查看更多>>摘要：? 2021 Phytochemical Society of EuropeAustalides, a series of natural meroterpenoids, were mainly isolated from marine-derived fungal genera Aspergillus and Penicillium. To date, a total of 38 austalides have been reported, which are divided into five subclasses including 5/6/6/6 tetracyclic, 5/6/6/6/6 pentacyclic, 5/6/6/6/7 pentacyclic, 5/6/6/6/6/5 hexacyclic, and 5/6/6/6/5/6/5 heptacyclic types. Biogenetically, austalides are derived from 6-[(2E,6E) farnesyl]-5,7-dihydroxy-4-methylphthalide, and have been found to possess diversified bioactivities such as antitumor, anti-inflammatory, antimicrobial, antiviral, antifouling, promoter enhancement, as well as α-glucosidase, AP-1 transcription factor, endo-1,3-β-D-glucanase and osteoclast di?;erentiation inhibitory effects. Their unusual molecular frameworks and diverse biological activities have also attracted great interest of synthetic scientists to synthesize them. This review describes the research progress on the chemical structures, bioactivities and synthesis of austalides since 1981, and aim to provide a scientific basis for the discovery and utilization of austalides.
NSTL
Elsevier