查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo new compounds named 4-(4-hydroxybenzyl)-isofraxidin (1) and 1''-methoxyl-bavacoumestan B (2), along with five known compounds (3–7) were isolated from the EtOAc-soluble extract of Abrus cantoniensis. Their structures were elucidated with spectroscopic and physico-chemical analyses. All isolates were evaluated for their cytotoxic activities against four cancer cell lines including HepG2, SMMC-7721, A549 and MCF-7. Among them, compounds 1 and 5 exhibited significant cytotoxic activity on the above four cell lines. In particular, 1 showed the potent cytotoxic activity on HepG2 and SMMC-7721 cells with IC50 values of 4.31 ± 0.5 and 3.24 ± 0.9 μM, respectively.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeThree new (psganpenes A-C), one known eremophilane sesquiterpene and one newrelated derivative (psganpene D) were isolated from the culture of endophytic fungus Nemania sp. HDF-Br-5, which derived from Pseudotsuga gaussenii Flous, anendangered conifer endemic to China. Their structures were deduced by extensive spectroscopic methods. All isolates were screened for cytotoxicity and antibacterial activity. Psganpene D showed promising cytotoxicity against KB, HCT116 and Hela cell strains, with IC50 values in the range of 15.1–32.3 μM.
查看更多>>摘要：? 2022Dactylicapnos torulosa (D. torulosa) has been traditionally used as a therapeutic remedy. Here, a combined strategy using both phytochemical and biological approaches was conducted to discern the effective components of D. torulosa. Three new alkaloids, namely, (1–3), Torulosine A, 1-Methoxypseudoprotopine and 1,14-Dimethoxyprechilenine together with 33 (4–36) known compounds were isolated. The structures of the new compounds were fully established by extensive analysis of HR-ESI-MS NMR and CD spectroscopic data. These compounds were then screened using zebrafish bioassay methods for antithrombotic activities. Compounds 5 and 7 had the best antithrombotic effect with prevention rates of 100% at 50 μM, and Compounds 8, 4, 9 and 11 at 50 μM had prevention rates of 81.3%, 79.4%, 84.4% and 79.3%, respectively. The antithrombotic effect of compounds may be related to their inhibitory effect on platelet aggregation. The present study contributes to the diverse chemical and bioactivity data of the Dactylicapnos genus.
查看更多>>摘要：? 2022Two formerly undescribed labdane-type diterpenoids, scoparicols C (1) and D (2), one previously unreported scopadulane-type diterpenoid 1β-hydroxydulcinodal-13-one (3), along with six known biogenetically related analogs (4?9) were separated from the aerial parts of a traditional ethnological herb, Scoparia dulcis. Spectroscopic techniques including MS NMR and ECD were employed to characterize the structures of these molecules. While the oxidation at C-1 in 3 was reported for scopadulane-type diterpenoids for the first time, compound 7 was first obtained as a natural product in the present work. The cytotoxicity of all the isolates against four tumor cell lines (MCF-7, MDA-MB231, Hela and A549) were tested, with selective compounds showing activity in the IC50 range of 4.31–28.6 μM.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeThree undescribed lanostane triterpenoids, ganoellipsic acids A–C (1–3), together with seven known Ganoderma lanostanoids (4–10), were isolated from artificially cultivated fruiting bodies of Ganoderma ellipsoideum, strain BCC 16634. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The C-25 absolute configuration of 1 was determined to be 25S using the phenylglycine methyl ester (PGME) method.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeTenvermectins (TVMs) belongs to the 16-membered macrolactone family antibiotics with attractive insecticidal properties. In order to discover more potent TVM derivatives, microbial transformation of TVM-A and TVM-B by Penicilium griseofulvum CICC 40293 and Bacillus subtilis ATCC 6633 were investigated and offered us six new metabolites (1-5, 7) with regioselectivity, especially rare glycosuccinylated products, in addition to two known compounds (6, 8). Their chemical structures were well characterized via HR-ESI-MS and 1D/2D NMR spectra. All these metabolites exhibited good acaricidal and nematicidal activities against Tetranychus cinnabarinus and Bursaphelenchus xylophilus. These results indicated that the metabolites 1-8 can serve as potential leads for future development of new insecticides.
查看更多>>摘要：? 2022Phytochemical investigation of the aerial part of Hypericum japonicum afforded two new xanthones (1-2), together with twelve known compounds (3-14). Their structures with absolute configurations were elucidated by analysis of MS NMR and their experimental and calculated electronic circular dichroism spectra. All of the isolated compounds were tested for their lipid-lowering activities. Compounds 10, 11, 13 exhibited potent lipid-lowering activities (with LDL-Uptake rates 3.02, 2.68 and 1.99, respectively, compared with vehicle control, which was designated as 1.00) and compounds 2-5 showed moderate activities (with LDL-Uptake rates 1.46, 1.41, 1.31 and 1.51, respectively).
查看更多>>摘要：? 2022 Phytochemical Society of EuropeAdenocarcinomas comprise a significant class of cancers that occur in several organs (e.g., lung, pancreas, breast, colon, and endometrium). These highly lethal tumor types are predominantly invasive with metastatic tendency. As a pharmacological option for the treatment of adenocarcinomas, curcumin has been widely used in combination with various therapeutic modalities. However, poor stability and low bioavailability of the curcumin has restricted its application in clinic. Therefore, nanoparticle-based curcumin was produced to fortify the pharmacokinetics of curcumin. Enhanced cytotoxicity and bioavailability of curcumin have been obtained by synthesizing new curcumin analogs via chemical modification. This review article aimed to survey recent findings on the role of curcumin in the treatment of adenocarcinomas in several organs and described key players of underlying molecular pathways such as the anti-proliferative, anti-apoptosis, anti-metastasis, anti-inflammatory, and immunomodulatory mechanisms. We also described new approaches to producing curcumin-loaded nanoparticles and combinatorial regimens. A comprehensive literature search has been carried out on PubMed for obtaining the information related to the therapeutic activities of curcumin for adenocarcinomas therapy. The literature search resulted in many in vitro and some in vivo studies that evidenced the effectiveness of curcumin in modulating antitumor signaling pathways to treat adenocarcinomas. In addition, curcumin-loaded nanoplatforms can improve the efficacy against tumor cells. The present review provides a comprehensive view of the therapeutic aspects of curcumin as a treatment for multiple human adenocarcinomas, which warrants further investigation in clinical settings.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo new compounds lepidodromos A-B and (1-2) have been isolated from the methanol-soluble extract of the aerial parts of Lepidogrammitis drymoglossoides (Bak.) Ching (Family: Polypodiaceae) and their structures were determined by 1D, 2D NMR, and HR-ESI–MS. The comparisons of experimental and calculated CD curves were used to determine their absolute configurations. The antiproliferative test indicated that both compounds 1-2 displayed moderate biological activity against Hela cells with IC50 values of 17.8 and 20.4 μM, respectively.
查看更多>>摘要：? 2022 Phytochemical Society of EuropeTwo novel phenolic compounds, prunellanate A (1) and prunellanate B (2), together with a diterpenoid compound, prunelladiterpenol A (3), were successfully isolated from the fruit spikes of Prunella vulgaris L. (Figure 1). Their structures were determined after extensive spectroscopic analyses including IR NMR, HR-ESI-MS empirical electronic circular dichroism (ECD), and X-ray diffraction. The biological activities of these new compounds on NO production in LPS (Lipopolysaccharide)-simulated RAW264.7 cells were evaluated. Compounds 1 and 3 showed significant anti-inflammatory activities revealing IC50 values of 6.77 and 8.61 μM, respectively (aminoguanidine as positive control, IC50 20.33 ± 1.08 μM).
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