查看更多>>摘要：A facile Bronsted acid-promoted three-component reaction of 2-methoxythiophene, sulfinates and water at room temperature has been discovered. Under the mild conditions, a series of gamma-mercapto-beta-sulfonyl esters were obtained in moderate to good yields. The control experiments support the reaction mechanism involves in three processes: 1,5-H shift, Michael addition and ring opening in water. (C) 2022 Elsevier Ltd. All rights reserved.
查看更多>>摘要：A novel, simple, green, one pot and practical synthetic method is described for the preparation of phthalimide derivatives through a condensation reaction between of 2-formylbenzoic acid and aniline in the presence of Et3N as base and S-8 (Octasulfur) as oxidant in solvent free condition. This one-pot protocol provides these valuable desired compounds under mild conditions with excellent efficiency by using simple available starting materials. (C) 2022 Elsevier Ltd. All rights reserved.
查看更多>>摘要：An aminophenyl-functionalized diketopyrrolopyrrole (DPP) was designed and synthesized to react with acrolein. The cyclization reaction between acrolein and the aminophenyl group resulted in an increase in fluorescence at 612 nm in the emission spectrum, along with an 18 nm blue-shift from 630 to 612 nm. This phenomenon occurred because the formation of a quinolyl group led to the disturbance of photo-induced electron transfer from the electron-rich amine group to the electron-poor DPP core. (C) 2022 Elsevier Ltd. All rights reserved.
查看更多>>摘要：The synthetically useful aldehyde 2E,4E-5-bromo-2,4-pentadienal was subjected to the enantioselective Trost alkynylation protocol, yielding highly functionalized propargylic secondary alcohols in an enantioselective manner. In most cases, the isolated yields and enantiomeric excess of the products were modest to high, but several products were formed in both high yields and enantiomeric excess. (C) 2022 The Author(s). Published by Elsevier Ltd.
查看更多>>摘要：The [(P+B-P+)CuCl3-](2) complex (P+B-P+ = phosphonium-borate-phosphonium) featuring the dication-monoanion-type counterion was synthesized. The resulting cationic copper catalyst enhanced the Mukaiyama-Aldol reaction of ketene silyl acetals and ketones for the formation of protected tertiary alcohols. (C) 2022 Elsevier Ltd. All rights reserved.
查看更多>>摘要：In this work, the Pd@MOF-808 composite was prepared to effectively catalyze the Sonogashira and Heck reactions without the presence of organic phosphine ligands. The results showed that the developed catalyst provided an environment-friendly reaction condition for these two reactions with the existence of a variety of functional groups and substrates. In addition, the Pd@MOF-808 catalyst could be easily recovered and reused for up to 5 times with less deterioration of catalytic performance. (C) 2022 Elsevier Ltd. All rights reserved.
查看更多>>摘要：Talarophilone (1), a novel ring-opened azaphilone, along with two known analogues were obtained from the culture of the Gastrodia elata-derived endophytic fungus Talaromyces sp. YUD18002. The structure of the new compound was elucidated using spectroscopic methods and its absolute configuration was confirmed by a single-crystal X-ray diffraction analysis and electronic circular dichroism (ECD) analysis aided by TDDFT-ECD calculations. Talarophilone represented the first ring-opened azaphilone featuring ester group at C-6' functionality. A putative biosynthetic pathways for compounds 1-3 were proposed. The in vitro cytotoxic activities of the new compound were also investigated. 2022 Elsevier Ltd. All rights reserved. (C) 2022 Elsevier Ltd. All rights reserved.
查看更多>>摘要：The Groebke-Blackburn-Bienayme' Reaction (GBBR) is a well-established multi-component method to form imidazoles using cyclic amidines. In order to expand the scope of this reaction, we have explored the GBBR with acyclic amidines. We found that the acyclic amidine, benzamidine performed similarly to cyclic amidines with the electronics of the aldehyde having a significant influence on reaction yield. Other acyclic amidines including guanidine were less successful however the guanidine derivative, acetylguanidine showed promise. These findings suggest that acyclic amidines have the potential to be used to develop new imidazoles which can be further functionalized. (C) 2022 Elsevier Ltd. All rights reserved.
查看更多>>摘要：Agitating a mixture of N-(diphenylmethyl)arylaldimine,(BuOK)-Bu-t and catalytic CuCl2 in THF under O-2 atmosphere at 75 degrees C for several hours produces corresponding vicinal diimine. This transformation takes place via a copper-catalyzed oxidative homo-coupling of the in situ generated azaallyl anion, in which molecular oxygen serves as the effective terminal oxidant. 1,2-diarylethane-1,2-diamine dihydrochloride is obtained upon hydrolysis with hydrochloric acid. (C) 2022 Elsevier Ltd. All rights reserved.
查看更多>>摘要：A practical protocol for the stereodivergent synthesis of 2-alkylidene-1,3-N,X-heterocycles (X = O, S, NR) from the reactions of alpha-CF3 carbonyls and bis-nucleophiles has been developed under metal-free and ambient conditions. The reaction proceeds via the tandem defluorination of alpha-CF3 carbonyls followed by sequential nucleophilic substitution with two heteroatoms of bis-nucleophiles in a stereodivergent manner. (C) 2022 Elsevier Ltd. All rights reserved.
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