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期刊信息/Journal information
中华神经医学杂志
南方医科大学珠江医院
中华神经医学杂志

南方医科大学珠江医院

徐如祥

月刊

1671-8925

journal@126.com

020-61643273

510282

广州市工业大道中253号珠江医院

中华神经医学杂志/Journal Chinese Journal of NeuromedicineCSCD北大核心CSTPCD
查看更多>>中华医学会主办。本刊主要刊载神经医学的新理论、新进展、新技术、新业务等，内容涵盖神经外科、神经内科以及神经生物等基础神经科学领域。本刊设置的主要栏目有基础研究、临床研究、专家论坛、国际动态、短篇论著、经验交流、病例报告、综述等，目前已成为展示和共享我国神经科学领域学术成就和科研成果的重要载体和平台。杂志迄今已被美国《化学文摘（CA）》、俄罗斯《文摘杂志（AJ）》、《中文核心期刊要目总览》、《中国科技论文统计源期刊（中国科技核心期刊）》、《中国科学引文数据库》等国内外数据库和检索机构收录。
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    散发型克雅氏病合并新型冠状病毒感染后迅速进展1例报道并文献复习

    杨宁刁勋张媛肖向建...
    178-180页
    查看更多>>摘要：克雅氏病（Creutzfeldt-Jakob disease，CJD）又称朊蛋白病，是一种潜伏期长、病程较短、可传播的罕见致命性疾病。自2019年开始全球大流行的2019冠状病毒病（Corona virus disease 2019，COVID-19）是一种由严重急性呼吸综合征冠状病毒2（severe acute respiratory syndrome Coronavirus 2，SARS-CoV-2）感染引起的呼吸系统疾病，其高传染性及高变异性导致目前仍在继续流行，或将长期存在。迄今为止，国外已多次报道在COVID-19患者中观察到了许多不同表现的神经系统并发症，并提出SARS-CoV-2可能影响神经变性病发生发展的假设。2023年初，河北省人民医院神经内科收治了1例以头晕、步态不稳为首发症状的患者，完善相关检查后仍不能明确诊断，在此期间患者SARS-CoV-2检测呈阳性后，病情迅速进展，最终确诊为CJD，故推测COVID-19可能与CJD的迅速进展存在相关性。笔者现将该例患者的具体诊治过程报道如下，以期提高临床工作者对CJD及SARS-CoV-2的认识。

    克雅氏病新型冠状病毒感染朊蛋白神经免疫

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    血栓调节素-凝血酶-高迁移率族蛋白1通路在慢性硬膜下血肿发生发展中的作用研究进展

    武泽军赵君爽胡钧涛刘凯...
    181-185页
    查看更多>>摘要：慢性硬膜下血肿（CSDH）是一种位于硬脑膜边界细胞层内，由包膜包被的血液、血凝块及其降解产物的集合体。血肿腔内的炎症反应、凝血功能障碍、新生毛细血管生成异常等病理生理过程在CSDH的发生发展中起重要作用。高迁移率族蛋白1（HMGB1）可介导炎症反应、血管生成及止血等过程，血栓调节素（TM）则可通过与HMGB1结合，以依赖凝血酶的方式降解HMGB1。目前研究已证实CSDH的血肿液中TM、HMGB1及其下游相关因子的表达异常增高，但TM-凝血酶-HMGB1通路在CSDH发生发展中的作用尚不完全明确。本文围绕TM-凝血酶-HMGB1通路在CSDH发生发展中的作用研究进展进行综述，旨在为CSDH的发病机制及治疗新靶点研究提供一些参考。 Chronic subdural hematoma (CSDH) is a collection of blood, blood clots and their degradation products, encapsulated by membrane and located within dural border cell layer. Pathophysiological processes such as inflammatory responses within hematoma cavity, coagulation abnormalities, and abnormalities in neovascularization play significant roles in CSDH development. High mobility group box 1 (HMGB1) can mediate processes such as inflammation, angiogenesis, and hemostasis, while thrombomodulin (TM) can bind with HMGB1 and rely on thrombin to degrade HMGB1. Current research has confirmed that the expressions of TM, HMGB1, and their downstream related factors are abnormally increased in the hematoma fluid of CSDH however, the role of TM-thrombin-HMGB1 pathway in CSDH development is not fully clear. This article reviews the role of TM-thrombin-HMGB1 pathway in CSDH development, aiming to provide some references for pathogenesis and new therapeutic targets of CSDH.

    慢性硬膜下血肿血栓调节素凝血酶高迁移率族蛋白1

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    细胞膜修饰纳米粒子治疗脑部恶性肿瘤的研究进展

    杨晶孙逸初梁飞沈自强...
    186-191页
    查看更多>>摘要：细胞膜修饰纳米粒子（NPs）作为一种新型的治疗脑部恶性肿瘤的手段，近年来受到广泛关注。该方法通过保留源细胞膜的特性，提高了NPs的靶向性、生物相容性和体内循环时间，可确保药物高效作用于颅内病灶。本文围绕近年该领域研究进展，尤其是细胞膜修饰NPs穿透血脑屏障、免疫逃逸、药物输送的优势，以及不同细胞膜修饰NPs的效果进行综述，以期为脑部恶性肿瘤的治疗提供新的视角。 Cell membrane-modified nanoparticles (NPs) have attracted widespread attention as a new approach for malignant brain tumors in recent years. This method can enhance the targeting, biocompatibility, and circulation time of NPs by preserving the characteristics of source cell membrane, thereby ensuring efficient drug delivery to intracranial lesions. This paper focuses on the research progress in this field, especially advantages of NPs penetrating the blood-brain barrier, immune evasion and drug delivery, as well as modified effect of different cell membrane on NPs, in order to provide help for treatment of malignant brain tumors.

    细胞膜修饰纳米载药系统脑部恶性肿瘤血脑屏障靶向治疗

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    基质相互作用分子1在缺血性脑卒中的研究进展

    李瑞鑫苏刚王娅沈明辉...
    192-196页
    查看更多>>摘要：基质相互作用分子1（STIM1）是钙池操纵性钙内流（SOCE）的关键成分，通过感知内质网腔内存储Ca2+含量以控制质膜Ca2+通道的开放与关闭，进而影响细胞粘附、迁移、基因表达和增殖等过程。研究表明，在缺血性脑卒中（IS）的发生发展过程中，STIM1在神经元、内皮细胞和血小板等多种细胞中表达异常，在高血压调控以及促进血栓形成、激活细胞自噬、介导细胞凋亡和促进神经炎症的病理过程中发挥重要作用。本文对STIM1在IS发生发展和预后评估中的研究进展进行总结，力求为寻找IS的潜在治疗靶点提供理论参考。 Stromal interaction molecule 1 (STIM1) is a key component mediating store-operated calcium entry (SOCE), which controls the opening and closing of plasma membrane Ca2+ channels by sensing the Ca2+ content of endoplasmic reticulum luminal stores, and thus affects the processes of cell adhesion, migration, gene expression and proliferation. Studies have shown that STIM1 is abnormally expressed in a variety of cells such as neurons, endothelial cells and platelets during ischemic stroke (IS) development it plays an important role in the pathological processes regulating hypertension, promoting thrombosis, activating cellular autophagy, mediating apoptosis and promoting neuroinflammation. This review summarizes the research progress of STIM1 in the development and prognostic assessment of IS, and seeks to provide theoretical references for potential therapeutic targets for IS.

    基质相互作用分子1缺血性脑卒中机制治疗预后

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    椎-基底动脉延长扩张综合征的血管内治疗研究进展

    葛润泽冯欣李西锋张炘...
    197-201页
    查看更多>>摘要：椎-基底动脉延长扩张综合征（VBD）是一种罕见且具有挑战性的疾病。VBD主要与酶的作用和血流动力学的改变密切相关，以缺血性脑卒中、神经压迫症状、脑积水等临床症状为主要表现。随着VBD治疗实践以及近年来介入技术及材料的发展，VBD的血管内治疗成为焦点。本文围绕近年来VBD的血管内治疗研究进展进行综述，旨在为临床工作者提供参考。 Vertebrobasilar dolichoectasia is a rare and challenging disorder. Vertebrobasilar dolichoectasia is closely related to enzyme action and hemodynamic changes, and is characterized by ischemic stroke, neurological compression symptoms, hydrocephalus, and other clinical symptoms. With development of interventional techniques and materials in recent years, endovascular treatment of vertebrobasilar dolichoectasia has become the focus. This article summarizes the current endovascular treatment of vertebrobasilar dolichoectasia, aiming to provide references for clinicians.

    椎-基底动脉延长扩张综合征研究进展血管内治疗抗血小板药物

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    功能性近红外光谱技术在脑卒中后抑郁及认知障碍中的应用研究进展

    姬忠敏李道静张爱梅刘凯...
    202-207页
    查看更多>>摘要：近年来，脑卒中后抑郁（PSD）、脑卒中后认知障碍（PSCI）等作为常见的脑卒中后相关非运动症状，逐渐受到学者们的关注。功能性近红外光谱（fNIRS）技术作为一种新兴的非侵入性神经成像技术，现已广泛应用于神经系统疾病的研究，其可以通过监测脑血液循环和氧合信号的变化，评估患者功能状态和康复情况，目前在PSD及PSCI中的应用研究也越来越多。本文主要围绕fNIRS技术在早期识别PSD、PSCI及探索其神经机制、评估治疗效果等方面的应用研究进展，以及fNIRS技术在临床应用中的优缺点和未来研究方向进行综述，以期为脑卒中患者的情感障碍、认知障碍康复研究提供一些参考借鉴。 In recent years, post-stroke depression (PSD) and post-stroke cognitive impairment (PSCI) have gradually attracted the attention of scholars as common stroke-related non-motor symptoms. As an emerging non-invasive neuroimaging tool, functional near-infrared spectroscopy (fNIRS) has been widely used in the study of neurological diseases, which can evaluate the functional status and recovery of these patients by monitoring changes in cerebral blood circulation and oxygenation signals fNIRS is now being increasingly used in PSD and PSCI studies. This review mainly focuses on the research progress of fNIRS in identifying PSD and PSCI, exploring their neural mechanisms, and evaluating treatment effects, as well as advantages, disadvantages and future development prospects of fNIRS in clinical application, so as to provide some references for research on rehabilitation of affective disorders and cognitive disorders in stroke patients.

    功能性近红外光谱技术脑卒中脑卒中后抑郁脑卒中后认知障碍

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    不宁腿综合征发病相关的风险因素研究进展

    王宝艳吴杰李端阳张瑞林...
    208-216页
    查看更多>>摘要：不宁腿综合征（RLS）是常见的感觉运动障碍性疾病，虽然不会对生命造成威胁，但严重影响患者的生活质量。RLS的发病机制目前尚不明确，其发病与多种风险因素相关，包括遗传因素和非遗传因素。遗传因素涉及骨髓嗜病毒整合位点1（MEIS1）、BTB结构蛋白9（BTBD9）、增殖蛋白激酶5（MAP2K5）、酪氨酸磷酸酶D（PTPRD）等20余种风险基因，非遗传因素包括地域、年龄、性别、肥胖、内科相关疾病、神经精神疾病及药物等。本文围绕RLS发病风险因素及其相关机制的研究进展进行综述，以期为全面了解RLS发病机制、促进其早期预防及有效治疗提供参考。 Restless legs syndrome (RLS) is a common sensorimotor disorder. Although it does not pose a threat to life, it seriously affects the quality of life of patients. RLS pathogenesis is still unclear, and its incidence is associated with a variety of risk factors, including genetic factors and non-genetic factors. Genetic factors involve more than 20 risk genes, such as meis homeobox 1 (MEIS1), BTB domain containing 9 (BTBD9), mitogen-activated protein kinase kinase 5 (MAP2K5), and protein tyrosine phosphatase receptor type Db (PTPRD). Non-genetic factors include regional age, gender, obesity, medical related diseases, neuropsychiatric diseases and drugs. This paper reviews the recent advance in risk factors and related pathogenesis of RLS to provide references for early prevention and treatment of the disease.

    不宁腿综合征风险因素遗传因素非遗传因素发病机制

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