To investigate the mechanism by which BQTL decoction inhib-its osteoclast differentiation in vitro and validate these findings through in vivo experiments.We employed MTS assays to assess the potential proliferative or toxic effects of BQTL on bone marrow macrophages(BMMs)at various concentrations.TRAcP experiments were conduc-ted to examine BQTL's impact on osteoclast differentiation.RT-PCR and Western blot ana-lyses were utilized to evaluate the relative expression levels of osteoclast-specific genes and proteins under BQTL stimulation.Finally,in vivo experiments were performed using an osteo-porosis model to further validate the in vitro findings.This study revealed that BQTL sup-pressed receptor activator of NF-κB ligand(RANKL)-induced osteoclastogenesis and osteo-clast resorption activity in vitro in a dose-dependent manner without observable cytotoxicity.The inhibitory effects of BQTL on osteoclast formation and function were attributed to the downregulation of NFATc1 and c-fos activity,primarily through attenuation of the MAPK,NF-κB,and Calcineurin signaling pathways.BQTL's inhibitory capacity was further examined in vivo using an ovariectomized(OVX)rat model,demonstrating a strong protective effect against bone loss.BQTL may serve as an effective therapeutic TCM for the treatment of post-menopausal osteoporosis and the alleviation of bone loss induced by estrogen deficiency and related conditions.
      原文链接:
    • NETL
    • NSTL
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    Tianxiangdan(TXD)alleviates myocardial ischemia reperfusion-in-duced ferroptosis through the activation of estrogen receptor alpha(ERα)

    Yuanjia YueYu LiXing RongZhao Ji...
    102-110页
    查看更多>>摘要：Tianxiangdan(TXD),a traditional Chinese herbal remedy,demonstrates efficacy in mitigating myocardial ischemia-reperfusion(I/R)-induced damage.This study employed network phar-macology to evaluate the therapeutic targets and mechanisms of TXD in treating I/R.High-performance liquid chromatography-mass spectrometry(HPLC-MS)identified 86 com-pounds in TXD.Network pharmacological analysis predicted potential target genes and their modes of action.Cardiac function,ischaemic ST changes,lactate dehydrogenase(LDH),malondialdehyde(MDA),superoxide dismutase(SOD)activity,myocardial fiber,and infarct size were assessed using in vivo and in vitro I/R injury models.Estrogen receptor alpha(ERα)protein expression and estradiol(E2)levels were measured to confirm TXD's impact on estro-gen levels and ERα expression.To examine if TXD reduces I/R injury through ERα,an AZD group(300 nmol·L-1 AZD9496 and 15％TXD serum)was compared to a TXD group(15％TXD serum).The study hypothesized that TXD upregulates the ERα-mediated iron metamorphosis pathway.I/R injury-induced ferroptosis was identified using a Fer-1 group(1.0 μmol·L-1 Fer-1 and 15％TXD serum)to elucidate the potential association between ferroptosis and ERαproteins.A DCFH-DA probe detected reactive oxygen species(ROS)and Fe2+,while Western blotting assessed target protein expression.Both in vitro and in vivo experiments demon-strated that TXD attenuated I/R injury by reducing elevated ST-segment levels,improving cardiac injury biomarkers(LDH,MDA,and SOD),alleviating pathological features,and pre-venting I/R-induced loss of cell viability in vitro.The effects and mechanisms of TXD on I/R in-jury-associated ferroptosis were investigated using I/R-induced H9c2 cells.The TXD group showed significantly decreased ROS and Fe2+levels,while the AZ group(treated with AZD9496)exhibited increased levels.The TXD group demonstrated enhanced expression of ERα and glutathione peroxidase 4(GPX4),with reduced levels of P53 protein and ferritin-heavy polypeptide 1(FTH1).The AZ group exhibited contrasting effects on these expression levels.The literature indicated a novel connection between ERα and ferroptosis.TXD activ-ates the ERα signaling pathway,promoting protection against I/R-induced myocardial cell ferroptosis.This study provides evidence supporting TXD use for myocardial ischemia treat-ment,particularly in older female patients who may benefit from its therapeutic outcomes.
      原文链接:
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    Amoenucles A-F,novel nucleoside derivatives with TNF-α inhibitory activities from Aspergillus amoenus TJ507

    Yeting ZhangZhengyi ShiChunhua ZhaoLanqin Li...
    111-118页
    查看更多>>摘要：Amoenucles A-F(1-6),six previously undescribed nucleoside derivatives,and two known analogs(7 and 8)were isolated from the culture of Aspergillus amoenus TJ507.Their struc-tures were elucidated through spectroscopic analysis,single-crystal X-ray crystallography,and chemical reactions.Notably,3 and 4 represent the first reported instances of nucleosides with an attached pyrrole moiety.Of particular significance,the absolute configuration of the sugar moiety of 1-4 was determined using nuclear magnetic resonance(NMR),electric circu-lar dichroism(ECD)calculations,and a hydrolysis reaction,presenting a potentially valuable method for confirming nucleoside structures.Furthermore,1,2,and 5-8 exhibited potential tumor necrosis factor α(TNF-α)inhibitory activities,which may provide a novel chemical template for the development of agents targeting autoimmune and inflammatory diseases.
      原文链接:
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